1 results match your criteria: "Port Said University Port Said 42526 Egypt aliabuelmaaty8@gmail.com.[Affiliation]"
Synthesis and biological research of new imidazolone-sulphonamide-pyrimidine hybrids as potential EGFR-TK inhibitors and apoptosis-inducing agents.
RSC Adv
June 2024
Zoology Department, Faculty of Science, Port Said University Port Said 42526 Egypt
Article Synopsis
- New effective antitumor agents targeting the EGFR are necessary due to their significance in cancer treatment, leading to the creation of imidazolone-sulphonamide-pyrimidine hybrids as analogs to existing EGFR inhibitors.
- Among the synthesized compounds, 4-(Furan-2-ylmethylene)imidazolone-sulphonamide-pyrimidine 6b displayed the strongest cytotoxicity against breast cancer MCF-7 cells, with an IC value of 1.05 μM, outperforming the standard treatment doxorubicin.
- The studies indicated that compound 6b not only inhibits EGFR kinase but also causes MCF-7 cells to arrest at the G1 phase