693 results match your criteria: "Poroma"

Eccrine poroma localized in the second toe.

Radiol Case Rep

November 2022

Department of Surgery Salah Aziez Institute, University of Sfax, Tunisia.

Eccrine poroma is a rare adult benign adnexal tumor that originates in the excretory pore of the sweat gland. It is a small reddish lesion, protuberant, fleshy, and well-defined. It is located preferably in the palms of the hands and the soles of the feet [1].

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The role of reflectance confocal microscopy in the diagnosis of eccrine poroma: A retrospective case-control study.

Exp Dermatol

November 2022

Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Eccrine poroma (EP) is a rare benign adnexal tumor that may mimic benign or malignant tumors and differential diagnosis may be difficult under clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) examination may add important information to diagnosis and subsequent management of solitary lesions for which dermoscopy can be challenging. The aim of the present study was to investigate features of EP at RCM in order to detect the characteristics that might aid in the differential diagnosis of EP versus other solitary lesions (benign or malignant).

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Intraabdominal dissemination of porocarcinoma; A case report.

Int J Surg Case Rep

September 2022

Department of General Surgery, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; Department of General Surgery, Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Introduction: Porocarcinoma is a rare malignancy of dermal sweat glands commonly diagnosed in the seventh decade of life. It frequently evolves from a de novo benign poroma. These tumors present as a mass/nodule, ulcer, papule, or wart.

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Background: Poroma is a benign, exclusively cutaneous, adnexal tumor with a predilection for palmoplantar skin.

Objective: To analyze the clinical characteristics of poroma in our population.

Material And Methods: Retrospective study of patients diagnosed with poroma between 2002 and 2021.

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Pigmented eccrine poroma in an atypical location.

An Bras Dermatol

August 2022

Department of Dermatology, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

Eccrine poroma is the term that includes benign neoplasms of the terminal duct of the eccrine sweat glands, which may clinically and dermoscopically resemble other melanoma and non-melanoma skin tumors. They are often located on the extremities (especially palms and soles), presenting as normochromic or erythematous papules and nodules, measuring up to 2 cm. Pigmented variants are uncommon, accounting for less than 20% of cases.

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Background: Poromas, and their malignant counterparts, porocarcinomas, harbor recurrent translocations involving YAP1-MAML2, YAP1-NUTM1, and infrequently WWTR1-NUTM1; YAP1-NUTM1 being the most common in porocarcinomas. NUT immunohistochemistry (IHC) can be used to identify NUTM1-translocated tumors. This study sought to investigate potential novel NUTM1-fusion partners among NUT IHC-positive poromas and porocarcinomas.

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Dermatoscopic Features of a Metastatic Eccrine Porocarcinoma Arising on Lymphedema.

Dermatol Pract Concept

May 2022

Second Department of Dermatology-Venereology, Attikon General University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

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Syringocystadenoma Papilliferum and Eccrine Poroma Arising in Verrucous Epidermal Nevus: A Case Report and Multidimensional Skin Imaging Evaluation.

Dermatol Pract Concept

May 2022

Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China.

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Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.

J Eur Acad Dermatol Venereol

September 2022

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Article Synopsis
  • Cutaneous adnexal tumours (ATs) are a diverse group of benign and malignant growths derived from skin glands, often resembling other skin tumors, which can complicate diagnosis.
  • This study systematically reviewed literature to outline the clinical and dermoscopic characteristics of ATs, using databases like PubMed and Cochrane, ultimately analyzing 206 articles that detailed 372 AT cases.
  • Findings revealed that the majority of ATs were apocrine-eccrine in nature, primarily benign, and emphasized the need to differentiate ATs from more common skin tumors like basal cell carcinoma and squamous cell carcinoma.
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Head and Neck Porocarcinoma: SEER Analysis of Epidemiology and Survival.

J Clin Med

April 2022

Department of Plastic, Reconstructive and Aesthetic Surgery, Geneva University Hospitals, University of Geneva, 1205 Geneva, Switzerland.

Unlabelled: Porocarcinoma is a rare malignant adnexal tumor. Little is known about the location of the disease in the head and neck. Our aim is to offer the largest analysis of demographic, pathological, and treatment patterns of head and neck porocarcinoma in comparison with other locations of the neoplasm from an epidemiologically representative cohort.

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Porocarcinoma is a rare type of skin cancer that develops from the intraepidermal ductal part of eccrine sweat glands. It can arise de novo or from poroma ground with high potential for locoregional metastatic spread, morbidity, and mortality. It mostly occurs in elderly patients.

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Originally described in a rare subset of poorly differentiated squamous cell carcinomas termed NUT carcinomas, rearrangements are now known to characterize a wide spectrum of neoplasms including sarcomas, poromas/porocarcinomas, unclassified adnexal carcinomas and pediatric acute lymphoblastic leukemia. The advent of next-generation sequencing (NGS) has led to the identification of a multitude of novel fusion partners in addition to , which was initially reported in the majority of NUT carcinomas. -rearranged sarcomas usually harbor fusions with the MAD gene family (, , ) and present as spindle cell proliferations in diverse locations in patients of all ages.

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Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant transformation. However, the impact of chronic light exposure on the microenvironment of EPCs and EPs has not been investigated yet.

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Eccrine porocarcinoma is a rare skin adnexal malignant neoplasm that may arise from a pre-existing benign eccrine poroma or without a predisposing factor. It is a highly invasive neoplasm and has a strong metastatic potential. The most frequently affected organs are the lymph nodes and rarely solid organs such as the liver, lungs and breast.

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Poromas or poroid tumors are a group of rare, benign cutaneous neoplasms derived from the terminal eccrine or apocrine sweat gland duct. There are four poroma variants with overlapping features: dermal duct tumor (DDT), eccrine poroma, hidroacanthoma simplex, and poroid hidradenoma, of which DDT is the least common. Clinically, the variants have a nonspecific appearance and present as solitary dome-shaped papules, plaques, or nodules.

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Fusion-positive skin/adnexal carcinomas.

Genes Chromosomes Cancer

May 2022

Pathologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany.

Gene fusions have been increasingly identified as central events driving oncogenesis in a variety of benign and malignant neoplasms of different histogenesis originating in diverse organs. While some fusion-driven neoplasms may occur at any body site, certain genotypes and their associated phenotypic entities cluster to specific body site/organ, albeit with variable frequencies among anatomic locations. In the last two decades, several skin adnexal entities driven by specific fusions have been described; some of them represent new entities (eg, secretory carcinoma harboring NTRK fusions), while others are old established entities with newly discovered underlying gene fusions (eg, poroid neoplasms harboring NUTM1, YAP1, and WWTR1 fusions).

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Background: Cysts of the skin are observed frequently and their diagnoses are generally straightforward. However, atypical cystic lesions for which differentiation is indistinct have been noted.

Methods: We examined five cases of trichilemmal cyst with proteinaceous material (TCPM), which required differentiation from sweat duct/gland tumors.

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Article Synopsis
  • Cutaneous sweat gland tumors are rare neoplasms related to sweat glands, making their diagnosis complex due to diverse features and complicated terminology.
  • Recent research has identified various genetic alterations, particularly gene fusions, that aid in diagnosing these tumors and show connections to similar tumors in other glands.
  • The review discusses the latest immunohistochemical and molecular markers for diagnosing multiple types of sweat gland tumors, along with tumors lacking known molecular changes and future research possibilities.
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Combined Poroma and Verruca Plantaris.

Am J Dermatopathol

May 2022

Departments of Dermatology and Pathology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.

A 76-year-old female patient presented with a peculiar new exophytic-appearing, flesh-colored skin lesion on her left hallux. Owing to its atypical appearance, the neoplasm was biopsied. Histologic sections demonstrated numerous thickened, anastomosing cord-like structures composed of bland appearing adnexal keratinocytes attached to the epidermis and extending into the superficial dermis.

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Eccrine porocarcinomas (EPCs) are rare tumours, albeit the most common malignant adnexal tumours of the skin. They can present with very heterogeneous clinical and dermoscopic features, rendering diagnosis limited to histopathological examination alone. We share 2 cases of EPCs, one of which arose in a patient with a prior diagnosis of cutaneous squamous cell carcinoma (SCC) and another whose EPC was likely a malignant transformation of an existing poroma.

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Eccrine porocarcinoma (EPC) is a rare malignancy of the sweat glands. Currently, there is no standard algorithm for its presentations, diagnosis, and management. However, immunotherapy is an emerging option that may be crucial to the treatment of EPC.

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