693 results match your criteria: "Poroma"
A Rare Case of Pigmented Eccrine Poroma on the Trunk Mimicking Malignant Melanoma.
Clin Case Rep
December 2024
Department of Dermatology Razi Hospital, Tehran University of Medical Sciences (TUMS) Tehran Iran.
Representative clinical images in this study can increase awareness regarding the clinical similarity between this benign adnexal tumor and malignant melanoma and highlight the importance of pathological examination.
View Article and Find Full Text PDFEccrine poroma versus eccrine porocarcinoma: a comparative study of clinicopathological features.
An Bras Dermatol
December 2024
Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm, commonly arising from its benign counterpart, eccrine poroma (EP), but potential unrevealed clinicopathological differences between them are not well understood.
Objectives: This study aimed to identify clinicopathological features of EP and EPC and describe the factors that may be associated with the malignant transformation of EP by comparing the two groups.
Methods: A total of 37 cases of EP and 22 cases of EPC diagnosed between January 2017 and June 2023 were retrospectively reviewed, and the clinical and histopathological characteristics were compared using statistical methods.
Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases.
Histopathology
November 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France.
Article Synopsis
Exploring the driver events of eccrine poromas and porocarcinomas: A retrospective, cross-institutional study of 54 cases.
Br J Dermatol
November 2024
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
A Pedunculated Eccrine Poroma Presented as a Skin Tag on the Right Thigh of a Female Individual: A Case Report.
Cureus
October 2024
Department of Medicine, Broomfield Hospital, Mid and South Essex National Health Service (NHS) Foundation Trust, Essex, GBR.
Poroma is a relatively rare benign adnexal neoplastic lesion that usually affects elderly patients in the extremities, with an unclear pathogenesis. It is notable for having a variety of morphological appearances that make diagnosis challenging, particularly when observed on an uncommon anatomical site. Here, we present a case of a woman in her mid-50s who presented with a skin pedunculated lesion over the right thigh.
View Article and Find Full Text PDFSyringocystadenoma Papilliferum-Like Features in Poroma: An Unusual Morphologic Pattern of Poroma or True Synchronous Occurrence of 2 Distinct Neoplasms?
Am J Dermatopathol
December 2024
Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX; and.
Article Synopsis
- Poromas are benign skin tumors originating from sweat glands, often appearing as pink or red bumps primarily on hairless areas like palms and soles.
- A 70-year-old woman had a poroma on her abdomen that showed some histological features similar to another neoplasm, syringocystadenoma papilliferum (SCAP), but lacked certain defining characteristics of SCAP.
- This case, showing rare SCAP-like features within a poroma, emphasizes the need for careful diagnosis as it may simply reflect a variation of poromas, rather than representing two different tumors.
Eccrine Poroma of the Palm: A Case Report and Literature Review.
Cureus
September 2024
Orthopaedic Surgery, Kandang Kerbau (KK) Women's and Children's Hospital, Singapore, SGP.
Eccrine poroma is a non-cancerous tumor that arises from the intraepidermal portion of the eccrine sweat glands. It usually appears as a solitary lesion on an extremity, commonly on the foot or sole, and is often subject to delayed or inaccurate diagnosis in clinical settings. This article describes a rare case of eccrine poroma located on the palm.
View Article and Find Full Text PDFPoroid Hidradenoma: A Rare Finger Lesion.
Cureus
September 2024
Surgery, Harlem Hospital Center, New York, USA.
Article Synopsis
- Poroid hidradenomas are rare tumors that develop from eccrine sweat glands and typically present as nodules made up of cuticular and poroid cells.
- They are classified under poroid neoplasms, which also includes other similar tumors like hidroacanthoma simplex and eccrine poroma, and their diagnosis can be complicated due to similarities with other tumors.
- A case study of a 56-year-old woman with a nodular lesion on her finger confirmed a poroid hidradenoma through histopathological analysis, emphasizing the necessity for careful clinical evaluation and diagnosis for these uncommon dermatological issues.
Clinical Differential Diagnosis of Poroma and Poroma Mimicker: Retrospective, Multi-Center Study in Korea.
Ann Dermatol
October 2024
Department of Dermatology, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea.
Poroid Neoplasms: A Clinicopathological Study of 13 Cases.
Clin Pathol
September 2024
Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger.
Article Synopsis
- Poroid neoplasms (PN) are diverse tumors that originate from sweat glands, and their classification and identifying features can be difficult.
- A study conducted at the Niamey National Hospital from February 2020 to February 2024 found 13 cases of benign poroid neoplasms, mostly classic poromas, with a majority being misdiagnosed as malignant before surgery.
- The results indicate that these tumors often have apocrine ductal features and tend to occur in younger patients and non-palmoplantar areas, challenging traditional understandings of their characteristics.
YAP1::NR4A3 and YAP1::NCOA2 fusions in poroma: expanding the spectrum of molecular alterations in poroid tumors.
Virchows Arch
October 2024
CARADERM, French Network of Rare Cutaneous Cancer, Lille, France.
Apocrine poroma: a case with multiple lesions.
An Bras Dermatol
August 2024
Department of Dermatology, Hospital do Servidor Público Estadual, São Paulo, SP, Brazil.
Longstanding red, lobular nodule on an elderly male's thigh.
JAAD Case Rep
September 2024
Department of Dermatology, HCA Healthcare/Mercer University School of Medicine/Orange Park Hospital, Orange Park, Florida.
Eccrine poroma on the abdomen: A rare and atypical site.
Indian J Dermatol Venereol Leprol
August 2024
Department of Dermatology, Armed Forces Medical College, Pune, India.
Pedunculated eccrine poromas on non-acral sites.
BMJ Case Rep
August 2024
Dermatology, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Article Synopsis
- A woman in her 50s with breast cancer had some strange red growths on her neck and chest, but didn’t feel any pain from them.
- Doctors looked at the growths and thought they could be several different things, but after testing, they found out these growths were a rare type called eccrine poroma (EP).
- The woman had the growths removed using a special heat method, and a year later there was no sign of them coming back, showing how important it is to recognize EP when looking at similar-looking skin issues.
Eccrine Poroma of the Thigh: An Unusual Diagnosis.
Indian J Dermatol
June 2024
From the Department of Dermatology, Venereology and Leprosy, ESI-PGIMSR, New Delhi, India E-mail:
Immunohistochemistry for YAP1 N-terminus and C-terminus highlights metaplastic thymoma and high-grade thymic epithelial tumors by different staining patterns.
Virchows Arch
September 2024
Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
Article Synopsis
- Metaplastic thymoma (MT) is a rare type of thymic tumor that has a specific genetic fusion (YAP1::MAML2), similar to skin tumors called poromas.
- Recent studies revealed that MT lacks YAP1 C-terminus expression, but the expression of YAP1 N-terminus in MT and other thymic epithelial tumors (TETs) needed further exploration.
- In an examination of 14 MT cases, it was found that MT consistently showed a distinct staining pattern (YAP1[N]-positive, YAP1[C]-negative), while other TETs like type B3 thymoma exhibited variable staining, highlighting the need for more research on YAP1's role
Gene expression profiling in porocarcinoma indicates heterogeneous tumor development and substantiates poromas as precursor lesions.
J Dtsch Dermatol Ges
August 2024
Institute of Human Genetics, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Article Synopsis
- Malignant sweat gland tumors, particularly eccrine porocarcinoma (EP), are rare, with about 18% of benign eccrine poroma (EPO) cases progressing to EP, highlighting a need for more understanding of EP biology and mutations involved in this transformation.
- Transcriptome profiling of 23 EP and normal skin samples showed significant gene expression diversity and downregulation in EP, including specific genes that indicated a stepwise transition from normal skin to EPO to EP.
- The study suggests that EP has a complex molecular nature linked to tumor development, with potential involvement of the p53 and EGFR pathways, and calls for further research with larger sample sizes to validate these findings.
3D line-field confocal optical coherence tomography (LC-OCT) volume rendering of eccrine poroma.
Ital J Dermatol Venerol
October 2024
Unit of Dermatology, Department of Medical and Surgical Sciences, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy.
Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Hum Pathol
August 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, 32224, USA. Electronic address:
Article Synopsis
- - Sweat gland neoplasms are complex and rare skin tumors, making them a tricky area for doctors who study skin diseases (dermatopathology) and recent research has revealed different biological markers for several types of these tumors.
- - A study evaluated various sweat gland tumors in patients, using techniques like immunohistochemistry and RNA sequencing to help identify specific tumor types based on their unique features.
- - Findings showed that specific tests, such as p63 IHC, BRAF V600E IHC, and MAML2 FISH, can effectively assist in accurately diagnosing sweat gland tumors, offering valuable tools for pathologists when the usual assessment is unclear.
An Unusual Collision Tumor: Eccrine Poroma with Hidradenoma.
Indian J Dermatol
April 2024
From the Department of Dermatology, University Hospital Hassan II, URL CNRST N15, Human Pathology, Biomedicine and Environment Laboratory, Faculty of Medicine, Pharmacy and Dental of Fez. Sidi Mohamed Ben Abdellah University, Fez, Morocco E-mail:
Pigmented Eccrine Poroma on the Palm Mimicking Nodular Melanoma.
Dermatol Pract Concept
April 2024
Laboratory ID - Investigação em Dermatologia, Rio de Janeiro, Brazil.
Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
Histopathology
October 2024
CARADERM Network.
Article Synopsis
- Porocarcinoma is a malignant sweat gland tumor that can develop from benign poromas, and recent studies have identified specific genetic fusions like PAK1/2/3 in some cases.
- In a study of 12 porocarcinoma patients, most were older males with tumors located on various parts of the body, and some patients developed distant metastases.
- The research indicates that PAK1/2/3 fusions might drive cancer development in porocarcinomas that do not have YAP1 rearrangements, highlighting a potential target for treatment.
Eyelid Eccrine Poroma: A Case Report and Literature Review.
Cureus
May 2024
Ophthalmology, 12 de Octubre Hospital, Complutense University, Madrid, ESP.
Article Synopsis
- - Eccrine poroma is a rare, non-cancerous tumor that develops from sweat gland cells, mainly found on the palms and soles, with very few cases occurring on the face or eyelids.
- - Proper diagnosis through biopsy excision is essential to differentiate it from more serious tumors and prevent recurrence or progression to a malignant form called porocarcinoma.
- - The paper discusses a case of a 23-year-old male whose eyelid poroma was confirmed through biopsy after being misdiagnosed as molluscum contagiosum; there has been no recurrence after four years.
Nuclear pseudoinclusions as a clue for NUTM1-rearranged poroid tumours recognition.
Histopathology
August 2024
Department of Pathology, University Hospital of Tours, Tours, France.