1,415 results match your criteria: "Porokeratosis"
Porokeratosis ptychotropica: Case reports and literature review.
Ann Dermatol Venereol
December 2024
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China. Electronic address:
Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis that frequently mimics the clinical manifestations of various squamoproliferative disorders. It lacks a specific definition and adequate understanding. Diagnosis is difficult clinically and remains controversial in some published cases.
View Article and Find Full Text PDFDisseminated Superficial Actinic Porokeratosis Treated with Topical Simvastatin: Evaluation of Therapeutic Response with Dermoscopy.
Dermatol Pract Concept
October 2024
Dermatology Department, Hospital Provincial del Centenario de Rosario, Universidad Nacional de Rosario, Rosario, Argentina.
Scalp Porokeratosis: Dermoscopy Key Role in Unmasking a Hidden Condition.
Dermatol Pract Concept
October 2024
Ankara University, Medicine Faculty, Department of Dermatology, Ankara, Turkey.
Disseminated Superficial Non-actinic Porokeratosis: A Consequence of Post-traumatic Immunosuppression.
Cureus
November 2024
Oncologic Dermatology, Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Disseminated superficial porokeratosis (DSP) is a very uncommon dermatologic condition of unknown etiology, characterized by the clonal proliferation of atypical keratinocytes associated with aberrant keratinocyte differentiation. These lead to the development of the specific cornoid lamella that separates atypical from normal keratinocytes. DSP is most frequently encountered in immunosuppressed patients.
View Article and Find Full Text PDFTopical atorvastatin in the management of porokeratosis.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, PGIMER, Chandigarh, India.
Porokeratoses-A Rare Group of Dermatoses.
Medicina (Kaunas)
November 2024
Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35010 Rzeszow, Poland.
Porokeratoses represent a rare group of skin diseases characterized by abnormal keratinization. The condition may have a genetic background and can be triggered by environmental factors, including UV exposure and infections. Several clinical variants of porokeratosis can be distinguished, including Mibelli's porokeratosis, disseminated superficial actinic porokeratosis, superficial disseminated porokeratosis, and porokeratosis palmaris plantaris et disseminata.
View Article and Find Full Text PDFDisseminated superficial actinic porokeratosis in an elderly patient undergoing androgen deprivation therapy for advanced prostate cancer: exploring the potential association.
Dermatol Reports
September 2024
Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia; Dr. Cipto Mangunkusumo National Central General Hospital, Central Jakarta, Indonesia.
Porokeratosis is a group of chronic dermatoses characterized by the presence of cornoid lamellae. Disseminated superficial actinic porokeratosis (DSAP) is a common subtype, presenting as multiple small annular scaly lesions primarily in sun-exposed areas. While previous studies have documented DSAP in prostate cancer patients, the association with androgen deprivation therapy (ADT) has not been reported.
View Article and Find Full Text PDFSuccessful treatment of porokeratosis of Mibelli with pathogenesis-directed treatment of topical cholesterol-lovastatin.
Pediatr Dermatol
January 2024
Division of Pediatric Dermatology, Department of Pediatrics, University of Texas at Austin-Dell Medical School, Austin, Texas, USA.
Disseminated superficial actinic porokeratosis treated with tretinoin and calcipotriene.
JAAD Case Rep
November 2024
Department of Dermatology, Mayo Clinic Arizona, Scottsdale, Arizona.
Disseminated Superficial Actinic Porokeratosis: A Systematic Treatment Review.
Am J Clin Dermatol
November 2024
Sir Charles Gairdner Hospital, Nedlands, Western, Australia.
Background: Disseminated superficial actinic porokeratosis (DSAP) is a disorder of keratinization characterised by small, brown plaques with elevated keratotic rims, typically occurring on sun exposed areas. DSAP poses a risk for malignant transformation, emphasising the need for effective management strategies.
Objective: The aim of this study was to review the current reported management options for DSAP.
Lovastatin/cholesterol cream for the treatment of disseminated superficial actinic porokeratosis: a retrospective cohort study.
Int J Dermatol
October 2024
Department of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Penile and Scrotal Porokeratosis: A Single-Institution Experience.
Am J Dermatopathol
November 2024
Pathologists Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Article Synopsis
- The study investigates porokeratosis localized to the penis and scrotum, analyzing data from patients diagnosed between 2000 and 2022.
- Nine patients were included, with a median age of 51, and most had either penile or scrotal lesions, while one had extensive lesions affecting multiple areas.
- The findings indicate that clinical diagnosis can be challenging and highlights the importance of histopathological examination, as follow-ups showed no recurrence or malignant transformation in patients after biopsy removal.
Malignant Transformation in Porokeratosis Ptychotropica: A Systematic Review.
Acta Derm Venereol
October 2024
Department of Dermatology, National University Hospital, Singapore; Department of Medicine, National University of Singapore, Singapore.
Porokeratosis ptychotropica (PP) is a rare and unusual variant of porokeratosis. There is a dearth of information on the natural history, epidemiology, and optimal treatment options. This study aimed to characterize the worldwide distribution, epidemiology, clinical features, and treatments attempted for all reported cases of porokeratosis ptychotropica.
View Article and Find Full Text PDF[Translated article] RF- Relationship Between Porokeratosis and Skin Cancer.
Actas Dermosifiliogr
October 2024
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
Epidermal second-hit mutation in gene associated with linear porokeratosis.
Genes Dis
January 2025
Department of Dermatology, The Children's Hospital of Fudan University, Shanghai 201102, China.
Establishment of a Mouse Model for Porokeratosis Due to Mevalonate Diphosphate Decarboxylase Deficiency.
Skin Res Technol
September 2024
Department of Dermatology, Huashan Hospital, Shanghai Institute of Dermatology, Fudan University, Shanghai, China.
Introduction: Porokeratosis (PK) is an autoinflammatory keratinization disease (AIKD) characterized by circular or annular skin lesions with a hyperkeratotic rim, pathologically shown as the cornoid lamella. Four genes that cause PK are associated with the mevalonate (MV) pathway. In Chinese PK patients, mevalonate diphosphate decarboxylase (MVD) is the most common causative gene.
View Article and Find Full Text PDFWood's Light in Inflammatory And Autoimmune Dermatoses, Infections and Skin Cancer.
Actas Dermosifiliogr
September 2024
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España; Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Figures, Girona, España. Electronic address:
Article Synopsis
- Wood's light (WL) is an effective and inexpensive diagnostic tool, but its usage is not very common among dermatologists.
- In conditions like porokeratosis and various pigmentary disorders, WL shows specific fluorescence patterns that help in diagnosis, such as the "diamond necklace" sign for porokeratosis and bluish fluorescence for vitiligo.
- WL is also valuable in identifying skin infections with distinct fluorescence colors, and it aids in determining surgical margins for certain skin cancers, although results can vary.
A Clinico-Epidemiological Study on Porokeratosis.
Indian J Dermatol
August 2024
Department of Dermatology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.
Article Synopsis
- Porokeratosis (PK) is a chronic skin condition that presents as elevated, hyperkeratotic papules or plaques with a distinct raised border, linked to mutations in the mevalonate kinase enzyme.
- The study involved 11 patients, mostly females, with Mibelli's type being the most common form observed; diagnostic techniques included clinical evaluation, dermoscopy indicating a double-marginated border, and histopathological examination showing the cornoid lamella.
- Regular monitoring is essential for early detection of potential malignant changes in PK variants, emphasizing the importance of using dermoscopy for non-invasive diagnosis.
Porokeratosis of Mibelli Treated With Topical 2% Lovastatin/2% Cholesterol Ointment.
Cureus
July 2024
Department of Dermatology, Poznan University of Medical Sciences, Poznan, POL.
Article Synopsis
- Porokeratosis is a skin condition caused by disruptions in the isoprenoid pathway, leading to lesions made up of parakeratotic cells, often linked to genetic mutations impacting cholesterol synthesis.
- A case study of a 56-year-old male with Mibelli porokeratosis showed that traditional treatments were ineffective for a persistent finger lesion that didn’t heal for two years.
- The introduction of a topical ointment containing 2% lovastatin and 2% cholesterol resulted in significant improvement after nine months, suggesting promising potential for this treatment approach in managing porokeratosis.
Article Synopsis
- The case highlights the varied forms of porokeratosis (PK), showing a patient with different types of lesions on the skin, including facial and body areas.
- Factors such as UV exposure, infections, and a weakened immune system may lead to these diverse symptoms in one individual.
- Regular check-ups for possible cancerous changes are crucial, especially for older patients with a long history of PK and previous cancer conditions.
Porokeratosis ptychotropica without genitogluteal involvement - A rare presentation.
Indian J Dermatol Venereol Leprol
July 2024
Department of Dermatology, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.
MVD Variants Identified in a Rare Clinical Variant of Porokeratosis: A Case Report of Disseminated Superficial Porokeratosis (DSP) in a Chinese Patient.
Clin Cosmet Investig Dermatol
August 2024
Department of Dermatology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Article Synopsis
- Porokeratosis includes various hereditary and acquired skin disorders that involve the abnormal growth of skin cells known as keratinocytes.
- These disorders show different symptoms but share a common feature in their tissue structure called the cornoid lamella.
- This study reveals a unique case of disseminated superficial porokeratosis linked to mutations in the MVD gene, enhancing our knowledge of its genetic causes and potential treatment options.
Porokeratoses: an update on pathogenesis and treatment.
Int J Dermatol
August 2024
Department of Dermatology, Edouard Herriot Hospital, Lyon, France.
Article Synopsis
- Porokeratoses (PK) are rare skin conditions caused by issues with the mevalonate metabolic pathway, showing various subtypes that can manifest in the same individual or family.
- All PK subtypes exhibit a unique histopathological feature known as the cornoid lamella and are more severe in immunosuppressed patients, with their development linked to specific gene mutations requiring a secondary triggering event.
- Treatment options have historically included physical and topical methods with mixed success, but new therapies targeting the metabolic pathway, like statins combined with cholesterol, show greater effectiveness, despite some cases remaining difficult to manage.
Line-field confocal optical coherence tomography for the differential diagnosis of porokeratosis from clinical mimickers: a preliminary study.
Clin Exp Dermatol
November 2024
Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences, Siena University Hospital, Siena, Italy.
Article Synopsis
- Porokeratosis variants are uncommon skin conditions that can often be misdiagnosed, mimicking more common skin issues.
- A new technology called line-field confocal optical coherence tomography (LC-OCT) allows for non-invasive imaging of the skin, providing detailed views up to 500µm deep.
- In a study with 54 patients, LC-OCT showed high reliability in diagnosing porokeratosis variants and identified unique features not visible in traditional histology, suggesting it could help avoid unnecessary biopsies.
Genitogluteal porokeratosis with dystrophic calcinosis on the scrotum.
Ann Dermatol Venereol
September 2024
Department of Dermatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400011, China. Electronic address: