7 results match your criteria: "Population Health Sciences and MRC Integrative Epidemiology Unit at the University of Bristol[Affiliation]"

Article Synopsis
  • Antenatal corticosteroids (ACS) are commonly used to improve outcomes for preterm births, but there are significant gaps in knowledge regarding their safety, long-term effects, and appropriate timing and dosage.
  • The Consortium for the Study of Pregnancy Treatments (Co-OPT) was established to investigate the safety of medications during pregnancy, creating an extensive international birth cohort to analyze ACS exposure and its effects on pregnancy and neonatal outcomes.
  • The Co-OPT ACS cohort includes data on 2.28 million pregnancies from multiple countries, providing valuable information on ACS exposure rates and a follow-up for various health outcomes in children, aiming to address concerns about overtreatment and the efficacy of ACS usage.
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Background: Eating disorders are stigmatised. Little is known about whether stigma has decreased over time and which groups hold more stigmatising beliefs.

Aims: To explore whether stigma towards eating disorders has changed between 1998 and 2008 and whether it varies by sociodemographic characteristics.

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A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is explained by conventional cardiovascular risk factors (CVRFs) is not known. We examined the association between a history of SGA, LGA or preterm birth and cardiovascular disease among 23,284 parous women and quantified the contribution of individual CVRFs to the excess cardiovascular risk using an inverse odds weighting approach.

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Introduction: Preterm delivery (<37 weeks) predicts later cardiovascular disease risk in mothers, even among normotensive deliveries. However, development of subclinical cardiovascular risk before and after preterm delivery is not well understood. We sought to investigate differences in life course cardiovascular risk factor trajectories based on preterm delivery history.

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Aim: To evaluate whether history of pregnancy complications [pre-eclampsia, gestational hypertension, preterm delivery, or small for gestational age (SGA)] improves risk prediction for cardiovascular disease (CVD).

Methods And Results: This population-based, prospective cohort study linked data from the HUNT Study, Medical Birth Registry of Norway, validated hospital records, and Norwegian Cause of Death Registry. Using an established CVD risk prediction model (NORRISK 2), we predicted 10-year risk of CVD (non-fatal myocardial infarction, fatal coronary heart disease, and non-fatal or fatal stroke) based on established risk factors (age, systolic blood pressure, total and HDL-cholesterol, smoking, anti-hypertensives, and family history of myocardial infarction).

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We examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trøndelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline models, we estimated differences in nonfasting lipid levels from before to after first birth in parous women and between parous and nulliparous women.

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