940 results match your criteria: "Pontone); and Cleveland Clinic Lou Ruvo Center for Brain Health[Affiliation]"
Parkinsonism Relat Disord
January 2025
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address:
Background: Exercise confers motor benefits in Parkinson's disease (PD) and may even have disease modifying effects. While the impact of exercise on motor symptoms and quality of life is well-studied in PD, its relationship with cognitive performance warrants further attention.
Methods: In people with PD, self-reported exercise information was quantified using the Rapid Assessment of Physical Activity (RAPA).
Eur Radiol
January 2025
Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), di Cagliari-Polo di Monserrato s.s. 554 Monserrato (Cagliari), Cagliari, 09045, Italy.
Objective: The purpose of this study was to explore microvascular function impairment using first-pass cardiovascular magnetic resonance (CMR) in patients with Takotsubo syndrome (TS). Moreover, we explored myocardial microcirculation in patients with TS and related this to demographic data, cardiovascular risk factors, clinical parameters, cardiac biomarkers, and cardiac function.
Methods: This retrospective study performed CMR first-pass perfusion scans in 42 consecutive patients with TS (37 females, 70.
Eur Heart J Imaging Methods Pract
January 2025
Perioperative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, Via C. Parea 4, Milan 20138, Italy.
Stress computed tomography perfusion (CTP) delivers a comprehensive evaluation of both the anatomical and functional aspects in a single examination. It stands out as the only non-invasive technique capable of quantifying coronary stenosis and assessing its functional impact, offering a consolidated diagnostic and management approach for patients with confirmed or suspected coronary artery disease (CAD). This very practical review ('How to.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
January 2025
Department of Cardiology, University of Rennes, CHU Rennes, Inserm, LTSI - UMR 1099, Rennes, France.
Structural, architectural, contractile or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodeling has become a cornerstone diagnostic and prognostic marker. The structure and the function of LA and left atrial appendage (LAA) which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillation (AF), cardioembolism, heart failure and mitral valve diseases.
View Article and Find Full Text PDFJACC CardioOncol
December 2024
Cardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.
Cardiac masses encompass a diverse range of benign and malignant tumors as well as pseudotumors. Accurate histologic identification is essential for guiding appropriate treatment, yet the diagnostic process remains challenging. Although biopsy is traditionally the diagnostic gold standard, its invasive nature and associated risks limit its application.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
January 2025
Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Aim: Computed tomography (CT)-derived extracellular volume fraction (ECV) is a non-invasive method to quantify myocardial fibrosis. Evaluating CT-ECV during aortic valve replacement (AVR) planning CT in severe aortic stenosis (AS) may aid prognostic stratification. This meta-analysis evaluated the prognostic significance of CT-ECV in severe AS necessitating AVR.
View Article and Find Full Text PDFInt J Cardiol
December 2024
Cardiology Unit, Department of Interdisciplinary Medicine (DIM), University of Bari "Aldo Moro", University Hospital Consortium Polyclinic of Bari, Piazza G. Cesare 11, 70124 Bari, Italy.
Radiology
December 2024
From the Centro Cardiologico Monzino, IRCCS, Via C. Belgioioso 173, Milan, Italy (D.A., S.M., D.T., E.C., G.L., S. Galli, G.M., L.G., G.T., S.T., S. Gili, P.M., P.O., V.M., D.M., M.S., C.G., E.M., A.B., M.E.M., A.A., A F., G.P., A.L.B.); Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy (D.A.); IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy (E.C., G.M., L.G., V.M., D.M., M.S., E.G., P.P., E.M., A.L.B.); Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium (J.S., M.B., E.G., P.P., K.S., T.M., C.C.); Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan (K.S., T.M.); Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy (G.P.); and Department of Radiology, Azienda Ospedaliera di Padova, Padua, Italy (L.Z.).
Background The detection of in-stent restenosis (ISR) with coronary CT angiography (CCTA) is challenging, but CT perfusion (CTP) has demonstrated improved diagnostic accuracy over CCTA in patients with stents. However, there are limited data on the performance of dynamic CTP, which allows noninvasive adjudication of regional myocardial blood flow. Purpose To compare the diagnostic performance of regadenoson-stress dynamic CTP with that of CCTA, using fractional flow reserve (FFR) and the index of microvascular resistance (IMR) as reference standards for epicardial coronary circulation and coronary microcirculation, respectively.
View Article and Find Full Text PDFJ Clin Med
November 2024
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Polyclinic University Hospital, 70124 Bari, Italy.
Anderson-Fabry disease (AFD) remains a therapeutic challenge despite advances in early diagnosis and the availability of enzyme replacement therapies (ERTs). While early initiation of therapy can mitigate disease progression, resistance mechanisms-such as the development of anti-drug antibodies-limit the efficacy of current treatments, particularly in patients with severe genetic variants. Chaperone therapy provides a targeted option for a subset of patients, yet significant gaps remain in treating those with complete enzyme deficiency.
View Article and Find Full Text PDFEur Heart J Case Rep
October 2024
Centro Cardiologico Monzino IRCCS, Milan, Italy.
Background: Acute mitral regurgitation due to papillary muscle rupture is a severe complication of acute myocardial infarction. Transcatheter edge-to-edge repair is emerging as an effective alternative to surgical treatment, with encouraging outcomes. Leaflet adverse events are rare and are associated with relapse of significant mitral regurgitation.
View Article and Find Full Text PDFComput Methods Programs Biomed
February 2025
Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCSS, via Carlo Parea 4, Milan, 20138, Italy; Department of Biomedical, Surgical and Dental Sciences, Università degli studi di Milano, Via della Commenda 10, Milan, 20122, Italy.
Background And Objectives: Structural Valve Deterioration (SVD) is the main limiting factor to the long-term durability of the bioprosthetic valves used for Transcatheter Aortic Valve Implantation (TAVI), a minimally invasive technique for the treatment of severe aortic stenosis. The aim of this retrospective study is to perform patient-specific computational analyses of blood dynamics shortly after TAVI to identify hemodynamic indices that correlate with a premature onset of SVD which is detected at 5-10 years long-term follow-up exam after TAVI.
Methods: The study population comprises fourteen patients: seven cases with SVD at long-term follow-up were identified and seven cases without SVD were randomly extracted from the same cohort.
Int J Cardiol
January 2025
Centro Cardiologico Monzino IRCCS, Milan, Italy; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, University of Milan, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Electronic address:
Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.
Methods: Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively.
J Clin Med
October 2024
IRCCS Humanitas Research Hospital, Via Alessandro Manzoni, 56, Rozzano, 20089 Milano, Italy.
The growing awareness of tricuspid regurgitation (TR) and the fast-expanding array of devices aiming to percutaneously repair or replace the tricuspid valve have underscored the central role of multi-modality imaging in comprehensively assessing the anatomical and functional characteristics of TR. Accurate phenotyping of TR, the right heart, and pulmonary vasculature via echocardiography, computed tomography, and, occasionally, cardiovascular magnetic resonance and right heart catheterization is deemed crucial in choosing the most suitable treatment strategy for each patient and achieving procedural success. In the first part of the present review, key imaging factors for patient selection will be discussed.
View Article and Find Full Text PDFBiomedicines
October 2024
Head and Neck Oncology Unit, Istituto Nazionale Tumori di Napoli IRCCS "G. Pascale", 80131 Naples, Italy.
Checkpoint inhibitors (ICIs) have demonstrated substantial efficacy in the treatment of numerous solid tumors, including head and neck cancer. Their inclusion in the therapeutic paradigm in metastatic lines of treatment has certainly improved the outcomes of these patients. Starting from this assumption, numerous studies have been conducted on ICIs in other earlier disease settings, including studies conducted in patients in neoadjuvant settings.
View Article and Find Full Text PDFMov Disord
January 2025
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background: Motor and nonmotor fluctuations adversely impact the quality of life in Parkinson's disease (PD). Dysautonomia, a feature frequently associated with PD and a possible adverse effect of dopaminergic therapy, may be comorbid with fluctuations.
Objective: We sought to evaluate the effect of dysautonomia on motor and nonmotor fluctuations in PD.
Mov Disord
October 2024
Department of Neurology, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
Eur Heart J Case Rep
October 2024
Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, via Carlo Parea 4, 20138 Milan, Italy.
Background: Cardiac magnetic resonance (CMR) is gaining an important role in the setting of acute coronary syndromes: it gives prognostic information based on oedema and late gadolinium enhancement (LGE) extension in acute myocardial infarction, and has a diagnostic value in myocardial infarction with nonobstructive coronary arteries (MINOCA) thanks to its capability to distinguish, based on different LGE patterns, ischaemic and non-ischaemic myocardial injuries.
Case Summary: We describe a case of acute myocardial infarction involving a recurrent apical branch showing an atypical intramyocardial LGE pattern in the medium inferior septum.
Discussion: An intramyocardial LGE pattern might be determined by an ischaemic injury involving the interventricular septum.
Diagnostics (Basel)
October 2024
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Polyclinic University Hospital, 70124 Bari, Italy.
Cardiac amyloidosis (CA) is a cardiac storage disease caused by the progressive extracellular deposition of misfolded proteins in the myocardium. Despite the increasing interest in this pathology, it remains an underdiagnosed condition. Non-invasive diagnostic techniques play a central role in the suspicion and detection of CA, also thanks to the continuous scientific and technological advances in these tools.
View Article and Find Full Text PDFEur Heart J Imaging Methods Pract
January 2024
Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Brain
December 2024
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg 20251Germany.
Eur Heart J
November 2024
Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Charité Mitte, Charitéplatz 1, 10117 Berlin, Germany.
JACC Cardiovasc Imaging
December 2024
Division of Cardiovascular Medicine, University of Virginia Health System, Charlottesville, Virginia, USA. Electronic address:
J Neurol Neurosurg Psychiatry
September 2024
Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Psychiatric University Hospital, Zurich, Switzerland
Background And Objectives: Neuropsychiatric symptoms (NPS) are common in older people with cognitive impairment and Alzheimer's disease (AD). No biomarkers to detect the related pathology or predict the clinical evolution of NPS are available yet. This study aimed to identify plasma proteins that may serve as biomarkers for NPS and NPS-related clinical disease progression.
View Article and Find Full Text PDFJ Cardiol
September 2024
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Polyclinic University Hospital, Bari, Italy. Electronic address:
Background: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have revolutionized the therapeutic scenario of heart failure, demonstrating favorable effects on mortality and quality of life. Previous studies have yielded conflicting data regarding the effects on ventricular arrhythmias.
Methods: A prospective observational study was conducted to investigate the anti-arrhythmic properties of SGLT2 inhibitors evaluating the intra-patient difference in major adverse arrhythmic cardiac events (MAACE) over a six-month period in patients with chronic heart failure who were undergoing continuous monitoring using a cardiac implantable electronic device.