The Huntington's Disease Gene Discovery.

The gene for Huntington's disease (HD) was discovered in 1993, after an international collaborative initiative that led researchers to remote regions of South America. It was the most remarkable milestone, since George Huntington's initial description. Through the phenomenological discussions led by Jean-Martin Charcot and Willian Osler, and finally Americo Negrette's reports, which served as the inspiration for the Venezuela Project led by Nancy Wexler, the journey toward discovering the Huntington's disease (HD) gene was marked by substantial efforts.

"On Chorea": 150 Years of the Beginning of Hope.

"On Chorea" by George Huntington was published on April 13, 1872, in The Medical and Surgical Reporter of Philadelphia. Despite being a milestone in the recognition of the disease that later would bear his name, some myths and curiosities continue to surround the history of this publication and its author. In this History, the authors pay tribute to the 150th anniversary of the publication of this iconic article.

Endovascular treatment of P3 segment of posterior cerebral artery aneurysm with stent and coils.

Posterior cerebral artery (PCA) aneurysms are rare and usually arise from proximal portion of the artery. The distal location is even less frequent, and aneurysms in this location tend to be larger and dissecting. Although they can be treated by direct surgery, recently endovascular procedures have been preferred in some centers.

Dural Arteriovenous Fistula Associated with Dental Implant.

Background: Dural arteriovenous fistulas (DAVFs) are characterized by pathologic shunts between meningeal arteries and venous sinuses, without nidus. Although many lesions are considered idiopathic, there may be an association with inflammatory processes, including sinus thrombosis, venous hypertension, craniotomy, trauma, and infections.

Case Description: A 50-year-old woman with an infectious complication of a dental implant evolved with an occipital DAVF.

Cerebellar mutism after embolization of vermian arteriovenous malformation.

Background: Cerebellar mutism is usually associated with posterior fossa tumor surgery.

Case Report: We report a case of a 17-year-old female, presented with headache and tremor after hemorrhage from a vermian arteriovenous malformation. She was successfully treated by embolization; however, on immediate postoperative, she developed persistent mutism.

Microscopic evaluation of the dentinal walls of extracted human teeth following electrochemical dissolution of fragmented nickel-titanium instruments.

Electrochemical dissolution is a method in which fluoridated solution in direct contact with the fractured instrument receives an electrical current that speeds up fragment dissolution. The aim of this study was to assess the integrity of dentinal walls during the electrochemical dissolution of fractured rotary endodontic instruments in extracted human teeth. Forty-five human mandibular incisors subjected to the electrochemical dissolution process using fluoride solution with low NaCl concentration (LC group: NaF 12 g/L + NaCl 1 g/L, pH = 5.

The distribution of cardiac diagnostic testing for acute coronary syndrome in the Brazilian healthcare system: A national geospatial evaluation of health access.

Background: Little is known about the utilization of cardiac diagnostic testing in Brazil and how such testing is related with local rates of acute coronary syndrome (ACS)-related mortality.

Methods And Results: Using data from DATASUS, the public national healthcare database, absolute counts of diagnostic tests performed were calculated for each of the 5570 municipalities and mapped. Spatial error regression and geographic weighted regression models were used to describe the geographic variation in the association between ACS mortality, income, and access to diagnostic testing.

Electrochemical dissolution of fractured nickel-titanium instruments in human extracted teeth.

Aim: To assess the effect of sodium chloride concentration in fluoridated solutions during the electrochemical dissolution of fractured rotary endodontic instruments.

Methodology: Two solutions were assessed (solution 1: NaF 12 g L  + NaCl 1 g L , pH = 5.0; and solution 2: NaF 12 g L  + NaCl 180 g L , pH = 5.

Endovascular Therapeutic Occlusion of the Posterior Cerebral Artery: An Option for Ruptured Giant Aneurysm in a Child.

The incidence of intracranial aneurysms in the pediatric population is low, and surgical clipping remains a good long-term treatment option. However, posterior circulation aneurysms are even more complex to manage in children than in adults. We report a case of a giant aneurysm of the posterior cerebral artery in a 10-year-old boy presenting with subarachnoid hemorrhage.