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Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association.

Patients And Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study.

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