Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea.

Introduction: Understanding the diverse pathogenetic pathways in obstructive sleep apnea (OSA) is crucial for improving outcomes. microRNA (miRNA) profiling is a promising strategy for elucidating these mechanisms.

Objective: To characterize the pathogenetic pathways linked to OSA through the integration of miRNA profiles, machine learning (ML) and bioinformatics.

Effect of occlusal appliances on the sleep of individuals with bruxism: A systematic review and meta-analyses.

Objective: This systematic review determined whether occlusal appliance use influences the sleep of individuals with sleep bruxism.

Material And Methods: Six databases and the gray literature were searched to identify randomized and non-randomized clinical trials comparing slow wave sleep and sleep quality of sleep bruxers before and after occlusal appliance use. The Risk of Bias was assessed using Cochrane tools and Meta-analyses were performed to compare data.

Prediction of severity of obstructive sleep apnea by awake impulse oscillometry.

Objective/background: Obstructive sleep apnea (OSA) is a common disease, which poses a significant health threat. Initial diagnostics with polygraphy or polysomnography are time consuming and expensive. Therefore, there is an unmet medical need for simplification, especially to exclude healthy patients from elaborate and unnecessary diagnostics.

Sleep spindle variation in patients with Parkinson's disease on first nights of sub-optimal deep brain stimulation.

Objective: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson's disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson's disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.

40 Hz Visual Stimulation During Sleep Evokes Neuronal Gamma Activity in NREM and REM Stages.

Study Objectives: Visual stimulation at 40 Hz is being tested as a non-invasive approach against dementias such as Alzheimer's disease. Applying it during sleep could increase convenience, duration, and efficacy of stimulation. Here, we tested the feasibility of 40 Hz visual stimulation during sleep in a proof-of-concept study.

Efficient Screening in Obstructive Sleep Apnea Using Sequential Machine Learning Models, Questionnaires, and Pulse Oximetry Signals: Mixed Methods Study.

Background: Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by frequent pauses or shallow breathing during sleep. Polysomnography, the gold standard for OSA assessment, is time consuming and labor intensive, thus limiting diagnostic efficiency.

Objective: This study aims to develop 2 sequential machine learning models to efficiently screen and differentiate OSA.

An Alternative In-Home Protocol to Diagnose and Treat Obstructive Sleep Apnea.

 Obstructive sleep apnea (OSA) is a major public health problem of pandemic proportions. In-laboratory OSA diagnosis and continuous positive airway pressure (CPAP) titration are insufficient, considering the number of patients affected. Finding alternative ways to diagnose and treat OSA is mandatory, especially in this era of the coronavirus disease 2019 (COVID-19) pandemic.

2024 Standardization of Polysomnography Reports - A Consensus of the Brazilian Sleep Association.

 The absence of standardized reporting for sleep medicine exams across different laboratories can lead to misinterpretation, diagnostic inconsistencies, and suboptimal treatment strategies. This document seeks to establish guidelines for the development of sleep study reports, covering recordings from studies of types 1 to 4, and represents the official position of Associação Brasileira do Sono (ABS; Brazilian Sleep Association) on the standardization of polysomnography (PSG) and cardiorespiratory polygraphies.  The recommendations for the items to be reported in PSG records were developed by means of a Delphi study, comprised of two voting rounds.

2024 Position Statement on the Use of Different Diagnostic Methods for Sleep Disorders in Adults - Brazilian Sleep Association.

 The current document represents the official position of Associação Brasileira do Sono (ABS; Brazilian Sleep Association) on the application of different sleep studies and provides specific recommendations for the use of different types of polysomnography (PSG) and respiratory polygraphy.  The present document was based on existing guidelines. The steering committee discussed its findings and developed recommendations and contraindications, which were refined in discussions with the advisory committee.

Sleep Apnea Events Recognition Based on Polysomnographic Recordings: A Large-Scale Multi-Channel Machine Learning approach.

The gold standard for detecting the presence of apneic events is a time and effort-consuming manual evaluation of type I polysomnographic recordings by experts, often not error-free. Such acquisition protocol requires dedicated facilities resulting in high costs and long waiting lists. The usage of artificial intelligence models assists the clinician's evaluation overcoming the aforementioned limitations and increasing healthcare quality.

Clinical study of two mandibular advancement devices in the treatment of Obstructive Sleep Apnea: a pilot randomized controlled trial.

Objective: A preliminary clinical evaluation of the efficacy, comfort, and adverse reactions of two mandibular advancement devices (MADs) in the treatment of Obstructive Sleep Apnea (OSA).

Methods: Forty patients with mild-to-severe OSA were recruited and randomly divided into two groups. They were treated with Shark-fin or Silensor MAD, respectively.

Is the Otolithic Function Affected in Patients with Obstructive Sleep Apnea Syndrome?

Background:  While cardiovascular and neurological diseases induced by obstructive sleep apnea syndrome (OSAS) hypoxia are well established, the association between neuro-otological diseases and OSAS is not entirely understood. Vestibular and audiological tests have been used to evaluate the degeneration of neurons in the brainstem caused by recurrent hypoxia.

Purpose:  Evaluation of the vestibular-evoked myogenic potential (VEMP) test findings applied to detect the possible influence on the vestibular reflex arc due to hypoxia in patients diagnosed with OSAS using Activity-Specific Balance Confidence (ABC) and Berg Balance Scale (BBS) scales determination of scores.

Assessing the impact of apnea duration on the relationship between obstructive sleep apnea and hearing loss.

Objectives: The relationship between obstructive sleep apnea (OSA) and hearing loss (HL) remains uncertain. This study aimed to investigate the relationship between OSA and HL, and to identify which factors play a key role.

Methods: A retrospective review was conducted of 90 subjects diagnosed with OSA.

The deficiencies of epworth sleepiness scale in the evaluation of excessive daytime sleepiness in obstructive sleep apnea and related factors.

Background: Epworth Sleepiness Scale(ESS) is widely used in the assessment of excessive daytime sleepiness (EDS) despite certain deficiencies. It was aimed to evaluate the factors associated with low ESS scores in subjects investigated for OSA.

Methods: In this cross sectional study, we recorded the ESS and Pittsburg sleep quality index (PSQI) scores of patients undergoing polysomnography in our sleep center between November 2022-January 2023.

The influence of transcranial alternating current stimulation on EEG spectral power during subsequent sleep: A randomized crossover study.

Objective: To evaluate the instant impact of transcranial alternating current stimulation (tACS) on sleep brain oscillations.

Methods: Thirty-six healthy subjects were randomly assigned to receive tACS and sham stimulation in a crossover design separated by a one-week washout period. After stimulation, a 2-h nap polysomnography (PSG) was performed to obtain Electroencephalogram (EEG) data and objective sleep variables, and self-reported subjective sleep parameters were collected at the end of the nap.

Screening moderate to severe obstructive sleep apnea with wearable device.

Background: Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder usually diagnosed through polysomnography (PSG). Moderate to severe OSA can significantly increase morbidity and mortality. Existing screening tools have limited accuracy.

Pediatric Obstructive Sleep Apnea: Diagnostic Challenges and Management Strategies.

Pediatric obstructive sleep apnea (OSA) is a prevalent yet often underdiagnosed condition affecting 1-5% of children globally, with higher prevalence in populations such as those with Down syndrome and obesity. Characterized by recurrent upper airway obstruction during sleep, OSA can lead to serious health consequences, including neurocognitive deficits, behavioral issues, and cardiovascular complications. The diagnosis is complicated by symptom overlap with conditions like Attention-Deficit/Hyperactivity Disorder (ADHD) while polysomnography (PSG) remains the gold standard for diagnosis, access to this test is limited in many regions.

Update on the aetiopathogenesis of obstructive sleep apnea: Role of inflammatory and immune mediated mechanisms.

Obstructive sleep apnea (OSA) is often a lifestyle disease associated with obesity, which is rapidly evolving as a major health concern with diverse multisystemic implications. To prevent and mitigate its adverse effects and reduce its burden on society, its aetiopathogeneses must be precisely understood. Numerous studies focusing on the range of diverse anatomic, functional, and lifestyle factors have already been carried out to determine the possible contributory roles of these factors in OSA.

U-Shaped Relationship Between MSpO Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.

SiCRNN: A Siamese Approach for Sleep Apnea Identification via Tracheal Microphone Signals.

Sleep apnea syndrome (SAS) affects about 3-7% of the global population, but is often undiagnosed. It involves pauses in breathing during sleep, for at least 10 s, due to partial or total airway blockage. The current gold standard for diagnosing SAS is polysomnography (PSG), an intrusive procedure that depends on subjective assessment by expert clinicians.

Deriving Accurate Nocturnal Heart Rate, rMSSD and Frequency HRV from the Oura Ring.

Cardiovascular diseases are a major cause of mortality worldwide. Long-term monitoring of nighttime heart rate (HR) and heart rate variability (HRV) may be useful in identifying latent cardiovascular risk. The Oura Ring has shown excellent correlation only with ECG-derived HR, but not HRV.

Sleep-Disordered Breathing in Patients with Chronic Heart Failure and Its Implications on Real-Time Hemodynamic Regulation, Baroreceptor Reflex Sensitivity, and Survival.

Impairment in autonomic activity is a prognostic marker in patients with heart failure (HF), and its involvement has been suggested in cardiovascular complications of obstructive sleep apnea syndrome (OSAS) and Cheyne-Stokes respiration (CSR). This prospective observational study aims to investigate the implications of sleep-disordered breathing (SDB) on hemodynamic regulation and autonomic activity in chronic HF patients. Chronic HF patients, providing confirmation of reduced ejection fraction (≤35%), underwent polysomnography, real-time hemodynamic, heart rate variability (HRV), and baroreceptor reflex sensitivity (BRS) assessments using the Task Force Monitor.

Sleep Characteristics Among Children with a Parental History of Alcohol Use Disorder.

Purpose Of Review: The purpose of the review was to examine findings on sleep characteristics among children with a parental history of alcohol use disorder (CPHAUDs) in different age groups. We identified unanswered questions and discussed directions for future research. We also discussed the implications of these current findings on alcohol prevention and intervention programs.

Impaired Attention in Children with Obstructive Sleep Apnea: A Preliminary Study of Behavior Combined with Neuroelectrophysiology.

Objective: To investigate how attention is affected in children with obstructive sleep apnea (OSA) using the attention network test (ANT) combined with event-related potential (ERP) and time-frequency analysis.

Methods: Eighty-seven children aged 6-11 years with symptoms of snoring or mouth breathing during sleep were recruited from the Sleep Center of Beijing Children's Hospital from May to July, 2023. All participants completed the Mini-mental State Examination and Attention Deficit Hyperactivity Disorder rating scale.

Survival benefit of CPAP therapy among dialysis patients with obstructive sleep apnea.

Background And Hypothesis: We observed lower risk of all-cause mortally among continuous positive airway pressure (CPAP) users compared to those non-users using a large polysomnography (PSG) registry. However, the effect of CPAP on mortality risk has not been examined in dialysis patents.

Methods: We studied 9841 patients with PSG performed from September 1990 to 2010 in Nakamura clinic, Okinawa.