329 results match your criteria: "Polymorphous Light Eruption"
Lichenoid paraneoplastic pemphigus in a patient presenting with follicular lymphoma: a review of the literature.
Arch Dermatol Res
November 2024
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1295 NW 14th St, Miami, FL, 33125, USA.
Article Synopsis
- Paraneoplastic pemphigus (PNP) is a rare autoimmune blistering disease linked to cancer, typically presenting with severe mouth sores and varied skin eruptions.
- The case study details a patient with follicular lymphoma (FL) who developed symptoms of PNP, prompting a review of current treatment options and understanding of the disease.
- Despite potential remission from related cancers, PNP has a low 5-year survival rate, highlighting the urgent need for more research and suggesting that T cell immunosuppressive therapy might help FL patients with PNP.
Unveiling ferroptosis: a new frontier in skin disease research.
Front Immunol
October 2024
Science Education Department, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
Article Synopsis
- Ferroptosis is a unique type of regulated cell death that differs from apoptosis, necrosis, and autophagy, and is gaining attention for its involvement in skin diseases.
- The review explores how ferroptosis, characterized by iron buildup and lipid damage, affects several skin conditions like psoriasis, dermatitis, and melanoma, while also comparing it to other cell death processes.
- It discusses the role of ferroptosis in five skin diseases and examines potential therapies targeting ferroptosis to improve skin disease management and treatment.
Photopatch testing: Clinical characteristics, test results, and final diagnoses from the North American Contact Dermatitis Group, 2009-2020.
Contact Dermatitis
December 2024
Department of Dermatology, University of Colorado, Aurora, Colorado, USA.
Article Synopsis
- Photoallergic contact dermatitis (PACD) is a hypersensitivity reaction triggered by allergens only when exposed to UV light, requiring photopatch testing (PhotoPT) for diagnosis.* -
- A study from 2009-2020 involving 454 patients revealed that most were women, aged 21-60, and the majority were White; results showed 119 positive tests, predominantly related to sunscreen agents like benzophenones.* -
- Among the diagnosed conditions, approximately 17.2% of patients had PACD, while other diagnoses included allergic contact dermatitis, polymorphous light eruption, and chronic actinic dermatitis, highlighting the need for photopatch testing in these cases.*
[Solar urticaria and polymorphous light eruption].
Dermatologie (Heidelb)
July 2024
Zentrum für Dermatologie, Allergologie und Dermatochirurgie, Helios Universitätsklinikum Wuppertal, Wuppertal, Deutschland.
Article Synopsis
- Solar urticaria is a rare skin condition triggered by UV radiation or visible light, likely caused by an allergic reaction, leading to severe symptoms that significantly affect patients' quality of life.
- Polymorphous light eruption, in contrast, is a more common condition resulting from a type IV allergic reaction to photoallergens, with skin lesions that heal despite sun exposure and generally less impact on quality of life.
- Both conditions are diagnosed through light provocation and can benefit from a treatment approach called light hardening, highlighting their distinct clinical features and management strategies.
Article Synopsis
- * Limited treatment options exist for skin of color patients experiencing these pigmentation changes, and current evidence-based treatments lack robust sample sizes.
- * The text discusses three case studies of atypical dyschromia in individuals with darker skin, emphasizing the persistent nature of pigmentation changes even after active diseases are treated.
Tofacitinib: A Treatment Option for Recalcitrant Polymorphic Light Eruption and Its Mechanistic Rationale.
Dermatitis
June 2024
From the Department of Dermatology, Venereology and Leprosy, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Article Synopsis
- - Polymorphous light eruption is an allergic skin reaction triggered by sunlight, and it involves a type IV hypersensitivity to unknown skin antigens caused by UV exposure.
- - A study assessed the effectiveness of tofacitinib in seven patients who had not responded to other treatments; results showed significant relief from itching and faster healing.
- - Tofacitinib works by inhibiting certain enzymes (JAK1 and JAK3) that contribute to inflammation, helping to lower the overactive immune response seen in polymorphous light eruption.
Summer and spring elbow rashes is a variant of polymorphous light eruption: confirmation by photoprovocation and histopathology in a series of five cases.
Front Med (Lausanne)
October 2023
Photobiological Dermatology Laboratory, Medical Research Center, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, Spain.
Article Synopsis
- * Five patients with these elbow lesions underwent UVA light testing, demonstrating that UVA exposure can provoke the characteristic skin lesions associated with this condition.
- * The findings confirmed that these elbow rashes are indeed a variant of polymorphous light eruption, supported by histological evidence and the presence of specific skin characteristics after UVA exposure.
Could red and near-infrared emitting fabric technology improve the severity of psoriasis, polymorphous light eruption, and alopecia areata?
J Dermatolog Treat
December 2023
Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Article Synopsis
- This pilot study explored the effectiveness of a garment that emits red and near-infrared (NIR) light as a treatment for inflammatory skin issues like psoriasis, polymorphous light eruption (PMLE), and alopecia areata (AA).
- Fourteen patients wore the Lumiton® garment for 12 weeks, with outcomes measured through patient feedback and clinical assessments of their skin conditions.
- Results showed that patients with psoriasis and PMLE experienced improvements, while those with AA also reported better scores, suggesting this light-emitting apparel could potentially enhance treatment outcomes for these conditions, though the study had limitations such as small sample size and ongoing medication use.
Actinic Lichen Planus: Significance of Dermoscopic Assessment.
Cureus
March 2023
Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- - Actinic lichen planus (LP) is a rare variant of lichen planus, a chronic inflammatory skin condition affecting 1-2% of the population, typically presenting as pruritic, purplish, polygonal papules.
- - In actinic LP, lesions appear in sun-exposed areas like the face and hands, with the absence of Koebner's phenomenon, and may be confused with conditions such as discoid lupus erythematosus and granuloma annulare.
- - Dermoscopy is a valuable, non-invasive tool for diagnosis, revealing features like "Wickham's striae," and treatment generally involves corticosteroids; a case study describes a 50-year-old woman whose
Demographics and clinical presentations of 844 patients with light and dark skin types with polymorphous light eruption and chronic actinic dermatitis evaluated over 23 years.
Photodermatol Photoimmunol Photomed
March 2023
Division of Photobiology and Photomedicine, Department of Dermatology, Henry Ford Health, Detroit, Michigan, USA.
Article Synopsis
- Polymorphous light eruption (PMLE) and chronic actinic dermatitis (CAD) were traditionally thought to mostly affect White individuals, but recent studies show a higher prevalence among people with darker skin, especially African Americans.
- The study reviewed 844 PMLE patients and 60 CAD patients at a dermatology center over about 23 years, finding a significant occurrence of these conditions in dark-skinned individuals compared to light-skinned individuals.
- Recognizing variants like pinpoint papular PMLE in dark-skinned patients is key for proper diagnosis and treatment, as they may be confused with other skin conditions like lichen nitidus.
Polymorphous light eruption treated with omalizumab.
Photodermatol Photoimmunol Photomed
January 2023
Department of Dermatology, Hospital Universitario Cruces, Barakaldo, Spain.
Association of polymorphous light eruption with NOD-2 and TLR-5 gene polymorphisms.
J Eur Acad Dermatol Venereol
November 2022
Department of Dermatology, University Hospital Regensburg, Regensburg, Germany.
Article Synopsis
- - Polymorphous light eruption (PLE) is a skin condition triggered by UV-B radiation, linked to reduced Langerhans cell depletion and genetic factors, particularly in NOD-2 and TLR-5 genes.
- - A study involving skin biopsies from 143 PLE patients and 104 healthy controls found that certain genetic variations, especially in the NOD-2 and TLR-5 genes, occurred more frequently in PLE patients compared to controls.
- - The findings suggest that these genetic variations are not only common in PLE but also share similarities with severe acute graft-versus-host disease (aGvHD), indicating potential underlying immunological connections between these conditions.
Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin.
Dermatol Ther (Heidelb)
July 2022
Department of Dermatology, CHU Nice, University Côte d'Azur, Nice, France.
Article Synopsis
- Polymorphic light eruption (PLE) is a common skin condition triggered by sunlight, and its exact causes are still not fully understood, potentially involving immune system reactions and skin stress responses.
- In a clinical study with 15 participants, a broad-spectrum sunscreen containing UVA and UVB filters along with ectoin was tested for its ability to prevent PLE reactions when exposed to increasing doses of UVA radiation.
- Results showed that the treated side of the chest experienced no PLE reactions or significant skin changes, while the untreated side reacted positively in 13 subjects, suggesting the sunscreen may effectively protect against UVA-induced PLE.
Diagnostic testing of eczematous dermatitis with incomplete response to dupilumab.
J Am Acad Dermatol
September 2022
Department of Dermatology, University of California, San Francisco, California; Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, California. Electronic address:
The Immunogenetics of Photodermatoses.
Adv Exp Med Biol
March 2022
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.
Article Synopsis
- Photodermatosis is an abnormal skin reaction to light, classified mainly into idiopathic photodermatoses and drug-related photodermatoses, focusing on their epidemiology and genetic aspects.
- Idiopathic photodermatoses include conditions like polymorphous light eruption and solar urticaria, with a higher prevalence in younger individuals, and they show varying characteristics between Caucasians and Asians.
- Drug-induced photodermatoses can be either phototoxic or photoallergic reactions, and can sometimes mimic other skin conditions, such as lupus erythematosus, complicating diagnosis and treatment.
CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides.
Postepy Dermatol Alergol
December 2021
Department of Pathology, Duzce University, School of Medicine, Duzce, Turkey.
Article Synopsis
- CD123-positive plasmacytoid dendrocytes (PDCs) are commonly found in cutaneous lupus erythematous (CLE), indicating their potential significance in skin diseases.
- The study analyzed 76 cases across various skin conditions, revealing that CLE had the highest proportion of CD123-positive PDCs compared to polymorphous light eruption (PLE), pityriasis rosea (PR), and mycosis fungoides (MF).
- The findings suggest that PDCs may play a key role in the development of CLE and PLE, and that CD123 can effectively differentiate these conditions from MF and PR.
Drug triggered pruritus, rash, papules, and blisters - is AGEP a clash of an altered sphingolipid-metabolism and lysosomotropism of drugs accumulating in the skin?
Lipids Health Dis
November 2021
Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, Jakob-Kienzle-Str. 17, D-78054, Villingen-Schwenningen, Germany.
Article Synopsis
- Drug reactions like rash and photosensitivity are uncommon and their causes, including individual susceptibility, are not well understood.
- Certain drugs such as amiodarone and chlorpromazine are known to cause skin issues, but not everyone reacts the same way, indicating a complex interaction with individual responses to stress.
- A proposed model links the metabolism of ceramides in the skin to adverse drug reactions, hinting at new methods to assess risk and manage reactions related to conditions like AGEP and other light-induced skin reactions.
A photodistributed eruption in an immunosuppressed patient.
JAAD Case Rep
September 2021
Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
Does smoking affect your skin?
Postepy Dermatol Alergol
June 2021
Department of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.
Article Synopsis
- Smoking poses serious health risks, including increased chances of chronic disorders, cancer, and premature death due to carcinogens.
- Nicotine is linked to various skin diseases and conditions, such as psoriasis and skin cancer.
- Education in medical settings can help change smoking habits and protect individuals from its harmful effects.*
Contribution of phototesting in the diagnosis of photodermatoses: Retrospective study of 100 cases.
Photodermatol Photoimmunol Photomed
March 2022
Dermatology, allergology and photobiology Department, Grenoble-Alpes University Hospital, Grenoble, France.
Article Synopsis
- Photodermatoses are inflammatory skin conditions triggered by sunlight, and diagnosing them often requires specialized phototesting, which is becoming less available in French medical centers.!* -
- This study evaluated phototesting's effectiveness in diagnosing photodermatosis by analyzing 100 patients at a university hospital between 2014 and 2018, finding that it confirmed diagnoses in 60% of cases and eliminated the possibility in 13% of cases.!* -
- The most common type identified was polymorphous light eruption (PLE), followed by photocontact dermatitis and solar urticaria, highlighting the importance of maintaining phototesting capabilities for effective diagnosis and treatment of these conditions.!*
Histopathologic Spectrum of Findings Associated With Tattoos: Multicenter Study Series of 230 Cases.
Am J Dermatopathol
August 2021
Pathologist, Pathology Department, Hospital University German Trias I Pujol, Barcelona, Spain.
Article Synopsis
- Reactions to tattoos can mimic skin conditions or tumors, making histopathological analysis essential for accurate diagnosis and treatment direction.
- The study analyzed biopsies from 1992 to 2019 from several hospitals in Spain and Switzerland, focusing on different types of tattoos and their associated reactions.
- Out of 477 biopsies, 230 met the criteria for inclusion, with the findings indicating a range of inflammatory responses and various age groups affected, highlighting the importance of understanding tattoo reactions in clinical practice.