7,436 results match your criteria: "Polyarteritis Nodosa"

Background: Polyarteritis nodosa is a relatively uncommon type of systemic necrotizing vasculitis that primarily affects medium-sized arteries. While gastrointestinal involvement is known in polyarteritis nodosa, heavy gastrointestinal bleeding due to gastric ulceration is relatively uncommon. We present the case of an 81-year-old male of Chinese ethnicity who experienced severe gastrointestinal bleeding as a result of polyarteritis nodosa and an innovative treatment approach for a better patient outcomes.

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Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis that can lead to the formation of refractory lower limb ulcers requiring amputation. The standard treatment for severe PAN involves combination therapy with steroids and cyclophosphamide; however, some cases prove to be challenging. Recently, case reports have described the use of biological agents for PAN treatment.

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The patient was a 48-year-old man who had developed acute myocardial infarction 3 years earlier. He started experiencing recurrent attacks of abdominal pain 2 years earlier. One month before the presentation, he developed perforative peritonitis, which was treated with right hemicolectomy.

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Article Synopsis
  • The study investigates the effectiveness of a new imaging technique, fluorine-18-labeled FAP inhibitor (FAPI-42), for detecting systemic vasculitis in patients, comparing it to the standard FDG imaging technique.
  • A retrospective analysis of 30 patients revealed that FAPI-42 had a higher detection rate for lesions (100% vs. 93.3%) and identified more lesions overall compared to FDG (161 vs. 145).
  • FAPI-42 also showed a moderate correlation with inflammatory markers, suggesting it may be a valuable tool for assessing systemic vasculitis severity.
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The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disorder caused by loss of function mutations in the ADA2 gene (previously the CECR1 gene) on chromosome 22q11. The clinical spectrum of the disease is remarkably broad, and its presentations mimic features of polyarteritis nodosa, such as livedoid rash, hematological abnormalities (e.g.

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Coronary polyarteritis nodosa.

Lancet Rheumatol

November 2024

Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

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Mechanisms and Screening for Atherosclerosis in Adults With Vasculitis.

Arterioscler Thromb Vasc Biol

November 2024

Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.J.H., Z.S.W.).

Vascular inflammation is a hallmark of both primary systemic vasculitis and atherosclerosis. As such, cardiovascular events are common in patients with vasculitis and likely due to both direct vascular inflammation and accelerated atherosclerosis. Direct cardiac involvement is possible in all vasculitides, though more commonly described in Takayasu arteritis, polyarteritis nodosa, and eosinophilic granulomatosis with polyangiitis.

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Article Synopsis
  • Polyarteritis nodosa (PAN) is a type of vasculitis that causes inflammation of medium to small arteries, potentially affecting multiple organs, including the testes.
  • Angiography can be used as a diagnostic method instead of tissue biopsy or surgery.
  • This text discusses a case where angiographic findings show involvement of the testicular arteries in PAN, which has not been reported in previous studies.
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Background/purpose: Our objective was to investigate real-world outcomes and treatment strategies in individuals affected by DADA2 using over 10-year period real-life experience.

Methods: This descriptive analysis encompassed all adult/pediatric patients with DADA2 from our Vasculitis Research Center prospective database. Patients on anti-TNF therapy have been specifically examined, analyzing the treatment's duration, indications, and outcomes.

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Hospitalist-performed skin biopsy in the diagnosis of skin disease.

Arch Dermatol Res

November 2024

Department of General Internal Medicine, Akashi Medical Center, 743-33 Yagi, Ohkubo-cho, Akashi, Hyogo, 674-0063, Japan.

In hospitalized patients, dermatologist intervention can lead to rapid identification and treatment of skin disease. However, many medical centers lack a specialized dermatologist, so skin biopsies might instead be performed by hospitalists. We aimed to determine the impact of skin biopsies performed by hospitalists on the diagnosis of skin conditions.

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Introduction And Importance: Adenosine deaminase 2 (DADA2) deficiency is a monogenic autoinflammatory disease caused by biallelic mutations in the ADA2 gene. Small- and medium-sized vessels may be involved and can cause various clinical symptoms, including features resembling polyarteritis nodosa (PAN). In this article, the authors discuss a unique case of DADA2 disease in which a patient presented with a bilateral renal subcapsular hematoma.

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Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis preferentially targeting medium-sized arteries. PAN has two clinical entities: systemic PAN (sPAN) and cutaneous PAN (cPAN). cPAN is a skin-limited vasculitis, while ulcerative cPAN often predicts a higher risk of recurrence and a worse prognosis.

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Resilience and Beyond the Acute Phase Challenges: Case Series on Prolonged COVID-19 Infection in Immunocompromised Individuals.

Infect Drug Resist

October 2024

Division of Pulmonary Medicine and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Article Synopsis
  • COVID-19 can lead to severe illness in immunocompromised individuals, who may struggle to clear the virus, risking persistent infections.
  • Four cases of persistent COVID-19 pneumonia were examined, involving patients with conditions like lymphoma, vasculitis, and post-kidney transplant, with notable testing results for IgG antibodies.
  • It's crucial to consider ongoing COVID-19 infection in immunocompromised patients with symptoms or unchanged chest X-rays after treatment, as early diagnosis can lead to better outcomes.
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18 F-FDG PET/CT in the Evaluation of Polyarteritis Nodosa.

Clin Nucl Med

December 2024

From the Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ.

A 61-year-old man with a medical history of human immunodeficiency virus well controlled on antiretroviral therapy presented for distal sensorimotor symptoms, fatigue, and recurrent fevers. Erythrocyte sedimentation rate and C-reactive protein were both elevated. Antineutrophilic cytoplasmic antibody and antinuclear antibodies were negative.

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French protocol for diagnosis and management of Cogan's syndrome.

Rev Med Interne

October 2024

Service de médecine interne, hôpital Saint-Antoine, AP-HP, Sorbonne université, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France. Electronic address:

Article Synopsis
  • * It typically affects Caucasians equally across genders and can also be associated with other autoimmune diseases like polyarteritis nodosa.
  • * While ocular symptoms often have a good prognosis with potential recovery of vision, cochleo-vestibular issues can lead to serious and irreversible hearing loss, and treatment options are not well-established due to the condition's rarity.
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Polyarteritis nodosa (PAN) is a rarely seen vasculitis that often affects small-sized and medium-sized arteries. PAN can present with diverse clinical features depending on the organs involved, including potential cardiac involvement. Typical cardiac manifestations of PAN in the paediatric age group include pericarditis, valvular heart disease and coronary artery aneurysms.

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Introduction And Importance: Spontaneous coronary artery dissection is a rare cause of acute coronary syndromes not related to atherosclerosis. It involves the sudden tearing of the coronary artery wall, separating the inner intimal lining from the outer vessel wall, typically affecting a single coronary vessel. In 20% of cases, the cause of spontaneous coronary artery dissection is unknown.

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Article Synopsis
  • Coronary artery vasculitis is a rare illness that mainly affects the heart's blood vessels and can happen because of conditions like Kawasaki Disease.
  • A 6-year-old boy with cancer died suddenly because of a blood clot in his heart caused by this vasculitis, likely linked to Kawasaki Disease.
  • Researchers are studying the features of Kawasaki Disease by looking at many studies from the past to learn more about how it affects people of all ages.
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A delayed diagnosis of polyarteritis nodosa may lead to critical limb-threatening ischemia (CLTI). A 74-year-old woman presented with left-foot pain and was treated with oral vasodilators and antiplatelet agents. However, the distal ischemia progressed to CLTI, including gangrene of the fingers and toes, and bilateral foot dropping appeared because of peroneal nerve paralysis.

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Article Synopsis
  • * Out of 282 surgeries, 22 were performed on patients with connective tissue disease, revealing that these patients experienced lower limb salvage rates (75% vs. 94%) and wound healing rates (52% vs. 86%) after 12 months compared to those with arteriosclerosis.
  • * The findings suggest that patients with CLTI due to connective tissue disease have poorer outcomes after distal bypass, indicating the need for more targeted approaches in their treatment.
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Top 10 Clinical Pearls in Vasculitic Neuropathies.

Semin Neurol

September 2024

Department of Neurology, Virginia Commonwealth University, Richmond, Virginia.

Article Synopsis
  • Vasculitic neuropathies are inflammatory conditions affecting the peripheral nerves, often caused by systemic vasculitis or related disorders, leading to painful sensory and motor deficits.
  • Diagnosis involves extensive tests, including lab work, electrodiagnostics, and tissue biopsies, while treatment typically includes immunosuppressants and pain management.
  • Timely recognition and intervention are crucial to prevent serious complications, including permanent nerve damage or fatal outcomes.
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