132 results match your criteria: "Politecnico e Universitario[Affiliation]"

BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity.

Int J Mol Sci

January 2024

Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

Article Synopsis
  • A recently identified diarylpentanoid shows promise as a growth inhibitor for cancer cells with low toxicity to non-tumor cells, having a GI value of 0.17 to 0.45 µM.
  • The compound promotes mitotic arrest by disrupting spindle assembly, resulting in apoptotic cell death.
  • A library of analogs was synthesized and tested, revealing four active compounds that caused significant mitotic arrest and enhanced antimitotic effects, with one compound demonstrating the highest efficacy through spindle dynamics interference.
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Treatment of Equine Tarsus Long Medial Collateral Ligament Desmitis with Allogenic Synovial Membrane Mesenchymal Stem/Stromal Cells Enhanced by Umbilical Cord Mesenchymal Stem/Stromal Cell-Derived Conditioned Medium: Proof of Concept.

Animals (Basel)

January 2024

Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.

Horses are high-performance athletes prone to sportive injuries such as tendonitis and desmitis. The formation of fibrous tissue in tendon repair remains a challenge to overcome. This impels regenerative medicine to develop innovative therapies that enhance regeneration, retrieving original tissue properties.

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Enteric protozoan parasites, such as sp., , spp., and , may have implications for both animal and human health.

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Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction.

Pharmaceutics

December 2023

UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.

Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule-targeting antimitotic agents (e.

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Prickly Connections: Sociodemographic Factors Shaping Attitudes, Perception and Biological Knowledge about the European Hedgehog.

Animals (Basel)

November 2023

CISAS-Center for Research and Development in Agrifood Systems and Sustainability, Polytechnic Institute of Viana do Castelo, NUTRIR (Technological Center for AgriFood Sustainability), Monte de Prado, 4960-320 Melgaço, Portugal.

The modern lifestyle of humans is leading to a limited exposure to nature. While several wild species are adapting and thriving in anthropic environments, natural history knowledge is declining, and positive attitudes and behaviours towards nature are facing challenges. Because anticipating attitudes and engendering broad-based support for nature-related measures requires a good grasp of social contexts, we set out to evaluate the sociodemographic factors driving the perception, attitudes towards, and natural history knowledge of a keystone species-the European hedgehog.

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Carcass Yields and Meat Composition of Roosters of the Portuguese Autochthonous Poultry Breeds: "Branca", "Amarela", "Pedrês Portuguesa", and "Preta Lusitânica".

Foods

November 2023

CISAS, Escola Superior Agrária, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Álvares, 4900-347 Viana do Castelo, Portugal.

Poultry meat is an important part of the human diet, and the valorisation of autochthonous breeds is a determinant for the sustainability of the rural areas. The increasing demand for niche products demands for better knowledge of the carcass characteristics and meat quality of these local populations. The present study aims to characterise the roosters' meat from the "Branca" (BR), "Amarela" (AM), "Pedrês Portuguesa" (PP), and "Preta Lusitânica" (PL) breeds.

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The sustainability of agroecological systems, biodiversity protection, animal welfare, and consumer demand for higher quality products from alternative and extensive farming methods have reinforced interest in local breeds that are well adapted to low-input environments. However, food safety needs to be safeguarded to reinforce consumer confidence. The aim of this study was to conduct a preliminary investigation on the occurrence of spp.

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Ultrasound Landmarks in the Approach to the Common Peroneal Nerve in a Sheep Model-Application in Peripheral Nerve Regeneration.

Life (Basel)

September 2023

Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal.

Peripheral nerve injury (PNI) remains a medical challenge with no easy resolution. Over the last few decades, significant advances have been achieved in promoting peripheral nerve regeneration, and new assessment tools have been developed, both functional and imaging, to quantify the proportion and quality of nerve recovery. The exploration of new animal models, larger, more complex, and with more similarities to humans, has made it possible to reduce the gap between the results obtained in classic animal models, such as rodents, and the application of new therapies in humans and animals of clinical interest.

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This study aimed to identify species recovered from the oral cavity of patients with kidney transplantation. Two swabs were taken from the oral cavities of 40 patients before and after transplantation, cultured on Sabouraud dextrose agar, and yeasts identified. Antifungal drug susceptibility testing was performed with fluconazole and itraconazole.

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Teeth Damage during General Anesthesia.

J Clin Med

August 2023

School of Dentistry, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), 4585-116 Gandra PRD, Portugal.

Introduction: Dental injuries during anesthesia, especially when advanced airway management is required, represent a legal problem. Factors such as poor dental condition and excessive pressure during intubation contribute to dental damage. The maxillary central incisors are commonly affected.

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Biomaterials with antifungal strategies to fight oral infections.

Crit Rev Biotechnol

September 2024

Faculty of Engineering, LEPABE - Laboratory for Process Engineering, Environment, Biotechnology and Energy, University of Porto, Porto, Portugal.

Oral fungal infections pose a threat to human health and increase the economic burden of oral diseases by prolonging and complicating treatment. A cost-effective strategy is to try to prevent these infections from happening in the first place. With this purpose, biomaterials with antifungal properties are a crucial element to overcome fungal infections in the oral cavity.

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Article Synopsis
  • Degenerative myelopathy (DM) is a chronic spinal cord disease similar to ALS, caused mainly by SOD1 gene mutations, with no known specific treatment and a typical survival time of 6-12 months after symptoms start.
  • A study tested an intensive neurorehabilitation protocol combined with mesenchymal stem cells (MSCs) on 13 non-ambulatory DM dogs, comparing outcomes between a group with intensive care (INSCP) and a less intensive ambulatory rehabilitation group (ARP).
  • Results showed that the INSCP group had a significant increase in survival time (averaging 438 days) compared to the ARP group (274 days), suggesting the potential for improved quality of life and functional status in DM dogs
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Combination Therapy as a Promising Way to Fight Oral Cancer.

Pharmaceutics

June 2023

UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra, Portugal.

Oral cancer is a highly aggressive tumor with invasive properties that can lead to metastasis and high mortality rates. Conventional treatment strategies, such as surgery, chemotherapy, and radiation therapy, alone or in combination, are associated with significant side effects. Currently, combination therapy has become the standard practice for the treatment of locally advanced oral cancer, emerging as an effective approach in improving outcomes.

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It is now well-accepted that psychostimulants act on glial cells causing neuroinflammation and adding to the neurotoxic effects of such substances. Neuroinflammation can be described as an inflammatory response, within the CNS, mediated through several cytokines, reactive oxygen species, chemokines and other inflammatory markers. These inflammatory players, in particular cytokines, play important roles.

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Background: Clear aligners (CA) are used 22 h daily, creating a bite-block effect. This work aims to (i) analyze occlusal changes before the beginning of treatment, after the first set of CA and after the use of additional aligners; (ii) compare planned occlusal contacts with the ones obtained after the first set of CA; (iii) analyze the occlusal changes occurred after reaching the orthodontic goals after 3 months of using CA only at night; (iv) evaluate and characterize which tooth movements did not allow the treatment to be completed at the end of the first set of aligners, and finally (v) verify the possible relation between the changes in occlusal contact and areas and parameters such as case complexity and facial biotype.

Materials And Methods: A quantitative, comparative, and observational longitudinal cohort study design was implemented to evaluate the clinical data and the complexity levels of cases receiving CA.

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Characterization of Oral spp. Biofilms in Children and Adults Carriers from Eastern Europe and South America.

Antibiotics (Basel)

April 2023

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Doutor Roberto Frias, 4200-465 Porto, Portugal.

Article Synopsis
  • The study focused on characterizing biofilms formed by non-Candida albicans Candida species (NCACs) collected from the oral mucosa of individuals across different age groups in Eastern Europe and South America.
  • Researchers assessed how well these strains could form biofilms and their capacity to produce key matrix components, as well as their resistance to antifungal treatments.
  • Findings revealed that children were more susceptible to NCAC infections, as their biofilms contained more matrix components, which contributes to increased resistance to treatment and potential for recurring infections.*
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The Impact of the Virulence of Isolated from Dogs.

Vet Sci

May 2023

Microbiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

is a pathogenic bacterium that can cause serious infections in both humans and animals, including dogs. Treatment of this bacterium is challenging because some strains have developed multi-drug resistance. This study aimed to evaluate the antimicrobial resistance patterns and biofilm production of clinical isolates of obtained from dogs.

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Because of public health concerns, much greater scrutiny is now placed on antibiotic use in pets, especially for antimicrobial agents that have human analogs. Therefore, this study aimed to characterize the phenotypic and genotypic profiles of multidrug-resistant bacteria isolated from nasal swabs samples taken from a one-year-old male Serra da Estrela dog with rhinorrhea that was treated with amikacin. An extended-spectrum β-lactamases (ESBL) was isolated in the first sample taken from the left nasal cavity of the dog.

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Article Synopsis
  • Updated data on chronic respiratory diseases (CRDs) are essential for preventing and controlling these conditions as part of achieving the UN's goal of reducing premature mortality from non-communicable diseases by 2030.
  • From 1990 to 2019, global, regional, and national estimates were analyzed for various CRDs, including COPD and asthma, to assess their impact on mortality, disability, and overall prevalence.
  • In 2019, CRDs resulted in 4 million deaths and 454.6 million cases worldwide, with conditions like COPD being the leading cause of death among CRDs, despite a decline in age-standardized rates for most diseases over the period analyzed.
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Treatment of unilateral or bilateral maxillary lateral incisor agenesis is challenging, time-consuming, expensive, and requires careful treatment planning, predictability, and esthetics. This review aimed to identify differences in esthetic perception among orthodontists, general dentists, differentiated dentists, and laypersons, which may interfere with treatment options. EBSCO, PubMed, ScienceDirect, Cochrane Library databases, and Google Scholar were searched using keyword pairing and a Boolean expression, "(congenitally missing OR agenesis OR hypodontia) AND (maxillary lateral incisors) AND (esthetic perception OR smile) AND (laypersons OR dental professional OR general dentist OR orthodontists).

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Role of the Dietary Phytochemical Curcumin in Targeting Cancer Cell Signalling Pathways.

Plants (Basel)

April 2023

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal.

The diarylheptanoid curcumin [(1,6)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] is one of the phenolic pigments responsible for the yellow colour of turmeric ( L.). This phytochemical has gained much attention in recent years due to its therapeutic potential in cancer.

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Lipidic compounds found in soils surrounding human decomposing bodies and its use in forensic investigations - A narrative review.

Sci Justice

May 2023

TOXRUN - Toxicology Research Unit, University Institute of Health Sciences, CESPU, CRL, 4585-116 Gandra, Portugal; LAQV-REQUIMTE, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; CESPU, Cooperativa de Ensino Superior Politécnico e Universitário, Gandra, Portugal.

Following decomposition of a human body, a variety of decomposition products, such as lipids, are released into the surrounding environment, e.g. soils.

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Recall of delirium and related distress in elderly hospitalized patients: A prospective study.

Porto Biomed J

December 2022

Centro de Investigação em Tecnologias e Serviços de Saúde, Rede de Investigação em Saúde (CINTESIS@RISE), Departamento de Neurociências Clínicas e Saúde Mental, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

Delirium is a very common neuropsychiatric disorder in the elderly, with a significant physical and psychological burden. Much is still unknown about its psychological effects. This study aims to identify the proportion of patients who recall delirium and to analyze the distress caused by it.

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The number of spp. infections and drug resistance are dramatically increasing worldwide, particularly among immunosuppressed patients, and it is urgent to find novel compounds with antifungal activity. In this work, the antifungal and antibiofilm activity of thymoquinone (TQ), a key bioactive constituent of black cumin seed L.

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Effectiveness of Self-Adhesive Resin Luting Cement in CAD-CAM Blocks-A Systematic Review and Meta-Analysis.

Materials (Basel)

April 2023

UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), Cooperativa de Ensino Superior Politécnico e Universitário (CESPU), Rua Central de Gandra 1317, 4585-116 Gandra, Portugal.

Self-adhesive resin cements (SARCs) are used because of their mechanical properties, ease of cementation protocols, and lack of requirements for acid conditioning or adhesive systems. SARCs are generally dual-cured, photoactivated, and self-cured, with a slight increase in acidic pH, allowing self-adhesiveness and increasing resistance to hydrolysis. This systematic review assessed the adhesive strength of SARC systems luted to different substrates and computer-aided design and manufacturing (CAD/CAM) ceramic blocks.

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