1 results match your criteria: "Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona[Affiliation]"
Resolution of sickle cell disease-associated inflammation and tissue damage with 17-resolvin D1.
Blood
January 2019
Department of Medicine, University of Verona, Policlinico GB Rossi-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Article Synopsis
- Resolvins (Rvs) are natural lipid molecules that help resolve inflammation, which is crucial in diseases like sickle cell disease (SCD) that are marked by inflammation and blood flow problems.
- A study using humanized SCD mice found that 17-resolvin D1 (17RvD1) effectively reduces inflammation and vascular issues by decreasing blood cell recruitment and neutrophil activity after hypoxia/reoxygenation events.
- The protective effects of 17RvD1 are linked to enhancing the removal of dead cells, reducing pro-inflammatory signals, and blocking a key inflammatory pathway (NF-κB), suggesting it could be a new treatment for SCD's inflammation-related complications.