Critical heart failure associated with beta-blocker-induced cardiac phospholipidosis: a case report.

Background: Drug-induced phospholipidosis (DIPL) is an acquired lysosomal storage disorder characterized by the accumulation of lamellar bodies and phospholipids, typically associated with the use of cationic amphiphilic drugs (CADs). Over 200 marketed CADs, including widely prescribed β-blockers, have the potential to induce phospholipid deposition in various organs. In rare cases, DIPL may lead to secondary cardiomyopathy.

Onychomycosis with gray-green staining caused by .

We report a case of onychomycosis due to Fusarium solani with gray-green staining, which improved after nail plate removal and antifungal liquid of effinaconazole. Fungal cultures revealed light-brown and dark-green colonies. Gray-green nail might have occurred due to the combination of these colonies, which necessitated differentiation from green nail.

Comparative analysis of gut microbiota in hormone-sensitive and castration-resistant prostate cancer in Japanese men.

Gut microbiota plays a crucial role in the development and progression of prostate cancer, with previous studies indicating that certain bacterial taxa are more abundant in castration-resistant prostate cancer (CRPC) compared to hormone-sensitive prostate cancer (HSPC). Notably, the composition of gut microbiota can vary significantly by geographic region, and Japanese individuals have a distinct microbial profile. However, research exploring these differences within Japanese populations remains limited.

Thrombus Extruded From the Re-Entry Point of an Aortic Dissection in the Common Carotid Artery.

This case highlights the fact that in Stanford type A aortic dissection, there are cases of re-entry points in the common carotid artery from which thrombus protrudes. If it is a thrombus, there is a possibility of embolization, requiring immediate therapeutic intervention.

Selection of anti-cytokine biologics by pretreatment levels of serum leucine-rich alpha-2 glycoprotein in patients with inflammatory bowel disease.

Serum leucine-rich alpha-2 glycoprotein (LRG) can monitor disease activities during biologics treatment in patients with inflammatory bowel disease (IBD). It is unclear whether the pretreatment serum LRG level can predict clinical effectiveness including serum trough levels of ustekinumab in patients with IBD. This multicenter prospective cohort study included 184 patients (Crohn's disease, 104; ulcerative colitis, 80) who received ustekinumab (n = 119) or anti-tumor necrosis factor (n = 65) between January 2019 and March 2023.

Efficacy and safety of LB-P9 on hair health: a randomized, double-blind, placebo-controlled clinical trial.

Introduction: Numerous factors influence hair health, including genetic predisposition, hormonal changes, stress, nutritional deficiencies, medical conditions, or medications. With the rising interest in maintaining hair health, alternative approaches such as functional cosmetics and food products are gaining attention. Probiotics, health-beneficial live microorganisms, are emerging as potential candidates for improving hair health.

ENHANCED RECOVERY AFTER CAESAREAN SECTION - AN IMPROVED PATHWAY THAN CONVENTIONAL CARE FOR REDUCING HOSPITAL STAY.

Background: With the help of an evidence-based approach called "Enhanced Recovery After Surgery" (ERAS), patients can receive standardised perioperative care and recover more quickly. Many surgical specialities, such as orthopaedics, gynaecological onco-surgery, breast surgery, urology, and colorectal surgery, use ERAS protocols extensively. Improved postoperative recovery is beneficial in lowering hospital stays, and costs, and increasing patient satisfaction.

Panaroma of microglia in traumatic brain injury: a bibliometric analysis and visualization study during 2000-2023.

Background: Traumatic brain injury (TBI) is a critical global health concern characterized by elevated rates of both morbidity and mortality. The pathological and physiological changes after TBI are closely related to microglia. Microglia, the primary immune cells in the brain, are closely linked to the mechanisms and treatment of TBI.

Clinical Outcomes Following Low-Dose Second-Generation "Ranger" Drug-Coated Balloon Angioplasty for Femoropopliteal Artery Disease.

Purpose: To reveal the rate of 1-year freedom from restenosis and to determine the factors associated with the restenosis risk in femoropopliteal (FP) lesions treated with a Ranger drug-coated balloon (DCB) in real-world clinical settings.

Methods: This multicenter, prospective observational study enrolled 1131 patients and 1453 de novo or restenotic FP lesions (mean age=75±9 years; female=35.3%, mean lesion length=19.

A Case of Syphilis Associated With Genital and Extragenital Hard Chancres, Inguinal Lymphadenitis, and Systemic Symptoms.

Syphilis is a sexually transmitted infection caused by the spirochete (TP) subspecies . Syphilis can be transmitted via contact with infected bodily fluids, such as blood or semen, congenital infection, blood transfusion, or organ transplantation. After a brief incubation period, the disease manifests with signs and symptoms such as genital ulcers, erythematous papules on the palms and soles, fever, and lymphadenopathy.

Large Branchial Cleft Cyst of Face and Neck.

Objective: The authors present a case of a patient with a large branchial cleft cyst on the right side of the neck and face that rapidly increased after eating Angelica-stewed chicken.

Methods: An older adult patient was admitted to West China Hospital on February 28, 2021, with a large branchial cleft cyst. Resection of the right cervical cystic tumor and partial resection of the parotid gland were performed.

Prognostic Utility and Cutoff Differences in NT-proBNP Levels Across Subgroups in Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry.

Objectives: N-terminal pro brain natriuretic peptide (NT-proBNP) is a biomarker for myocardial stress that is used in diagnosing and prognosticating heart failure (HF). However, its interpretation is complicated by clinical factors. This study aims to clarify the prognostic value of NT-proBNP in patients with heart failure with preserved ejection fraction (HFpEF), and risk-prediction cutoffs considering various clinical factors.

Factors associated with recurrence after drug-coated balloon therapy for femoropopliteal in-stent restenosis.

Purpose: To evaluate the impact of intravascular ultrasound (IVUS)-evaluated tissue morphology on recurrence following drug-coated balloon (DCB) angioplasty for the treatment of femoropopliteal in-stent restenosis (FP-ISR).

Methods: This study was a single-center, retrospective, observational study. Study subjects were 65 FP-ISR lesions (mean lesion length: 165 ± 88 mm, occlusive restenosis: 25%) in 53 patients (age: 76 ± 8, diabetes mellitus: 66%) who underwent DCB angioplasty and whose IVUS data of tissue morphology were available.

Incidence of Angiographic Deterioration Following Inframalleolar Angioplasty and Its Impact on Outcomes in Patients With Chronic Limb-Threatening Ischemia Requiring Repeat Intervention.

Background: Clinical impact of inframalleolar (IM) angioplasty in patients with chronic limb-threatening ischemia (CLTI) is still controversial.

Methods And Results: This single-center, retrospective study included 168 patients with CLTI and tissue loss who underwent angioplasty for IM lesions. Angiographic follow up was performed at reintervention between April 2010 and December 2020.

Phase II trial evaluating the long-term efficacy and peripheral sensory neuropathy of capecitabine plus oxaliplatin (XELOX) as adjuvant therapy in Japanese patients with operated stage III colon cancer.

Adjuvant oxaliplatin plus capecitabine (XELOX) therapy is recommended for patients with curatively resected colon cancer. However, prospective data on its practical application in Japanese patients are limited. Therefore, we aimed to conduct a long-term clinical evaluation of the efficacy and safety of adjuvant XELOX in patients with curatively resected stage III colon cancer (MCSCO-1024).

Culprit vessel revascularization prior to complete angiography as a strategy to minimize delays in primary percutaneous coronary intervention for patients with ST-elevation myocardial infarction: a systematic review and meta-analysis.

The rapid restoration of blood flow in patients with acute myocardial infarction with ST elevation through percutaneous coronary intervention (PCI) is crucial for the survival of this population. Attempts to decrease the time from diagnosis of ST-segment elevation myocardial infarction (STEMI) to arrival at the catheterization laboratory have been extensively investigated. However, strategies during the procedure aiming to reduce the time to reperfusion are lacking.