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Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population.
AIDS
March 2013
aUniversity College London, London, UK bUniversidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil cThe University of California, San Francisco, San Francisco, California, USA dUniversity of New South Wales, Sydney, New South Wales, Australia eHIV Unit and irsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain fWojewodzki Szpital Zakazny, Warsaw, Poland gCopenhagen University Hospital, Copenhagen, Denmark.
Background: Due to the success of antiretroviral therapy (ART), it is relevant to ask whether death rates in optimally treated HIV are higher than the general population. The objective was to compare mortality rates in well controlled HIV-infected adults in the SMART and ESPRIT clinical trials with the general population.
Methods: Non-IDUs aged 20-70 years from the continuous ART control arms of ESPRIT and SMART were included if the person had both low HIV plasma viral loads (≤400 copies/ml SMART, ≤500 copies/ml ESPRIT) and high CD4(+) T-cell counts (≥350 cells/μl) at any time in the past 6 months.