Differentiation of glioblastoma G4 and two types of meningiomas using FTIR spectra and machine learning.

Brain tumors are among the most dangerous, due to their location in the organ that governs all life processes. Moreover, the high differentiation of these poses a challenge in diagnostics. Therefore, this study focused on the chemical differentiation of glioblastoma G4 (GBM) and two types of meningiomas (atypical - MAtyp and angiomatous - MAng) were done using Fourier Transform InfraRed (FTIR) spectroscopy, combined with statistical, multivariate, machine learning and rate of spectrum changes methods.

Prioritising Relevant Polychlorinated Naphthalene (PCN) Congeners for Human Dietary Exposure Studies.

Following a decline in the production and use of polychlorinated naphthalenes (PCNs) and the restrictions introduced by the Stockholm Convention, dietary intake represents the most significant pathway of human exposure to these dioxin-like contaminants. PCNs occur ubiquitously in foods, originating from the legacy of historical production that is now globally redistributed, as well as from ongoing industrial and domestic combustion sources which have a stronger influence on occurrence patterns in countries where they were not produced. Recent studies have benefited from a wider set of available PCN reference standards, enabling more accurate reporting of a diverse range of congeners.

Shielding siRNA by peptide-based nanofibers: An efficient approach for turning off EGFR gene in breast cancer.

Peptide-based self-assembled nanosystems show great promise as non-viral gene and siRNA delivery vectors. In the current study, we designed and functionalized nanofibers for the delivery of siRNA, targeting and silencing EGFR gene overexpressed in triple-negative breast cancer. The nanofiber-mediated siRNA delivery was characterized in terms of zeta potential, morphology, and structural stability by circular dichroism spectroscopy.

Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed when the disease is already at an advanced stage. Chemotherapy typically has only a modest effect, making surgery the most effective treatment option. However, only a small percentage of patients are amenable to surgery.

Digital upgrade of drainage detention devices for forced retention.

Current urban challenges related to local urban flooding require effective preventive measures. This applies particularly to various methods of stormwater retention, including forced retention, and solutions that enable cooperation between small individual retention systems and drainage systems. Therefore, this study presents the results of research on the hydraulic efficiency of controllable systems, which combine the features of an on-site tank with the solutions of network tanks to increase the retention of stormwater in drainage systems.

Effectiveness of non-invasive vagal nerve stimulation in Parkinson's disease: A comprehensive systematic review and meta-analysis.

Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by movement impairments. Vagus nerve stimulation (VNS) is a non-invasive brain stimulation technique that has shown promise in treating various neurological conditions, including PD. This systematic review aimed to evaluate the existing evidence on the efficacy of nVNS in managing PD symptoms.

Physicochemical characteristics of chitosan molecules: Modeling and experiments.

Chitosan, a biocompatible polysaccharide, finds a wide range of applications, inter alia as an antimicrobial agent, stabilizer of food products, cosmetics, and in the targeted delivery of drugs and stem cells. This work represents a comprehensive review of the properties of chitosan molecule and its aqueous solutions uniquely combining theoretical modeling and experimental results. The emphasis is on physicochemical aspects which were sparsely considered in previous reviews.

Do Risk Factors for HCC Impact the Association of CT/MRI LIRADS Major Features With HCC? An Individual Participant Data Meta-Analysis.

Guidelines suggest the Liver Imaging Reporting and Data System (LI-RADS) may not be applicable for some populations at risk for hepatocellular carcinoma (HCC). However, data assessing the association of HCC risk factors with LI-RADS major features are lacking. To evaluate whether the association between HCC risk factors and each CT/MRI LI-RADS major feature differs among individuals at-risk for HCC.

- a large-scale dataset of 3D medical shapes for computer vision.

Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

Effect Analysis of Early Rehabilitation Therapy Combined with Repetitive Transcranial Magnetic Stimulation on Postoperative Rehabilitation of Sports Knee Injury.

Objective: To analyze the effectiveness of combined early rehabilitation therapy and repetitive transcranial magnetic stimulation (rTMS) in the postoperative rehabilitation of patients with sports knee injuries (SKI).

Methods: A total of 62 SKI patients from June 2021 to June 2022 were randomly selected by computer and divided into group A (31 cases, early rehabilitation therapy) and group B (31 cases, early rehabilitation therapy +rTMS) by numbered envelope method. The effects of the two groups were compared.

Integrated Care Implemented in the Children's Hospital From the Interwar Period as the Source of Good Practices for the Contemporary Concept of Coordinated Care Based on the WHO Model.

Intro: The article tests the hypothesis that we can draw practical knowledge from the experience of service providers operating in the past. The research questions were formulated: can the historical example of the organization of medical care in the Polish Children's Hospital named after Karol and Maria be used as a viable example today? Is it relevant for contemporary practitioners? And do we still use the knowledge of predecessors? The authors decided to use the interwar Hospital and an operating paediatric ward of the Child-Friendly Hospital for a comparative analysis.

Methods: The model of the European Regional Office of the World Health Organization for integrated delivery of health services was adopted as the analysis framework.

A high-gain gap waveguide-based 16 × 16 slot antenna array with low sidelobe level for mmwave applications.

This study presents the design of a high-gain 16 × 16-slot antenna array with a low sidelobe level (SLL) using a tapered ridge gap waveguide feeding network for Ka-band applications. The proposed antenna element includes four cavity-backed slot antennas. A tapered feeding network is designed and utilized for unequal feeding of the radiating elements.

Higher education staff development: a need-oriented approach based on survey research.

Continuous professional development of university employees is crucial to implementing the mission of higher education institutions. University staff work includes various activities related to teaching, research studies, and cooperation with the industrial sector. It motivated authors to identify crucial areas and skills that should be developed at the academic level.

Photosynthetic response of Solidago gigantea Aition and Calamagrostis epigejos L. (Roth) to complex environmental stress on heavy metal contaminated sites.

Studies of in situ plant response and adaptation to complex environmental stresses, are crucial for understanding the mechanisms of formation and functioning of ecosystems of anthropogenically transformed habitats. We study short- and long-term responses of photosynthetic apparatus (PSA) and anti-oxidant capacity to complex abiotic stresses of common plants Calamagrostis epigejos and Solidago gigantea in semi-natural (C) and heavy metal contaminated habitats (LZ). We found significant differences in leaf pigment content between both plant species growing on LZ plots and their respective C populations.

Environmental and social correlates of the plumage color polymorphism in an urban dweller, feral pigeon (Columba livia f. domestica).

We examined how urban environments affect the abundance, proportion, and diversity of plumage color morphs in feral pigeons. Five major plumage color morphs (black, blue, white, red, and mixed) were counted in sixty 25-ha plots in Poznań City (Poland). Generalized additive models were used to study the correlations among abundance, proportion of morphs, and environmental factors.

Optimization of microwave components using machine learning and rapid sensitivity analysis.

Recent years have witnessed a tremendous popularity growth of optimization methods in high-frequency electronics, including microwave design. With the increasing complexity of passive microwave components, meticulous tuning of their geometry parameters has become imperative to fulfill demands imposed by the diverse application areas. More and more often, achieving the best possible performance requires global optimization.

Impact of magnetorheological fluid composition on their behaviour in gradient pinch mode.

Magnetorheological (MR) fluids can be utilized in one of the fundamental operating modes of which the gradient pinch mode has been the least explored. In this unique mode non-uniform magnetic field distributions are taken advantage of to develop a so-called Venturi-like contraction in MR fluids. By adequately directing magnetic flux the material can be made solidified in the regions near the flow channel wall, thus creating a passage in the middle of the channel for the fluid to pass through.

Nucleation and growth of zinc-templated mesoporous selenium nanoparticles and potential non-thermal effects during their microwave-assisted synthesis.

The effects of 5.8-GHz microwave (MW) irradiation on the synthesis of mesoporous selenium nanoparticles (mSeNPs) in aqueous medium by reduction of selenite ions with ascorbic acid, using zinc nanoparticles as a hard template and cetyltrimethylammonium bromide (CTAB) as a micellar template, are examined for the first time with a particular emphasis on MW-particle interactions and the NPs morphology. This MW-assisted synthesis is compared to 2.

Dual-fluorescent starch biopolymer films containing 5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine powder as a functional nanofiller.

Physical and photophysical properties of starch-based biopolymer films containing 5-(4-nitrophenyl)-1,3,4-thiadiazol-2-amine (NTA) powder as a nanofiller were examined using atomic force microscopy (AFM), Fourier-transform infrared spectroscopy (FTIR), stationary UV-Vis and fluorescence spectroscopy as well as resonance light scattering (RLS) and time-resolved measurements, and where possible, analyzed with reference to pristine NTA solutions. AFM studies revealed that the addition of NTA into the starch biopolymer did not significantly affect surface roughness, with all examined films displaying similar Sq values ranging from 70.7 nm to 79.

Experimental and computational analysis of SnS encapsulated into carbonized chitosan as electrode material for potassium ion batteries.

Tin sulphide compounds (SnS, x = 1, 2) are potential anode materials for potassium-ion batteries (PIBs) due to their characteristic layered structure, high theoretical capacity, non-toxicity and low production cost. However, they suffer from significant volume changes resulting in poor performance of such anodes. In this work incorporation of SnS into the carbon structure was expected to overcome these disadvantages.

Wignerian symplectic covariance approach to the interaction-time problem.

The concept of the symplectic covariance property of the Wigner distribution function and the symplectic invariance of the Wigner-Rényi entropies has been leveraged to estimate the interaction time of the moving quantum state in the presence of an absolutely integrable time-dependent potential. For this study, the considered scattering centre is represented initially by the Gaussian barrier. Two modifications of this potential energy are considered: a sudden change from barrier to barrier and from barrier to well.

The comparison of the antioxidant, antibacterial and antiviral potential of Polish fir honeydew and Manuka honeys.

The aim of the present study was to compare the antioxidant, antibacterial and antiviral activities of Podkarpackie coniferous honeydew honey and Manuka honey. The quality of tested honey samples (honeydew-12 and Manuka-4) regarding honey standard was evaluated as well as additional indicators (methylglyoxal, total phenolics and HPTLC phenolic profile, antioxidant potential, glucose oxidase activity, and hydrogen peroxide) were compared. Antibacterial potential was analyzed against Gram-positive (S.

Finite element analysis of RC beams using static experimental data to predict static and dynamic behaviors.

This study comprehensively compares dynamic and static forces in reinforced concrete (RC) beams, utilising experimental and finite element analysis (FEA) methodologies. Experimental tests involve monotonic two-point loading of 1 m x 150 mm x 150 mm RC beams using a universal testing machine (UTM). Deflection measurements are taken at three distinct locations (S1-S3) using various sensors, including force resisting sensor (FRS), flex sensor (FLS), MEMS accelerometer, and Piezoelectric sensors.

Impact of gut colonization by antibiotic-resistant bacteria on the outcomes of autologous stem cell transplantation in multiple myeloma.

Patients undergoing autologous stem cell transplantation (auto-SCT) face elevated risks of infections. Additionally, patients colonized in the gastrointestinal tract with antibiotic-resistant bacteria (ARB) are at higher risk of infection with ARB and other infections. Therefore, patients colonized with ARB before auto-SCT should present with an exceptionally high incidence of infections.

General procrastination and bedtime procrastination as serial mediators of the relationship between temporal perspective and sleep outcomes.

Adequate and sufficient sleep is essential for good health, effective functioning, and well-being, yet recent trends show increasing sleep deprivation, especially among adolescents and young adults. General procrastination and bedtime procrastination understood as the tendency to delay going to bed without external pressure, may contribute to sleep deprivation and fatigue. This study investigated how individual differences in time perspective are related to sleep sufficiency and daytime fatigue, two different sleep outcomes.