The IL-23/Th17 pathway inhibitors in the treatment of psoriasis and the risk of skin malignancies: a review.

Psoriasis and psoriatic arthritis are chronic inflammatory conditions that constitute a significant global health burden due to their prevalence and impact on quality of life. A deeper comprehension of psoriasis and psoriatic arthritis pathogenesis has recently led to the emergence of novel classes of biologics targeting the IL-23/Th17 pathway. The specific role of interleukin-12, -23, and -17 in cancer as either promoters or inhibitors is under investigation in various studies.

Is there still a place for neutrophil gelatinase-associated lipocalin to serve as a biomarker in psoriasis?

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) is believed to be involved in the pathogenesis of psoriasis, and its serum level was previously found to decline after administration of biologics, UV, and cyclosporine therapy.

Aim: To investigate whether NGAL may serve as a biomarker of disease activity in psoriasis vulgaris.

Material And Methods: To measure the level of NGAL in serum, 36 patients with psoriasis vulgaris and 33 healthy controls were enrolled.

Impact of ozone concentration on the treatment effectiveness of diabetic foot syndrome: a pilot single-centre study.

Introduction: Diabetic foot syndrome (DFS) a severe complication of diabetes which can result in ulcers, infections, or tissue damage in the feet.

Aim: To compare the treatment effectiveness in patients with DFS using local O therapy depending on the O concentration.

Material And Methods: The study included 50 patients, 24 male and 26 female ones, in the age range between 39 and 84 years, with DFS.

Specificity and sensitivity of questionnaires in the diagnosis of allergic diseases.

Introduction: Due to their widespread character, allergic diseases are a significant challenge in the field of public health and clinical practice. The available clinimetric tools, including standardized and validated questionnaires, play an important role in determining the incidence of a particular allergic disease in the targeted population.

Aim: We attempted to evaluate the specificity and sensitivity of modified and standardized questions from the ISSAC and ECRHS questionnaires in the diagnosis of allergic diseases.

Alexithymia in people with tattoos.

Introduction: Tattoos are a form of body modifications. Alexithymia is a complex personality structure that includes emotional and cognitive deficits such as difficulty in recognizing and describing feelings.

Aim: To assess the prevalence of alexithymia among tattooed individuals.

Collision tumours: our recent experience.

Introduction: Collision skin lesions (CSL) are rare clinical and pathological entities, posing significant diagnostic and therapeutic challenges. These lesions comprise at least two distinct cell populations - benign and/or malignant neoplasms - that are adjacent yet clearly demarcated. CSL were categorized as collision tumours into three types: two benign lesions, one benign and one malignant lesion, and two malignant lesions, with the most common being basal cell carcinoma (BCC) and melanocytic naevus.

SCALPDEX Questionnaire: creation and validation of the Polish language version.

Introduction: Assessing the quality of life (QoL) in patients with various diseases is essential for understanding their well-being and guiding clinical management. Dermatological conditions, particularly those affecting the scalp, significantly impact QoL due to their visible nature, which can affect appearance and social interactions. While general QoL instruments like the Dermatology Life Quality Index (DLQI) exist, disease-specific tools like SCALPDEX are necessary for capturing the unique challenges faced by patients with scalp disorders.

Relationship between cigarette smoking and chronic spontaneous urticaria. Is there a difference in neutrophil-lymphocyte ratio?

Introduction: Chronic spontaneous urticaria (CSU) is defined as the appearance of itchy wheals and/or angioedema for at least 6 weeks. Cigarette smoking is one of the world's most common addictions. It is a cause of serious diseases such as renal cancer or thromboembolic incidents.

Epidemiological, economic and humanistic burden of cervical intraepithelial neoplasia in Europe: A systematic literature review.

Introduction: High-grade cervical intraepithelial neoplasia (CIN) is a premalignant lesion of the cervix caused by persistent human papillomavirus (HPV) infection, which can lead to cervical cancer. Despite ongoing primary prevention efforts, considerable burden of illness remains. This study assessed the epidemiological, economic, and humanistic burden associated with high-grade CIN among adult women in Europe.

MOTS-c Impact on Muscle Cell Differentiation and Metabolism Across Fiber Types.

Background/aims: MOTS-c belongs to a group of mitochondrial peptides involved in metabolic processes in the body. This peptide has garnered increasing attention since its discovery in 2015 because of its potential to ameliorate metabolic parameters in animals with diabetes or insulin resistance. MOTS-c is involved in muscle metabolism; however, little is known about its role in fiber differentiation.

Geographic differences in the phenology of gonadal development and moult, but not of egg laying, are genetically based in a small songbird.

To forecast how fast populations can adapt to climate change, it is essential to determine the evolutionary potential of different life-cycle stages under selection. In birds, timing of gonadal development and moult are primarily regulated by photoperiod, while laying date is highly phenotypically plastic to temperature. We tested whether geographic variation in phenology of these life-cycle events between populations of great tits () has a genetic basis, indicating that contemporary genetic adaptation is possible.

The promise of community-driven preprints in ecology and evolution.

Publishing preprints is quickly becoming commonplace in ecology and evolutionary biology. Preprints can facilitate the rapid sharing of scientific knowledge establishing precedence and enabling feedback from the research community before peer review. Yet, significant barriers to preprint use exist, including language barriers, a lack of understanding about the benefits of preprints and a lack of diversity in the types of research outputs accepted (e.

Psychosocial working conditions and subjective well-being amongst platform workers compared to freelancers and traditional workers in Poland.

. Technological development in the field of access to work has caused changes in the market and developed new strategies of professional activity. Within the gig economy, new forms of work have emerged.

Rationale and design of the FAIR-HF2-DZHK05 trial: Ferric carboxymaltose assessment of morbidity and mortality in patients with iron deficiency and chronic heart failure.

Aims: While it is widely accepted that intravenous (IV) iron improves functional capacity, symptoms, and cardiovascular outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF) diagnosed with iron deficiency (ID), three recently published cardiovascular outcome trials (AFFIRM-AHF, IRONMAN and HEART-FID) of IV iron supplementation in HF failed to demonstrate a significant benefit on their respective primary endpoints. Dosing of IV iron after the initial correction of baseline ID - by design or as a result of trial circumstances - was relatively low (i.e.

Chemical and physical properties of orthoconic liquid crystals: H NMR spectroscopy and molecular dynamics simulations.

In the field of chiral smectic liquid crystals, orthoconic antiferroelectric liquid crystals (OAFLCs) have attracted the interest of the scientific community due to the very high tilt angle, close to 45°, and the consequent optical properties. In the present study, the first H NMR investigation is reported on two samples, namely 3F5HPhF9 and 3F7HPhF8, showing the phase sequence isotropic-SmC*-SmC* and the phase sequence isotropic-SmA-SmC*-SmC*, respectively, when cooling from the isotropic to the crystalline phases. To this aim, the liquid crystals were doped with a small amount of deuterated probe biphenyl-4,4'-diol-d.

Protocol for Oligonucleotides Characterization Using Hydrophilic Interaction Chromatography.

Oligonucleotides (ONs) are an increasingly popular category of molecules in the pharmaceutical landscape, particularly attractive for the treatment of genetic and rare diseases. However, analyzing these molecules presents significant challenges, due to their highly hydrophilic nature, multiple negative charges, and the presence of closely related impurities resulting from the complex solid-phase synthesis process. Ion pairing reverse-phase liquid chromatography (IP-RPLC) is the preferred technique for ONs analysis but is not ideal for mass spectrometry (MS) coupling.

First molecular detection of hemotropic Mycoplasma spp. and molecular screening of other vector-borne pathogens in camels from the greater Cairo metropolitan area, Egypt.

In Egypt, knowledge about vector-borne bacterial pathogens in camels remains limited. To address this gap, 181 blood samples from adult one-humped camels (Camelus dromedarius) in the greater Cairo metropolitan area were collected from October 2021 to March 2022. Through PCR assays, four pathogens were detected, where Anaplasmataceae being the most common (54.

Anti-IL-5 treatment, but not neutrophil interference, attenuates inflammation in a mixed granulocytic asthma mouse model, elicited by air pollution.

Introduction: Diesel exhaust particles (DEP) have been proven to aggravate asthma pathogenesis. We previously demonstrated that concurrent exposure to house dust mite (HDM) and DEP in mice increases both eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) and also results in higher levels of neutrophil-recruiting chemokines and neutrophil extracellular trap (NET) formation compared to sole HDM, sole DEP or saline exposure. We aimed to evaluate whether treatment with anti-IL-5 can alleviate the asthmatic features in this mixed granulocytic asthma model.

Nedosiran in pediatric patients with PH1 and relatively preserved kidney function, a phase 2 study (PHYOX8).

Background: Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder with dysregulated glyoxylate metabolism in the liver. Oxalate over-production leads to renal stones, progressive kidney damage and renal failure, with potentially life-threatening systemic oxalosis. Nedosiran is a synthetic RNA interference therapy, designed to reduce hepatic lactate dehydrogenase (LDH) to decrease oxalate burden in PH.

Analysis of the spatial distribution of metabolites in Aloe vera leaves by mass spectrometry imaging and UHPLC-UHRMS.

This study presents an investigation of the chemical composition of Aloe vera leaf tissue with a focus on the spatial distribution of compounds. The composition was studied using two mass spectrometry imaging techniques: silver-109 nanoparticles assisted laser desorption/ionization mass spectrometry imaging (AgNPs-LDI-MSI) and laser ablation-remote atmospheric pressure photoionization/chemical ionization mass spectrometry imaging (LARAPPI/CI-MSI) and the identification was aided by ultra-high-performance liquid chromatography and ultra-high-resolution mass spectrometry (UHPLC-UHRMS) analysis. The results showed an abundance of phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties, making it a beneficial food additive and food packaging material.

An ultrawideband monopulse feed with slant polarization for tracking radar systems.

An ultrawideband slant-polarized monopulse feed is designed and fabricated for microwave applications. The proposed configuration features four end-launched diagonal horns allowing for the production of sum and difference channels in two principal planes. The key advantage of this proposed monopulse antenna over traditional monopulse feeds is its ability to combine the benefits of ultrawideband performance with slant polarization while maintaining acceptable side lobe level.

Essential and risk elements in horses affect haematology, serum biochemistry and oxidative status parameters.

The abundance of chemical elements in the blood of horses can indicate the physiological balance, health of animal as well as can be taken as an indicator of environmental pollution. The aim of this work was to analyse haematological, biochemical parameters, TOS, FRAP, SOD, Gpx, TAS and their correlations with concentrations of essential and risk elements in blood of horses stabled in two different locations: The National Stud Farm Topoľčianky (n = 11; 11 stallions, consisting of the breeds 6 Lipizzan, 3 Slovak warmblood, 2 Holsteiner) and Experimental Centre at Institute of Animal Husbandry, SUA in Nitra (n = 10; 4 stallions, 5 geldings, 1 mare, 4 stallions, 5 geldings and 1 mare, consisting of the breeds 3 Slovak warmblood, 4 Czech warmblood, 3 Holsteiner). Blood samples were obtained from horses (n = 21) from two localities in the Slovak Republic during May.

Mechanical properties of modern restorative "bioactive" dental materials - an in vitro study.

This study aimed at assessing the mechanical properties and degradation of commercial bioactive materials. The bioactive materials (Activa Bioactive Restorative, Beautifil Flow Plus F00, F03, Predicta Bulk Bioactive) and composite resin Filtek Supreme Flow were submitted to flexural and diametral tensile strength tests (FS, DTS), modulus of elasticity (ME) evaluation, and analysis of aging in 70% ethanol and saliva on their hardness and sorption. The results for DTS ranged from 33.