The transcriptional and translational landscape of HCoV-OC43 infection.

The coronavirus HCoV-OC43 circulates continuously in the human population and is a frequent cause of the common cold. Here, we generated a high-resolution atlas of the transcriptional and translational landscape of OC43 during a time course following infection of human lung fibroblasts. Using ribosome profiling, we quantified the relative expression of the canonical open reading frames (ORFs) and identified previously unannotated ORFs.

Investigation of the canine elbow joint innervation in 100 joints.

The canine elbow joint is innervated by four nerves: the musculocutaneous, median, radial, and ulnar nerves. There is little data in the veterinary literature examining the course of the articular branches of those nerves. There is also no agreement as to their anatomical location in the joint capsule nor to their number.

Use of AI methods to assessment of lower limb peak torque in deaf and hearing football players group.

Monitoring and assessing the level of lower limb motor skills using the Biodex System plays an important role in the training of football players and in post-traumatic rehabilitation. The aim of this study was to build and test an artificial intelligence-based model to assess the peak torque of the lower limb extensors and flexors. The model was based on real-world results in three groups: hearing ( = 19) and deaf football players ( = 28) and non-training deaf pupils ( = 46).

Isokinetic strength and jumping abilities of teenage soccer players playing in different field positions.

Soccer is a sport being performed in a very dynamic manner. It requires soccer players to be able to develop high muscle force in a very short period of time. The aim of the study was to evaluate the strength and jumping abilities of young soccer players playing in different positions on the field.

Influence of sterilization and exposure to the Ringer's solution on physicochemical properties of nitrocarburized 316 LVM steel.

The aim of the study was to investigate the influence of the nitrocarburizing process carried out in low temperature plasma using the active screen at 440 °C on the structure and physicochemical properties of the 316LVM steel. In the paper, results of micro-structure and phase composition of the layers, roughness, and surface wettability, potentiodynamic pitting corrosion resistance, penetration of ions into the solution as well as biological tests were present. The studies were conducted for the samples of both mechanically polished and nitrocarburized surfaces, after sterilization, and exposure to the Ringer's solution.

Morphometric assessment of mandibles with complications resulting from temporomandibular joint ankylosis in children from 4 months to 3 years of age.

: The main aim of this paper was to perform the morphological assessment of children's mandibles of different etiology of dys-functions within the temporomandibular joint, from isolated idiopathic ankylosis to craniofacial malformations co-existing with genetic disorders. : The investigations encompassed seven patients at the age of 0-3. Measurements were conducted on the basis of data obtained from computed tomography.

Influence of heat treatment method on selected physicochemical and biological properties of fluoride-substituted calcium apatite.

: The synthesis of fluoridated apatite consists of several stages, among which the heat treatment has a significant impact on the physical and chemical properties. The present study aims to elucidate the influence of two different sintering methods on fluoride-substituted apatite properties. : For this purpose, a two F-substituted apatites were produced by heat treatment in different ways called "rapid sintering" and "slow sintering".

Importance of the assessment of knee joint function after a stroke.

: This study aimed to assess knee joint function in post-stroke patients using wireless motion sensors and functional tests. This type of evaluation may be important for improving gait quality. : The study included 25 post-stroke patients (age 53.

Analysis of vibrations transmitted to the feet of a wheelchair user.

: The aim of the study was to quantitatively evaluate the vibrations received on the wheelchair footrest and to determine whether wheelchair users are at risk of vibration-white foot. This assessment was made using the ISO 2631 standard. : The measurements were taken on the footrest of a universal wheelchair.

Evaluation of frictional wear in a follow-up screw-rod kinematic node in GGS transpedicular stabilization.

: The aim of this study was to evaluate the abrasive wear of the sliding screw-rod joint used in growth guidance system (GGS) stabilizers, allowing for the translation of the screw along the rod during the spinal growth process in a standard and modified system. : The study used single kinematic screw-rod pairs made of titanium alloy Ti6Al4V. Mechanical tests (cyclic loads) simulated the stabilizer's operation under conditions similar to actual use.

The real rotational capacity of the human joints - the muscular and gravitational torques and the foot as a platform.

The purpose was to answer what is the relationship between torques acting on the human body, how does the triceps calf muscle balance the weight of a tilted body and what is the foot's role in the titling body? Two research models were developed. Model 1 - the one-sided lever system consists of a flat bar with, an axis of rotation, used to determine the weight and torque at a given point on it. Model 2 - the two-sided lever system consists of a flat bar imitating a tilted body counteracted by the Achilles tendon, and a platform imitating a foot.

Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice.

Background: The current study investigated the effects of high-fat diet on acute response to 3,4-methylenedioxypyrovalerone (MDPV) in mice. MDPV is a beta-cathinone derivative endowed with psychostimulant activity. Similarly to recreational substances, consumption of palatable food stimulates the mesolimbic dopaminergic system, resulting in neuroadaptive changes.

From cytogenetics to cytogenomics: a new era in the diagnosis of chromosomal abnormalities in domestic animals.

Identification of chromosomal abnormalities is an important issue in animal breeding and veterinary medicine. Routine cytogenetic diagnosis of domestic animals began in the 1960s with the aim of identifying carriers of centric fusion between chromosome 1 and 29 in cattle. In the 1970s, chromosome banding techniques were introduced, and in the 1980s, the first cytogenomic techniques, based on the development of locus- and chromosome-specific probes, were used.

Kombucha fortified with Cascade hops (Humulus lupulus L.): enhanced antioxidative and sensory properties.

In recent years, there has been a surge in the production of kombucha-a functional beverage obtained via microbial fermentation of tea. However, fresh, unpasteurized kombucha is sensitive to quality deterioration as a result of, among other factors, oxidation. The addition of hops seems to be promising, due to their antioxidative properties, which may improve the stability of kombucha.

Severe bradycardia in patients with obstructive sleep apnoea and good early response to CPAP.

Background: Obstructive sleep apnoea (OSA) may lead to heart rhythm abnormalities including bradycardia. Our aim was to ascertain clinical and echocardiographic parameters in patients with OSA in whom severe bradycardia was detected in an outpatient setting, as well as to evaluate the efficacy of CPAP therapy on heart rate normalization at the early stages of treatment.

Methods: Fifteen patients mild, moderate or severe OSA and concomitant bradycardia were enrolled.

Alternative Role of B/b Knob-Hole Interactions in the Fibrin Assembly.

The self-assembly of fibrin is a vital process in blood clotting, primarily facilitated by the interactions between knobs "A" and "B" in the central E region of one molecule and the corresponding holes "a" and "b" in the peripheral D regions of two other fibrin molecules. However, the precise function of the interactions between knob "B" and hole "b" during fibrin polymerization remains a subject of ongoing debate. The present study focuses on investigating intermolecular interactions between knob "B" and hole "b".

The Intermittent Pneumatic Compression Influences Edema Fluid Movement and Promotes the Compensatory Drainage Pathways in Patients with Breast Cancer Related Lymphedema.

Upper limb lymphedema is the most common complication after breast cancer therapy. Suddenly disturbed lymphatic transport in the affected arm causes tissue fluid accumulation in tissue spaces, limb enlargement, and secondary changes in tissue. Early compression therapy is necessary.

Predictors of Arrhythmia Recurrence After Cryoballoon Ablation for Persistent Atrial Fibrillation: A Sub-Analysis of the Cryo Global Registry.

Introduction: Freedom from recurrences of atrial tachyarrhythmia (ATA) is suboptimal after pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (PsAF). This sub-analysis from the Cryo Global Registry sought to investigate predictors of ablation success after PVI using cryoballoon ablation (CBA) for PsAF.

Methods And Results: ATA recurrence was defined as ≥ 30 s recurrence of atrial fibrillation, atrial flutter or atrial tachycardia after a 90-day blanking period and through 12-months.

Diet quality indicators and organic food consumption in mothers of young children.

Background: The health benefits of organic food provide one reason for consuming it. Various studies have shown that regular organic food consumers (REG eco-con) follow a healthier diet. However, this topic has not been explored in Poland.

Peroneus brevis split tear - A challenging diagnosis: A pictorial review of magnetic resonance and ultrasound imaging. Part 1. Anatomical basis and clinical insights.

Diagnosing peroneus brevis split tears is a significant challenge, as many cases are missed both clinically and on imaging. Anatomical variations within the superior peroneal tunnel can contribute to peroneus brevis split tears or instability of the peroneal tendons. However, determining which anatomical variations predispose patients to these injuries remains challenging due to conflicting data in the literature.

Incorporating thermal co-evaporation in current-matched all-perovskite triple-junction solar cells.

Thermal co-evaporation of halide perovskites is a solution-free, conformal, scalable, and controllable deposition technique with great potential for commercial applications, particularly in multi-junction solar cells. Monolithic triple-junction perovskite solar cells have garnered significant attention because they can achieve very high efficiencies. Nevertheless, challenges arise in fabricating these devices, as they require multiple layers and precise current matching across complex absorber stacks.

Evaluation of the Effectiveness of Using LED Light Combined With Chromophore Gel in Treating Acne Vulgaris - Preliminary Study.

Purpose: The aim was to quantitatively evaluate the effectiveness of LED light therapy combined with photoacceptor substances having anti-acne properties in reducing the symptoms of acne vulgaris.

Patients And Methods: 15 subjects aged 20 to 24 who suffered from moderate or severe acne lesions. The treatments were performed using a LED device (465-880 nm).

Desensitization With Imlifidase for HLA-Incompatible Deceased Donor Kidney Transplantation: A Delphi International Expert Consensus.

Highly sensitized (HS) patients in need of kidney transplantation (KTx) typically spend a longer time waiting for compatible kidneys, are unlikely to receive an organ offer, and are at increased risk of antibody-mediated rejection (AMR). Desensitization using imlifidase, which is more rapid and removes total body immunoglobulin G (IgG) to a greater extent than other methods, enables transplantation to occur between HLA-incompatible (HLAi) donor-recipient pairs and allows patients to have greater access to KTx. However, when the project was launched there was limited data and clinical experience with desensitization in general and with imlifidase specifically.

Large language models for pretreatment education in pediatric radiation oncology: A comparative evaluation study.

Background And Purpose: Pediatric radiotherapy patients and their parents are usually aware of their need for radiotherapy early on, but they meet with a radiation oncologist later in their treatment. Consequently, they search for information online, often encountering unreliable sources. Large language models (LLMs) have the potential to serve as an educational pretreatment tool, providing reliable answers to their questions.