Development of a new tool to simultaneously measure soil-gas permeability and CO concentration as important parameters for geogenic radon potential assessment.

This study assessed the geogenic radon potential using PECAME, an innovative tool designed to simultaneously measure soil-gas permeability and CO concentration - two key parameters for understanding radon transport in soil. Comparative field studies using the RADON-JOK device in various geological settings in Japan and Poland demonstrate the effectiveness of PECAME. These studies reveal a strong correlation between PECAME and RADON-JOK, with an R value of 0.

Elimination of oral foci of infection might lead to clinical improvement of Graves' orbitopathy.

Purpose: Graves' disease (GD) and Graves' orbitopathy (GO) are multifactorial disorders with links to the gut microbiome and autoimmunity. It is observed that patients with GD exhibit altered gut microbiome diversity. However, little is known about the role of oral microbiota in GD and GO.

Description of changes in chemical bonding along the pathways of chemical reactions by deformation of the molecular electrostatic potential.

Context: The analysis of the changes in the electronic structure along intrinsic reaction coordinate (IRC) paths for model reactions: (i) ethylene + butadiene cycloaddition, (ii) prototype SN2 reaction Cl + CH3Cl, (iii) HCN/CNH isomerization assisted by water, (iv) CO + HF → C(O)HF was performed, in terms of changes in the deformation density (Δr) and the deformation of MEP (ΔMEP). The main goal was to further examine the utility of the ΔMEP as a descriptor of chemical bonding, and to compare the pictures resulting from Δr and ΔMEP. Both approaches clearly show that the main changes in the electronic structure occur in the TS region.

Basic Science and Pathogenesis.

Background: Alzheimer's disease (AD) is characterized by an acquired, progressive impairment of cognitive functions. The pathogenesis of this disease remains unknown. It is explained based on the following theories: amyloid cascade, inflammation, vascular, and infection hypothesis.

Basic Science and Pathogenesis.

Background: Tauopathies are a group of neurodegenerative disorders which are characterized by the accumulation of abnormal tau protein in the brain. However, the mechanistic understanding of pathogenic tau formation and spread within the brain remains elusive. Astrocytes are major immune reactive cells in the brain and have been implicated in exacerbating tau pathology by releasing extracellular vesicles (AEVs) containing pro-inflammatory cytokines and chemokines upon activation.

Basic Science and Pathogenesis.

Background: Cognitive disorders are a growing cause of morbidity and mortality worldwide. Diagnostic approaches to improve early diagnosis of cognitive disorders are constantly being sought. The pathogenesis of cognitive impairment is multifactorial and complex.

Advancing dynamic quantum crystallography: enhanced models for accurate structures and thermodynamic properties.

X-ray diffraction (XRD) has evolved significantly since its inception, becoming a crucial tool for material structure characterization. Advancements in theory, experimental techniques, diffractometers and detection technology have led to the acquisition of highly accurate diffraction patterns, surpassing previous expectations. Extracting comprehensive information from these patterns necessitates different models due to the influence of both electron density and thermal motion on diffracted beam intensity.

Outflows from Naked Singularities, Infall through the Black Hole Horizon: Hydrodynamic Simulations of Accretion in the Reissner-Nordström Space-Time.

We performed the first simulations of accretion onto the compact objects in the Reissner-Nordström (RN) space-time. The results obtained in general relativity are representative of those for spherically symmetric naked singularities and black holes in a number of modified gravity theories. A possible application of these calculations is to the active galactic nuclei with their powerful jets and outflows.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Luminescence of the CsZrCl under High Pressure.

The photoluminescence (PL) and Raman spectra of the CsZrCl crystal over a wide range of pressures were studied in this work for the first time. PL measurements were performed up to 10 GPa, while the Raman spectra were measured up to 20 GPa. The PL data revealed a linear blue shift of the emission maximum from about 2.

Effects of Sympathetic Denervation in Metabolism Regulation: A Novel Approach for the Treatment of MASLD?

Although metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease, has become the most common chronic liver disorder, its complex pathophysiology has not been fully elucidated up to date. A correlation between elevated sympathetic activation and MASLD has been highlighted in recent preclinical and clinical studies. Furthermore, increased sympathetic activity has been associated with the main mechanisms involved in MASLD, such as lipid accumulation in the liver, insulin resistance, and metabolic dysregulation, while it has been also correlated with the progression of MASLD, leading to liver fibrosis.

Anesthesia and Pain Management for Scoliosis Surgery: A Narrative Review.

Study Design: This was a narrative review.

Objective: The objective of this review was to summarize the current evidence and knowledge gaps regarding anesthesia and pain management for scoliosis surgery, including multimodal analgesia, and identify the best anesthetic approach to scoliosis surgery that ensures patient safety and pain relief even in the postoperative period, with minimal influence on SSEP monitoring.

Summary Of Background Data: Spinal surgeries and fusions for scoliosis are associated with high pain levels.

Telemedicine in cancer care: lessons from COVID-19 and solutions for Europe.

The COVID-19 pandemic challenged healthcare delivery, especially cancer care. Telemedicine emerged as an important tool to reduce disease transmission risks, maintain continuity of care, and improve accessibility. This study explores temporary measures during the pandemic as well as challenges and facilitators for integrating telemedicine into the European healthcare landscape in five case countries, focusing on cancer care.

NHC-Au-xanthate complexes.

We report the synthesis, isolation, and comprehensive characterization of N-heterocyclic carbene gold xanthate (NHC-Au-X, X - xanthate) complexes. These easily accessible complexes demonstrate significant versatility as photocatalysts, facilitating [2+2]-cycloadditions, and as π-catalysts in the intramolecular hydroxylation of allenes and hydrohydrazination of alkynes.

Investigation of the Effect of Sb Ion on the Spectroscopic Properties of Eu-Doped YVO Nanosized Materials.

This paper discusses the origin of emission quenching in yttrium orthovanadate codoped with Eu and Sb ions. Highly crystalline yttrium orthovanadate nanoparticles with chemical composition YEuSbVO ( = 0-5.4 mol %, = 0-2.

Static and dynamic balance in physically active females with pronated feet.

Background: Understanding and assessing static and dynamic balance and their relationship with the function of the medial longitudinal arch of the foot is crucial for people with pronated feet.

Purpose: This study aimed to assess the medial longitudinal arch height and postural balance in physically active females with pronated feet.

Methods: A case-control study.

SCXRD, CSP-NMRX and microED in the quest for three elusive polymorphs of meloxicam.

Crystal structure determination is a crucial aspect of almost every branch of the chemical sciences, bringing us closer to understanding crystallization, polymorphism, phase transitions, and the relationship between a structure and its physicochemical and functional properties. Unfortunately, many molecules notoriously crystallize as microcrystalline powders, providing a significant challenge in establishing their structures. In this work, we describe the crystal structure determination of three elusive polymorphs of the anti-inflammatory drug meloxicam (MLX) using three approaches, of which only one was successful for each crystal phase.

Human Footprint and Forest Disturbance Reduce Space Use of Brown Bears (Ursus arctos) Across Europe.

Three-quarters of the planet's land surface has been altered by humans, with consequences for animal ecology, movements and related ecosystem functioning. Species often occupy wide geographical ranges with contrasting human disturbance and environmental conditions, yet, limited data availability across species' ranges has constrained our understanding of how human pressure and resource availability jointly shape intraspecific variation of animal space use. Leveraging a unique dataset of 758 annual GPS movement trajectories from 375 brown bears (Ursus arctos) across the species' range in Europe, we investigated the effects of human pressure (i.

The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis.

The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties . Here, we report the design and synthesis of a number of new derivatives inspired by the structure of thiazolidine-2,4-dione (TZD).

Comparative immunogenicity assessment of biosimilar natalizumab to its reference medicine: a matching immunogenicity profile.

Background: Biosimilar natalizumab (biosim-NTZ) is the first biosimilar monoclonal antibody of reference natalizumab (ref-NTZ) for treatment of relapsing forms of multiple sclerosis (MS). Within the totality of evidence for demonstration of biosimilarity, immunogenicity assessments were performed in healthy subjects and patients with relapsing-remitting MS (RRMS) to confirm a matching immunogenicity profile between biosim-NTZ and ref-NTZ.

Methods: Immunogenicity of biosim-NTZ versus ref-NTZ was evaluated in two pivotal clinical studies.

Religion and flourishing among Afro-Trinidadians: the influence of proneness to guilt/shame and forgiveness by God on the relationship between religious commitment and health.

Background: Religiousness has been consistently linked to positive health outcomes and flourishing, yet the underlying mechanisms are complex and not well-understood. The forgiveness and relational spirituality model offers a framework to explore the moderated mediation among religious commitment, health, and forgiveness by God. Understanding these relationships among university students and community residents in Trinidad and Tobago can provide valuable insights into the role of religiousness in promoting wellbeing.

A Single-Center Experience: Integrated Management in Primary Central Nervous System Lymphoma.

The present study reports a single-center experience conducted at Józef Struś Multispecialty City Hospital in Poznań, Poland, in diagnosing and treating two patients with primary central nervous system lymphoma (PCNSL), one immunocompetent and one immunodeficient (AIDS). PCNSL is an extremely rare neoplasm with a poor prognosis and non-specific treatment on the basis of immunocompetency. Standard treatment consists of high-dose methotrexate (HD-MTX) being the background of a multimodal therapy, including other chemotherapeutic agents with and without radiation.

Identification and Management of CKD-Associated Pruritus: Current Insights.

Chronic kidney disease-associated pruritus (CKD-aP) is a frequent and distressing problem for individuals with chronic kidney disease (CKD) and end-stage renal disease. It affects around 20% of those with CKD and 40% of those with end-stage renal disease. Despite its clear association with poorer psychosocial and medical outcomes, it is often underreported by patients and frequently remains unnoticed by healthcare providers.

Organotin(IV) derivatives of 4-chloro-2-methylphenoxyacetic acid: synthesis, spectral characterization, X-ray structures, anticancer, enzyme inhibition, antileishmanial, antimicrobial and antioxidant activities.

Four organotin(IV) carboxylate complexes; (CH)SnL (), CHSnL (), (CH)SnL () and (CH)SnL () are synthesized by the condensation reaction of organotin(IV) chlorides with sodium-4-chloro-2-methylphenoxyacetate (). The FT-IR spectra suggested bridging/chelating bidentate coordination of the ligand to the tin atom. Single-crystal XRD analysis authenticated the FT-IR findings for and .