Illuminating the dark mess of fibers: Application of circular cross polarized light in unravelling the bone tissue structure of the dermal pectoral girdle of Metoposaurus krasiejowensis.

Current understanding of the histology of the dermoskeleton of tetrapods comes from fossilized and recent remains of skulls, osteoderms, carapace, plastron and other postcranial material which were always investigated using linear cross polarized light (LCPL) microscopy. The pectoral girdle of vast majority of non-amniote tetrapods, including temnospondyls evolved large ventrally located dermal bones- the interclavicle and a pair of clavicles. Despite that, there is a lack of information about the bone tissue structure from these postcranial dermal bones.

Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: A FIDELITY analysis.

Aims: This post hoc analysis aimed to assess the efficacy and safety of the non-steroidal mineralocorticoid receptor antagonist finerenone by baseline diuretic use in FIDELITY, a pre-specified pooled analysis of the phase III trials FIDELIO-DKD and FIGARO-DKD.

Methods And Results: Eligible patients with type 2 diabetes (T2D) and chronic kidney disease (CKD; urine albumin-to-creatinine ratio [UACR] ≥30-<300 mg/g and estimated glomerular filtration rate [eGFR] ≥25-≤90 ml/min/1.73 m, or UACR ≥300-≤5000 mg/g and eGFR ≥25 ml/min/1.

Exploring the link between inflammation and brain function after metabolic-bariatric surgery: A year-long fMRI study.

Background: Metabolic-bariatric surgery (MBS) transcends weight loss and offers wide-ranging health benefits, including positive effects on brain function. However, the mechanisms behind these effects remain unclear, particularly in the context of significant postoperative changes in the inflammatory profile characteristic of MBS. Understanding how inflammation influences postoperative brain function can enhance our decision-making on patient eligibility for MBS and create new opportunities to improve the outcomes of this popular treatment.

Defect Engineered Ru-CoMOF@MoS Heterointerface Facilitate Water Oxidation Process.

Catalyst design plays a critical role in ensuring sustainable and effective energy conversion. Electrocatalytic materials need to be able to control active sites and introduce defects in both acidic and alkaline electrolytes. Furthermore, producing efficient catalysts with a distinct surface structure advances our comprehension of the mechanism.

Superhero in a skirt: Psychological resilience of Ukrainian refugee women in Poland. A thematic analysis.

This study delves into the diverse experiences of Ukrainian refugee women in Poland amid the ongoing Russian war, employing a community-based participatory action research approach in collaboration with a Polish foundation aiding Ukrainian war refugees. With the practical aim of formulating recommendations for the third sector assisting refugees, 33 semi-structured interviews ( = 40.29; = 11.

Error mitigation in forensic handwriting examination: the examiner's perspective.

Like other pattern recognition disciplines, forensic handwriting examination relies on various human factors. Expert opinions in the field are based on visual analysis and comparison, and the evaluation of findings is generally conducted without reference to tabulated data. This high level of subjectivity may contribute to bias and error in the examination process.

A highly accurate family of stable and convergent numerical solvers based on Daftardar-Gejji and Jafari decomposition technique for systems of nonlinear equations.

This study introduces a family of root-solvers for systems of nonlinear equations, leveraging the Daftardar-Gejji and Jafari Decomposition Technique coupled with the midpoint quadrature rule. Despite the existing application of these root solvers to single-variable equations, their extension to systems of nonlinear equations marks a pioneering advancement. Through meticulous derivation, this work not only expands the utility of these root solvers but also presents a comprehensive analysis of their stability and semilocal convergence; two areas of study missing in the existing literature.

Conversion Therapy for Stage IV Gastric Cancer: Report From the Expert Consensus Meeting at KINGCA WEEK 2024.

Conversion therapy is a treatment strategy that shifts from palliative systemic therapy to curative surgical treatment for primary and/or metastatic stage IV gastric cancer (GC). To address its clinical statements, the Korean Gastric Cancer Association aims to present a consensus on conversion therapy among experts attending KINGCA WEEK 2024. The KINGCA Scientific Committee and Development Working Group for Korean Practice Guidelines prepared preformulated topics and 9 clinical statements for conversion therapy.

New connective tissue structure of the wrist area - research on fetal material.

The correct function of the upper limb depends on the cooperation and coordination of the muscular and skeletal systems as well as the connective tissue elements present in it. Connective tissue forms fascia, connective tissue membranes and ligaments. Connective tissue mostly develops from the mesenchyme.

Occurrence of sleep disorders and the value of body mass index of seniors and the quality of their aging.

Aim: The aim of the study was to assess the occurrence of sleep disorders and the value of body mass index in seniors, taking into account their quality of aging and participation in classes at Universities of the Third Age (UTAs).

Methods: The study involved 631 (100%) seniors from the Silesian Voivodeship, aged 60 to 96 years (𝑥̅ = 70.28 ± 6.

Super-Resolution Goes Viral: T4 Virus Particles as Versatile 3D-Bio-NanoRulers.

In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications into the 3D domain. Various methodologies have been developed that enable isotropic resolution at the nanometer scale, facilitating the visualization of 3D subcellular structures with unprecedented clarity. Central to this progress is the need for reliable 3D structures that are biologically compatible for validating resolution capabilities.

Evaluation of sectional anatomic, micro-computed tomographic, and magnetic resonance imaging features of the thorax in Syrian hamsters (Mesocricetus auratus).

Clinically, the rodent thorax is important because of the variety of problems that may affect the heart, lungs, and other thoracic structures. Syrian hamsters are the most common pet and experimental hamster species. Sectional imaging of small mammals is widely increasing in use for clinical and research settings; however, no reports on the thoracic sectional imaging anatomy in this species have been made.

An unusual variant of an accessory thoracic muscle.

Background: The anterior thoracic wall musculature presents significant morphological variability. The current literature describes a few accessory thoracic muscles (ATMs) and discusses possible clinical implications. The dissection report describes an unusual ATM variant.

Anthropometric analysis of the external nose in young adults.

Background: Anthropometric analysis of the midface is essential, especially for rhinoplasty surgeons, medical aesthetics, medical jurisprudence, and anthropology. The aim of this study was to provide data to describe of the anthropometric dimensions of the nose and face among Caucasian young adults in order to establish reference values.

Materials And Methods: The study was conducted among 289 Polish students (115 men and 174 women).

A Concurrent Validity Study of the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI) in Infants with an Elevated Likelihood or Diagnosis of Autism.

Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether the concurrent validity of the MSEL and CDI differs based on autism likelihood and diagnosis.

Hydrogen Sensing via Heterolytic H2 Activation at Room Temperature by Atomic Layer Deposited Ceria.

Ultrathin atomic layer deposited ceria films (< 20 nm) are capable of H2 heterolytic activation at room temperature, undergoing a significant reduction regardless of the absolute pressure, as measured under in-situ conditions by near ambient pressure X-ray photoelectron spectroscopy. ALD-ceria can gradually reduce as a function of H2 concentration under H2/O2 environments, especially for diluted mixtures below 10%. At room temperature, this reduction is limited to the surface region, where the hydroxylation of the ceria surface induces a charge transfer towards the ceria matrix, reducing Ce4+ cations to Ce3+.

Population pharmacokinetics and exposure-response analysis of durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer.

Purpose: Durvalumab in combination with gemcitabine/cisplatin has shown a favorable benefit-risk profile in the TOPAZ-1 study for advanced biliary tract cancers (BTC). This analysis evaluated the population pharmacokinetics (PopPK) of durvalumab, and exposure-response for efficacy and safety (ERES) of TOPAZ-1.

Methods: The PopPK model for durvalumab was updated using data from 5 previously analysed studies and TOPAZ-1.

Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave.

Prognostic significance of the timing in the cardiac cycle of the first (TP1) and second (TP2) systolic peak of the central aortic pulse wave is ill-defined. Incidence rates and standardized multivariable-adjusted hazard ratios (HRs) of adverse health outcomes associated with TP1 and TP2, estimated by the SphygmoCor software, were assessed in the International Database of Central Arterial Properties for Risk Stratification (IDCARS) (n = 5529). Model refinement was assessed by the integrated discrimination (ID) and net reclassification (NR) improvement.