Effectiveness and adverse effects of immersive technologies used for rehabilitation of patients with non-specific neck pain: a systematic review.

Objective: The aim of this study is to evaluate the effectiveness of immersive technologies in the rehabilitation of patients with non-specific neck pain and identify any potential side effects associated with their use.

Design: Systematic review.

Subjects/patients: Individuals with non-specific neck pain.

Validation of the PANAMA-Score for Survival and Benefit of Adjuvant Therapy in Patients with Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX.

Aim: To validate the prognostic value of the PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection of pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX.

Background: The PANAMA-score was developed to guide prognostication in patients after neoadjuvant therapy and resection for PDAC. As this score focuses on the risk for residual disease after resection, it might also be able to select patients who benefit from adjuvant after neoadjuvant therapy.

Tetra-coordinated organoboron complexes with triaminoguanidine-salicylidene based ligands: aggregation induced enhanced emission and mechanoresponsive features.

Organoboron complexes have garnered significant attention due to their remarkable optical properties and diverse applications. However, synthesizing stable fused five-, six- and seven-membered organoboron complexes possess significant challenges. In this study, we successfully developed novel mono-nuclear (6-8 & 10) and di-nuclear (9) organoboron complexes supported by triaminoguanidine-salicylidene based -symmetric Schiff base ligands one-step condensation reaction with excess phenylboronic acid.

New taxa and a combination in Glomerales (Glomeromycota, Glomeromycetes).

This article presents the results of morphological studies, as well as comparisons and phylogenetic analyzes of sequences of four arbuscular mycorrhizal fungi (AMF, phylum Glomeromycota): , strain 211, Isolate 517, and Isolate 524. strain 211 was previously characterized only by sequences of the 45S nuc rDNA region (= 18S, partial, ITS-1-5.8S-ITS2, 28S, partial) and the gene (without any morphological data) that were deposited in GenBank under the incorrect name " strain 211".

Assessment of interocular symmetry of choroidal vascularity index and thickness in patients with systemic sclerosis: a prospective study.

Purpose: Systemic sclerosis (SSc) affects blood vessels, internal organs, and skin. In ophthalmology, SSc impacts the choroid. The choroidal vascularity index (CVI) measures the vascular component of the choroid and may serve as a biomarker for the disease staging and prognosis.

Identifying the Activated Carbon Electrode Aging Pathways in Lithium-Ion Hybrid Capacitors.

This paper reports on several mechanisms of carbon aging in a hybrid lithium-ion capacitor operating with 1 mol L LiPF in an ethylene carbonate/dimethyl carbonate 1:1 vol/vol electrolyte. Carbon electrodes were subjected to a constant polarization protocol (i.e.

Cu(ii) binding to an antimicrobial shrimp peptide - a small step for structural chemistry, a big leap for medicinal applications.

PvHCt, a 23-amino acid long, histidine-rich peptide derived from shrimp, becomes strongly antimicrobial upon Cu(ii) ion binding. We describe Zn(ii) and Cu(ii) complexes of this peptide, aiming to understand how metal binding and structure correlates to biological activity. Using NMR, UV-vis, CD and FTIR spectroscopies, along with cyclic voltammetry, potentiometry, and DFT calculations, we demonstrate that Cu(ii) binds to the central and C-terminal regions of the peptide, inducing significant structural changes.

Virtual environments as a novel and promising approach in (neuro)diagnosis and (neuro)therapy: a perspective on the example of autism spectrum disorder.

Over the last three decades, dynamically evolving research using novel technologies, including virtual environments (VEs), has presented promising solutions for neuroscience and neuropsychology. This article explores the known and potential benefits and drawbacks of employing modern technologies for diagnosing and treating developmental disorders, exemplified by autism spectrum disorder (ASD). ASD's complex nature is ideal for illustrating the advantages and disadvantages of the digital world.

Which Method of the Radiologic Measurements of the Angle of Curvature in Idiopathic Scoliosis is the Most Reliable for an Inexperienced Researcher?

Aim: The aim of the examination was to determine which of the three measurement methods Cobb (CB), Ferguson (FR), and Centroid (CN) has the best repeatability and reliability when the measurements are made by inexperienced researchers.

Methods: Three researchers (from the student research group) measured the angle of spine curvature on X-rays of the entire spine in standing anteroposterior view in 50 patients with severe idiopathic scoliosis qualified for surgery. Cobb, Ferguson, and Centroid methods were used.

Impact of #PCOSweightloss: A global X hashtag analysis study of weight loss narratives in the PCOS community.

Introduction: Social media plays a significant role in fostering communities around health and wellness. The hashtag #PCOSweightloss has become a pivotal forum on the platform X, where individuals exchange experiences, share information, and motivate each other concerning weight loss strategies connected with Polycystic Ovary Syndrome (PCOS).

Objective: This study aims to analyze the trends of #PCOSweightloss on X to gain insights into the social media metrics, including overall hashtag reach, key themes, and potential influence on management practices of PCOS.

Investigating the relationship between prenatal androgen exposure and sleep quality: a comprehensive study using anthropometric measurements, questionnaires, actigraphy, and polysomnography.

Background: The 2D:4D digit ratio (DR), representing the relative length of the index finger to the ring finger, is an anthropometric marker that shows sexual dimorphism, with males typically having a lower ratio than females. This parameter is linked to prenatal androgen exposure (PAE), which influences sexual differentiation of the brain and behavior. This study aimed to investigate the correlation between PAE and sleep among young adults.

ULaMDyn: enhancing excited-state dynamics analysis through streamlined unsupervised learning.

The analysis of nonadiabatic molecular dynamics (NAMD) data presents significant challenges due to its high dimensionality and complexity. To address these issues, we introduce ULaMDyn, a Python-based, open-source package designed to automate the unsupervised analysis of large datasets generated by NAMD simulations. ULaMDyn integrates seamlessly with the Newton-X platform and employs advanced dimensionality reduction and clustering techniques to uncover hidden patterns in molecular trajectories, enabling a more intuitive understanding of excited-state processes.

Al doped silica glass: investigation of structural response and defect interactions based on crystalline models.

High purity quartz glass is an important material in high-tech industries like semiconductors and photovoltaics due to, among other properties, its good mechanical performance at high temperatures. Small amounts of Al in silica glass (in the range between 20 ppm and 100 ppm) have previously been shown to increase the viscosity of the SiO glass. The underlying mechanism for this increase is, however, not well understood.

Multifaceted Action of 1,8-Cineole in Antibacterial and Anti-inflammatory Treatment of Respiratory Tract Diseases.

1,8-cineole, renowned for its versatile therapeutic properties, has long been utilized in the treatment of respiratory system disorders. Its potential for oral administration offers a new dimension as an effective systemic therapy with anti-inflammatory and antibacterial effects. Maintaining stable levels of the compound in the body enhances treatment efficacy and reduces the risk of recurrence.

Are there any session-to-session changes in ventilation during a weekly hemodialysis cycle?

Significant changes in pre-dialytic partial pressure of CO (pCO) during a week-long cycle of hemodialysis (HD) can be an effect of the intermittent supplementation of bicarbonate to correct chronic acidosis in patients. Mathematical modeling efforts carried out using the same parameters before each HD session might fail to produce accurate predictions of pCO and plasma bicarbonate concentration (C) because of this variability. A numerical model describing acid-base equilibrium changes during HD was applied to predict pCO, pH, and C in 24 chronic HD patients, using both fixed parameters for the whole week and estimating a new value of minute ventilation (V) and net acid generation rate (G) for each interdialytic interval.

Fetal cardiac function in pregnancy affected by congenital heart disease: protocol for a multicentre prospective cohort study.

Background: Congenital heart disease (CHD) is the most common fetal malformation, and it can result first in cardiac remodeling and dysfunction and later in cardiac failure and hydrops. A limited number of studies have evaluated cardiac function in fetuses affected by CHD. Functional parameters could potentially identify fetuses at risk of cardiac failure before its development.

A comprehensive allele specific expression resource for the equine transcriptome.

Background: Allele-specific expression (ASE) analysis provides a nuanced view of cis-regulatory mechanisms affecting gene expression.

Results: An equine ASE analysis was performed, using integrated Iso-seq and short-read RNA sequencing data from four healthy Thoroughbreds (2 mares and 2 stallions) across 9 tissues from the Functional Annotation of Animal Genomes (FAANG) project. Allele expression was quantified by haplotypes from long-read data, with 42,900 allele expression events compared.

Effects of proton pump inhibitor (PPI) use on migraine - a critical review.

Background: Proton pump inhibitor (PPI) drugs are widely used and are among the most significant achievements of modern pharmacology. Their primary purpose is treating and preventing gastric acid-related disorders. Migraine and PPI intake are prevalent, and many people are affected by both.

Cost-efficient behavioral modeling of antennas by means of global sensitivity analysis and dimensionality reduction.

Computational tools, particularly electromagnetic (EM) solvers, are now commonplace in antenna design. While ensuring reliability, EM simulations are time-consuming, leading to high costs associated with EM-driven procedures like parametric optimization or statistical design. Various techniques have been developed to address this issue, with surrogate modeling methods garnering particular attention due to their potential advantages.

Impact of high pressure impregnation and air drying on the quality of Dosidicus gigas slices.

Humboldt squid (Dosidicus gigas) is the most abundant cephalopod in the fishing industry, and its high nutritional and organoleptic properties make it a go-to food product for consumers. Therefore, developing new processing techniques seems imperative to minimize quality deterioration and provide products with appropriate characteristics. The study aimed to determine the effect of high-pressure impregnation (HPI) pretreatment on hot air-drying kinetics and the quality of Humboldt squid slices.

Changes in structural composition of field margins and related landscape homogenization following EU accession of Poland.

Field margins have considerable ecological significance in farming landscapes, but are subject to constant changes resulting from natural processes and anthropogenic pressures. Understanding the balance of these processes is important from an ecological and conservation perspective. We measured 20 variables related to margin composition, woody vegetation and adjacent cropland fragmentation in 70 field margins in SW Poland in 2004 and 2006 (Poland's accession to the EU), and then resurveyed in 2021 by using the same protocol.

Efficacy and safety of the activin signalling inhibitor, sotatercept, in a pooled analysis of PULSAR and STELLAR studies.

Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Sotatercept is a first-in-class activin signalling inhibitor that acts to restore the balance between the growth-promoting and growth-inhibiting signalling pathways.

Methods: This post-hoc, exploratory, pooled analysis combines data from the double-blind placebo periods of the phase 2 PULSAR (NCT03496207) and phase 3 STELLAR (NCT04576988) studies.

Minimum initiatory concentration distribution of Mecillinam in clinical Staphylococcus saprophyticus isolates from Europe.

Background: Staphylococcus saprophyticus is the second most common bacteria causing uncomplicated urinary tract infections (UTI). It is considered non-susceptible to mecillinam, with no defined breakpoint and only few available minimal inhibitory concentration (MIC) observations. However, this consideration does not correlate with clinical outcome.

Toxicological profile of Acovenoside A as an active pharmaceutical ingredient - prediction of missing key toxicological endpoints using in silico toxicology methodology.

Acovenoside A, a cardenolide glycoside from Acokanthera oppositifolia, demonstrates significant therapeutic potential in cardioprotection and oncology, particularly against non-small cell lung cancer (NSCLC). However, its toxicological profile requires thorough evaluation for safe pharmaceutical application. For this purpose a comprehensive in silico methods were applied, including ACD/Labs Percepta, STopTox, admetSAR 3.