Brain Midline Approximation to Improve Symmetry Analysis of Brain CT Scans.

Analysis of the symmetry of the brain hemispheres at the level of individual structures and dominant tissue features has been the subject of research for many years in the context of improving the effectiveness of imaging methods for the diagnosis of brain tumor, stroke, and Alzheimer's disease, among others. One useful approach is to reliably determine the midline of the brain, which allows comparative analysis of the hemispheres and uncovers information on symmetry/asymmetry in the relevant planes of, for example, CT scans. Therefore, an effective method that is robust to various geometric deformations, artifacts, varying noise characteristics, and natural anatomical variability is sought.

Early childhood growth and nutritional status in India: trends in five National Family Health Surveys spanning 1992 and 2021.

Background/objective: To evaluate the weight and height status of under-five children between 1992 and 2021 in relation to nutritional context.

Subjects/methods: The study is based on the lengths/heights and weights of children <5 years in five national surveys (n = 505,026). After evaluating normality of the distributions, heights, and weights were expressed as z-scores relative to the WHO reference.

Influence of local (air temperature) and wide-scale (North Atlantic Oscillation) climate indices on the first arrival dates of the Common Wood Pigeon (Columba palumbus) at breeding site in SE Poland.

In this study, a relationship between climate indices (local - air temperatures, and wide-scale - North Atlantic Oscillation) and first arrival dates (FAD) of a short-distant migratory bird, the Common Wood Pigeon (Columba palumbus) at a breeding site in SE Poland (Lublin) was investigated. Temporal patterns of FAD on a multi-year scale (20 years within 39 years between 1982 and 2020) were also studied. Additionally, correlations between mean air temperature at Lublin and sites along the spring migration route with various distances from the breeding site and various time lags were searched for.

The ISC machinery assembles [2Fe-2S] clusters by formation and fusion of [1Fe-1S] precursors.

Iron-sulfur clusters are essential metallocofactors synthesized by multiprotein machineries via an unclear multistep process. Here we report a step-by-step dissection of the [2Fe-2S] cluster assembly process by the Escherichia coli iron-sulfur cluster (ISC) assembly machinery using an in vitro reconstituted system and a combination of biochemical and spectroscopic techniques. We show that this process is initiated by iron binding to the scaffold protein IscU, which triggers persulfide insertion by the cysteine desulfurase IscS upon the formation of a complex with IscU.

Exogenous LEA proteins expression enhances cold tolerance in mammalian cells by reducing oxidative stress.

Understanding the molecular mechanisms that confer cold resistance in mammalian cells might be relevant for advancing medical applications. This study aimed to exploit the protective function of Late Embryogenesis Abundant (LEA) proteins, known to provide resistance to low temperatures in extremophiles and plants, by their exogenous expression in mammalian cells, and compare their effects with the well characterized antioxidant, vitamin E.Remarkably, the expression of LEA proteins in mammalian cells exerted cold-protective effect similar to Vitamin E.

Modelling of P-wave velocity changes in coal seams with increased depth: a case study.

Seismic profiling in a coal seam enables the determination of anomalous changes in the P-wave velocity compared to reference velocity at a specific mining depth, indicating potential stress changes. This information can improve the coal exploitation processes in advance at greater depths, especially in seismic hazard areas. This study aims to update the empirical mathematical formula for calculating reference P-wave velocities in coal seams by including new data measured at greater depths.

Impact of pollution on microbiological dynamics in the pistil stigmas of Orobanche lutea flowers (Orobanchaceae).

Our understanding of the basic relationships of microbiota associated with flowers is still quite limited, especially regarding parasitic plant species. The transient nature of flower parts such as pistil stigmas provides a unique opportunity for temporal investigations. This is the first report of the analysis of bacterial and fungal communities associated with the pistil stigmas of the lucerne parasite, Orobanche lutea.

Breaking ICD Codes: Identifying Ambiguous Respiratory Infection Codes via Regional Diagnosis Heterogeneity.

Purpose: We aimed to analyze regional variations in the assignment of (ICD-10) codes to acute respiratory infections, seeking to identify notable anomalies that suggest diverse diagnoses of the same condition.

Methods: We analyzed national weekly diagnosis data for acute respiratory infections (ICD-10 codes J00-J22) in Poland from 2010 to 2019, covering all 380 county-equivalent administrative regions and encompassing 292 million consultations. Data were aggregated into age brackets.

Involvement of aSPOC in the online updating of reach-to-grasp to mechanical perturbations of hand transport.

Humans adjust their movement to changing environments effortlessly via multisensory integration of the effector's state, motor commands, and sensory feedback. It is postulated that frontoparietal (FP) networks are involved in the control of prehension, with dorsomedial (DM) and dorsolateral (DL) regions processing the reach and the grasp, respectively. This study tested (5F, 5M participants) the differential involvement of FP nodes (ventral premotor cortex - PMv, dorsal premotor cortex - PMd, anterior intraparietal sulcus - aIPS, and anterior superior parietal-occipital cortex - aSPOC) in online adjustments of reach-to-grasp coordination to mechanical perturbations that disrupted arm transport.

Diurnal dynamics of the Zbtb14 protein in the ventral hippocampus are disrupted in epileptic mice.

Our previous in silico data indicated an overrepresentation of the ZF5 motif in the promoters of genes in which circadian oscillations are altered in the ventral hippocampus in the pilocarpine model of temporal lobe epilepsy in mice. In this study, we test the hypothesis that the Zbtb14 protein oscillates in the hippocampus in a diurnal manner and that this oscillation is disrupted by epilepsy. We found that Zbtb14 immunostaining is present in the cytoplasm and cell nuclei.

Differences in treatment outcome between translational platforms in developing therapies for gastrointestinal cancers.

The variability in translational models profoundly impacts the outcomes and predictive value of preclinical studies for gastrointestinal (GI) cancer treatments. Preclinical models, including 2D cell cultures, 3D organoids, patient-derived xenografts (PDXs), and animal models, provide distinct advantages and limitations in replicating the complex tumor microenvironment (TME) of human cancers. Each model's unique biological and structural differences contribute to discrepancies in treatment responses, challenging the direct translation of experimental results to clinical settings.

Additively Manufactured Subperiosteal Implants for the Rehabilitations of Lateral Incisors Agenesis - a case series.

Background: Tooth agenesis, particularly the absence of upper lateral incisors, presents substantial challenges for clinicians due to the associated bone atrophy, which limits the use of traditional implant solutions. Current options, such as endosseous implants combined with guided bone regeneration (GBR), often fail due to insufficient osseointegration in atrophic bone. This study aims to evaluate the effectiveness of custom-made, additively manufactured subperiosteal implants in addressing these challenges METHODS: This retrospective study assessed 16 custom-made subperiosteal implants used in 12 patients (10 females, 2 males; mean age 25 ± 2.

The modulation of low molecular weight sulfur compounds levels in visceral adipose tissue of TLR2-deficient mice on a high-fat diet.

Obesity treatment requires an individualized approach, emphasizing the need to identify metabolic pathways of diagnostic relevance. Toll-like receptors (TLRs), particularly TLR2 and TLR4, play a crucial role in metabolic disorders, as receptor deficiencies improves insulin sensitivity and reduces obesity-related inflammation. Additionally, hydrogen sulfide (HS) influences lipolysis, adipogenesis, and adipose tissue browning through persulfidation.

The transcriptional and translational landscape of HCoV-OC43 infection.

The coronavirus HCoV-OC43 circulates continuously in the human population and is a frequent cause of the common cold. Here, we generated a high-resolution atlas of the transcriptional and translational landscape of OC43 during a time course following infection of human lung fibroblasts. Using ribosome profiling, we quantified the relative expression of the canonical open reading frames (ORFs) and identified previously unannotated ORFs.

Investigation of the canine elbow joint innervation in 100 joints.

The canine elbow joint is innervated by four nerves: the musculocutaneous, median, radial, and ulnar nerves. There is little data in the veterinary literature examining the course of the articular branches of those nerves. There is also no agreement as to their anatomical location in the joint capsule nor to their number.

Use of AI methods to assessment of lower limb peak torque in deaf and hearing football players group.

Monitoring and assessing the level of lower limb motor skills using the Biodex System plays an important role in the training of football players and in post-traumatic rehabilitation. The aim of this study was to build and test an artificial intelligence-based model to assess the peak torque of the lower limb extensors and flexors. The model was based on real-world results in three groups: hearing ( = 19) and deaf football players ( = 28) and non-training deaf pupils ( = 46).

Isokinetic strength and jumping abilities of teenage soccer players playing in different field positions.

Soccer is a sport being performed in a very dynamic manner. It requires soccer players to be able to develop high muscle force in a very short period of time. The aim of the study was to evaluate the strength and jumping abilities of young soccer players playing in different positions on the field.

Influence of sterilization and exposure to the Ringer's solution on physicochemical properties of nitrocarburized 316 LVM steel.

The aim of the study was to investigate the influence of the nitrocarburizing process carried out in low temperature plasma using the active screen at 440 °C on the structure and physicochemical properties of the 316LVM steel. In the paper, results of micro-structure and phase composition of the layers, roughness, and surface wettability, potentiodynamic pitting corrosion resistance, penetration of ions into the solution as well as biological tests were present. The studies were conducted for the samples of both mechanically polished and nitrocarburized surfaces, after sterilization, and exposure to the Ringer's solution.

Morphometric assessment of mandibles with complications resulting from temporomandibular joint ankylosis in children from 4 months to 3 years of age.

: The main aim of this paper was to perform the morphological assessment of children's mandibles of different etiology of dys-functions within the temporomandibular joint, from isolated idiopathic ankylosis to craniofacial malformations co-existing with genetic disorders. : The investigations encompassed seven patients at the age of 0-3. Measurements were conducted on the basis of data obtained from computed tomography.

Influence of heat treatment method on selected physicochemical and biological properties of fluoride-substituted calcium apatite.

: The synthesis of fluoridated apatite consists of several stages, among which the heat treatment has a significant impact on the physical and chemical properties. The present study aims to elucidate the influence of two different sintering methods on fluoride-substituted apatite properties. : For this purpose, a two F-substituted apatites were produced by heat treatment in different ways called "rapid sintering" and "slow sintering".

Importance of the assessment of knee joint function after a stroke.

: This study aimed to assess knee joint function in post-stroke patients using wireless motion sensors and functional tests. This type of evaluation may be important for improving gait quality. : The study included 25 post-stroke patients (age 53.

Analysis of vibrations transmitted to the feet of a wheelchair user.

: The aim of the study was to quantitatively evaluate the vibrations received on the wheelchair footrest and to determine whether wheelchair users are at risk of vibration-white foot. This assessment was made using the ISO 2631 standard. : The measurements were taken on the footrest of a universal wheelchair.

Evaluation of frictional wear in a follow-up screw-rod kinematic node in GGS transpedicular stabilization.

: The aim of this study was to evaluate the abrasive wear of the sliding screw-rod joint used in growth guidance system (GGS) stabilizers, allowing for the translation of the screw along the rod during the spinal growth process in a standard and modified system. : The study used single kinematic screw-rod pairs made of titanium alloy Ti6Al4V. Mechanical tests (cyclic loads) simulated the stabilizer's operation under conditions similar to actual use.

The real rotational capacity of the human joints - the muscular and gravitational torques and the foot as a platform.

The purpose was to answer what is the relationship between torques acting on the human body, how does the triceps calf muscle balance the weight of a tilted body and what is the foot's role in the titling body? Two research models were developed. Model 1 - the one-sided lever system consists of a flat bar with, an axis of rotation, used to determine the weight and torque at a given point on it. Model 2 - the two-sided lever system consists of a flat bar imitating a tilted body counteracted by the Achilles tendon, and a platform imitating a foot.