LC-MS profiling and cytotoxic activity of Angiopteris helferiana against HepG2 cell line: Molecular insight to investigate anticancer agent.

Liver cancer is one of the most prevalent malignant diseases in humans and the second leading cause of cancer-related mortality globally. Angiopteris helferiana was mentioned as a possible anticancer herb according to ethnomedicinal applications. However, the molecular docking and chemical profiling of the bioactive phytoconstituents accountable for the reported anticancer action still require research.

Life expectancy and health care spending in South Asia: An econometric analysis.

Affordable health care is often a result of increased government spending on the health sector. Out-of-pocket expenses remain the primary health care funding source in many South Asian nations. Lack of adequate public funding for health services, difficulty in obtaining health insurance, and high out-of-pocket costs can result in indebtedness, reductions in actual consumption, and decreased access to health care services.

Utilization and associated factors of growth monitoring and promotion services among young children in Gorkha district of Nepal.

Introduction: Promotion of child health during the first thousand days from conception to the child's second birthday is vital for survival, growth and development. Growth monitoring and promotion services are key to the early detection of growth faltering and preventing malnutrition and promoting child health. This study aimed to assess the utilization of Growth Monitoring and Promotion (GMP) services and its associated factors among young children in Gorkha district of Nepal.

Understanding challenges and enhancing the competency of healthcare providers for disability inclusive sexual and reproductive health services in rural Nepal.

Background: Women with disabilities in rural Nepal face many challenges in accessing sexual and reproductive health services including harassment and unpleasant behavior by the healthcare providers. Though National Guideline for Disability Inclusive Health Service in Nepal is in place, there are gaps in providing the sexual and reproductive health needs of women with disabilities. There has been limited research exploring the competency and capacity of health care providers on providing sexual and reproductive health services and information for women living with disabilities.

Dengue dynamics in Nepal: A Caputo fractional model with optimal control strategies.

An infectious disease called dengue is a significant health concern nowadays. The dengue outbreak occurred with a single serotype all over Nepal in 2023. In the tropical and subtropical regions, dengue fever is a leading cause of sickness and death.

Unlocking potential: Evaluating Nepal's cooperative-backed vegetable value chain.

Cooperatives play a vital role in rural and agricultural development within value chains. They employ 279 million worldwide, and the top 300 earned $2.1 trillion in 2019, ranking as the 10th largest economy if considered a country.

Socioeconomic, Behavioural, and Health-related Characteristics of Older Adults.

Background: The global aging population is growing rapidly, and Nepal is no exception. This increase is driven by changes in socioeconomic conditions, health behaviours, and advancements in the health system. In Nepal, almost a quarter of the national population are older adults (≥45 years), whose health status is rarely elaborated.

Assessment of Antenatal Care Services Utilization and Its Associated Factors.

Background: Every pregnant woman supposed to have Antenatal care visits at least four times during 4th, 6th, 8th and 9th month of gestation. This contributes to the reduction in maternal mortality. The main objective of the study was to assess the utilization of antenatal care services and its associated factors in Pokhara Metropolitan.

Drug-related problems among type 2 diabetic patients in Sunwal Municipality of Western Nepal.

Background: Several diseases co-exist with diabetes such as hypertension, and dyslipidemia, leading to cases of non-adherence, several drug interactions, and an increased risk of adverse drug reactions among patients, which are often termed as drug-related problems (DRPs). The role of pharmacists in high-income countries is well-defined in identifying DRPs among type 2 diabetes patients. However, these roles still need to be explored within low- and middle-income countries.

40 Hz binaural beats entrainment enhances the mood and cognition of medical students.

Many medical students experience psychological distress from high academic demands, potentially harming their performance and mental health. Binaural beats (BB) stimulation, particularly gamma band entrainment, has been suggested to enhance neural communication, cognition, and reduce anxiety. This study aimed to determine whether 40 Hz BB could improve cognitive performance and mood in medical students.

Menstruation experiences and its association with psychological distress among school-going adolescent girls of Nepal: A cross-sectional study.

This study aimed to assess the relationship between menstruation-related attributes and mental distress in adolescent girls. A cross-sectional study was conducted in Rangeli Municipality, Nepal, among 270 adolescent girls. Data were collected using a self-administered questionnaire.

A New Ray of Hope in the Treatment of Seasonal Hyperacute Panuveitis: Could Intravitreal Triple Combination Therapy of an Antibiotic with Dual Steroids Play a Pivotal Role?

Introduction: Seasonal Hyperacute Panuveitis (SHAPU) is a blinding disease in Nepal with unknown aetiology. Henceforth, we proposed to study the treatment outcome of a triple intravitreal combination therapy of dual steroids triamcinolone (long-acting steroid) and dexamethasone (short-acting steroid) along with antibiotic moxifloxacin for patients with severe stage of SHAPU.

Methods: A prospective study was conducted among the SHAPU patients presenting in severe stages during the September to December 2023 outbreak.

Therapeutic potential of : Chemical isolation and validation of ethnomedicinal claims through and assessment of antioxidant and anti-inflammatory properties.

(L.) Ridsdale has been used by different ethnic communities to manage diseased conditions that can be traced to oxidative stress and cellular inflammations but scientific evidences to support the claim are scanty. The objective of this study was to isolate and identify the antioxidants present in the aerial parts of perform their molecular docking against proteins to inspect whether the traditional uses of the plant can be validated by an in-silico approach.

Characteristics of Spinal Cord Injury Presenting to Tertiary Care Center in Gandaki province of Nepal: A Descriptive Cross-sectional Study.

Introduction: Spinal cord injury is one of the common injury which causes damage to the spinal cord due to trauma, diseases or degenerations leading to disability and decreasing life expectancy. The study aims to find the characteristics of spinal cord injury presenting at a tertiary care centre.

Methods: A Descriptive hospital based cross-sectional study was conducted at Pokhara, Gandaki Province, from 28th March to 25th September, 2023.

Post-discharge Outcomes of COVID-19 Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

Introduction: Understanding the post-discharge outcomes of COVID-19 patients is essential for informed healthcare planning and support services. This study aimed to assess the physical health status of COVID-19 patients three months after discharge from a tertiary care hospital in Kathmandu, Nepal.

Methods: A descriptive follow-up study design was used, involving 200 COVID-19 discharged patients.

Exploring the Sociodemographic Factors and Consequences related to Alcohol Consumption among Older Indigenous Community of a District in Nepal: A Qualitative Study.

Introduction: Alcoholism is a major global public health concern associated with numerous health conditions. Alcohol use has been a cultural part of several ethnic groups in Nepal. This study aimed to explore the qualitative dimension of alcohol use, its promoting factors, and consequences in Nepalese communities.

Effectiveness of art-based health education on anemia and health literacy among pregnant women in Western Nepal: A randomized controlled trial.

Objective: As Nepalese pregnant women vary widely in literacy levels and cultural backgrounds and are reluctant to make decisions about their health, general interventions are insufficient to improve maternal anemia. This study aimed to assess the effectiveness of "face-to-face health education using educational material created using pictures, photos, and nomograms" in reducing anemia and improving health literacy.

Methods: A total of 156 Nepalese pregnant women with hemoglobin (Hb) levels below 11.