8,698 results match your criteria: "Pneumonia Mycoplasma"

The contribution of the lung microbiota to pneumonia in children of varying severity remains poorly understood. This study utilized metagenomic next-generation sequencing (mNGS) technology to elucidate the characteristics of lung microbiota and their association with disease severity. This retrospective study analyzed bronchoalveolar lavage fluid (BALF) mNGS data of 92 children diagnosed with pneumonia between January 2021 and July 2022.

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Pulmonary thromboembolism due to Mycoplasma pneumoniae in children: a case report and literature review.

BMC Pediatr

December 2024

Department of Pediatric Respiratory and Immunology Nursing, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China.

Background: Mycoplasma pneumoniae (MP) is a common respiratory pathogen in children that can sometimes lead to extrapulmonary manifestations. Among these, pediatric pulmonary thromboembolism (PE) is clinically rare but carries significant implications. However, it is often underrecognized, and its diagnosis and treatment are not well understood.

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Background: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory disease in children. Some patients may develop long-term respiratory issues such as chronic cough and wheezing due to complications. These complications increase the health burden for children with MPP, highlighting the need to understand their risk factors in order to improve disease prognosis.

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Purpose Of Review: Define the utility of adjunctive macrolide therapy in patients with more severe forms of community-acquired pneumonia (CAP).

Recent Findings: Guidelines recommend adjunctive macrolide therapy as an option for patients with CAP, admitted to the hospital. A large data set collected both retrospectively and prospectively, including several recent randomized controlled trials (RCTs) have shown that adjunctive macrolide therapy can reduce mortality and improve outcomes in patients with severe CAP, more effectively than other alternative therapies.

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Introduction: Macrolide-unresponsive pneumonia (MUMPP) cases have been rapidly increasing. The primary reason for this increased incidence is the pathogen's acquisition of resistance through mutations in 23S rRNA genes. Due to the unfeasibility of testing for macrolide susceptibility at the time of admission, this study aimed to assess the clinical features of pediatric MUMPP, using insights from laboratory tests and patterns of chest radiographic resolution.

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Purpose: To investigate the clinical characteristics of Mycoplasma pneumoniae (MP) pneumonia (MPP) combined with pulmonary embolism (PE) in children.

Methods: 291 hospitalized pediatric cases with MPP were enrolled from January 2018 to May 2024 and divided into the PE group (141 cases) and non-PE control group (150 cases). Clinical data of both groups were analyzed and compared.

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Long non-coding RNA MMTP mediates necroptosis in alveolar macrophages during Mycoplasma hyopneumoniae infection by enhancing TNF-α transcription.

Int J Biol Macromol

December 2024

Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China; GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou 225300, China; School of Animal Medicine, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

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We conducted a retrospective review of children tested for Mycoplasma pneumoniae from January 1, 2020-June 30, 2024. M. pneumoniae PCR positivity increased starting in November 2023, peaking at 18.

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Background: pneumonia (MPP) is a common disease of childhood pneumonia, and atelectasis is a serious comorbidity. Traditional diagnostic methods for MPP are limited by low accuracy, emphasizing the need for improved diagnostic approaches. This study aimed to establish a predictive scoring model for early detection of MPP complicated with atelectasis following standardized treatment.

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This editorial reflects on the research, which investigates the potential of serum markers to predict the severity of infections. pneumonia (MPP) is a prevalent cause of respiratory infections in children, often leading to significant morbidity. Predicting the severity of MPP can significantly enhance patient management and outcomes.

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Article Synopsis
  • Mycoplasma pneumonia (MPP) is a leading cause of pneumonia in children, and this study focused on severe cases (SMPP) to evaluate laboratory characteristics and risk factors.
  • Researchers analyzed data from 447 hospitalized children with MPP, finding that those with SMPP had notably different laboratory results compared to those with ordinary MPP, including higher inflammation markers and lower lymphocyte levels.
  • Key predictors for identifying high-risk SMPP in children were determined, including elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6), which are crucial for improving clinical management and interventions.
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Article Synopsis
  • The use of non-pharmaceutical interventions (NPIs) during COVID-19 led to a decrease in various respiratory illnesses but created a build-up of susceptible individuals for future outbreaks.
  • Unlike other respiratory pathogens that rebounded quickly after NPIs, Mycoplasma pneumoniae (Mp) outbreaks have been significantly delayed, with reports of delays over three years in Europe and Asia.
  • Researchers are employing mathematical models to forecast a significant Mp outbreak in the US, highlighting the impact of NPIs and decreasing immunity on the duration of epidemic delays.
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Objective: The present study aimed to assess the predictive value of Ig Mycoplasma pneumoniae (MP)-DNA, high-density lipoprotein (HDL), natural killer (NK) cell, and platelet (PLT) levels for the diagnosis of severe MP pneumonia (SMPP) in children with MP pneumonia (MPP).

Methods: Children with MPP admitted to our hospital from August 2022 to February 2024 were selected and assigned to the non-SMPP (NSMPP) and SMPP groups according to whether they had severe pneumonia. The following parameters were analyzed and compared between the two groups by the rank-sum test: age; Ig MP-DNA level; white blood cell, neutrophil (N), and monocyte counts; platelet (PLT), C-reactive protein (CRP), lactate dehydrogenase (LDH), triglycerides, high-density lipoprotein (HDL), low-density lipoprotein, and procalcitonin levels; and levels of T cells, CD4 T cells, CD8 T cells, B cells, and NK cells.

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This cohort study evaluated the associations of C-reactive protein-neutrophil to lymphocyte ratio (C-NLR) and lymphocyte-CRP ratio (LCR) with refractory Mycoplasma pneumoniae pneumonia (RMPP), and the predictive values of C-NLR and LCR for RMPP and prolonged fever in children based on 389 children with MPP. The associations of NLR, C-NLR, and LCR with RMPP and prolonged fever were evaluated by logistic regression analysis. C-NLR was correlated with an increased risk of RMPP in children [odds ratio (OR) = 3.

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Article Synopsis
  • - The EPIC study analyzed data from 2,272 adults hospitalized for pneumonia to understand the prevalence of Mycoplasma pneumoniae (Mp) using PCR testing on throat swabs from 2010 to 2012.
  • - Only 43 patients (1.8%) tested positive for Mp, primarily affecting younger adults (median age: 45), with some experiencing severe cases leading to ICU admissions, but no in-hospital deaths were reported.
  • - Factors linked to higher Mp detection included being younger and having certain radiographic findings, indicating the need for better testing methods to improve diagnosis and treatment options for pneumonia patients.
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Massive Deep Venous Thrombosis in a Child with Necrotizing Pneumonia Due to Mycoplasma Pneumonia Infection.

Infect Drug Resist

November 2024

Department of Infectious Disease, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, People's Republic of China.

Article Synopsis
  • * An 8-year-old boy with macrolide-resistant pneumonia developed thrombosis in critical areas, including the pulmonary artery and larger veins, leading to abdominal pain and dangerous thrombi sizes.
  • * After standard anti-infection and anticoagulation treatments failed to alleviate his symptoms and manage the risk of thrombus detachment, the patient underwent specialized procedures that successfully improved his condition and prevented recurrence, underscoring the importance of early thrombosis recognition in pediatric cases.
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Parsonage-Turner-syndrome associated with infection.

Respirol Case Rep

December 2024

Klinik für Pneumologie Evangelische Lungenklinik Berlin Berlin Germany.

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Article Synopsis
  • * Data from 106 children were analyzed, showing that those in the observation group (pulmicort respules and azithromycin) had faster recovery times and fewer complications than those treated with azithromycin alone.
  • * After one week of treatment, the observation group also showed higher inflammatory marker levels but had lower immunoglobulin levels, suggesting a more effective response to treatment, resulting in a significantly lower complication rate.
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The mechanism of baicalin in improving pulmonary inflammatory response and injury and regulating intestinal flora in Mycoplasma pneumoniae pneumonia mice.

Cell Signal

February 2025

Heilongjiang Academy of Traditional Chinese Medicine, 142 Sanfu Street, Xiangfang District, Harbin 150080, Heilongjiang, China.

Article Synopsis
  • Mycoplasma pneumoniae is a common cause of respiratory infections, and this study investigates how baicalin (BIA) affects lung inflammation and gut bacteria in mice with pneumonia and intestinal dysbiosis.
  • In the experiment, MPP mice were treated with varying doses of BIA, where researchers measured lung inflammation, bacterial presence, immune response markers, and gut flora composition.
  • The results indicated that BIA helped reduce lung inflammation and injury, and improved gut bacterial diversity by inhibiting the TLR4/NF-κB signaling pathway in the affected mice.
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Unravelling Antimicrobial Resistance in : Genetic Mechanisms and Future Directions.

Vet Sci

November 2024

Australian Centre for Antimicrobial Resistance Ecology, Faculty of Sciences, Engineering and Technology, School of Animal and Veterinary Science, The University of Adelaide, Adelaide, SA 5005, Australia.

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