2,016 results match your criteria: "Plasmacytoma Extramedullary"
Chemokine Receptor 4-Targeted PET/CT with [Ga]pentixather in Newly Diagnosed Multiple Myeloma: a Comparative Study with [Ga]pentixafor PET/CT.
Mol Imaging Biol
December 2024
Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Center for Rare Diseases Research Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Article Synopsis
- The study compared the effectiveness of two imaging methods, [Ga]pentixather PET/CT and [Ga]pentixafor PET/CT, in detecting multiple myeloma in newly diagnosed patients.
- Results showed that [Ga]pentixather had a higher detection rate and better lesion uptake values than [Ga]pentixafor, suggesting it may be more effective for assessing tumor load.
- Additionally, both PET scans indicated that higher tumor burden was associated with more advanced stages of the disease according to the Durie-Salmon Staging system.
A rare case of maxillary sinus and buccal space involvement of extramedullary plasmocytoma: Cross-sectional imaging findings and review of the literature.
Radiol Case Rep
November 2024
Department of Experimental and Clinical Medicine, 'Magna Graecia' Università di Catanzaro, Catanzaro 88100, Italy.
Article Synopsis
- Extramedullary plasmacytoma (EMP) is a type of plasma cell neoplasm, which can be confused with other similar conditions like multiple myeloma and solitary plasmacytoma of the bone.
- The case highlights a rare instance where EMP affected both the maxillary sinus and the buccal cavity, emphasizing the importance of accurate diagnosis to avoid mismanagement.
- Advanced imaging techniques, particularly diffusion-weighted imaging (DWI), were crucial in distinguishing EMP from other cancers such as squamous cell carcinoma and non-Hodgkin lymphoma.
Uncommon Presentation of Solitary Plasmacytoma in the Nasal Cavity: Diagnostic and Therapeutic Challenges.
Cureus
July 2024
Department of Radiation Therapy, Centre Hospitalier Universitaire Mohammed VI, Oujda, MAR.
Article Synopsis
- Extramedullary solitary plasmacytoma (SP) is a rare tumor, especially in the head and neck regions, as demonstrated in a case involving an 82-year-old man with nasal cavity SP.
- The patient was found to have an advanced tumor unfit for surgery and initially received radiotherapy at a total dose of 50 Gy.
- After nine months, the tumor recurred, leading to palliative chemotherapy with cyclophosphamide, dexamethasone, and thalidomide, which showed a positive treatment response, highlighting the complexities of diagnosing and treating SP in unusual locations.
Radiotherapy vs Surgery for Survival and Locoregional Control of Head and Neck Extramedullary Plasmacytoma: A Systematic Review and Meta-Analysis.
JAMA Otolaryngol Head Neck Surg
October 2024
Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport.
Article Synopsis
- There are significant gaps in research regarding the treatment outcomes and survival rates of extramedullary plasmacytoma (EMP), particularly for different treatment methods like radiotherapy and surgery.
- The study systematically reviews existing literature, utilizing databases to analyze the effectiveness of radiotherapy versus surgical treatment outcomes for EMP in the head and neck region.
- Results indicate that while overall survival rates are comparable between treatments, radiotherapy reduces the likelihood of progression to multiple myeloma and offers better disease-free survival rate at the 5-year mark compared to surgery.
Extraosseous Plasmacytomas: A Radiologist's Perspective-A Narrative Review of the Literature.
Diagnostics (Basel)
August 2024
Department of Radiology, General University of Patras, 61000 Patras, Greece.
Article Synopsis
- * EPs can appear in various body parts, including the lungs, breasts, and abdominal organs, making them tough to diagnose due to their similar imaging characteristics to other conditions.
- * The review highlights the importance of imaging for detecting EPs, but emphasizes that a histological confirmation is essential for an accurate diagnosis, especially for patients with a history of multiple myeloma, as timely diagnosis can greatly improve
MYC translocation is a valuable marker for the development and relapse of extramedullary disease in multiple myeloma.
Eur J Haematol
December 2024
Department of Hematology, Peking Union Medical College Hospital, Beijing, China.
Article Synopsis
Solitary extramedullary plasmacytoma of the lung with rapid transition to multiple myeloma : A rare case report and brief literature review.
Rom J Intern Med
December 2024
Department of Internal Medicine, Ross University School of Medicine, Bridgetown, Barbados.
Article Synopsis
- Solitary extramedullary plasmacytomas (SEPs) are rare tumors made up of abnormal plasma cells and can sometimes turn into a more serious condition called multiple myeloma (MM).
- A 72-year-old woman went to the hospital because she was having trouble breathing and fainting, and tests showed she had SEPs in her lung and later confirmed that she also had multiple myeloma.
- This case is important because it highlights how quickly SEPs can change into MM, stressing the need for serious treatment when diagnosed.
Laryngeal plasmacytoma in a patient with Down's syndrome.
Autops Case Rep
August 2024
Al-Rassoul Al-Aazam Hospital, Otolaryngology-Head and Neck Surgery Department, Beirut, Lebanon.
Article Synopsis
- Extramedullary plasmacytoma is a rare tumor made up of plasma cells, usually found in soft tissues outside the bone marrow, most commonly in the head and neck region.
- A 38-year-old female with Down's syndrome experienced symptoms like hoarseness and respiratory distress, leading to the discovery of a 1x1 cm lesion in her larynx during a laryngoscopy.
- The lesion was diagnosed as a solitary extramedullary plasmacytoma, marking the first known case in a Down's syndrome patient, which highlights the need for specialized treatment and awareness of potential tumors in this demographic.
A Case Report of the Atypical Presentation of Multiple Myeloma Manifesting as a Sternal Mass.
Cureus
July 2024
Department of Medical Oncology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, IND.
Article Synopsis
- * Symptoms of MM often include fatigue, kidney issues, and bone pain; however, atypical cases like the one involving a 65-year-old male with a sternal tumor can complicate diagnosis, as traditional symptoms may be absent.
- * This case underscores the importance of a thorough and coordinated approach in diagnosing and treating unusual MM presentations to ensure timely and effective care.
Solitary Testicular Plasmacytoma: A Case Report.
Urol Int
December 2024
Department of Urology, Misugikai Otokoyama Hospital, Kyoto, Japan.
Article Synopsis
- Plasmacytoma of the testis is a rare type of cancer that can appear as a solitary tumor or alongside multiple myeloma, with a generally good prognosis from localized treatments like surgery or radiation.
- A case of a 69-year-old man with a solitary testicular plasmacytoma showed that initial treatment was successful, but he later developed bone lesions, leading to the need for chemotherapy.
- The findings suggest that while STP is rare and its prognosis can be unclear, systemic chemotherapy may be necessary for recurrence, emphasizing the importance of long-term patient follow-up.
Case report: Dual-targeted BCMA and CS1 CAR-T-cell immunotherapy in recurrent and refractory extramedullary multiple myeloma.
Front Immunol
August 2024
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- CAR-T-cell immunotherapy has improved treatment for multiple myeloma, focusing on various targets like BCMA and CS1, but still faces issues like antigen escape and limited CAR-T cell lifespan.
- A case study featured a patient with recurrent multiple myeloma who developed a problematic tumor in the muscles that persisted even after CAR-T-cell treatment targeting BCMA and CS1, leading to surgical intervention.
- Findings indicated that elevated MYBL2 levels in the tumor tissue might be linked to the ineffectiveness of the dual-target CAR-T therapy, suggesting that high MYBL2 expression is associated with a worse prognosis in such patients.
Widespread purplish-red plaques with plasma cell infiltrate: A rare type of lichen planus.
J Cutan Pathol
December 2024
Department of Dermatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- Rare skin diseases with plasma cell infiltration can transition from benign to malignant, featuring presentations like purplish or reddish-brown plaques and nodules.
- A unique case of lichen planus showed typical histopathological features but involved unusual plasma cells with restricted light chain expression.
- Patients should be monitored for changes in their rash, and clinicians may need to perform repeated biopsies and multisystem evaluations to track the disease's progression.
Extramedullary plasmacytoma with associated multiple myeloma as a presentation of the posterior mediastinal mass: a rare clinical encounter.
BMJ Case Rep
August 2024
Oncology/Hematology, Citizens Memorial Hospital, Bolivar, Missouri, USA.
Article Synopsis
- * The primary treatment for plasmacytoma is definitive radiotherapy, which can potentially cure cases that occur outside the bone, while prognosis is generally better when there's no concurrent multiple myeloma and worse with high-risk genetic factors.
- * A specific case involved an elderly male with health issues experiencing difficulty swallowing and breathing, leading to the diagnosis of a rare plasmacytoma in the posterior mediastinum, highlighting the importance of quick diagnosis and treatment. *
Extramedullary Intracranial Plasmacytomas: A Systematic Review of Literature.
Asian J Neurosurg
June 2024
Department of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Extramedullary plasmacytoma (EMP) is an uncommon disorder characterized by the development of abnormal plasma cell tumors outside the bone marrow. These tumors are typically observed in various locations, including the upper respiratory tract, gastrointestinal tract, and other soft tissues. Among the less explored manifestations of EMP is intracranial EMP, which remains poorly understood due to the limited literature available on the subject.
View Article and Find Full Text PDFRadiotherapy for Solitary Bony or Extramedullary Plasmacytoma.
Cancer Diagn Progn
July 2024
Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan.
Background/aim: This study aimed to determine the oncological outcomes associated with curative radiotherapy for solitary bony or extramedullary plasmacytomas by drawing on clinical data from a single tertiary center. This study aimed to provide a comprehensive understanding of the efficacy of radiotherapeutic interventions and delineate the patterns of disease recurrence.
Patients And Methods: Eleven consecutive patients diagnosed with solitary bony or extramedullary plasmacytomas and treated between May 2007 and November 2023 were retrospectively screened.
Central nervous system multiple myeloma: A real-world multi-institutional study of the Greek Myeloma Study Group.
Am J Hematol
October 2024
Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Athens, Greece.
Central nervous system (CNS) involvement is a rare and aggressive complication of multiple myeloma (MM). We identified 54/4352 MM patients (1.2%), who developed CNS-MM between 2000 and 2022.
View Article and Find Full Text PDFCase report: An uncommon presentation of extramedullary plasmacytoma without a concurrent diagnosis of multiple myeloma.
Front Oncol
June 2024
Head and Neck Cancer Department, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Article Synopsis
- * The case study focuses on a 72-year-old male with swallowing difficulties and an EMP that didn't respond to radiation, but diagnosis excluded multiple myeloma.
- * Successful treatment involved surgical removal of the EMP, followed by systemic therapy, leading to the patient's complete recovery and effective disease management.
Isolated Abducens Nerve Palsy: A Rare Manifestation of Recurrent Extramedullary Myeloma.
J Radiol Case Rep
June 2024
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Multiple myeloma is a plasma cell neoplasm, which may present as a solitary plasmacytoma and, uncommonly, as an extramedullary plasmacytoma. Intracranial plasmacytomas may manifest in central nervous system involvement as cranial nerve palsies. Cranial nerve six palsy is the most common in cases of malignancy.
View Article and Find Full Text PDFMultiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma.
View Article and Find Full Text PDFDaratumumab-based regimens for patients with multiple myeloma plus extramedullary plasmacytomas or paraskeletal plasmacytomas: initial follow-up of an Italian multicenter observational clinical experience.
Ann Hematol
May 2024
Haematology, Ospedale A. Perrino, Brindisi, Italy.
Article Synopsis
- Myeloma with extramedullary plasmacytomas (EMP) shows significantly worse outcomes compared to paraosseous plasmacytomas (PP), and existing treatments have been ineffective.
- A study evaluated the effectiveness of daratumumab-based treatments in 102 myeloma patients, finding similar overall response rates for both groups at diagnosis, but lower rates at relapse.
- Despite EMP patients having shorter median overall survival at diagnosis, there were no significant differences in treatment timelines or responses between EMP and PP patients during relapse, suggesting daratumumab may be beneficial even in difficult cases.
Multifocal Extramedullary Plasmacytoma of the Thyroid With Cervical and Paratracheal Lymph Node Involvement and Progression to Multiple Myeloma.
Cureus
April 2024
Department of Head and Neck Surgery, Orlando Health Cancer Institute, Orlando, USA.
Extramedullary plasmacytomas without evidence of systemic illness make up less than 5% of all plasma cell neoplasms. The incidence of extramedullary plasmacytoma of the thyroid region is exceedingly rare. This report discusses the case of a 72-year-old male with extramedullary plasmacytoma of the thyroid.
View Article and Find Full Text PDFCyberKnife stereotactic radiosurgery for extramedullary plasmacytoma in the external auditory canal: illustrative case.
J Neurosurg Case Lessons
May 2024
2Department of Neurosurgery, Stanford University School of Medicine, Stanford, California.
Background: Plasmacytoma, a rare plasma cell disorder, often presents as a solitary or multiple tumors within the bone marrow or soft tissues, typically associated with multiple myeloma. Extramedullary plasmacytomas (EMPs), particularly those located in the external auditory canal (EAC), are exceedingly rare and pose significant treatment challenges given their location, anatomical complexity, and high risk of recurrence.
Observations: The authors report the case of a 72-year-old male with a history of multiple myeloma, presenting with recurrent left EAC plasmacytoma.
Extramedullary plasmacytoma of the orbit complicating the evolution of multiple myeloma in complete remission.
Leuk Res Rep
April 2024
Hematology Department, Fattouma Bourguiba Hospital of Monastir, Avenue Farhat Hached, Monastir 5000, Tunisia.
Orbital plasmacytoma is rare and has only been reported in the context of the initial diagnosis of multiple myeloma. Moreover, isolated orbital plasmacytoma without any signs of multiple myeloma is extremely rare. We report the case of a 59-year-old female patient diagnosed with IgA Kappa multiple myeloma.
View Article and Find Full Text PDFHidden intruder: Plasmacytoma causing uncontrolled epistaxis in an elderly patient.
Radiol Case Rep
July 2024
Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Article Synopsis
- Extramedullary plasmacytoma (EMP) is a rare tumor made up of abnormal plasma cells, accounting for only 3% of plasma cell tumors and differing from multiple myeloma.
- An 89-year-old male patient with a history of hypertension was admitted with severe nosebleeds that could not be controlled, leading to the suspicion of angiofibroma and subsequent embolization.
- After undergoing functional endoscopic sinus surgery, the patient was unexpectedly diagnosed with plasmacytoma through histology results, and he was later discharged for further treatment.