2,016 results match your criteria: "Plasmacytoma Extramedullary"

Primary pulmonary plasmacytoma: A case report.

Medicine (Baltimore)

December 2024

Department of Respiratory and Critical Care Medicine, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.

Rationale: Extramedullary plasmacytoma is an extremely rare malignant clonal plasmacytoma, which can occur in any tissue or organ of the body other than bone marrow hematopoietic tissue. Lesions mostly occur in the head and neck or upper respiratory tract, and rarely in the lower respiratory tract. Primary plasmacytoma of the lung, also known as primary pulmonary plasmacytoma (PPP), is rarer and is mainly diagnosed on the basis of the histopathology of biopsy tissue.

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Multiple myeloma (MM) is the second most prevalent hematologic malignancy, particularly affecting the elderly. The disease often begins with a premalignant phase known as monoclonal gammopathy of undetermined significance (MGUS), solitary plasmacytoma (SP) and smoldering multiple myeloma (SMM). Multiple imaging modalities are employed throughout the disease continuum to assess bone lesions, prevent complications, detect intra- and extramedullary disease, and evaluate the risk of neurological complications.

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Extra-medullary Plasmacytomas: A Case Series of Rare Hematological Tumors.

Cureus

November 2024

Department of Hematology, Agadir Faculty of Medicine and Pharmacy, Agadir, MAR.

Solitary plasmacytoma is a rare malignant tumor belonging to the family of plasma cell proliferation. It accounts for a small portion of plasma cell tumors and remains a rare condition. We report three cases of rare extraosseous plasmacytomas in young patients.

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Article Synopsis
  • * Diagnostic imaging confirmed the mass as a plasma cell tumor, and after a successful endoscopic surgery to remove it, the patient showed significant improvement and was discharged quickly.
  • * The report emphasizes the need for thorough diagnostic processes for patients with obstructive bronchial masses and suggests that early detection and treatment of plasmacytoma can lead to better patient outcomes, highlighting the importance of regular follow-ups to prevent recurrence.
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EMP in the head of the pancreas is difficult to diagnose, many of them postmortem, EUS-FNB in experienced hands in conjunction with immunohistochemistry and flow cytometry is a valuable tool.

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Multiple myeloma (MM) remains incurable, with poor outcomes in heavily pre-treated patients with plasmacytomas. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment option; however, outcomes after such therapy in patients with soft-tissue plasmacytomas and other bone lesions remain poorly understood. Data regarding these parameters is scarce within the specific context of CAR T-cell treatment.

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Introduction: Solitary extramedullary plasmacytomas (SEP) of the head and neck are rare and pose unique challenges. This study aimed to explore the clinical spectrum and treatment outcomes of these neoplasms using multimodal management.

Methods: A retrospective review of 13 patients with SEP of the head and neck.

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Introduction: Multiple myeloma (MM) with pulmonary extramedullary disease is rare and usually associated with poor prognosis, and no data on daratumumab-based regimens have been reported yet.

Case Presentation: Here, a 64-year-old man with pulmonary plasmacytoma received daratumumab-based regimens and has achieved a very good partial response with lung mass disappearance and overall survival of 16 months. He did not receive autologous stem cell transplantation because of several comorbidities, such as severe drug-induced neuropathy and JAK2-mutated myeloproliferative neoplasm with marked splenomegaly.

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Totally implantable venous access port metastasis in a patient with multiple myeloma.

Radiol Case Rep

January 2025

Department of Radiology, Henry Ford Health, Detroit, MI 48202, USA.

Article Synopsis
  • Multiple myeloma is a type of blood cancer that involves the growth of unusual plasma cells in the bone marrow, with extramedullary plasmacytomas being a rare form that can develop outside the bone marrow.
  • A case of a 63-year-old man with multiple myeloma presented with a swollen port site, and imaging showed a mass that turned out to be a metastatic subcutaneous plasmacytoma.
  • This case highlights the need to recognize and accurately diagnose skin-related plasmacytomas in patients with venous access ports to prevent misdiagnosis and unnecessary treatments.
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Breast plasmacytoma is an uncommon extramedullary manifestation of multiple myeloma (MM). This case presents a primary extramedullary plasmacytoma and progression to MM with breast involvement after 12 years of discovering the disease. The patient is a 54-year-old woman who initially presented with a right humerus pathological fracture that turned out to be a primary extramedullary plasmacytoma.

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Article Synopsis
  • Patients with multiple myeloma and soft-tissue plasmacytoma (STP) have a poor prognosis, despite new treatments and bone marrow transplants.
  • A study of 120 STP patients showed a 67% rate of partial response to first-line treatment, with median progression-free survival (PFS) of 10.5 months and overall survival (OS) of 24.5 months.
  • Secondary STP and organ involvement were identified as significant negative factors affecting PFS and OS, highlighting the need for customized treatment strategies, including immunotherapies.
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Article Synopsis
  • The study focuses on plasmacytomas initially diagnosed through head and neck symptoms, analyzing 7 patients admitted to a hospital from 2013 to 2022 for better understanding of the condition.
  • Patients were diagnosed via histopathology, with lesions in areas like the nasopharynx and nasal sinuses, and many presented with atypical symptoms and metastasis.
  • Treatment varied, with surgery being common, and individualized approaches post-surgery showing promising outcomes, indicating early detection could improve survival rates despite the overall risks associated with plasmacytomas and multiple myeloma.
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Article Synopsis
  • Kidney disease is a common issue in patients with multiple myeloma (MM) and can lead to higher morbidity and mortality, with a study analyzing the kidney function of these patients during their first year of treatment.
  • The research was conducted on 167 patients between 2009 and 2019, many of whom had high blood pressure and severe stages of MM, with significant portions having reduced kidney function at diagnosis.
  • Factors like anemia and high protein levels were linked to worse kidney function, but having better initial kidney health and undergoing stem cell transplantation significantly improved recovery over 12 months.
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Adding Evidence to Plasmacytoma: A Case Series.

Cureus

September 2024

Oncopathology, Saar Diagnostics, Ranchi, IND.

Plasmacytoma is a rare tumor of plasma cells with two primary variants: solitary bone plasmacytoma (SBP) and extramedullary plasmacytoma (EMP). It poses diagnostic challenges at times. Radiotherapy (RT) is the curative modality in the majority of cases.

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[Extramedullary plasmacytoma of the liver: report of a case].

Zhonghua Bing Li Xue Za Zhi

October 2024

Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200438, China.

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Article Synopsis
  • Multiple myeloma (MM) initially manifesting in the sphenoid sinus and skull base is rare, with a systematic review of 34 cases highlighting the challenges of early diagnosis and treatment, particularly for the IgD-λ subtype.
  • A unique case of IgD-λ MM showed symptoms like dizziness and blindness, leading to a confirmed diagnosis and a wide range of diagnostic tests, including advanced imaging and biopsies.
  • The study emphasizes the importance of using CT and MRI scans for detecting bone damage, and suggests that endoscopic procedures are effective for tissue biopsies, which can improve diagnosis in asymptomatic regions like the paranasal sinuses.
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Article Synopsis
  • Chronic lymphocytic leukemia (CLL) is usually a slow-growing cancer that is manageable for most patients.
  • In some cases, however, it can transform into a more aggressive form or lead to other conditions like non-Hodgkin's lymphoma or multiple myeloma.
  • This case report focuses on a unique patient who has been diagnosed with both CLL and an extramedullary plasmacytoma, exploring their treatment.
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Article Synopsis
  • * A case study is presented of a 54-year-old woman with a painless mass in her palate, who was diagnosed with EMP after surgery, and treated with radiation therapy, showing no signs of recurrence over seven years.
  • * The study suggests that combining surgery and radiation could be an effective treatment for high-risk EMP patients with primary palatal lesions, based on the positive outcome of the case presented.
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A rare encounter in the nasopharynx: Extramedullary plasmacytoma.

Radiol Case Rep

December 2024

Department of Radiology, National Institute of Oncology, CHU Ibn Sina, Faculty of Medicine and Pharmacy of Rabat, Rabat, Morocco.

Article Synopsis
  • Extra-medullary plasmacytoma (EMP) is a rare type of tumor, primarily found in the head and neck area, particularly the paranasal sinuses and nasopharynx.
  • Diagnosis of EMP requires histological confirmation of a single plasma cell lesion, minimal plasma cells in the bone marrow, and no significant organ damage typical of multiple myeloma.
  • A case study of a 55-year-old male with recurrent nosebleeds led to the discovery of an EMP in the nasopharynx, confirmed through endoscopy and MRI, along with pathology and bone marrow analyses.
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Article Synopsis
  • * The case study highlights a patient with relapsed-refractory EMD who initially presented with a para-osseous plasmacytoma that later evolved into a soft-tissue plasmacytoma with different immunoglobulin characteristics.
  • * The authors propose a link between immunoglobulin patterns and patient prognosis, suggesting that these biochemical markers could be integrated into overall risk assessments for the disease.
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Septal plasmacytoma: Dilemma of diagnosis.

Med J Armed Forces India

June 2024

Associate Professor, Department of ENT, Armed Forces Medical College, Pune, India.

Article Synopsis
  • Plasmacytomas are harmful tumors formed by the unusual growth of plasma cells and can occur in bones or soft tissues, with extramedullary types being rare, especially in the head and neck region.
  • An 80-year-old male was treated for a localized plasmacytoma in the nasal septum, successfully removed via endoscopic surgery, followed by radiation therapy, and has shown no signs of recurrence after one year.
  • Effective management of plasmacytomas requires a teamwork approach for diagnosis and treatment, and it's crucial to check for any broader systemic involvement before confirming a diagnosis of solitary plasmacytoma.
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