15 results match your criteria: "Plant Poisoning Licorice"
[Adverse effects of licorice consumed as food: An update].
Rev Med Interne
September 2023
Centre antipoison de Paris, Fédération de toxicologie (FeTox), hôpital Fernand-Widal (AP-HP), 200, rue du faubourg Saint-Denis, 75010 Paris, France; Université Paris Cité, Inserm UMR-S 1144, optimisation thérapeutique en neuropsychopharmacologie, 75006 Paris, France; UFR de médecine, université de Paris, 75006 Paris, France.
Article Synopsis
- Licorice refers to a plant and its roots, especially Glycyrrhiza glabra, which is widely used in herbal medicine, food, cosmetics, and pharmaceuticals.
- Glycyrrhizin, a key component of licorice, is processed in the body into metabolites that can lead to health issues like apparent mineralocorticoid excess syndrome, particularly after chronic high doses.
- Symptoms of glycyrrhizin poisoning include hypertension and fluid retention, and the diagnosis involves clinical evaluation and lab tests, with treatment focusing on symptom relief and discontinuing licorice use.
Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice.
Imeta
March 2022
Hebei Key Laboratory of Soil Ecology, Centre for Agricultural Resources Research, Institute of Genetics and Developmental Biology Chinese Academy of Sciences Shijiazhuang China.
Article Synopsis
- Mass cadmium poisoning poses significant health risks globally, and dietary intervention is proposed as a practical solution.
- A study identified licorice as an effective herbal food that can detoxify cadmium in mice, leading to over 50% reduction of blood cadmium levels within a month.
- Licorice not only decreased cadmium levels in the body but also improved liver health and altered gut microbiota, suggesting its potential as a dietary intervention against cadmium poisoning.
Article Synopsis
- Herbal medications are becoming popular for treating COVID-19, but while many are generally safe, some can cause serious toxicities.
- The article reviews various herbal preparations that have been proposed for COVID-19 treatment, including those recommended by government agencies and others promoted through media.
- Despite some anecdotal success of these herbal remedies, there's a lack of clinical trial data to support their effectiveness, necessitating awareness of the potential toxic effects among healthcare workers.
The intervention effect of licorice in d-galactose induced aging rats by regulating the taurine metabolic pathway.
Food Funct
September 2018
Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92, Wucheng Road, Taiyuan, China.
Article Synopsis
- - Licorice has been recognized for its various health benefits, including its ability to reduce cognitive damage and oxidative stress in aging rats treated with d-galactose.
- - The study utilized 1H NMR-based metabolomics to examine changes in metabolism and identified taurine as a key biomarker linked to aging in these rats.
- - Results showed reduced taurine levels and specific key enzymes in aging rats, while licorice administration increased taurine and enzyme levels, suggesting that licorice helps combat aging by influencing the taurine metabolic pathway.
[The Indigenization of Licorice and Its Meaning During the Early Days of the Joseon Dynasty].
Uisahak
August 2015
Handok Museum of Medicine and Pharmacy, Eumseong-gun, Chungcheongbuk-do, KOREA.
This article explores the indigenization of licorice(Glycyrrhiza uralensis Fisch.) which was the most important medicine of the Oriental Medicine. There are a lot of records on licorice even before the Joseon Dynasty.
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- Licorice has detoxifying properties that can help treat drug poisoning and its side effects, though the specifics of how it works are not fully known.
- The study found that licorice boosts the expression of certain enzymes and transporters involved in drug metabolism and detoxification, specifically phase II and phase III enzymes.
- It suggests that licorice may activate the Nrf2 signaling pathway, which plays a key role in enhancing the body’s ability to process and eliminate drugs.
Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality.
Br J Clin Pharmacol
April 2015
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, via Balzaretti 9, 20133, Milano, Italy.
Article Synopsis
- The review aimed to gather data on adverse effects from plant food supplements, misidentification of poisonous plants, and interactions with traditional medications/nutrients.
- The research involved searching databases like PubMed and Embase for relevant studies up to June 2014, evaluating papers based on WHO guidelines.
- Results showed that 39 out of 66 examined plants had documented adverse effects, while severe reactions were rare, with a few fatal cases reported, indicating that adverse effects from botanicals are generally infrequent.
[Study on acute toxicity test of different processed products of Radix polygalae].
Zhongguo Zhong Xi Yi Jie He Za Zhi
March 2012
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091.
Article Synopsis
- The study aimed to evaluate the acute toxicity of water and ethanol extracts from various processed forms of Radix Polygalae to assess safety for clinical use.
- The researchers prepared different extracts, measured saponin levels, and observed toxicity effects in mice over fourteen days, using modified methods to calculate the lethal dose (LD50).
- Findings revealed that licorice processed Radix Polygalae was the most toxic due to its high saponin content, while honey processed Radix Polygalae had the least toxicity, highlighting a direct link between saponin levels and toxicity.
[Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center].
Schweiz Med Wochenschr
June 1996
Schweizerisches Toxikologisches Informationszentrum (STIZ), Zürich.
Article Synopsis
- The study aimed to analyze plant poisonings in Switzerland over 29 years, focusing on their types, frequency, and severity.
- Out of nearly 25,000 reported cases of toxic plant exposure, only a small fraction resulted in severe poisonings, with just five fatalities, all in adults.
- Specific toxic plants like Atropa belladonna, Datura stramonium, and Colchicum autumnale were linked to severe symptoms including anticholinergic syndrome, photodermatitis, and liver failure.
My engagement with steroids: a review.
Steroids
January 1995
General Clinical Research Center, University of California, San Francisco 94110, USA.
Article Synopsis
- The study of mineralocorticoid hypertensive disorders revealed unique cases, such as 17 alpha-hydroxylase deficiency, that led to new insights into aldosterone production and regulation.
- New measurement techniques utilizing an anesthetic were developed to assess deoxycorticosterone (DOC) metabolites, revealing complex regulatory mechanisms that differ for DOC and cortisol.
- Research indicated that licorice consumption can cause a specific form of hypertension characterized by low renin and aldosterone levels, and the recovery of cortisol metabolism was significantly delayed after stopping licorice intake.
Article Synopsis
- Four women with severe systo-diastolic hypertension and low potassium levels were treated for conditions unresponsive to prior medication.
- All subjects had a history of regularly consuming liquorice-based products, which contributed to their hypertension and hypokalemia.
- After stopping liquorice consumption, potassium levels returned to normal within 6 to 15 days, while blood pressure and other health indicators stabilized more gradually.