176 results match your criteria: "Plant Poisoning Glycosides ‚AEi Cardiac"
Laurel but Hardy: unintended poisoning, a case report of oleander misidentification as bay laurel.
Toxicol Rep
December 2023
USD Poison Control Center, Azienda Ospedaliera Universitaria integrata, Verona, Italy.
Article Synopsis
- Oleander is a toxic plant with harmful cardiac glycosides that can lead to symptoms mimicking digoxin toxicity, such as gastrointestinal issues and heart problems.
- An 84-year-old man accidentally ingested an oleander leaf infusion, mistaking it for bay laurel, and experienced symptoms, requiring emergency treatment and monitoring.
- The case highlights the need for careful clinical evaluation in oleander poisoning, as standard tests may not effectively measure its cardiac glycosides, and prolonged monitoring is crucial for patient safety.
A study of socio clinical, biochemical and electrocardiographic changes of yellow oleander seed poisoning in India.
Bioinformation
March 2023
Department of General Medicine, K.A.P Viswanatham Govt Medical College, Trichy - 17, India.
Article Synopsis
- Yellow oleander is a toxic shrub found in tropical regions, with all parts, especially the seeds, containing harmful cardiac glycosides that can affect the heart and nervous system.
- A study conducted over six months showed that yellow oleander seed poisoning was mainly prevalent in individuals aged 21-40, with symptoms like vomiting, abdominal pain, and palpitations, particularly worsening with crushed seeds and delayed medical treatment.
- Electrocardiogram (ECG) changes correlated with elevated serum potassium levels and cardiotoxicity, which was notably higher in patients who ingested the seeds on an empty stomach, although the severity of outcomes was not directly linked to the number of seeds consumed or the quantity ingested.
Fatal poisoning due to ingestion of boiled oleander leaf extract.
J Forensic Sci
January 2024
Department of Clinical Toxicology, Saitama Medical University, Iruma-gun, Saitama, Japan.
Article Synopsis
- Nerium oleander is a toxic ornamental shrub that contains a harmful substance called oleandrin, which can lead to fatal consequences if ingested.
- An 80-year-old man ingested boiled oleander leaf extract in a suicide attempt, resulting in severe heart issues and metabolic complications upon arrival at the emergency room.
- Despite attempts to treat his critical condition with advanced medical interventions like extracorporeal membrane oxygenation, he ultimately succumbed to poisoning, with oleandrin levels significantly higher than those in prior fatal cases.
Persistent Cardioactive Glycosides Intoxication Related to Gastric Phytobezoar of Oleander Leaves.
Eur J Case Rep Intern Med
July 2023
Intensive Care Unit, Regional Hospital of Lugano, Department of Critical Care, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Article Synopsis
- Nerium oleander contains toxic cardiac glycosides, and ingestion can lead to severe medical emergencies.
- A case of a 73-year-old man illustrates the dangers: he suffered serious symptoms including altered consciousness and heart block after consuming oleander leaves.
- Treatment involved various medications and ultimately required gastroscopy to remove an oleander phytobezoar, highlighting the need for aggressive interventions in cases of oleander intoxication.
Of mixed vegetables and cardiac arrhythmias - confused with : A case series of accidental digitoxin intoxications.
J Cardiol Cases
August 2023
Department of Internal Medicine II, Centre for Complementary Medicine, Freiburg University Hospital Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Article Synopsis
- A case series of two women, aged 35 and 60, experienced severe nausea and vomiting after consuming mixed vegetables, which they mistakenly thought included borage but may have contained toxic foxglove leaves.
- An electrocardiogram showed abnormal heart activity, and testing revealed elevated levels of digitoxin, a toxin from foxglove, in both patients.
- Both women required close monitoring and treatment but fully recovered, highlighting the dangers of misidentifying edible plants and the need for prompt medical attention in such cases.
A toxic shrub turned therapeutic: The dichotomy of Nerium oleander bioactivities.
Toxicon
March 2023
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India. Electronic address:
Article Synopsis
- - Nerium oleander L. is a medicinal plant used for treating cancers and hyperglycemia, primarily in regions like India, Turkey, Morocco, and China, but it is also highly toxic, causing severe harm when ingested.
- - The plant contains polyphenolic compounds and cardiac glycosides, particularly oleandrin, which have shown potential anti-cancer effects in lab studies but can also lead to fatal poisoning in humans and animals.
- - Research indicates that gut microbiota and various other factors, such as dosage, treatment methods, and environmental influences, significantly impact the differing pharmacological benefits and toxic effects of oleander.
Identification of antinutritional, antioxidant, and antimicrobial activity of plants that cause livestock poisoning in Bojonegoro Regency, Indonesia.
Vet World
September 2022
Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Jl. Fauna No. 2 Karangmalang, Yogyakarta, 55281, Indonesia.
Article Synopsis
- The study examines the antinutritional factors in various plant leaves from Bojonegoro Regency that cause livestock poisoning, while also highlighting their potential health benefits.
- By using 70% ethanol extraction and qualitative analysis, the presence of harmful compounds like tannins and alkaloids was confirmed, alongside beneficial antioxidant and antibacterial properties.
- Results showed that cassava peels and sweet potato leaves exhibited strong antioxidant activity, while Chinese leaves demonstrated significant antibacterial effects, suggesting that these plants can be both harmful and beneficial when processed correctly.
Forage and You Shall Find: Cardiac Glycoside Poisoning and the Danger of Foraging.
Mil Med
July 2023
Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Article Synopsis
- Amateur foraging, while beneficial for individuals and the environment, risks unintentional poisoning from potentially toxic plants, such as common milkweed.
- A case study highlighted a 38-year-old woman who suffered symptoms including vomiting and bradycardia after consuming boiled milkweed pods, revealing the dangers of misidentification.
- Military services are considering foraging to support troops, but training is crucial for identifying safe plants to prevent severe poisoning or fatal incidents.
Bintaro (Cerbera odollam and Cerbera manghas): an overview of its eco-friendly use, pharmacology, and toxicology.
Environ Sci Pollut Res Int
June 2023
Department of Life Sciences, Vivekananda Global University, Jaipur, India.
Article Synopsis
- Bintaro, a tropical mangrove plant found in regions like Asia and Australia, is known for its poisonous fruit and is closely related to Cerbera odollam, often called the "Indian suicide tree" due to its association with poisoning incidents.
- The seeds contain a toxic compound called Cerberin that disrupts heart function, making it potentially lethal.
- Despite its toxicity, Bintaro has medicinal properties, including anticancer effects and antioxidant activities, and is also utilized as an insecticide, pesticide, and antifungal agent.
Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology.
Front Pharmacol
February 2022
Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, China.
Article Synopsis
- * Despite its benefits, oleandrin has a narrow therapeutic window with serious toxicities, especially cardiotoxicity, making its clinical use difficult.
- * The review discusses oleandrin's sources, structure, detection methods, and pharmacokinetics, along with possible strategies to reduce its toxicity for safer clinical applications.
Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model.
Toxicol Lett
October 2021
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, München, Germany. Electronic address:
Article Synopsis
- - Poisoning from Nerium oleander and Thevetia peruviana is prevalent in Southeast Asia due to their toxic cardiac glycosides, which can inhibit Na/K-ATPase and potentially lead to deadly heart arrhythmias.
- - The study utilized hiPSC-derived cardiomyocytes and a microelectrode array to evaluate the cardiac effects of various compounds from oleander, revealing that all compounds reduced field potential duration and caused beat arrest at certain concentrations.
- - The tested substances were ranked for their cardiac effects, with neriifolin being the most potent, followed by oleandrin, digitoxigenin, and peruvoside, while thevetin A had no arrhythmic effects up to 100
Cardiac Glycoside Research?
Toxins (Basel)
May 2021
Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technická 5, Prague 6, Czech Republic.
Article Synopsis
- * CGs inhibit the sodium-potassium pump (Na/K-ATPase), leading to cell death due to disrupted ionic balance, but they also have potential therapeutic uses, particularly in treating cardiovascular diseases and possibly cancer.
- * The anticancer properties of CGs may involve their interaction with Na/K-ATPase as a receptor that influences cell signaling, providing a pathway for their repurposing in cancer treatments and drawing attention to specific compounds like digitoxin, digoxin, and ouabain.
Article Synopsis
- Herbal medications are becoming popular for treating COVID-19, but while many are generally safe, some can cause serious toxicities.
- The article reviews various herbal preparations that have been proposed for COVID-19 treatment, including those recommended by government agencies and others promoted through media.
- Despite some anecdotal success of these herbal remedies, there's a lack of clinical trial data to support their effectiveness, necessitating awareness of the potential toxic effects among healthcare workers.
[A poisonous spring smoothie with wild herbs: accidental intoxication with foxglove (Digitalis purpurea)].
Ned Tijdschr Geneeskd
November 2020
St. Antonius ziekenhuis, afd. Klinische Farmacie,Nieuwegein.
Article Synopsis
- - The ingestion of wild plants is becoming more common in society, but this increases the risk of poisoning, particularly from the toxic foxglove plant, which contains harmful cardiac glycosides.
- - A case study involves a 43-year-old woman who experienced severe symptoms after mistakenly drinking a smoothie made with foxglove instead of a safe plant.
- - Clinicians should be vigilant for foxglove poisoning in patients presenting with ongoing gastrointestinal issues and specific heart abnormalities after consuming wild plants.
Calotropis poisoning with severe cardiac toxicity A case report.
J Family Med Prim Care
August 2020
Department of Division of Critical Care, Christian Medical College, Vellore, Tamil Nadu, India.
Article Synopsis
- Calotropis is a common plant in the Indian Subcontinent used by traditional healers for various medical treatments despite its toxicity.
- All parts of the plant can cause serious health issues, including gastrointestinal, skin, and eye problems, due to the presence of toxic compounds.
- A case is reported where a patient suffered cardiovascular collapse after using Calotropis to treat a snake bite, emphasizing the serious risks associated with the plant's cardiotoxic effects.
Negligible Oleandrin Content of Hot Dogs Cooked on Nerium oleander Skewers.
J Med Toxicol
January 2021
UC Irvine School of Medicine, Medical Education, 836 Health Sciences Road, Irvine, CA, 92697-4089, USA.
Article Synopsis
- The Nerium oleander plant has toxic compounds called cardenolides that can poison humans if ingested.
- A study was conducted to see if hot dogs cooked on Nerium oleander skewers could contain harmful levels of oleandrin.
- Results showed that the levels of oleandrin in hot dogs were very low, suggesting that the risk of poisoning from this method of cooking is minimal and likely based on a myth.
Dose and efficacy of repeated administrations of digoxin-specific antibody fragments: Case report of foxglove poisoning.
Basic Clin Pharmacol Toxicol
January 2021
Pharmacy Department, Bretagne Atlantique Hospital, Vannes, France.
Outbreak of Oleander () Poisoning in Dairy Cattle: Clinical and Food Safety Implications.
Toxins (Basel)
July 2020
Department of Veterinary Medicine, University of Bari, 70121 Bari, Italy.
Article Synopsis
- Oleander is a toxic shrub found in Mediterranean areas, causing occasional poisoning in livestock, particularly cattle, due to its toxic leaves containing cardiac glycosides like oleandrin.
- A study involving 50 lactating Fleckvieh cows revealed severe health issues and 13 deaths within 4 days after they ingested oleander pruning wastes mixed with their feed.
- The presence of oleandrin was confirmed in various samples, highlighting the shrub's high toxicity and the risk of it transferring into milk and dairy products, posing potential health risks for consumers.
Acute oleander poisoning: A study of clinical profile from a tertiary care center in South India.
J Family Med Prim Care
January 2020
Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Article Synopsis
- Yellow oleander is a toxic plant containing cardiac glycosides that can adversely affect the heart and nervous system; this study reviews cases of oleander poisoning and patient outcomes.
- Data from 30 adult patients showed common symptoms like vomiting, with metabolic issues such as hyperchloremia and metabolic acidosis frequently observed; half of the patients had ECG abnormalities.
- The use of temporary pacemakers in patients was linked to a longer hospital stay and the study highlights the need for further research on pacing's impact on survival in these cases.
A Case Report of Accidental Intoxication following Ingestion of Foxglove Confused with Borage: High Digoxinemia without Major Complications.
Case Rep Cardiol
November 2019
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milan, Italy.
Article Synopsis
- Foxglove leaves can be mistaken for borage, a safe food ingredient, but are actually poisonous due to the presence of cardiac glycosides, including digitoxin.
- A 55-year-old woman experienced severe symptoms after eating a pie made with what she thought were borage leaves, leading to her hospitalization with high digoxin levels.
- Further analysis revealed the presence of gitoxin, suggesting it might be more toxic than digoxin, highlighting the need for careful lab interpretation in cases of plant poisoning due to potential misidentification of glycosides.
Raising antibodies against epoxyscillirosidine, the toxic principle contained in Moraea pallida Bak. (Iridaceae), in rabbits.
J Immunol Methods
November 2019
Department of Paraclinical Sciences, University of Pretoria, Onderstepoort 0110, Gauteng, South Africa.
Article Synopsis
- Moraea pallida Bak. (yellow tulp) causes significant heart-related toxicity in South Africa, primarily due to a compound called epoxyscillirosidine.
- Researchers are exploring a vaccine development against this toxin, successfully conjugating it with various proteins to enhance immune response in rabbits.
- While initial trials showed low immunity, subsequent adjustments in dosage and adjuvant improved results, particularly with epoxyscillirosidine-KLH, showing promise for future studies on preventing yellow tulp poisoning and understanding cross-reactivity with related compounds.