A framework for modelling desert locust population dynamics and large-scale dispersal.

There is an urgent need for mathematical models that can be used to inform the deployment of surveillance, early warning and management systems for transboundary pest invasions. This is especially important for desert locust, one of the most dangerous migratory pests for smallholder farmers. During periods of desert locust upsurges and plagues, gregarious adult locusts form into swarms that are capable of long-range dispersal.

An epidemiological modeling investigation of the long-term changing dynamics of the plague epidemics in Hong Kong.

Identifying epidemic-driving factors through epidemiological modeling is a crucial public health strategy that has substantial policy implications for control and prevention initiatives. In this study, we employ dynamic modeling to investigate the transmission dynamics of pneumonic plague epidemics in Hong Kong from 1902 to 1904. Through the integration of human, flea, and rodent populations, we analyze the long-term changing trends and identify the epidemic-driving factors that influence pneumonic plague outbreaks.

Human genetic variation reveals FCRL3 is a lymphocyte receptor for .

is the gram-negative bacterium responsible for plague, one of the deadliest and most feared diseases in human history. This bacterium is known to infect phagocytic cells, such as dendritic cells and macrophages, but interactions with non-phagocytic cells of the adaptive immune system are frequently overlooked despite the importance they likely hold for human infection. To discover human genetic determinants of infection, we utilized nearly a thousand genetically diverse lymphoblastoid cell lines in a cellular genome-wide association study method called Hi-HOST (High-throughput Human in-vitrO Susceptibility Testing).

Identification and subcellular localization of proteins that interact with Duck plague virus pUL14 in infected host cells.

Duck plague (DP), which is caused by duck plague virus (DPV), is an infectious disease that severely harms the waterfowl breeding industry. The UL14 protein (pUL14) is a tegument protein encoded by the UL14 gene, which is located in the unique long (UL) region of the DPV genome. DPV pUL14 plays a crucial role in viral replication, likely by interacting with host and viral proteins that have yet to be identified.

Characterization of plastic ingestion in urban gull chicks and its implications for their use as pollution sentinels in coastal cities.

The increase of plastic pollution represents a significant ecological threat, particularly in human-impacted environments. However, the effects of plastic ingestion by urban wildlife are less understood. This study investigates the presence of microplastic (MPs; plastic <5 mm in size) and macroplastics (MaPs, plastic >5 mm in size) in yellow-legged gull (Larus michahellis) chicks inhabiting the urban marine ecosystem of Barcelona (northeastern Spain).

"Current and emerging drug therapies in Alzheimer's disease: A pathophysiological Perspective".

The analytical and experimental investigation of several targets and biomarkers that help in explaining significant cognitive deficits, covering drug development and precision medicine aimed at different chronic neurodegenerative conditions such as Alzheimer's disease (AD), Parkinson's disease, synaptic dysfunction, brain damage from neuronal apoptosis, and other disease pathologies; this served as the foundation for all phase studies. The focus of current therapeutic approaches is on developing humanized antibodies, agonist and antagonist drugs, receptors, signaling molecules, major targeted drug-metabolizing enzymes, and other metabolites to treat neurodegeneration in the AD brain brought on by tau hyperphosphorylation, amyloid plagues, or other cholinergic effects. The five A's-amnesia, agnosia, aphasia, apraxia, and anomia-are the typical symptoms associated with AD.

A Rat's Progress: Plague and the "Migratory Rat" in British India, 1896-1899.

Whether referring to oceanic travel on board of ships or to movement in terra firma, framings of the "migratory rat" formed a key epidemiological component of approaches to the Third Plague Pandemic (1894-1959) as the first pandemic to be understood as caused by a zoonotic disease. In this article, I examine the emergence and development of scientific framings of the migratory rat in the first, explosive years of the third plague pandemic in India (1896-1899). Examining publications and archival sources, I ask how this animal figure came to inform and transform epidemiological reasoning.

Draft genome sequences of evolutionary distant species representatives.

is the etiological agent of human plague. However, certain evolutionarily divergent subspecies have different host specificities and virulence capacity compared to the more commonly studied strains with pandemic potential. This resource examines 10 diverse isolates representing some of the most understudied subspecies commonly referred to as Pestoides.

Using virtual reality simulation to address racism in a healthcare setting.

Racism continues to plague Western societies' institutions, including the healthcare system. Despite the evidence of racism's negative impacts on healthcare providers, administrators, patients, and families, healthcare workers report hesitancy in taking action to address racism in the workplace. Simulation, with its experiential pedagogy and foundation in psychological safety, may be an educational tool to support practical training.

Serine/threonine protein kinase mediates rifampicin resistance in through interacting with ribosomal protein RpsD and affecting antioxidant capacity.

Unlabelled: Brucellosis, a zoonotic disease, has re-emerged in both humans and animals, causing significant economic losses globally. Recently, an increasing number of rifampicin-resistant strains have been isolated worldwide without detectable mutations in known antibiotic resistance genes. Here, this study identified the deletion of serine/threonine protein kinase (STPK) gene in as an efficient trigger for rifampicin resistance using bioinformatics predictions, a transposon mutant library, and gene mutation strains.

Giant Polyketide Synthases Biosynthesize a Marine Polyether Biotoxin.

Prymnesin toxins were probably the direct cause of the environmental catastrophe in the Oder river in 2022. They belong to the so-called ladder polyethers, which are among the most toxic non-proteinogenic substances and have caused a whole series of food poisoning in humans and numerous other incidents of fish deaths. Despite massive efforts, the enzymatic machinery has remained enigmatic.

Nanolasers: More than a decade of progress, developments and challenges.

As the demand for smaller and more compact lasers increases, the physical dimensions of laser diodes are already at the diffraction limit, which impairs this miniaturization trend and limits direct laser integration into photonic and especially nanophotonic circuits. However, plasmonics has allowed the development of a novel class of lasers that can be manufactured without being limited by diffraction, exhibiting ultralow energy consumption, small volumes, and high modulation speeds that could someday compete with their modern macroscale counterparts. Nevertheless, a wide variety of issues create roadblocks for further development and commercial adoption.

Design of a novel multi-epitope vaccine candidate against using advanced immunoinformatics approaches: An in silico study.

is the perilous pandemics that occurred in Asia and Europe. The bacterium has shown drug resistance that can cause the future pandemic and destroy the drug treatment against plague. As known, effective therapeutics such as designing potent vaccine that can aid world to protect against plague.

The Forgotten Knowledge: Pandemics in Islamic Manuscripts.

COVID-19 is far from the first pandemic in history. Classical manuscripts show that plague and pestilence have long troubled humanity which have had significant religious, social, and medical ramifications. However, these manuscripts have been neglected rather than being taken into consideration during the COVID-19 pandemic response.

Insecticide Resistance of Xenopsylla cheopis in Madagascar: Revision of Diagnostic Doses for Bioassay and Exploration of Biochemical Mechanisms.

The Oriental rat flea, Xenopsylla cheopis, is known worldwide as an efficient plague vector, including in Madagascar, where the disease remains a public health concern. Chemical control is the primary response method against X. cheopis in Madagascar.

The first mitogenome of the genus (Siphonaptera: Ceratophyllidae) and its phylogenetic implications.

belongs to Arthropoda, Insecta, Siphonaptera, Ceratophylloidea, Ceratophyllinae, . Only 2 species from the subfamily Ceratophyllinae have been sequenced for mitogenomes to date. The genus mitogenome research was still blank.

On the manipulator-focused response to manipulation cases.

In this paper, we identify a class of responses to cases of manipulation that we label . The key insight of such views is that being subject to the will of another agent significantly affects our freedom and moral responsibility. Though different authors take this key insight in different directions, and the mechanics of their views are quite different, these views turn out to share many key components, and this allows us to discuss several authors' views at the same time, highlighting a variety of challenges for such views and helping to identify pitfalls to avoid in further developments of views of this type.

Multiple "spaces": Using wildlife surveillance, climatic variables, and spatial statistics to identify and map a climatic niche for endemic plague in California, U.S.A.

Regional climatic features in endemic areas can help inform surveillance for plague, a bacterial disease typically transmitted by fleas and maintained in mammals. We use 7,954 coyotes (Canis latrans), a sentinel species for plague, screened for plague exposure by the California Department of Public Health - Vector-Borne Disease Section (CDPH-VBDS; 1983-2015) to identify and map plague-suitable local climates within California to empirically inform ongoing sampling and surveillance plans. Using spatial point processes, we compare the distributions of seropositive and seronegative coyotes within the "space" defined by the first two principal components of PRISM Climate Group 30-year average climate variables (primarily temperature and moisture).