680 results match your criteria: "Pityriasis Lichenoides"
Two cases of pityriasis lichenoides chronica successfully treated with methotrexate injection and upadacitinib, respectively.
Eur J Dermatol
October 2024
Department of Dermatology, The Fifth Affiliated Hospital, Sun Yat-sen University, 52 Meihua East Rd, Zhuhai, China.
A clinical case of pityriasis lichenoides chronica presenting with palpable purpura after streptococcal infection.
Folia Med (Plovdiv)
June 2024
Sofiamed University Hospital, St Kliment Ohridski University, Sofia, Bulgaria.
Article Synopsis
- Pityriasis lichenoides is a rare inflammatory skin condition characterized by red-brown papules and crusty lesions as they evolve over time.
- A 60-year-old woman developed the chronic form of this condition ten days after suffering from streptococcal pharyngitis, starting with purple spots on her legs and later developing red, scaly patches on other parts of her body.
- After treatment with methylprednisolone and hydroxychloroquine, her skin lesions improved significantly and did not return.
Pityriasis lichenoides et varioliformis acuta associated with Epstein-Barr virus infection.
Infection
August 2024
Department of Dermatology, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcala, Colmenar Viejo km 9.100, Madrid, 28034, Spain.
Onset of Pityriasis Lichenoides in Patients Treated With Biologic Therapy: A Systematic Review.
J Cutan Med Surg
July 2024
Queen's University School of Medicine, Kingston, ON, Canada.
Dupilumab for the treatment of pityriasis lichenoides chronica.
JAAD Case Rep
August 2024
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Pityriasis Lichenoides et Varioliformis Acuta Developing during Pembrolizumab Treatment for Bladder Cancer.
Case Rep Dermatol
May 2024
Department of Dermatology, Graduate School of Medicine, Mie University, Tsu, Japan.
Article Synopsis
- Anti-PD-1 immunotherapies, like pembrolizumab, boost T-cell activity against tumors but can cause immune-related adverse events, particularly skin issues like lichenoid reactions, eczema, and vitiligo.
- A case study highlights a 53-year-old man who developed a rare skin condition, pityriasis lichenoides et varioliformis acuta (PLEVA), after his 11th infusion of pembrolizumab for bladder cancer, showing significant dermatological changes confirmed by biopsy.
- The authors suggest that the anti-PD-1 therapy possibly increases cytolytic activity in T cells, leading to skin damage characterized by epidermal necrosis and specific inflammatory cell infiltration.
Immunophenotyping and viral studies in pityriasis lichenoides et varioliformis acuta lesions.
J Cutan Pathol
October 2024
Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Article Synopsis
- The study aimed to understand the causes of pityriasis lichenoides et varioliformis acuta (PLEVA) by analyzing the immune profile and searching for potential viral infections.
- Researchers examined skin samples from patients with PLEVA and those with other skin conditions, focusing on specific types of viruses and immune cells.
- Findings showed a higher presence of certain immune cells in PLEVA patients, suggesting immune damage to the skin, but no viral infections were detected in the samples tested.
Febrile ulceronecrotic Mucha-Habermann disease - a case and treatment review.
Dermatol Online J
April 2024
Departamento de Medicina, Servico de Medicina Interna, Unidade Local de Saude de Matosinhos EPE, Portugal.
Article Synopsis
- * It often leads to serious complications including issues in the blood, lungs, heart, gut, and brain.
- * Treatment typically involves corticosteroids and immunosuppressants like methotrexate, with a case presented showing a gradual treatment strategy for a patient not responding well to methotrexate.
Cytophagic histiocytic panniculitis leading to a diagnosis of acute myeloid leukemia with monocytic differentiation: A case report and literature review.
J Cutan Pathol
September 2024
Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Article Synopsis
- Cytophagic histiocytic panniculitis (CHP) is a condition characterized by benign phagocytic histiocytes that can engulf blood cells and is linked to various systemic diseases.
- A case study is presented about a 72-year-old woman who exhibited a skin rash resembling pityriasis lichenoides et varioliformis acuta (PLEVA), leading to a detailed skin biopsy.
- Ultimately, the biopsy indicated CHP, which triggered further investigations that revealed the patient had an underlying acute monocytic leukemia of myeloid lineage.
Pityriasis lichenoides (PL) is an uncommon skin rash. PL has two main forms: Pityriasis lichenoides et varioliformis acuta (PLEVA): this "acute" (fast) form comes on quickly. Pityriasis lichenoides chronica (PLC): this "chronic" (long) form often develops slowly and lasts longer.
View Article and Find Full Text PDFA case report of febrile ulceronecrotic Mucha-Habermann disease.
Transl Pediatr
April 2024
Department of Pediatric Critical Care Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- - FUMHD is a rare skin condition characterized by rapid onset of painful necrotic lesions, systemic symptoms like fever, and a complex diagnosis that requires ruling out other severe skin diseases.
- - A case study of a 13-year-old patient highlights a comprehensive treatment approach using corticosteroids, immunosuppressive therapy, and supportive care to manage the aggressive nature of FUMHD effectively.
- - The report emphasizes the importance of early diagnosis, prompt treatment, monitoring for infections, and addressing the psychological and social needs of the patient to enhance overall outcomes.
Utility of IL-36 immunostaining in distinguishing psoriasis from pityriasis rosea and pityriasis lichenoides.
J Cutan Pathol
August 2024
Department of Pathology and Dermatology, University of California San Francisco, San Francisco, California, USA.
Article Synopsis
- Psoriasis is a skin condition linked to high levels of a cytokine called IL-36, which differentiates it from similar skin disorders like pityriasis rosea (PR) and pityriasis lichenoides (PL).
- A study compared IL-36 immunostaining patterns in 21 cases of PR, 22 cases of PL, and 10 cases of psoriasis, using a grading scale to assess positivity.
- Results showed all psoriasis cases tested positive for IL-36, while all PR cases were negative, and a significant number of PL cases also had low or negative staining, indicating IL-36 could be a valuable marker for distinguishing these skin conditions.
Pityriasis lichenoides: assessment of 41 pediatric patients.
J Pediatr (Rio J)
August 2024
Pediatric Dermatology Division, Department of Pediatrics, Federal University of Paraná, UFPR, Curitiba, Brazil.
Article Synopsis
- The study evaluated characteristics and treatment responses of pediatric patients with pityriasis lichenoides over 43 years, focusing on those under 15 years old.
- A total of 41 patients were analyzed, with the majority having pityriasis lichenoides chronica (PLC), and the highest frequency of cases observed during specific years coinciding with infectious outbreaks.
- Remission occurred in 71.9% of cases, with better outcomes seen in patients who received phototherapy and those whose disease began after age 5.
Pityriasis following COVID-19 vaccinations: a systematic review.
Dermatol Reports
March 2024
Plastic Surgery Vegas, Las Vegas, NV, USA.
Article Synopsis
- A systematic review was conducted to investigate cutaneous reactions, specifically pityriasis eruptions, after COVID-19 vaccinations, revealing 47 case reports involving 94 patients.
- The findings showed that 64.9% had pityriasis rosea as the most common reaction, with Pfizer-BioNTech being the most reported vaccine associated with these skin reactions.
- The study highlighted a significant discrepancy in post-vaccination pityriasis reactions between Pfizer and Moderna vaccines, suggesting the need for further research to understand these differences better.
Efficacy and safety of excimer light (308 nm) in the treatment of pityriasis lichenoides chronica.
Photodermatol Photoimmunol Photomed
May 2024
Department of Dermatology and Andrology, Faculty of Medicine, Azhar University, Cairo, Egypt.
Article Synopsis
- Pityriasis lichenoides chronica is a persistent skin condition that can be effectively treated using phototherapy, specifically with Excimer light 308 nm.* -
- In a study involving 34 patients diagnosed with this condition, 31 achieved complete clearance, while two had partial success and one did not respond well.* -
- The results suggest that Excimer light therapy is a safe and effective option for treating pityriasis lichenoides chronica in patients of various ages and genders.*
Paediatric-onset lymphomatoid papulosis: results of a multicentre retrospective cohort study on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG).
Br J Dermatol
July 2024
Department of Dermatology, CHUV Lausanne, University of Lausanne, Switzerland.
Article Synopsis
- Lymphomatoid papulosis (LyP) is a rare skin disorder affecting T-cells, and there's limited information about its impact on children.
- A study analyzed data from 87 pediatric patients diagnosed with LyP over a 24-year period, noting that most cases were initially misdiagnosed and the average age at onset was 7 years.
- The prognosis appears positive, with a 100% overall survival rate, although 10% of patients had associated blood cancers, indicating a significantly higher risk of malignancy compared to the general youth population.
Pityriasis lichenoides et varioliformis acuta in a patient treated with cevostamab.
JAAD Case Rep
May 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Diseases categorized as autoinflammatory keratinization diseases (AiKDs), and their pathologies and treatments.
Nagoya J Med Sci
February 2024
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Article Synopsis
- Whole-exome and whole-genome sequencing have helped uncover the causes and mechanisms behind inflammatory keratinization diseases, leading to the classification of "autoinflammatory keratinization diseases (AiKDs)" since 2017.
- AiKDs are characterized by the abnormal activation of innate immunity in the skin, which results in hyperkeratosis and includes conditions like generalized pustular psoriasis and porokeratosis.
- The classification of AiKDs is evolving, as more diseases are identified under this category, enhancing our understanding of their underlying mechanisms and informing treatment options.
Febrile Ulceronecrotic Mucha-Habermann Disease Associated With Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature.
Am J Dermatopathol
April 2024
Department of Dermatology, Columbia University Irving Medical Center, New York, NY.
Article Synopsis
- Mucha-Habermann disease (MHD) is an inflammatory skin condition with symptoms resembling cutaneous T-cell lymphoma, while its severe variant, febrile ulceronecrotic MHD (FUMHD), presents with systemic symptoms and ulcers.
- A case study of a 21-year-old woman showed atypical lymphomatoid features of FUMHD alongside hemophagocytic lymphohistiocytosis (HLH), leading to significant clinical findings and a biopsy that indicated atypical CD8 + lymphocyte infiltration.
- Treatment using etoposide and dexamethasone resulted in rapid improvement of her symptoms, with the patient's skin lesions healing over time and confirming the MHD diagnosis; she has remained
Atypical plaque psoriasis: a clinicopathological study of 20 cases.
Int J Dermatol
August 2024
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- The study investigates how to differentiate atypical plaque psoriasis from similar skin conditions, especially when typical diagnostic features are absent.
- It analyzes clinical and pathological characteristics from 20 cases of atypical plaque psoriasis and 40 control cases, revealing significant differences in various features like parakeratosis and types of inflammatory cells.
- The findings aim to provide clinicians with better diagnostic tools to accurately identify and treat atypical plaque psoriasis by highlighting distinguishing features from its mimics.
Rapid recovery in a child with febrile ulceronecrotic Mucha-Habermann disease following intravenous immunoglobulin administration.
Pediatr Dermatol
May 2024
Department of Pathology, Christian Medical College and Hospital, Vellore, India.
Article Synopsis
- Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a serious skin disorder that can lead to severe health complications in children and requires prompt management to prevent fatal outcomes.
- Treatment options are limited due to the few reported cases and lack of substantial research, making it challenging to find effective therapies.
- A case study of a five-year-old child with FUMHD and seizures showed that while multiple treatments were ineffective, a single infusion of low-dose intravenous immunoglobulin led to rapid improvement and disease control.
Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications.
Clin Rev Allergy Immunol
December 2023
Department of Dermatology, University Children's Hospital Niño Jesús, 28009, Madrid, Spain.
Article Synopsis
- * Key genes involved include CARD14 and IL36RN, linked to various forms of psoriasis and other skin conditions, while newer mutations in JAK1, POMP, and EGFR have also been identified as contributing factors.
- * The review highlights the pathophysiology and clinical features of these diseases, introducing the term "NLRP1-associated autoinflammatory disease with epithelial dyskeratosis (NADED)" for a specific group related to NLRP1 mutations.
[Onychomadese nach Pityriasis lichenoides et varioliformis acuta, behandelt mit Methotrexat].
J Dtsch Dermatol Ges
December 2023
Department of Dermatology, Hospital Clínic Barcelona, University of Barcelona, Barcelona, Spain.