Our approach to the treatment of vestibular schwannomas with arachnoid dissection of the facial nerve.

Unlabelled: Preserving the function of the facial nerve is extremely important in surgery for vestibular schwannomas. Two methods of arachnoid dissection are described for resection of vestibular schwannoma via retrosigmoid approach (from the brain stem and internal auditory canal).

Objective: To evaluate the results of arachnoid dissection of the facial nerve from internal auditory canal when resecting the vestibular schwannoma.

[Surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele].

Background: In recent years, temporal lobe encephalocele has become more common in patients with focal drug-resistant epilepsy. Despite available experience, there are still no clear recommendations for choosing the extent of surgery in these patients.

Objective: To evaluate the effectiveness of diagnosis and surgical treatment of focal drug-resistant epilepsy associated with temporal lobe encephalocele.

[Safety of robot-assisted implantation of deep electrodes for invasive stereo-EEG monitoring].

Unlabelled: Robot-assisted implantation of deep electrodes for stereo-EEG monitoring has become popular in recent years in patients with drug-resistant epilepsy. However, there are still few data on safety of this technique.

Objective: To assess the incidence of complications in patients with drug-resistant epilepsy undergoing robot-assisted implantation of stereo-EEG electrodes.

Improvement of clinical and radiological manifestations of coxitis in patients with ankylosing spondylitis treated with tumor necrosis factor-α inhibitor golimumab: Results of a 24-Month prospective observation study (GO-COX Study).

Aim: The hip joint is the most commonly affected non-axial joint in ankylosing spondylitis (AS). Data on the effects of tumor necrosis factor-α inhibitors (TNFi) in AS patients with coxitis are limited. The aim of this study was evaluation of coxitis treated with the TNFi golimumab in real-world settings.

Immobilizing Interstitial Cardiac Fibrosis.

Background: The alterations in the endomysium and perimysium might cause compaction and gradual mechanical compression of cardiomyocytes resulting in their immobilization. This process finally leads to severe stiffening, so that the newly formed frame around individual cardiomyocytes and their clusters hinders normal diastole, and later systole. This phenomenon is referred to as immobilizing interstitial cardiac fibrosis (IICF).

Mapping the musician brain during awake craniotomy.

Direct cortical stimulation during awake craniotomy with speech testing became the «gold standard» in brain mapping and preserving speech zones during neurosurgical procedures. However, there are many other cerebral functions, and their loss can be very critical for certain patients. For example, such a function is production and perception of music for musicians.

Revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Unlabelled: Nowadays, vertebral stenosis is the most common indication for surgical treatment in patients over 65 years old in spine surgery. According to the literature, there are conflicting data on the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Objective: To evaluate the incidence and indications for revision surgery after previous spinal decompression and fusion for lumbar spinal stenosis.

Surgical treatment of tumors of the supplementary motor area.

Unlabelled: After surgical treatment of tumors of the supplementary motor area (SMA) post-operative speech and/or motor neurological deficit may occur.

Objective: To determinate frequency and reversibility of such deficit and identify risk factors for its development.

Material And Methods: We retrospectively analyzed postoperative outcomes in 34 patients with SMA tumors.

[Laparoscopic versus laparoscopy-assisted suturing of perforated peptic ulcers (meta-analysis)].

Objective: To compare laparoscopic and laparoscopy-assisted repair of perforated peptic ulcer using evidence-based methods.

Material And Methods: A systematic review and meta-analysis were carried out in accordance with the recommendations of the Ministry of Health of Russian Federation and

Unlabelled: Data searching was carried out in Russian and English languages using the E-library, Cochrane Library and PubMed databases. We analyzed titles and references in specialized journals and thematic reviews, respectively.

Modified posterior quadrant disconnection in surgical treatment of drug-resistant epilepsy in a patient with left temporal and occipital lobe malformation.

Unlabelled: Adults with large multilobar lesions of temporal, parietal and occipital lobes of the dominant hemisphere suffering from drug-resistant epilepsy were considered inoperable for a long time.

Objective: To demonstrate favorable postoperative outcome in a patient with massive periventricular heterotopia of the left temporal and occipital lobes complicated by drug-resistant epilepsy.

Material And Methods: We analyzed localization of the brain malformation (massive periventricular heterotopia) and its relationship with surrounding structures in a 38-year-old patient considering preoperative MRI, functional MRI and MR tractography data.

Surgical treatment of glial tumors of the paralimbic system.

Background: Tumors of the paralimbic system were considered inoperable for a long time due to high risk of postoperative complications. However, there have been significant changes in surgical tactics for these neoplasms over the past decades. Despite the improvement of surgical principles for these tumors and development of new approaches, risks of surgical treatment are still high (up to 33.

Skin microcirculation reactivity to local thermal hyperaemia in patients with COVID-19 - A pilot observational study.

Background: Endothelial dysfunction and microvascular disturbances are suggested to play a key role in higher morbidity and worse prognosis in patients with COVID-19 and cardiometabolic diseases.

Objective: Study was aimed to establish relationships between the skin microcirculation parameters and various clinical and laboratory indicators.

Methods: The study included 18 patients with moderate disease according to WHO criteria.

[Intraoperative ultrasound-assisted surgery of spinal tumors].

Objective: To improve technique of intraoperative ultrasound-assisted microsurgery of spinal tumors.

Material And Methods: There were 68 patients with 70 spinal tumors who underwent intraoperative ultrasound-assisted resection between 2007 and 2018. Age of patients varied from 21 to 80 (mean 48.

Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study.

Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in cardiac surgery patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 patients were included, 12 among them with the infectious complications.

[The economic prerequisites of implementation of innovative technologies of mass-spectrometry in diagnostic of bacterial infections].

The article presents the results of clinical economical analysis, based on "cost-effectiveness" technology, of MALDI-TOF MS, innovative medical technology of express identification of microorganisms, calculation of incremental indicator and application of notion "willingness-to-pay-threshold". Due to the extension of sanctions against the Russian Federation, this medical equipment for national laboratories becomes difficult to access and expensive, that conditions necessity to scientifically substantiate economical effectiveness of implementation of expensive innovative MALDI-TOF MS technology as instrument to contain global antibiotic resistance increase. The understanding of importance of express identification of microorganisms as well as other positive effects that can be achieved by using modern medical equipment on the basis of mass spectrometry results in improving medical care quality, increasing reputation level of medical institution, greater commitment of physicians and patients to microbiological analysis with purpose of prescription of rational antibiotic therapy and improving population health.

[Koblenz algorithm for open abdomen management].

The issue of laparostomy treatment is still controversial, since there are insufficient evidence-based data. German military surgeons have developed and implemented the «Koblenz algorithm» of laparostomy treatment into everyday practice. The algorithm was developed at the Bundeswehr Central Hospital in Koblenz (Germany).

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study.

Background: High serum levels of certain aromatic microbial metabolites (AMM) are associated with severity and mortality in critically ill patients. Omics-based studies suggest gut dysbiosis and reduced microbiome diversity in critical conditions. However, the landscape of gut microbial metabolites is still to be outlined, not to mention the interplay correlation between the metabolome and gut microbiome in critically ill patients.

[Combination of toxic multinodular goiter and primary hyperparathyroidism with rare ectopia of parathyroma].

A well-known feature of primary hyperparathyroidism (PHPT) is possible ectopic localization of parathyroid adenoma that can significantly complicate diagnostic process. Ectopia in the aortic window is extremely rare and accounts only 1% of ectopic parathyroid adenomas in the mediastinum and 0.24% among all parathyroid adenomas.

Pembrolizumab in Relapsed or Refractory Primary Mediastinal Large B-Cell Lymphoma.

Purpose: Patients with relapsed or refractory primary mediastinal large B-cell lymphoma (rrPMBCL) have a poor prognosis, and their treatment represents an urgent and unmet need. Because PMBCL is associated with genetic aberrations at 9p24 and overexpression of programmed cell death-1 (PD-1) ligands (PD-L1), it is hypothesized to be susceptible to PD-1 blockade.

Methods: In the phase IB KEYNOTE-013 (ClinicalTrials.

Risk factors and prognosis of voice disorders after surgical treatment of thyroid and parathyroid diseases.

Aim: To analyze risk factors and prognosis of voice disorders after surgical treatment of thyroid and parathyroid diseases.

Material And Methods: There were 1272 patients who were operated in the endocrine surgery department for the period from January 1, 2016 to April 30, 2017. We studied the incidence of VF paresis, VF paralysis, and persistent dysphonia as clinical outcomes.

[The possibility of applying historical concentration of thrombocytes in examination of donors.].

The historical concentration of thrombocytes is an average of three subsequent concentrations of thrombocytes before donation (during two years) in blood of donors. The evaluation was applied to characteristics of historical concentration of thrombocytes concerning concentration of thrombocytes in blood of 99 regular donors before every donation of apheresis thrombocytes. It is established that less than 20% dispersion between historical concentration of thrombocytes and value obtained in day of donation is observed in 96% of regular donors.