1,117 results match your criteria: "Pilomatrixoma"
Clinical and Histopathological Perspectives of Pilomatrixoma: A Case Report.
Indian J Otolaryngol Head Neck Surg
December 2024
Department of ENT and Head-Neck Surgery, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India.
Article Synopsis
- Pilomatrixoma is a rare, benign tumor from hair follicle cells, mostly seen in kids and young adults, exemplified by an 8-year-old boy with a growing neck lump over three months.* -
- A fine-needle aspiration showed characteristics of an adnexal tumor, leading to surgical removal, which confirmed the diagnosis of pilomatrixoma through histopathology.* -
- The case underscores the need for combined clinical and lab evaluation for accurate diagnosis and highlights successful surgery as key to preventing recurrence, providing valuable insights for pediatric care.*
Atypical and giant proliferating pilomatrixoma of the eyelid: a clinicopathological report.
BMC Ophthalmol
November 2024
Department of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background: Pilomatrixoma is an uncommon benign skin neoplasm originating from the hair follicle. Here, we report a rare case of giant and atypical proliferating pilomatrixoma affecting the eyelid.
Case Presentation: A 47-year-old male presented with a solitary, giant mass on his left upper eyelid, which had recently shown progressive enlargement.
High-grade Endometrial Carcinomas With Solid Basaloid Morphology and Geographic Necrosis Lacking Definitive Pilomatrix-like Features: Clinicopathologic Characteristics Including Aggressive Behavior and Novel Molecular Events.
Int J Gynecol Pathol
October 2024
Department of Pathology.
Article Synopsis
- High-grade endometrioid carcinomas can exhibit a solid basaloid morphology with geographic necrosis (SB-GN), which is a key characteristic of a new tumor type called pilomatrix-like high-grade endometrioid carcinoma (PiMHEC).
- A study screened 300 endometrial carcinomas for SB-GN, identifying four cases (1.3%) that demonstrated this pattern, all exhibiting aggressive behaviors despite some being mismatch repair (MMR) deficient.
- One SB-GN case met most diagnostic criteria for PiMHEC, revealing notable genetic mutations but lacking the typical shadow cells; molecular analyses indicated novel variants, suggesting SB-GN may indicate poor prognosis and potential treatment implications.
[A malignant pilomatrixoma in the tonsillar area of a dog].
Tierarztl Prax Ausg K Kleintiere Heimtiere
October 2024
Tierärztliche Klinik für Kleintiere Ettlingen, Ettlingen.
This case report discusses a 12-year-old West Highland White Terrier presented to the veterinary clinic with reverse sneezing and oral dysphagia. The endoscopic examination of the upper respiratory tract revealed a mass in the area of the right tonsil. Histologic examination confirmed the diagnosis of a malignant pilomatrixoma.
View Article and Find Full Text PDFClinical and epidemiological characteristics of pilomatricomas in a Mexican pediatric population.
Bol Med Hosp Infant Mex
October 2024
Pediatric Dermatology Service, General Hospital of Mexico Dr. Eduardo Liceaga, Ministry of Health. Mexico City, Mexico.
Article Synopsis
- Pilomatricoma is a benign skin tumor commonly found in children, but limited research exists on its epidemiology, often relying on basic statistics.
- A study conducted in Mexico City over six years involved 52 children with confirmed cases of pilomatricoma, revealing patterns such as pain linked to larger lesions and various risk factors, including age and lesion characteristics.
- The findings indicate that pilomatricomas vary in clinical presentation based on size, number, and location, with the head and neck being the most affected areas.
Retrosynthetic analysis via deep learning to improve pilomatricoma diagnoses.
Comput Biol Med
November 2024
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China; Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen, 518020, Guangdong, China; Department of Geriatrics, Shenzhen People's Hospital, (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. Electronic address:
Background: Pilomatricoma, a benign childhood skin tumor, presents diagnostic challenges due to its manifestation variations and requires surgical excision upon histological confirmation of its characteristic cellular features. Recent artificial intelligence (AI) advancements in pathology promise enhanced diagnostic accuracy and treatment approaches for this neoplasm.
Methods: We employed a multiscale transfer learning model, initiating the training process at high resolutions and adapting to broader scales.
Fine-needle Aspiration Biopsy of Pilomatrixoma (Cytological Features of Six Cases Histologically Approved).
J Cytol
July 2024
Department of Pathology, Prof. Dr. Cemil Tascioglu City Hospital, Cytopathology Division, İstanbul, Turkey.
Article Synopsis
- Pilomatrixoma is a rare, non-cancerous tumor linked to hair follicles, typically diagnosed through excisional biopsy, though fine-needle aspiration (FNA) is also used with limited reports on its cytological characteristics.
- This study analyzed six cases of pilomatrixoma, confirming diagnoses through cytological features such as various cell types and quantifying them on a scale to understand the tumor's characteristics.
- The findings highlight that although FNA can pose diagnostic challenges, indicators like ghost cells and basaloid cells can suggest pilomatrixoma, supported by other cellular features in cytology reports.
A Retrospective Study of the Clinicopathological Characteristics of Approximately 1,600 Pilomatricomas Treated at a Single Institution.
J Nippon Med Sch
September 2024
Department of Dermatology, Nippon Medical School.
Article Synopsis
- * The male-to-female ratio was 1:1.6, with the most common tumor location on the upper limbs, while preoperative diagnosis accuracy was only 48.5%, and many patients had delayed resections.
- * The study indicated that pilomatricoma is more prevalent in females and suggested that its characteristics, including pathological features and location, may differ based on ethnicity and other factors.
Article Synopsis
- * Accurate diagnosis relies on histopathological examination, which reveals specific cell characteristics and necessitates clinician awareness for timely intervention.
- * Treatment typically involves complete surgical excision, which effectively reduces the risk of recurrence and leads to favorable outcomes.
Pilomatrixoma of the Ankle: A Case Report.
Cureus
July 2024
College of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, RUS.
Article Synopsis
- Pilomatrixoma is a rare, benign skin tumor arising from hair follicle cells, often presenting as a firm, painless nodule predominantly on the head, neck, and upper extremities, but can occur in atypical spots like the ankle.* -
- A case study involved a 43-year-old female with a growing mass on her ankle, diagnosed through imaging and biopsy, confirming it as pilomatrixoma.* -
- Treatment typically involves surgical excision, which has low recurrence rates, and emphasizes the need for a thorough diagnostic process to identify this tumor, even when it appears in uncommon locations.*
Wnt/β-Catenin-Activated Nonpilomatrical Carcinoma of the Skin: A Case Series.
Mod Pathol
November 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; "Biologie des infections à polyomavirus" Team, UMR INRA ISP 1282, Université de Tours, Tours, France.
Article Synopsis
- The study investigates 16 primary cutaneous carcinomas with mutations in genes that activate the Wnt/β-catenin pathway, noting that these tumors lack matrical differentiation, which is typically associated with such mutations.
- The tumors predominantly affected elderly patients, with a median age of 80, and were mainly located on the head, neck, and upper limbs, leading to metastatic cases in some patients.
- Key findings include poor differentiation in tumor structure, distinct immunohistochemical profiles, and recurrent mutations in APC and CTNNB1, indicating that these tumors represent a unique group apart from other established skin tumor types.
Possible new defining presentation of mosaic tetrasomy 9p: multiple and recurrent pilomatrixoma.
Dermatol Online J
July 2024
Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Article Synopsis
- * Diagnosis involves karyotyping and chromosomal analysis, but there's a need for better recognition of cases with mild symptoms.
- * The article presents a unique adult case of mosaic tetrasomy 9p in a patient with multiple pilomatrixomas, suggesting this condition could be a new hallmark of the syndrome.
Pilomatrixoma of the Periorbital Region: A Retrospective Review.
Ophthalmic Plast Reconstr Surg
July 2024
Department of Ophthalmology, The Children's Hospital at Westmead.
Article Synopsis
- Pilomatrixoma is a benign tumor that can occur around the eyes but is often misdiagnosed; it's mostly found in the upper eyelid and eyebrow area.
- A study from 2010 to 2023 reviewed 77 cases, revealing a slight female predominance and most cases occurring in young people, with no malignant transformation noted.
- Complete surgical removal is usually effective, and while two recurrences were reported, they're rare, highlighting the importance for doctors to recognize this condition in younger patients.
Dermotoscope assisted diagnosis of adolescent bullous pilomatricoma: six case reports.
BMC Pediatr
July 2024
Department of Dermatology, Laishan Branch of Yantai Yuhuangding Hospital, Shuanghexi Road 59, Yantai, Shandong, China.
Article Synopsis
- Pilomatricoma (PM) is a benign skin tumor that originates from the hair matrix, typically appearing as a hard nodule on normal skin, making early detection difficult.
- A study analyzed six cases of bullous PM in primarily adolescent Chinese patients, noting a higher prevalence in females and a correlation between lesion location and vaccination sites.
- The findings highlight the distinct dermatoscopic features and histological characteristics of bullous PM, suggesting that dermatoscopy can serve as a quick and effective diagnostic tool.
Case report: Pilomatrix carcinoma with PDL1 expression and aberrant.
Front Immunol
June 2024
The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
Article Synopsis
- A 55-year-old male presented with a mass in the left inguinal area and swelling in the left leg, initially due to unrelieved pain; MRI results indicated significant damage and abnormal tissue signals related to a suspected tumor.
- A biopsy confirmed the mass to be a malignant pilomatrix carcinoma, with evidence of bone metastasis and a significant genetic mutation found through next-generation sequencing.
- The patient underwent chemotherapy with gemcitabine and nedaplatin, but the cancer progressed, suggesting that alternative treatments like PDL1 antibodies and CDK4/6 inhibitors could be more effective.
Giant perforating pilomatricoma with osseous metaplasia.
An Bras Dermatol
August 2024
Department of Surgical Pathology, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
Pilomatrixomas: 31 years of experience in population under and over 18 years of age.
Bol Med Hosp Infant Mex
May 2024
Departamento de Dermatopatología. Hospital General Dr. Manuel Gea González, Ciudad de México, México.
Article Synopsis
- Pilomatrixoma, a benign skin tumor linked to hair follicle development, is most common in children and adolescents, with a slight female predominance.
- A retrospective study at Dr. Manuel Gea González General Hospital analyzed 200 cases, revealing that the tumors primarily affected females with an average age of 22.98 years, most often located on the head.
- The study offers detailed demographic and clinical insights about pilomatrixomas, enhancing understanding and serving as a reference for future research and clinical applications.
Pilomatricoma Located at the Identical Position in the Right Upper Limb of the Twins: A Rare Case Report.
Clin Cosmet Investig Dermatol
May 2024
Department of Dermatology, The Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.
Article Synopsis
- A rare case study reports the presence of pilomatricoma in monozygotic twins, specifically in the same spot on their right upper arms.
- Both seven-year-old twins had a painless, irregular nodule that was excised surgically and diagnosed as pilomatricoma through histopathological examination.
- The twins showed no recurrence of the condition during a three-year follow-up, highlighting the potential influence of genetic factors in this rare skin condition.
Pilomatricomas: Benign lesions mimicking malignant tumors in older people.
Rev Esp Geriatr Gerontol
July 2024
Department of Dermatology, University Hospital Ntra. Señora de Valme, Sevilla, Spain.
Metastatic pilomatrix carcinoma treated with stereotactic body radiation therapy.
JAAD Case Rep
May 2024
Department of Radiation oncology, UC Irvine Medical Center, Orange, California.
Pathological, histochemical, and immune-histochemical studies on some canine-skin neoplasm at Sharkia province, Egypt.
Open Vet J
January 2024
Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Article Synopsis
- The study investigates skin tumors in dogs, focusing on their clinical, pathological, and immunohistochemical characteristics, conducted at Zagazig University's veterinary clinic from March 2022 to October 2023.
- A total of 25 dogs with skin swelling were analyzed, revealing that 65.52% of the tumors were malignant, with malignant melanomas being the most common at 17.24%.
- The research highlights the prevalence of various skin neoplasias in dogs, identifying multiple types of tumors while noting that benign tumors were less frequent.
Clinical and Pathological Features of Pilomatrixoma in Children: A Retrospective Study.
Dermatology
August 2024
Department of Dermatology and Venereology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Article Synopsis
- Pilomatrixoma is a benign skin tumor commonly seen in children, often leading to misdiagnosis, and this study examined its clinical and pathological features in 171 pediatric patients.
- The average age of patients was 5.7 years, with the majority of tumors found on the head and neck, and a notable percentage had small tumor volumes (≤1.0 cm3).
- Findings revealed low diagnostic accuracy rates for clinical and ultrasound evaluations (around 50% and 39% respectively), highlighting the need for better identification methods for this condition.
Post-traumatic Bullous Pilomatrixoma Exploring the Pathogenesis.
Am J Dermatopathol
July 2024
Mexican Institute of Social Security, Medical Benefits, Campeche, Mexico .
Article Synopsis
- The report discusses a unique case of bullous pilomatrixoma in a 10-year-old boy who developed a significant red nodule on his neck after suffering trauma.
- The nodule appeared rapidly and had a bullous (fluid-filled) characteristic, distinguishing it from typical pilomatrixoma cases.
- While the cause of this variant is not fully understood, prior research indicates that physical trauma might play a role in its onset.
A case of AA amyloidosis complicated by proliferating pilomatricoma and a review of the literature.
J Dermatol
October 2024
Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Japan.
Article Synopsis
- AA amyloidosis is typically linked to inflammatory diseases, but this case highlights a connection with solid tumors, specifically pilomatricoma.
- A 48-year-old man exhibited gastrointestinal AA amyloidosis alongside a giant, ulcerated tumor on his arm, leading to significant weight loss and diarrhea.
- After the tumor was surgically removed, the gastrointestinal symptoms resolved, demonstrating that excising the tumor may reduce systemic amyloidosis symptoms.