193 results match your criteria: "Picardie University Hospital[Affiliation]"

The frontal sharp transient (FST) consists of transient electrical activity recorded around the transitional period from the in to ex utero environment. Although its positive predictive value is assumed, nothing is known about its functionality or origin. The objectives were (i) to define its characteristics and (ii) to develop functional hypothesis.

View Article and Find Full Text PDF

Background: Liberating patients from mechanical ventilation (MV) requires a systematic approach. In the context of a clinical trial, we developed a simple algorithm to identify patients who tolerate assisted ventilation but still require ongoing MV to be randomized. We report on the use of this algorithm to screen potential trial participants for enrollment and subsequent randomization in the Proportional Assist Ventilation for Minimizing the Duration of MV (PROMIZING) study.

View Article and Find Full Text PDF

Aim: To determine the prognostic value of conventional electroencephalography (EEG) monitoring in neonatal hypoxic-ischemic encephalopathy (HIE).

Method: In this multicentre retrospective study, 95 full-term neonates (mean of 39.3wks gestational age [SD  1.

View Article and Find Full Text PDF

Background And Objective: The concern surrounding the association between Guillain-Barré syndrome (GBS) and vaccination has increased with the widespread use of COVID-19 vaccines. The aim of this study was to assess the potential association of GBS with mRNA-based or adenovirus-vectored COVID-19 vaccines.

Methods: Reports of GBS associated with mRNA-based or adenovirus-vectored COVID-19 vaccines were extracted from the WHO pharmacovigilance database, exposure data from the Our World in Data website, and the background rates of GBS from published data.

View Article and Find Full Text PDF

Assessment of Factors Associated with Morbidity and Textbook Outcomes of Laparoscopic Liver Resection in Obese Patients: A French Nationwide Study.

J Am Coll Surg

August 2022

From the Sorbonne Université, Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, AP-HP Pitie-Salpetriere Hospital, Paris, France (Genser, Lim, Goumard, Scatton).

Article Synopsis
  • Liver surgeons need to understand the outcomes of laparoscopic liver resection (LLR) specifically in obese patients, as this study focuses on comparing their results with non-obese patients.
  • The study analyzed data from over 3,000 patients, showing that while the rates of mortality were similar between obese and non-obese patients, the obese group faced higher overall morbidity and longer hospital stays but similar severe morbidity rates.
  • Although obesity did not increase the risk of severe complications, it was linked to a lower rate of achieving "textbook outcomes," indicating that while LLR is safe for obese patients, their recovery may present additional challenges.
View Article and Find Full Text PDF

Background: The literature data on the outcomes of radiofrequency catheter ablation for atrial fibrillation (AF) in women are contradictory.

Aim: To determine and compare the outcomes and complications of cryoballoon pulmonary vein isolation (cryo-PVI) in men vs. women, and to identify predictors of atrial tachyarrhythmia (ATa) recurrence.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to analyze the fatal effects of COVID-19 by examining the histopathological features in both ICU and non-ICU patients who died from the disease.
  • A total of 20 patients underwent multiorgan biopsies, revealing significant pulmonary damage, with various levels of alveolar damage and differing rates of acute and chronic lesions between ICU and non-ICU groups.
  • Findings also included the presence of viral RNA and associated viral replication markers in lung and kidney tissues, highlighting more severe lung and extrapulmonary injury in ICU patients compared to non-ICU patients.
View Article and Find Full Text PDF

Background: Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are rare, aggressive cutaneous T-cell lymphomas that may be difficult to treat. Mogamulizumab is a recent monoclonal antibody targeting the CCR4 receptor expressed on the surface of Sézary cells. It can be prescribed in MF/SS stages III to IV in the second line after systemic therapy or in stages IB-II after two unsuccessful systemic therapies.

View Article and Find Full Text PDF

Objective: In mitral insufficiency, trans-esophageal echocardiography (TEE) analysis of the mitral valve is an indispensable and irreplaceable examination to establish precisely the type of surgical repair to be performed and the exact length of neo-chordae to be used for an anatomical repair. The aim of our study is to find a predictive model of the Echographic Measurement (EM) variable according to the Manual Measurement (MM) variable of the mitral valve chordae, when the echocardiography measurement is not feasible.

Patients And Methods: This is a retrospective study on 191 patients undergoing mitral valve repair.

View Article and Find Full Text PDF

Transperineal ultrasound in routine uterine cervix measurement.

Arch Gynecol Obstet

February 2023

Obstetrics and Gynecology Department, CHU Amiens Picardie, Amiens-Picardie University Hospital, 1 rond-point du Pr Christian Cabrol, 80054, Amiens cedex 1, France.

Purpose: Transvaginal ultrasound (TVUS) is used in routine practice to evaluate cervical length (CL). This technique is nevertheless invasive and often viewed as uncomfortable, which is less the case with transperineal ultrasound (TPUS). This study was conducted in light of recent technological improvements in the ultrasound field to evaluate whether TPUS could be used as an alternative to TVUS in CL assessment.

View Article and Find Full Text PDF

Background: The optimal management of hypotensive patients during norepinephrine weaning is unclear. The primary study aim was to assess the ability of preload dependence to predict hypotension following norepinephrine weaning. The secondary aims were to describe the effect of norepinephrine weaning on preload dependence, and the cardiovascular effects of fluid expansion in hypotensive patients following norepinephrine weaning.

View Article and Find Full Text PDF

Background: Overall and respiratory management of preterm children are constantly evolving, which might have changed both the pathophysiology and neurodevelopmental consequences of bronchopulmonary dysplasia (BPD).

Objectives: The objective of this study is to determine whether the previously shown association between BPD and risk of developmental delay persists.

Methods: The study population was children born before 32 weeks' gestation from the French prospective cohort EPIPAGE-2.

View Article and Find Full Text PDF

Background: Network meta-analyses (NMAs) have become successful in addressing gaps in the comparative effectiveness of systemic treatments in moderate-to-severe psoriasis. However, their increasing number carries both a risk of overlap and reproducibility issues that can hamper clinical decision-making.

Objectives: In this overview, we aimed to assess redundancy across these NMAs and to describe their characteristics.

View Article and Find Full Text PDF

The neonatal transition involves physiological modifications as a consequence of the complexity of the perinatal period. Various strategies can be used to attain the same level of postnatal cerebral oxygenation, depending on the status of the infant at birth. We evaluated such strategies by recording 20 full-term newborns by near-infrared spectroscopy during the first 10 min of life.

View Article and Find Full Text PDF

Background: Electronic health records (EHRs, such as those created by an anesthesia management system) generate a large amount of data that can notably be reused for clinical audits and scientific research. The sharing of these data and tools is generally affected by the lack of system interoperability. To overcome these issues, Observational Health Data Sciences and Informatics (OHDSI) developed the Observational Medical Outcomes Partnership (OMOP) common data model (CDM) to standardize EHR data and promote large-scale observational and longitudinal research.

View Article and Find Full Text PDF

Background: The prescription of ceftriaxone should be limited to patients with biliary tract infections and those lacking intravenous access. A specific training session for prescribers about the clinical relevance and economic value of prescribing cefotaxime instead of ceftriaxone might decrease the use of the latter in geriatric medicine.

Objectives: To determine the clinical and economic impact of a training session for prescribers on the subsequent prescription of third-generation cephalosporin, that is, the percentage of appropriate prescriptions and the cost of third-generation cephalosporin administration before and after the training session.

View Article and Find Full Text PDF

Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients.

View Article and Find Full Text PDF

Diagnostic Value of F-Fluorodeoxyglucose Positron Emission Tomography Computed Tomography in Prosthetic Pulmonary Valve Infective Endocarditis.

JACC Cardiovasc Imaging

February 2022

Bordeaux University Hospital (CHU), Department of Pediatric and Adult Congenital Cardiology, Pessac, France; IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, Pessac-Bordeaux, France; INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, Bordeaux, France.

Article Synopsis
  • The study aimed to evaluate how effective F-FDG PET/CT is in diagnosing pulmonary prosthetic valve or conduit endocarditis (PPVE) in patients with congenital heart disease (CHD).
  • It was conducted as a retrospective multicenter analysis involving 66 cases of suspected PPVE across 8 French medical centers, finding that the imaging technique has decent sensitivity and specificity.
  • The results indicate that F-FDG PET/CT can significantly enhance diagnosis accuracy, helping reclassify cases and potentially improve treatment timing and patient outcomes.
View Article and Find Full Text PDF

Peripheral artery disease (PAD) is a common cause of morbidity and mortality; however, data on its etiology and evolution in patients under 50 years old are scarce. Therefore, we performed a retrospective analysis of data from medical records, including cardiovascular risk factors, etiology, medical and surgical treatment, and follow-up. We included all patients with PAD aged between 18 and 50 years attending our university hospital between 2005 and 2015.

View Article and Find Full Text PDF
Article Synopsis
  • Cryoballoon pulmonary vein isolation (PVI) is gaining popularity for treating persistent atrial fibrillation (AF), and this study analyzed its effectiveness and recurrence rates after the procedure.
  • Out of 399 patients treated, 90% completed a 12-month follow-up, revealing a 2-year freedom from arrhythmia at 51% for persistent AF and 27% for long-standing persistent AF.
  • Key predictors for recurrence included long-standing persistent AF and the size of the left atrial area/volume, with complications being rare (only a few cases of serious side effects).
View Article and Find Full Text PDF

Objective: The aim of this study was to build a predictive model of operative difficulty in open liver resections (LRs).

Summary Background Data: Recent attempts at classifying open-LR have been focused on postoperative outcomes and were based on predefined anatomical schemes without taking into account other anatomical/technical factors.

Methods: Four intraoperative variables were perceived by the authors as to reflect operative difficulty: operation and transection times, blood loss, and number of Pringle maneuvers.

View Article and Find Full Text PDF

Leprosy is currently uncommon in Europe: the diagnosed cases are almost all imported from endemic areas. We report on an autochthonous case of borderline lepromatous leprosy in a 71-year-old Portuguese woman. The case was complicated by a reversal reaction and then by erythema nodosum leprosum.

View Article and Find Full Text PDF

Background: Few studies addressing the safety and efficacy of biological therapy (BT) or apremilast (APR) in patients with psoriasis with a history of hematologic malignancy (HM) exist.

Aim: To describe the tolerance and efficacy of BT and APR in moderate-to-severe psoriasis in patients with a history of in-remission or evolving HM.

Methodology: A retrospective, multicenter chart review of the tolerance and efficacy of BT or APR in patients with moderate-to-severe psoriasis and a clinical history of in-remission or evolving HM.

View Article and Find Full Text PDF