Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks.

Introduction: Chinese herbal medicines are relatively inexpensive and have fewer side effects, making them an effective option for improving health and treating diseases. As a result, they have gained more attention in recent years. The weaning period is a critical stage in the life of yaks, often inducing stress in calves.

Challenges in Rehabilitation of a Tetanus Patient With Severe Complications.

Tetanus is a rare but life-threatening neurological disorder caused by neurotoxins produced by . Although mortality rates have significantly decreased with modern intensive care, severe cases remain challenging due to prolonged Intensive Care Unit (ICU) stays, complications, and rehabilitation barriers. We report the case of an 81-year-old male with a history of hypertension and femoral neck fracture who developed severe tetanus following a contaminated forehead laceration.

Report of a Rare Case of Acute Abdominal Pain Post-partum: Spontaneous Ureteral Rupture.

Spontaneous ureteral rupture is a rare cause of acute abdominal pain, particularly unusual during pregnancy or the post-partum period. While pregnancy-related changes like ureteral compression and dilation may play a role, no definitive mechanisms have been established. Clinicians should suspect ureteric injury in post-partum patients with free pelvic fluid.

CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials.

The CompSafeNano project, a Research and Innovation Staff Exchange (RISE) project funded under the European Union's Horizon 2020 program, aims to advance the safety and innovation potential of nanomaterials (NMs) by integrating cutting-edge nanoinformatics, computational modelling, and predictive toxicology to enable design of safer NMs at the earliest stage of materials development. The project leverages Safe-by-Design (SbD) principles to ensure the development of inherently safer NMs, enhancing both regulatory compliance and international collaboration. By building on established nanoinformatics frameworks, such as those developed in the H2020-funded projects NanoSolveIT and NanoCommons, CompSafeNano addresses critical challenges in nanosafety through development and integration of innovative methodologies, including advanced models, approaches including machine learning (ML) and artificial intelligence (AI)-driven predictive models and 1st-principles computational modelling of NMs properties, interactions and effects on living systems.

Peculiarities of cardio-respiratory relationships in qualified athletes with different types of heart rhythm regulation according to respiratory maneuver data.

Introduction: Our goal was to determine the differences in changes in cardiovascular and cardiorespiratory interaction indicators during a respiratory maneuver with a change in breathing rate in athletes with different types of heart rate regulation.

Methods: The results of a study of 183 healthy men aged 21.2 ± 2.

Community-based model for management and follow-up by non-physician healthcare workers to improve awareness, treatment, and control of hypertension: The COTRACO study protocol.

Introduction: Cardiovascular diseases are the leading cause of death and morbidity worldwide, with a significantly higher burden in low- and middle-income countries. Hypertension, a major risk factor for cardiovascular morbidity and mortality, remains under-diagnosed and poorly controlled, especially in regions such as Latin America. The HOPE-4 study demonstrated that the involvement of non-physician health workers (NPHWs), the use of standardized treatment algorithms, the provision of free antihypertensive drugs and home follow-up can significantly improve hypertension control and reduce cardiovascular risk, as demonstrated in Colombia and Malaysia.

Cockroaches as Reservoirs, Vectors, and Potential Sentinels of Multidrug-Resistant Bacteria in Ugandan Communities: A Retrospective Analysis.

Cockroaches could play a role in the transmission dynamics of antimicrobial-resistant bacteria (ARB) at variable interfaces in Ugandan communities, acting as both reservoirs and vectors. This study investigated the burden and diversity of ARB carried by cockroaches in human settlements in Uganda, so as to understand their role in the spread of these pathogens and their potential as sentinels in antimicrobial resistance (AMR) surveillance programs. A retrospective analysis was conducted on two unpublished studies by Makerere University students.

Physical symptoms distress and demoralization among haemodialysis patients; the mediating effect of spirituality and self-compassion. A cross-sectional questionnaire survey.

Background: Long-term haemodialysis patients often experience physical symptom distress (PSD) and varying levels of demoralization. Spirituality and self-compassion can help patients to cope these challenges. However, the interrelations between these variables remain underexplored, necessitating further investigation.

Development of a Complex Intervention for Promoting Participation in Resistance Exercise Among Community-Dwelling Frail Older Adults in China: A Multimethod Qualitative Study.

Background And Objectives: Regular resistance exercise (RE) showed a promising effect in reducing frailty in older adults. However, the participation of RE among this population remains low. This study was, therefore, aimed at developing a complex intervention tailored to community-dwelling frail older adults in China to promote participation in RE and reduce frailty ultimately.

β-Caryophyllene and Statins in Bone Fracture Healing - A Narrative Review.

Bone fractures are a leading cause of morbidity and healthcare expenditure globally. The complex healing process involves inflammation, cartilage formation, mineralization, and bone remodeling. Current treatments like immobilization, surgery, and bone grafting, though effective, pose significant challenges, such as prolonged recovery and high costs.

Utility of a Wearable Tracker to Assess Sleep Quality in Nurses and Their Spouses: A Prospective Cohort Study.

Introduction: Sleep disturbances among nurses engaged in night duty and their spouses need to be improved to ensure their ability to provide care and perform daily tasks. Therefore, an objective investigation is needed to establish a sleep improvement strategy.

Objective: To investigate the utility of a sleep tracker to assess sleep quality in nurses and spouses.

Fecal methylated syndecan-2 () testing for early screening of colorectal cancerous and precancerous lesions: A real-world retrospective study in China.

Background: Colorectal cancer (CRC) is a major public health concern and the second leading cause of cancer-related deaths worldwide. However, challenges remain in deploying effective screening strategies for early-stage CRC. This study aimed to evaluate the effectiveness of a fecal-based syndecan-2 () methylation test for the detection of colorectal lesions and CRC.

Online patients questions regarding reverse total shoulder arthroplasty pertain to timeline of recovery, specific activities, and limitations.

Background: Reverse total shoulder arthroplasty (rTSA) demonstrates favorable long-term data and has outpaced anatomic total shoulder arthroplasty and hemiarthroplasty as the most-performed shoulder arthroplasty procedure. As indications and outcomes continue to favor rTSA, patients may turn to the internet as an efficient modality to answer various questions or concerns. This study investigates online patient questions pertaining to rTSA and the quality of the websites providing information.

Silent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth?

Background: It has been claimed that tacrolimus may have harmful effects on the auditory system, where it has been linked to ototoxicity and sensorineural hearing loss (SNHL). We evaluated silent SNHL in kidney transplant recipients (KTRs) receiving tacrolimus and the different factors affecting it compared to healthy controls.

Materials And Methods: In this case control study, hearing functions were studied in 42 KTRs receiving tacrolimus as maintenance immunosuppressive therapy for more than 3 months in comparison to 27 age- and gender-matched healthy subjects using tympanometry, pure-tone audiometry (PTA), extended high frequency audiometry (EHFA), and transient evoked oto-acoustic emissions (TEOAEs).

Middle-aged man with primary hyperparathyroidism-associated psychosis: A case report.

Background: Primary hyperparathyroidism (PHPT) with mild hypercalcemia (Ca <12 mg/dL) often remains asymptomatic. However, PHPT may induce various psychiatric symptoms, including depression, cognitive dysfunction, and infrequently, psychotic symptoms, predominantly in older adults rather than in middle-aged or younger individuals.

Case‐presentation: A 48-year-old man, with no history of physical or mental illness, experienced delusions about a suspicious car in his neighborhood, believing it was linked to criminal activity.

An unusual case of deep vein thrombosis of the upper extremity following breast reduction.

Breast reduction surgery is a commonly performed procedure relieving physical discomfort and improving quality of life for individuals with macromastia. Despite its benefits, there are inherent risks associated with surgical intervention, one of which is the development of deep vein thrombosis (DVT). This relatively rare complication can lead to significant morbidity and mortality if not recognized and managed properly.

Sports and exercise medicine: Beyond injury management.

There is a limited awareness about the role of Sports and Exercise Medicine (SEM) among medical as well as nonmedical fraternity beyond just management of sports injuries. SEM professionals play a significant role in healthy general population and illness by designing and implementing specific primordial, primary and secondary preventive activities against the lifestyle disorders through exercise. In amateur and professional sports, they provide scientifically sound advice to enhance performance and prevent injuries through pre- and rehabilitative techniques.

Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007-2020 and Mendelian randomization analysis.

Introduction: Osteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. This study investigates the correlation and potential causality between SB, PA, and OA using both cross-sectional and Mendelian randomization (MR) analysis.

Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review.

Purpose: Social determinants of health have been related with kidney diseases and their outcomes. Financial toxicity (FT) refers to the negative impact of health care costs on clinical conditions. This scoping review aimed to evaluate the literature linking FT with renal diseases.

Relationship between fluid intake, hydration status and cortisol dynamics in healthy, young adult males.

Background: Previous studies have identified links between fluid intake, hydration related hormones and cortisol measured at one timepoint but have not considered how hydration may influence cortisol dynamics throughout the day. This study assessed associations between hydration status (copeptin, urinary osmolality, urine volume) and habitual fluid intake with cortisol dynamics.

Methods: The day before (DB) a 6-h laboratory visit, 29 male participants (age, 23±4y; BMI, 25.

Strengths of pelvic floor muscles in women with multiple sclerosis and its relationship with urinary incontinence and quality of life.

Background: Multiple sclerosis (MS) is a debilitating autoimmune disease that mostly affects women.

Objectives: In this study we evaluated the relationship of pelvic muscle strengths with urinary incontinence and quality of life in women with MS.

Materials And Methods: In this cross-sectional study 87 women with MS were recruited.

A cross-sectional study exploring the perception of exercise oncology in the Italian population.

Introduction: We aim to examine the population's perception of physical exercise in patients with cancer.

Materials And Methods: An anonymous survey was conducted to reach a sample of Italian adults. The questionnaire investigated sociodemographic factors, physical exercise levels, and perceptions about the importance, benefits, and safety of exercise, the support from oncologists and family/friends, as well as the capability and ease of patients of exercise.

Systematic review of musculoskeletal ultrasound learning methodologies.

Introduction/purpose: As the frequency and morbidity of musculoskeletal (MSK) disorders increase, the use of MSK ultrasound has become an important diagnostic and procedural tool. This has amplified the importance of quality MSK ultrasound training for medical professionals. This systematic review evaluated and compared peer-reviewed journal articles on learning methodologies for MSK ultrasound training.

Efficacy and safety of acupuncture monotherapy or combined with pelvic floor muscle training for female stress urinary incontinence: a systematic review and meta-analysis.

Background: Stress urinary incontinence (SUI) is involuntary urine leakage during effort. Pelvic floor muscle training (PFMT) is a common physical therapy for SUI, but has low adherence and its long-term effectiveness is uncertain. Drug therapy has side-effect problems and surgery has risks.

Chronic Lymphocytic Leukemia: 2025 Update on the Epidemiology, Pathogenesis, Diagnosis, and Therapy.

Disease Overview: Chronic lymphocytic leukemia (CLL) is the most frequent type of leukemia. It typically occurs in older patients and has a highly variable clinical course. Leukemic transformation is initiated by specific genomic alterations that interfere with the regulation of proliferation and apoptosis in clonal B-cells.