Consensus recommendations for managing osteoarthritic pain with topical NSAIDs in Asia-Pacific.

Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain.

Monoclonal antibodies for chronic pain: a practical review of mechanisms and clinical applications.

Context: Monoclonal antibodies are being investigated for chronic pain to overcome the shortcomings of current treatment options.

Objective: To provide a practical overview of monoclonal antibodies in clinical development for use in chronic pain conditions, with a focus on mechanisms of action and relevance to specific classes.

Methods: Qualitative review using a systematic strategy to search for randomized controlled trials, systematic and nonsystematic (narrative) reviews, observational studies, nonclinical studies, and case reports for inclusion.

Predictive factors and clinical biomarkers for treatment in patients with chronic pain caused by osteoarthritis with a central sensitisation component.

Aims: The aim of this non-systematic review was to provide a practical guide for clinicians on the evidence for central sensitisation in chronic osteoarthritis (OA) pain and how this pain mechanism can be addressed in terms of clinical diagnosis, investigation and treatment.

Methods: The authors undertook a non-systematic review of the literature including a MEDLINE search (search terms included central sensitisation, osteoarthritis, osteoarthrosis) for relevant and current clinical studies, systematic reviews and narrative reviews. Case reports, letters to the editor and similar literature sources were excluded.

Result of percutaneous disc decompression using nucleoplasty in Thailand: a randomized controlled trial.

Background: Chronic low back pain is a major social, economic and healthcare issue in the Thailand. Percutaneous techniques are rapidly replacing traditional open surgery in operations requiring discectomy, decompression and fusion. The percutaneous access to the disc was first used in the 1950s to biopsy the disc with needles.

Insall-Salvati ratio after arthroscopic anterior cruciate ligament reconstruction with patellar tendon graft.

Background: Arthroscopic anterior cruciate ligament (ACL) reconstruction with patellar tendon graft has been considered to be the gold standard treatment of anterior cruciate ligament injuries. Much morbidity could occur after this graft was harvested, such as the patellar tendon length change and anterior knee pain. Insall-Salvati ratio is one of the tools to determine the patella tendon length.

The study of anterior cruciate ligament footprint in Thai population: a human cadaveric study.

Background: Identification of the anterior cruciate ligament (ACL) footprint is critical for an anatomical ACL reconstruction. The osseous landmarks of the ACL footprint is one of the methods that can be used to determine the ACL insertion site. The size of ACL footprint on femur and tibia are also important for surgical decision.

Efficacy of portable vacuum dressing in chronic wound care: a prospective randomized control trial.

Background: Chronic wound is a common clinical condition and often cause treatment problems. This is because chronic wound usually require extended treatment period, which result in high hospital cost. The treatment of chronic wound depends on the type of wound, the cause of wound, and the physical status of patient.

Recurrent skull metastasis of hepatocellular carcinoma at 2 month post operation.

Several cases with skull metastases hepatocellular carcinoma have so far been reported in the English literature. However, recurrent skull metastasis hepatocellular carcinoma at 2 month post operation after craniectomy and total tumor removal has never been published. We reported a 57-year-old Thai female presented with a recurrent enlarging painless left parieto-occipital skull mass after 2 month post operation which confirmed by Cranial computerized tomography (CT).

Combination of alfacalcidol with calcium can improve quadriceps muscle strength in elderly ambulatory Thai women who have hypovitaminosis D: a randomized controlled trial.

Objective: The purpose of this study was to evaluate the efficacy of alfacalcidol and calcium on the improvement of muscle strength in ambulatory elderly Thai women in age group of 65 or more who have hypovitaminosis D.

Material And Method: Seventy-two postmenopausal women age 65 years or more were enrolled to this study. Blood was collected from all participants for measured of 25(OH)D3, intact PTH and vitamin D receptor (VDR) genotypes.

Exertional heatstroke: early recognition and outcome with aggressive combined cooling--a 12-year experience.

Objective: To determine the clinical outcomes of an aggressive combined cooling technique for exertional heatstroke in Thailand.

Methods: We analyzed patients who were diagnosed with exertional heatstroke between 1995 and 2007. Outcomes were assessed both in hospital and at 3 months follow-up.