Evaluation of lateral flow devices for rabies diagnosis in decomposed animal brain samples.

Background: The Direct Fluorescent Antibody Test (DFAT), the standard rabies confirmatory test, is less sensitive when used with decomposed brain samples, a frequent issue in rabies-endemic regions. This study evaluates the diagnostic accuracy of the ADTEC lateral flow device (LFD) for rabies post-mortem diagnosis using decomposed brain samples.

Methods: We used 34 animal heads submitted with a cold chain to an animal diagnostic laboratory located in central Philippines including 26 DFAT-positive and eight DFAT-negative samples.

Nursing students' personality traits, sleep quality, social media addiction, and academic performance: A multi-site structural equation model analysis.

Background: The associations between personality traits, sleep quality, social media addiction, and academic performance have been well-reported across the literature among university students. However, the interaction among these variables remains understudied among nursing students of underdeveloped countries like the Philippines.

Purpose: This study investigated the interrelationships of personality traits, sleep quality, social media addiction, and academic performance among Filipino nursing students.

Priests aging well: The role of gerotranscendence and its relationships with perceived health status, and life satisfaction among Catholic priests.

Aging in the priesthood presents unique challenges in America. Due to the declining number of priests serving the growing U.S.

Report of the Ninth Asian National Control Laboratory Network meeting in 2024, with a focus on regional harmonization of regulatory systems to prepare for cross-border transfer of plasma.

The National Institute of Food and Drug Safety Evaluation, under the Ministry of Food and Drug Safety in Korea, organized and hosted the 2024 Asian National Control Laboratory (NCL) Network meeting which focussed on regional harmonization of regulatory systems to prepare for cross-border transfer of plasma. The meeting brought together representatives from seven World Health Organization (WHO) member states, along with experts from the WHO, the WHO Regional Office for the Western Pacific, and Thailand Institute of Biological Products, for special lectures. Key topics included considerations for cross-border plasma transfers for fractionation, ensuring the safety of blood and blood products in the Western Pacific region, and the current status of local plasma-derived medicinal products (PDMPs) production in Thailand.

Burden of prolonged treatment delay among patients with common cancers in the Philippines.

Purpose: Prolonged treatment delay often leads to adverse cancer prognosis. However, the demographic and clinical predictors of higher treatment delay burden in the Philippines have not been thoroughly evaluated.

Methods: We conducted a population-based retrospective cohort study on patients diagnosed with common cancers who received cancer treatment, to quantify the burden of prolonged treatment delay in the Philippines among this population.

Clinical Outcomes of Rituximab Infusion Among Refractory Myasthenia Gravis Patients in the Philippines: A 10-Year Retrospective Study.

Background: Myasthenia gravis (MG) is an autoimmune disorder causing muscle weakness, with 10%-20% of cases becoming refractory to standard treatments. Rituximab, a CD20-targeting monoclonal antibody, has shown promise in refractory MG but lacks data from low- and middle-income countries (LMICs), such as the Philippines.

Methods: A retrospective, cross-sectional study was conducted in treatment-refractory MG patients in St.

Recognizing familial Huntington's disease in an Asian cohort: Insights from the Philippines.

Huntington's Disease (HD) is an autosomal-dominant, neurodegenerative condition characterized by extrapyramidal, psychiatric, and cognitive disturbances. In the Philippines, only one genetically confirmed sporadic case had been previously reported. This study aims to present ten additional cases of genetically proven familial HD.

Macroergonomic factors, coping style, and satisfaction analysis for nursing career pursuance: A perspective from the Philippines.

Nurse turnover is a continuous problem in the Philippines, a social phenomenon evident in due to change in career and nurse migration. The purpose of this study was to comprehensively assess the willingness of Filipino nurses to pursue nursing careers using an extended and modified macroergonomic factor framework. This study collected 314 valid responses from nurses in the Philippines.

Comparative Single-Cell Analysis Reveals Tendon Progenitor Dysfunction by Age-Associated Oxidative Stress and Its Restoration by Antioxidant Treatments.

Impaired healing of adult tendons with fibrosis remains clinical challenges while neonatal tendons have full functional restoration. However, age-associated cellular and molecular changes in tendon cells and tendon stem/progenitor cells (TSPCs) remain unknown. Here, comparative single cell transcriptomics of early postnatal (2 weeks old) and adult (20 weeks old) mouse tendons revealed that adult tendons have reduced number of TSPCs, decreased gene expression in tendon and cartilage development, and a greater population of fibro-tenogenic cells.

Reduction of enteric methane emission using methanotroph-based probiotics in Hanwoo steers.

Background: Methane emission from enteric rumen fermentation is a main source of greenhouse gas (GHG) emission and a major concern for global warming.

Results: In this study, we isolated methanotroph-methylotroph consortium NC52PC from the rumen after a series of sub-culture and repetitive streaking on an agar plate and polycarbonate membrane filter. The NC52PC comprises methanotroph species (Methylocystis sp.

Associations between socio-demographics, sexual knowledge and behaviour and sexually transmitted infections among reproductive-age women in Southeast Asia: Demographic Health Survey results.

Sexually Transmitted Infections (STIs) seriously affect population morbidity, mortality, and are a major public health problem worldwide. A cross-sectional study was conducted using the latest Demographic and Health Survey (DHS) data published between 2005 and 2022 for five Southeast Asian countries. The study's focus was on STI risk factors in the DHS of Timor-Leste, Philippines, Indonesia, Myanmar, and Cambodia.

Exploring the relationship between different modes of transportation and levels of physical activity among senior high school students of the University of Santo Tomas: a cross-sectional study protocol.

Introduction: Rapid changes in technology, communication and transportation prompted challenges in achieving the recommended level of physical activity. Although the students are returning for in-campus classes to promote more interaction and socialisation, the youth still fall short of living up to the desired level of physical activity. The mode of transportation plays a pivotal role in physical activity, yet its relationship is poorly elucidated.

Post-harvest motility and morphological changes of spermatozoa following caudal epididymal recovery in farmed common eland (Tragelaphus oryx) bulls.

The caudal epididymal recovery of spermatozoa has been utilised in game animal species to preserve genetically superior material after trophy hunting or slaughter, due to the difficulties of handling wild animals. Furthermore, the potential application of assisted reproductive techniques using harvested spermatozoa may contribute towards maintaining genetic diversity in isolated captive populations internationally. However, this technique requires clear and ideally simple protocols for the collection and handling of gametes after the death of the male animals, as the point of harvest is usually remote in game ranching.

Gorham stout disease in pregnancy.

Gorham-Stout disease (GSD) is a rare disorder characterized by spontaneous and progressive bone resorption. Its clinical presentation varies from unremarkable to life-threatening, making diagnosis and treatment challenging. Despite extensive research, no definitive correlations have been established between GSD and age, gender, race, or environmental and infectious risk factors.

Establishment and validation of risk prediction model to predict intravenous immunoglobulin-resistance in Kawasaki disease based on meta-analysis of 15 cohorts.

Background: Pediatric Kawasaki disease (KD) patients showing resistance to intravenous immunoglobulin (IVIG) are at risk of coronary artery lesions; thus, early prediction of IVIG resistance is particularly important. Herein, we aimed to develop and verify a novel predictive risk model for IVIG resistance in KD based on meta-analyses.

Methods: PubMed, Embase, and Web of Science databases were searched for cohort studies on the risk factors for IVIG resistance from January 2006 to December 2022.

Retrospective detection and whole genome sequencing identify the first local case of Pigeon Rotavirus A infection in Taiwan from 2018.

In 2018, pigeon Rotavirus A G18P[17] was identified in Australia as the causative agent of a disease outbreak presenting as vomiting and diarrhea, reminiscent of the young pigeon disease syndrome. This virus has subsequently been detected in several other countries, including Belgium, Denmark, Germany, Great Britain, Poland, and the United States. This study was conducted to determine the presence of pigeon Rotavirus A among archived samples collected in Taiwan, and to subsequently characterize the whole genome of a local isolate.

The path of therapeutic community process experience to recovery capital and psychological well-being as mediated by group working alliance: the role of locus-of-hope.

The therapeutic community (TC) is a social-learning treatment program for people with substance use disorders (PSUDs). Most studies focused on how the TC program facilitates positive recovery outcomes. Less emphasis was given to ethnically relevant patient dispositions that may influence the TC process from a collectivist context, especially from Asian developing countries like the Philippines.

Addressing the gap in preterm resuscitation practices in high-income and low-middle income countries: a multicenter survey of the Asian neonatal network collaboration.

Background: Optimum neonatal resuscitation practices are vital for improving neonatal survival and neurodevelopment outcomes, particularly in extremely preterm infants. However, such practices may vary between high-income countries (HICs) and low-middle-income countries (LMICs). This study aimed to evaluate the resuscitation practices of high-risk infants in a large multi-country sample of healthcare facilities among HICs and LMICs in Asia under the AsianNeo Network.

Disease-Related Knowledge, Stress, and Quality of Life of Parental Caregivers of Children with Cleft Lip and Palate in a Selected Hospital in Ho Chi Minh City, Vietnam.

Introduction: Cleft lip and palate (CLP) is one of the most common congenital anomalies worldwide, affecting approximately 2,000 children annually in Vietnam. Parental caregivers, particularly mothers, face considerable challenges in managing complex treatment pathways and addressing their children's multifaceted needs. This often leads to increased stress and decline in the quality of life (QoL).

Low Grade Pulmonary Spindle Cell Neoplasm in a 30-Year-Old Asymptomatic Female: A Diagnostic Dilemma: A Case Report.

Pulmonary spindle cell carcinoma is a highly malignant rare variant of sarcomatoid lung carcinomas. This is a case of an asymptomatic 30-year-old Filipino female with an incidental finding of pulmonary nodules on chest x-ray. Patient was diagnosed with Wilms tumor at the age of 2, S/P nephrectomy with no documented recurrence thereafter.