Social Media Content Analysis of Public and Private Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency Facebook Groups.

Background: As social media continue to grow as popular and convenient tools for acquiring and disseminating health information, the need to investigate its utilization by laypersons encountering common medical issues becomes increasingly essential.

Objectives: This study aimed to analyze the content posted in Facebook groups for Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency and how these engage the members of the group.

Methods: This study employed an inductive content analysis of user-posted content in both public and private Facebook groups catering specifically to G6PD deficiency.

Knowledge, Attitudes, and Practices in Colorectal Cancer Screening in the Philippines.

Background And Objective: Colorectal cancer (CRC) has the third highest incidence in the Philippines. Currently, there is a paucity in literature that is focused on the knowledge, attitudes, and perceptions of Filipinos regarding CRC screening. This is the first study in the Philippines that describes this.

Treatment landscape of patients with HER2+ early breast cancer: an overview.

Breast cancer is the most common malignancy in terms of incidence and is the leading cause of cancer deaths among women worldwide. In the Philippines, 33,079 new cases of breast cancer were documented in 2020 comprising 17.5% of all new cancer diagnoses.

Effectiveness of combined physical exercise and cognitive training in older adults with cognitive impairment: A systematic review and meta-analysis.

Falls among cognitively impaired older adults are a global concern. The aim of this study was to assess the efficacy of combining physical exercise and cognitive training to improve balance among older adults. A systematic search of databases, including Embase, Medline-OVID, CINAHL-EBSCOhost, and Central-Cochrane Library, was conducted from March 9 to April 6, 2023.

Evaluating the effects of sodium metabisulfite on the cognitive and motor function in .

Sodium metabisulfite is widely used as a preservative in many food and beverage products, yet its potential effects on cognitive and motor functions at low concentrations remain poorly understood. Evaluating learning, short-term memory, and motor activity is essential, as these functions are critical indicators of neurological health and could be impacted by low-level exposure to sodium metabisulfite. The aim of this study was to investigate the effects of sublethal concentrations of sodium metabisulfite on cognitive and motor functions using (fruit flies) as the model organism.

Pre- and Intraoperative Factors Associated With Improvement of Neck Pain After Laminoplasty for the Treatment of Cervical Myelopathy.

Study Design: Retrospective cohort study.

Objective: To (1) determine whether preoperative neck pain improves after laminoplasty for cervical myelopathy and identify factors that could predict improvements in neck pain.

Methods: A total of 88 patients with preoperative neck pain visual analogue scale (VAS) of ≥4, who underwent laminoplasty for cervical myelopathy, and were followed-up for >2 years were retrospectively reviewed.

Struggling with memory: anguish and hope in selected pandemic poems by migrant workers in Singapore.

The pandemic has tested the fortitude and resilience of a huge swath of humanity. Even measures undertaken to address the pandemic, primarily the massive vaccination campaigns, revealed a glaring disparity between and within societies. The collective grief, anxiety, and desire for survival have led to creative ways to contend with the crisis.

Social network sites (SNS) an archetype of techno-social stress: A systematic review.

Background: Social Networking Sites (SNS) are widely used platforms known for both their hedonic and social connectivity benefits. Although there is considerable interest in understanding how personal technostress affects individual well-being, a significant gap remains in the systematic exploration of this topic within the literature.

Methods: This review systematically examined 41 empirical studies from Scopus and PubMed published between 2014 and 2023, following PRISMA guidelines, and assessed for methodological quality using the Mixed Method Appraisal Tool.

Copromicroscopic Diagnosis and Prevalence of Parasitic Infections in Animals in Sitio Ibayo, San Mateo, Rizal, Philippines: Establishing a Sentinel Study for Zoonotic Disease Surveillance.

Background: This study investigates the prevalence and intensity of parasitic infections in animal fecal samples collected from Sitio Ibayo, San Mateo, Rizal, Philippines, a suburban community considered a potential sentinel site for zoonotic disease surveillance.

Methods: Using cross-sectional sampling, 132 animal fecal samples were collected in the area exhaustively. Samples were processed through direct smear with saline solution and Lugol's iodine and flotation technique using mini- and fill-FLOTAC.

Wildlife policy, the food system and One Health: a complex systems analysis of unintended consequences for the prevention of emerging zoonoses in China, the Democratic Republic of the Congo and the Philippines.

Introduction: Evolving human-wildlife interactions have contributed to emerging zoonoses outbreaks, and pandemic prevention policy for wildlife management and conservation requires enhanced consideration from this perspective. However, the risk of unintended consequences is high. In this study, we aimed to assess how unrecognised complexity and system adaptation can lead to policy failure, and how these dynamics may impact zoonotic spillover risk and food system outcomes.

Monophasic synovial sarcoma arising from the rectum presenting as intractable anal pain.

Synovial sarcoma is a rare malignant mesenchymal tumour typically found in the extremities, but it can also develop in the gastrointestinal tract, with the upper rectum being the most common site. We describe a case of a man in his 60s diagnosed with monophasic synovial sarcoma in the lower rectum, presenting with severe, intractable anal pain.

Modelling and Validation of a 6 MV Compact Linear Accelerator via Monte Carlo Simulation using Geant4 Application for Tomographic Emission (GATE).

To accurately model and validate the 6 MV Elekta Compactlinear accelerator using the Geant4 Application for Tomographic Emission (GATE). In particular, this study focuses on the precise calibration and validation of critical parameters, including jaw collimator positioning, electron source nominal energy, flattening filter geometry, and electron source spot size, which are often not provided in technical documentation. Methods: Simulation of the Elekta Compact6 MV linear accelerator was performed using the Geant4 Application for Tomographic Emission (GATE) v.

Global Perspectives on Returning Genetic Research Results in Parkinson Disease.

Background And Objectives: In the era of precision medicine, genetic test results have become increasingly relevant in the care of patients with Parkinson disease (PD). While large research consortia are performing widespread research genetic testing to accelerate discoveries, debate continues about whether, and to what extent, the results should be returned to patients. Ethically, it is imperative to keep participants informed, especially when findings are potentially actionable.

PHIStruct: Improving phage-host interaction prediction at low sequence similarity settings using structure-aware protein embeddings.

Motivation: Recent computational approaches for predicting phage-host interaction have explored the use of sequence-only protein language models to produce embeddings of phage proteins without manual feature engineering. However, these embeddings do not directly capture protein structure information and structure-informed signals related to host specificity.

Results: We present PHIStruct, a multilayer perceptron that takes in structure-aware embeddings of receptor-binding proteins, generated via the structure-aware protein language model SaProt, and then predicts the host from among the ESKAPEE genera.

Systematic review and meta-analysis on probiotics as treatment for food allergies among pediatric patients: A 2024 update.

This systematic review updated the available evidence on the effectiveness and safety of probiotics as treatment of food allergy among pediatric patients. We conducted a systematic search for all randomized controlled trials available until March 13, 2024 that evaluated the effectiveness and safety of probiotics for treating pediatric food allergy. Two authors independently conducted the search, screening, and data extraction.

Design of a Multiepitope Pan-Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach.

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious disease with devastating effects on the global pig industry. This warrants the development of effective control strategies, such as vaccines. However, previously developed inactivated vaccines have proven ineffective, while live-attenuated vaccines carry inherent safety risks.

Asian Pacific Society of Cardiology Position Statement on the Use of Transcatheter Aortic Valve Implantation in the Management of Aortic Stenosis.

Transcatheter aortic valve implantation (TAVI) has been established as an effective treatment modality in patients with severe aortic stenosis (AS) and the uptake of TAVI is rapidly growing in the Asia-Pacific region. However, there exist a heterogeneity in the management of aortic stenosis and the use of TAVI among countries in the region. Reasons for these differences include anatomic variations, disparity in healthcare resources and infrastructure, and the lack of consensus on the optimal management of AS in the Asia-Pacific region.

Factors Associated with Management of Workplace Violence Competence Among Chinese Nursing Interns.

Purpose: The cases of workplace violence (WPV) experienced by nurses and nursing students in recent years has become alarming high. However, managing and developing WPV competence among nursing students remain underreported. Therefore, this study investigated the current status of management of workplace violence competence (MWVC) and identify associated factors affecting their MWVC among nursing interns.

The urgency of now to end HIV vertical transmission for pregnant and breastfeeding women and their children in Asia and the Pacific.

The global strategy to #EndAIDS is underpinned by a call to end all inequities and to ensure no-one is left behind; but inequities continue, and people are still being left behind. Despite the advances seen in some populations and in some geographical areas, with ongoing high rates of HIV vertical transmission, ending HIV for pregnant and breastfeeding women and their children must be prioritised urgently. Focused on Asia and the Pacific, the region with the second largest number of people with HIV, in this viewpoint we highlight the heterogenous nature of global and regional success in eliminating vertical transmission of HIV.

Environmental factors affecting the BMI of older adults in the Philippines spatially assessed using machine learning.

This study aimed to assess the environmental variables affecting the Body Mass Index of older adults at neighborhood levels (1 ha) while mapping probability distributions of normal, overweight-obese, and underweight older adults. We applied a data-driven method that integrates open-access remote sensing products and geospatial data, along with the first nutritional survey in the Philippines with geo-locations conducted in 2021. We used ensemble machine learning of different presence-only and presence-absence models, all subjected to hyperparameter tuning and variable decorrelation.

Molecular characterization and zoonotic risk assessment of spp. in Philippine bats.

is a genus of parasitic protozoa known to cause diarrheal disease that impacts both humans and animals through infection of various vertebrate species. Bats are recognized as reservoirs for zoonotic pathogens, including . The Philippines, renowned for its rich biodiversity, is home to diverse bat species, providing a unique ecological setting to investigate infection dynamics.