Thulium laser extraction of angioembolization coils in patient presenting with nephrolithiasis: A case report.

Renal Artery Embolization (RAE) is a first-line treatment for arteriovenous fistula complications, which may occur following percutaneous nephrolithotomy (PCNL). A rare complication of RAE is metal coil migration, which may present with nephrolithiasis symptoms, including hematuria and flank pain. Imaging like Computed Tomography (CT) Angiography can help assess the risk of hemorrhage due to coil location relative to vasculature Subsequently, ureteroscopy can be done with thulium laser excision of the coils and lithotripsy of adherent stone.

Tumor integrin targeted theranostic iron oxide nanoparticles for delivery of caffeic acid phenethyl ester: preparation, characterization, and anti-myeloma activities.

Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells preferentially in the bone marrow. Currently, emerging chemotherapy drugs with improved biosafety profiles, such as immunomodulatory agents and protease inhibitors, have been used in clinics to treat MM in both initial therapy or maintenance therapy post autologous hematopoietic stem cell transplantation (ASCT). We previously discovered that caffeic acid phenethyl ester (CAPE), a water-insoluble natural compound, inhibited the growth of MM cells by inducing oxidative stress.

Delayed Graft Function in Kidney Retransplantation: United Network for Organ Sharing Data With Linked Primary and Retransplant.

Introduction: There are several articles exploring the risk factors for primary delayed graft function (DGF). However, current literature does not include many resources on the risk factors for DGF when it is a recipient's second kidney transplant or look at short-term graft and patient survival of DGF retransplants.

Methods: United Network for Organ Sharing data from January 2008 to June 2021 were analyzed.

Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells.

Multiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy.

Fusion of imaging and non-imaging data for disease trajectory prediction for coronavirus disease 2019 patients.

Purpose: Our study investigates whether graph-based fusion of imaging data with non-imaging electronic health records (EHR) data can improve the prediction of the disease trajectories for patients with coronavirus disease 2019 (COVID-19) beyond the prediction performance of only imaging or non-imaging EHR data.

Approach: We present a fusion framework for fine-grained clinical outcome prediction [discharge, intensive care unit (ICU) admission, or death] that fuses imaging and non-imaging information using a similarity-based graph structure. Node features are represented by image embedding, and edges are encoded with clinical or demographic similarity.

Graph-based Fusion Modeling and Explanation forDisease Trajectory Prediction.

We propose a relational graph to incorporate clinical similarity between patients while building personalized clinical event predictors with a focus on hospitalized COVID-19 patients. Our graph formation process fuses heterogeneous data, i.e.

Modeling and quantifying resurgence in the Evolutionary Theory of Behavior Dynamics.

McDowell's Evolutionary Theory of Behavior Dynamics (ETBD) has been shown to model a wide range of live organism behavior with excellent descriptive accuracy. Recently, artificial organisms (AOs) animated by the ETBD were shown to replicate the resurgence of a target response following downshifts in the density of reinforcement for an alternative response and across repeated iterations of the traditional three-phase resurgence paradigm in a manner commensurate with nonhuman subjects. In the current investigation, we successfully replicated an additional study that used this traditional three-phase resurgence paradigm with human participants.

Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity.

Recent studies have shown that RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro), and papain-like protease (PLpro) are necessary for SARS-CoV-2 replication. Among these three enzymes, PLpro exhibits both proteolytic and deubiquitinase (DUB) activity and is responsible for disrupting the host's innate immune response against SARS-CoV-2. Because of this unique property of PLpro, we investigated the inhibitory effects of phytochemicals on the SARS-CoV-2 PLpro enzyme.

Outcomes of Early Versus Late Tracheostomy in Patients With COVID-19: A Multinational Cohort Study.

Unlabelled: Timing of tracheostomy in patients with COVID-19 has attracted substantial attention. Initial guidelines recommended delaying or avoiding tracheostomy due to the potential for particle aerosolization and theoretical risk to providers. However, early tracheostomy could improve patient outcomes and alleviate resource shortages.

Graph-based Fusion Modeling and Explanation for Disease Trajectory Prediction.

We propose a relational graph to incorporate clinical similarity between patients while building personalized clinical event predictors with a focus on hospitalized COVID-19 patients. Our graph formation process fuses heterogeneous data, i.e.

De Novo PAX2 Mutation With Associated Papillorenal Syndrome: A Case Report and Literature Review of Penetrance and Expressivity.

We report the ocular findings of a Caucasian female with papillorenal syndrome (PAPRS) from a de novo mutation. She presented to our clinic with early-onset end-stage renal disease. Ophthalmologic exam revealed bilateral band keratopathy, abnormal optic disc configuration, and Elschnig spots, with preserved visual acuity.

Antiaging Mechanism of Natural Compounds: Effects on Autophagy and Oxidative Stress.

Aging is a natural biological process that manifests as the progressive loss of function in cells, tissues, and organs. Because mechanisms that are meant to promote cellular longevity tend to decrease in effectiveness with age, it is no surprise that aging presents as a major risk factor for many diseases such as cardiovascular disease, neurodegenerative disorders, cancer, and diabetes. Oxidative stress, an imbalance between the intracellular antioxidant and overproduction of reactive oxygen species, is known to promote the aging process.

Targeted Delivery of DNA Topoisomerase Inhibitor SN38 to Intracranial Tumors of Glioblastoma Using Sub-5 Ultrafine Iron Oxide Nanoparticles.

Effectively delivering therapeutics for treating brain tumors is hindered by the physical and biological barriers in the brain. Even with the compromised blood-brain barrier and highly angiogenic blood-tumor barrier seen in glioblastoma (GBM), most drugs, including nanomaterial-based formulations, hardly reach intracranial tumors. This work investigates sub-5 nm ultrafine iron oxide nanoparticles (uIONP) with 3.

Aloin isoforms (A and B) selectively inhibits proteolytic and deubiquitinating activity of papain like protease (PLpro) of SARS-CoV-2 in vitro.

The most common host entry point of human adapted coronaviruses (CoV) including SARS-CoV-2 is through the initial colonization in the nostril and mouth region which is responsible for spread of the infection. Most recent studies suggest that the commercially available oral and nasal rinse products are effective in inhibiting the viral replication. However, the anti-viral mechanism of the active ingredients present in the oral rinses have not been studied.

Contextual factors affecting the education needs of lymphoedema health professionals regarding genital oedema.

The impact of the care context on education needs of health professionals who conservatively manage patients with genital oedema is unknown. This study aimed to explore the contextual factors surrounding the treatment of patients with genital oedema that affect the education needs of lymphoedema practitioners, and identify interventions that might support both practitioners and patients. Following scoping groups in Australia and the US, formal focus groups were held with lymphoedema practitioners in England, Wales and the US, as part of an international mixed-method project in 2019.

Idiopathic Interstitial Pneumonias: A Review of the Past and Emerging Therapies.

PurposeThis article is an in-depth review of the complex classification, diagnosis, and treatment of idiopathic interstitial pneumonias (IIP), as well as emergence of new treatment options. Idiopathic interstitial pneumonias consist of various subgroup classifications that require expert analysis of imaging and histology to accurately diagnose this broad group of patients. Timely and accurate assessment of these patients is key in developing an appropriate pharmacological plan.

A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2020.

The number of articles related to antimicrobial stewardship published each year has increased significantly over the last decade. Keeping up with the literature, particularly the most innovative, well-designed, or applicable to one's own practice area, can be challenging. The Southeastern Research Group Endeavor (SERGE-45) network reviewed antimicrobial stewardship-related, peer-reviewed literature from 2020 that detailed actionable interventions.

Holding pharmacy educators accountable in the wake of the anti-racism movement: A call to action.

Introduction: The recent murders of Black Americans has forced our society to reevaluate how the various systems in our nation view race and to attempt to dismantle and rebuild the structures that reinforce and perpetuate racial group inequity.

Perspective: Cultural awareness education has been broadly integrated into pharmacy curricula across the country to comply with accreditation standards. Health disparities are currently addressed in the context of race and ethnicity but lack the connection to racism.