5,191 results match your criteria: "Pharyngitis Bacterial"

Evaluating academic detailing as an antibiotic stewardship intervention in primary healthcare settings in Croatia.

BMC Prim Care

December 2024

Department of Endocrinology, University hospital Dubrava, Zagreb, Croatia, and School of Medicine, and University of Zagreb, Zagreb, Croatia.

Background: Acute respiratory tract infections are common in primary healthcare care settings and frequently result in antibiotic prescriptions, despite being primarily viral. There is scarcity of research examining impact of academic detailing (AD) intervention on prescribing practices for these infections in resource-constrained healthcare settings like southeastern Europe. Therefore aim of this study was to evaluate impact of AD intervention as an antimicrobial stewardship measure on antibiotic prescribing for acute respiratory tract infections in primary setting in Croatia which is located in southeastern Europe.

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Aim: This work describes the validation of an in-house extraction free real-time polymerase chain reaction (PCR) for the detection of Group A Streptococcus (GAS) in throat swabs collected in gel amies.

Method: Throat swabs received by the laboratory were prospectively tested by routine bacterial culture and an in-house PCR assay targeting the GAS SpeB gene with a multiplexed RNaseP internal control. Samples with discrepant culture/PCR results had additional testing using the commercial Xpert Group A Strep PCR assay (Cepheid).

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Article Synopsis
  • Knowledge gaps in understanding human immunity to Streptococcus pyogenes have slowed vaccine development, prompting researchers to establish a human challenge model to study this infection.
  • The study analyzed antibody responses in serum and saliva from participants, revealing that those who developed pharyngitis had strong serum IgG responses to vaccine antigens but weaker mucosal IgA responses.
  • The findings indicate that past exposure to the bacteria affects immune responses, underscoring the need to consider these complexities when evaluating potential vaccines in future trials.
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LEMIERRE SYNDROME: A FORGOTTEN INFECTION.

J Ayub Med Coll Abbottabad

November 2024

Hayatabad Medical Complex Peshawar-Pakistan.

Article Synopsis
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Acute Epstein-Barr Virus and SARS-CoV-2 Coinfection: A Case Report.

Curr Health Sci J

September 2024

Postgraduate Program in Dentistry, Universidade do Grande Rio (UNIGRANRIO), Rio de Janeiro, Brazil.

Article Synopsis
  • An 18-year-old female was misdiagnosed with bacterial tonsillitis and treated with antibiotics, but subsequent tests revealed she had a coinfection of Epstein-Barr Virus (EBV) and SARS-CoV-2 (COVID-19).
  • Symptoms included throat pain, cough, and enlarged lymph nodes, while tests indicated active EBV infection and confirmed COVID-19.
  • This case highlights the challenge of diagnosing coinfections and the critical role of proper lab testing to avoid incorrect treatments that could worsen the patient's health.
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Centor scores associated poorly with rapid antigen test findings in children with sore throat.

Eur J Pediatr

November 2024

Institute of Clinical Medicine and Department of Pediatrics, University of Eastern Finland, Yliopistonranta 2, 70211, Kuopio, Finland.

Unlabelled: The Finnish Current Care Guideline recommends rapid antigen tests as the primary diagnostic tool for both adults and children with Centor score ≥ 3. We aimed to analyze the association of Centor score and rapid antigen test positivity of group A streptococcal pharyngitis (GAS) in Finnish children. We performed a retrospective single-center study from July 2019 to June 2022.

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Unlabelled: (1) Background: Group A Streptococcal (GAS) pharyngitis is common, resulting in numerous ambulatory visits. Accurate diagnosis is challenging. This study evaluated the clinical utility, cost, and performance of a nucleic acid amplification test (NAAT) for GAS detection, comparing it to a rapid antigen detection test (RADT) and throat culture.

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Article Synopsis
  • A case was reported involving a young woman with symptoms like fever, chest pain, and joint pain, ultimately leading to a diagnosis related to Lemierre's syndrome.
  • Investigations showed low platelet count, severe lung infection, and a blood clot in the internal jugular vein, with blood cultures identifying harmful bacteria.
  • Despite developing respiratory failure, the patient was treated successfully with high-flow nasal oxygen, highlighting the importance of quick diagnosis and management for a good outcome in rare cases like this.
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Primary pyomyositis, also known as tropical pyomyositis, is a primary bacterial infection of skeletal muscle following hematogenous infections. It is primarily caused by  or Group A  and predominantly affects children and young adults. Although rarely observed in temperate climates, its prevalence appears to be increasing.

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Review: Known, Emerging, and Remerging Pharyngitis Pathogens.

J Infect Dis

October 2024

Department of Pathology and Laboratory Medicine, Arkansas Children's Hospital, Little Rock, Arkansas, USA.

Pharyngitis is an inflammatory condition of the pharynx and/or tonsils commonly seen in both children and adults. Viruses and bacteria represent the most common encountered etiologic agents-yeast/fungi and parasites are infrequently implicated. Some of these are predominantly observed in unique populations (eg, immunocompromised or unvaccinated individuals).

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Review: Diagnostic Potential for Collaborative Pharyngitis Biomarkers.

J Infect Dis

October 2024

Department of Pathology and Laboratory Medicine, Arkansas Children's Hospital, Little Rock, AR, USA.

Pharyngitis is an inflammatory condition of the pharynx and/or tonsils commonly seen in both children and adults. Viruses and bacteria represent the most common encountered etiologic agents-yeast/fungi and parasites are infrequently implicated. Some of these are predominantly observed in unique populations (eg, immunocompromised or unvaccinated individuals).

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Article Synopsis
  • Rheumatic fever (RF), an autoimmune condition following untreated strep throat, mainly impacts children and can lead to serious heart issues, highlighting the need for awareness and prevention, especially in low-resource areas.
  • A study in Al-Baha, Saudi Arabia, surveyed 415 parents using an online questionnaire to evaluate their knowledge, attitudes, and practices regarding RF and RHD, revealing that most participants had poor knowledge and negative attitudes toward RF.
  • Results showed that only around 4.8% had good knowledge of RF, while 69.2% demonstrated good practices; females were more likely to have better practices than males, suggesting a need for enhanced educational initiatives by health authorities to improve understanding and prevention of these
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Article Synopsis
  • * The research included 60 children aged 2-17 with sore throats and high fevers, categorizing them into groups based on their diagnosis.
  • * Although IRT alone couldn't differentiate between bacterial and viral pharyngitis, it improved the prediction accuracy for streptococcal pharyngitis when used with the McIsaac score, achieving a 90% positive predictive value.
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Octinidine Gargles: A Boon in a Treatment of Acute Pharyngitis.

Indian J Otolaryngol Head Neck Surg

October 2024

Department of Otorhinolaryngology, CIMS, Lucknow, Uttar Pradesh India.

Pharyngitis is a disorder commonly reported in ENT OPDs. The most common cause of Pharyngitis in India is Group A streptococcus, with prevalence rates of 13% in children aged 5-15%. It can also be attributed to various other bacterial, viral and fungal agents.

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The CandyCollect device is a lollipop-inspired open fluidic oral sampling device designed to provide a comfortable user sampling experience. We demonstrate that the CandyCollect device can be coupled with a rapid antigen detection test (RADT) kit designed for Group A Streptococcus (GAS). Through experiments with pooled saliva spiked with we tested various reagents and elution volumes to optimize the RADT readout from CandyCollect device samples.

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Article Synopsis
  • - *Perimyocarditis and myopericarditis are inflammatory conditions affecting the heart and its surrounding membrane, often caused by viral infections, with nonrheumatic streptococcal myopericarditis being a rare form that can mimic heart attacks.* - *A case study describes a 22-year-old male who developed nonrheumatic streptococcal myopericarditis after having streptococcal pharyngitis, presenting symptoms like chest pain and tightness.* - *The patient was treated with a combination of antibiotics and anti-inflammatory medications, leading to symptom resolution and discharge with ongoing treatment.*
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Optimal Pediatric Outpatient Antibiotic Prescribing.

JAMA Netw Open

October 2024

Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: In the US, 50% of all pediatric outpatient antibiotics prescribed are unnecessary or inappropriate. Less is known about the appropriateness of pediatric outpatient antibiotic prescribing.

Objective: To identify the overall percentage of outpatient antibiotic prescriptions that are optimal according to guideline recommendations for first-line antibiotic choice and duration.

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