2 results match your criteria: "Pharmacology and Toxicology and Center of Molecular Biosciences Innsbruck[Affiliation]"
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.
Proc Natl Acad Sci U S A
February 2016
Département de Physiologie, Institut de Genomique Fonctionnelle, Laboratory of Excellence in Ion Channel Science and Therapeutics, UMR-5203, CNRS, F-34094 Montpellier, France; INSERM U661, F-34094 Montpellier, France; Université de Montpellier, F-34094 Montpellier, France;
Dysfunction of pacemaker activity in the sinoatrial node (SAN) underlies "sick sinus" syndrome (SSS), a common clinical condition characterized by abnormally low heart rate (bradycardia). If untreated, SSS carries potentially life-threatening symptoms, such as syncope and end-stage organ hypoperfusion. The only currently available therapy for SSS consists of electronic pacemaker implantation.
View Article and Find Full Text PDFFunctional properties of a newly identified C-terminal splice variant of Cav1.3 L-type Ca2+ channels.
J Biol Chem
December 2011
Institute of Pharmacy, Pharmacology and Toxicology and Center of Molecular Biosciences Innsbruck, Peter-Mayr-Strasse 1/I, A-6020 Innsbruck, Austria. Electronic address:
An intramolecular interaction between a distal (DCRD) and a proximal regulatory domain (PCRD) within the C terminus of long Ca(v)1.3 L-type Ca(2+) channels (Ca(v)1.3(L)) is a major determinant of their voltage- and Ca(2+)-dependent gating kinetics.
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