Proteomic Markers of Aging and Longevity: A Systematic Review.

This article provides a systematic review of research conducted on the proteomic composition of blood as part of a complex biological age estimation. We performed a comprehensive analysis of 17 publicly available datasets and compiled an integral list of proteins. These proteins were sorted based on their detection probability using mass spectrometry in human plasma.

AcidAGE: a biological age determination neural network based on urine organic acids.

Organic acids reflect the course of all important metabolic processes and the effects of diet, nutrient deficiency, lifestyle, and microbiota composition. In present work, we focused on identifying age-related changes in organic acids in urine, and creating a neural network model based on them to determine biological age. The investigation involves data on concentrations of 60 organic acids in urine of 863 samples.

[Hypoxic training in rehabilitation of patients at the early stages of recovery after SARS-CoV-2 pneumonia].

Objective: To evaluate efficacy and safety of hypoxic-hyperoxic therapy in rehabilitation after SARS-CoV-2 pneumonia.

Material And Methods: There were 44 patients aged 49-75 years in early recovery period after previous SARS-CoV-2 pneumonia (ICD-10 U07.1 and U07.

[Proximal fixation devices in endovascular repair of abdominal aortic aneyrysm with unfavourable proximal neck anatomy].

Abdominal aortic aneurysm is a common vascular disease requiring surgical treatment. Currently, endovascular aortic repair is a good alternative to open surgery. However, high incidence of unfavorable anatomical variants of the proximal landing zone limit the use of endovascular aortic repair in these patients.

[Surgical treatment of patients with obstructive hypertrophic cardiomyopathy].

Objective: To analyze in-hospital results of surgical treatment of patients with obstructive hypertrophic cardiomyopathy.

Material And Methods: There were 15 patients (8 women and 6 men) with obstructive hypertrophic cardiomyopathy and severe mitral insufficiency for the period from November 2017 to March 2019. Mean age of patients was 55.

[Control and prevention of kidney transplant rejection: the role and possibilities for the clinical use of regulatory T-cells in transplantation].

This article discusses the need to implement effective methods for monitoring immune status and rehabilitation of patients after kidney transplantation. Induction of immunological tolerance which allows minimizing or even completely canceling supportive immunosuppressive therapy is one of the key tasks in the field of organ transplantation. Regulatory T-cells (TREGs) play an important role in maintaining immunological homeostasis, including limiting kidney transplant rejection, and potentially contribute to the development of immunological tolerance.

Postoperative acute respiratory failure in cardiac surgery.

Objective: To evaluate incidence, causes and outcomes of acute respiratory failure (ARF) in patients after cardiac and aortic surgery.

Material And Methods: A retrospective trial included 3972 patients after elective cardiovascular procedures for the period 2013-2017. Inclusion criterion: sustained reduction of pulmonary function (PaO/FiO<300 mm Hg) in the postoperative period required mechanical ventilation or non-invasive positive pressure mask ventilation for at least 24 h.

[Aorto-esophago-bronchial and aorto-pulmonary fistulas in a patient with aortic aneurysm].

Aorto-esophageal and aorto-bronchial fistulas are rare and life-threatening diseases if emergency treatment is absent. The most of publications devoted to this problem are case reports describing successful treatment of patients with aorto-esophageal and aorto-bronchial fistulas by using of endovascular or open transthoracic surgery. However, we did not find reports of several aortic fistulas in a patient after previous aortic stenting.

[Isolated transaortic mitral valve repair for left ventricular outflow tract obstruction].

Hypertrophic cardiomyopathy (HCM) is congenital heart disease with prevalence 1 per 500. There are still unclear issues regarding optimal surgical strategy despite more than 50-year research of this disease. It is presented case report of surgical treatment of patient with obstructive HCM by using of non-standard volume and method of intervention.

Postoperative care in patients with DeBakey type I aortic dissection: criteria of aortic remodeling and risk factors of disease progression.

Aim: To present current treatment modes for DeBakey type I aortic dissection, to compare their early and mid-term postoperative results, to evaluate predictors of negative aortic remodeling after surgery.

Material And Methods: Retrospective cohort analysis included 78 patients with DeBakey type I aortic dissection who underwent surgical treatment in 2009-2017. Patients were divided into 3 groups depending on type of intervention: group I (n=22) - Elephant Trunk procedure, group II (n=29) - hybrid interventions, group III (n=27) - proximal aortic replacement alone.

[Hypertrophic cardiomyopathy: current state of the problem].

The main aspects of epidemiology, pathophysiology, medication and surgical treatment of hypertrophic cardiomyopathy (HCM) are reviewed in the article. The authors emphasize that surgical treatment is still the method of choice for HCM and can guarantee excellent immediate and long-term results with minimal risk.

[The role of lymphadenectomy for treatment of colorectal liver metastases with regional lymph nodes involvement].

Liver resection remains the method of choice for treatment of colorectal liver metastases with good long-term results. Regional lymph nodes involvement is significant negative prognostic factor. Moreover, it has been considered as a contraindication for liver resection for a long time.

[Endoscopic harvesting of internal mammary artery for coronary artery bypass grafting].

Endoscopic harvesting of internal mammary artery for minimally invasive coronary artery bypass surgery seems to be highly justified and expedient. Technical features of this procedure are reviewed in the article. There are certain advantages of this method including ligation of proximal branches, reduced surgical trauma, better cosmetic results and enhanced postoperative rehabilitation.

[Effectiveness of various approaches for acute malignant colonic obstruction].

Aim: To determine optimal treatment strategy for acute malignant colonic obstruction.

Material And Methods: 349 patients with acute malignant colonic obstruction were retrospectively analyzed for the period 2005-2017. All patients were divided into two groups depending on surgical approach.

[Contrast-enhanced ultrasonography as the most perspective diagnostic method for unstable atherosclerotic plaque of carotid artery].

Problem of internal carotid artery disease diagnosis appears to be crucial today. Complications of this pathology are strokes and transient ischemic attacks. There is no technology for their prediction or at least stratifying risks.

[Imaging of neoangiogenesis of internal carotid artery's atherosclerotic plaque by contrast-enhanced sonography and histological examination].

Previously, atherosclerosis was considered a disease accompanied exclusively by lipids accumulation. At present time success of fundamental and experimental science confirmed that atherosclerotic process is also associated with neovascularization and prolonged inflammatory response at all stages of atherogenesis from initial manifestations to thrombotic complications. The cause of atherosclerotic plaque instability is neovascularization, which is accompanied by intra-plaque hemorrhage and damage.

[Microbiological profile of postoperative infection in current oncology surgery].

Aim: To analyze in-hospital infection in oncology center within 2012-2016.

Material And Methods: There were 98 patients with nosocomial infection who underwent surgery for malignancies. Microbiological examination of biological materials was carried out by appropriate laboratories according to generally accepted methods.

[Surgical treatment of spine injuries].

The history of spinal fixation started in the 19 century and had an intensive development in subsequent years. Special progress in surgery for spinal traumatic injuries was noted in the Second World War. Last decades minimally invasive spinal surgical techniques are developed and introduced in everyday practice.

[Thoracoscopic subtotal esophageal resection for benign esophageal diseases].

Aim: To investigate the role of video-assisted subtotal esophageal resection in treatment of patients with benign esophageal diseases.

Material And Methods: Fifty-one patients with benign esophageal diseases have undergone subtotal esophageal resection in our department for the period 2010-2017. Thoracoscopic technique was applied in 25 cases, open approach - in 26 patients.

[Cardiopulmonary bypass and circulatory support in Petrovsky Russian Research Center for Surgery].

Since initial application of cardiopulmonary bypass (1960) and circulatory support (1977) unique methods of extracorporeal circulation have been developed at Petrovsky Russian Research Center for Surgery. Some of them were introduced for the first time in the country (USSR and then in the Russian Federation). It was possible due to creative team of Boris Vasilyevich Petrovsky, whose potential was aimed at expanding the indications for surgical treatment of cardiac, aortic, liver, lung and kidney diseases under artificial circulation and then circulatory support.

[Evolution of mitral valve replacement].

Historical development of mitral valve surgery at Petrovsky Russian Research Center for Surgery is described in the article. Evolution of artificial heart valves design and development of surgical techniques are presented.