Thermally activated processes: the underlying mechanism of activated state formation.

In the present manuscript, we highlight the contradictions in the thermally activated processes theory which treats a system's activated state as a state of the phonon subsystem. We offer an alternative model, in which the activated state is treated as an electron subsystem state. The mechanism of the activated state formation is as follows: thermal fluctuations excite electrons of some particles within the activation zone.

Intervention impact on quality of life in Ukrainians with post-traumatic stress disorder.

Background: The World Health Organization (WHO) estimates the prevalence of Post-Traumatic Stress Disorder (PTSD) among the population of Ukraine at approximately 25%. Almost half of the population, or 57%, is at risk of developing PTSD.

Methods: This longitudinal study included an assessment of QoL dynamics among 109 Ukrainian civilians with PTSD, before and after receiving complex treatment during the Russian-Ukrainian conflict.

Molecular descriptors and in silico studies of 4-((5-(decylthio)-4-methyl-4n-1,2,4-triazol-3-yl)methyl)morpholine as a potential drug for the treatment of fungal pathologies.

The article explores the polypharmacological profiling of 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine as a potential antimicrobial agent. The study utilized 15148 electronic pharmacophore models of organisms, ranked by the Tversky index. Detailed analysis revealed classical bonding patterns with selected enzymes, identifying key amino acid residues involved in complex formation.

The impact of negative factors of professional activities on the health of law enforcement officers.

Objective: Aim: To study the study the impact of negative factors of professional activities on the health of law enforcement officers.

Patients And Methods: Materials and Methods: The research involved 89 law enforcement officers (58 men, and 31 women) who served for a year in practical police units after graduating from a higher educational institution. Methods: analysis and generalization of scientific and methodological literature, anthropometry, physiometry, testing, and statistical methods.

Structure and dynamics of the course of chronic non-infectious somatic diseases in patients during war events on the territory of Ukraine.

Background: The work studied and compared the dynamics of changes in the course of hypertension, type 2 diabetes, and somatized disorders in Ukrainian population, in the 1st period before war (October 2021 - February 2022) and 2nd period during the war (March -July 2022). The choice of the study of the above-mentioned nosology is due, first of all, to the increase in cases of referrals to outpatient doctors regarding hypertensive crises, the increase in the frequency of patients' complaints about the lability of glycemic indicators during routine monitoring of glucose levels with ambulatory glucometers, the appearance of chronic pain syndrome of unspecified pathology with the beginning of war events.

Methods: 272 people were examined in Mykolaiv Region (Ukraine).

Physico-Chemical Properties of Laponite®/Polyethylene-oxide Based Composites.

This review aims to provide a literature overview as well as the authors' personal account to the studies of Laponite® (Lap)/Polyethylene-oxide (PEO) based composite materials and their applications. These composites can be prepared over a wide range of their mutual concentrations, they are highly water soluble, and have many useful physico-chemical properties. To the readers' convenience, the contents are subdivided into different sections, related with consideration of PEO properties and its solubility in water, behavior of Lap systems(structure of Lap-platelets, properties of aqueous dispersions of Lap and aging effects in them), analyzing ofproperties LAP/PEO systems, Lap platelets-PEO interactions, adsorption mechanisms, aging effects, aggregation and electrokinetic properties.

Types of morbidity presenting in frontline-bordering regions of Ukraine: the experience of deploying additional mobile medical units.

Introduction: On 24 February 2022, the full-scale military invasion of Russia into Ukraine has started, creating one of the largest humanitarian crises in Europe since the World War II. As of 27 July 2022 (by the time when the most of Russian advances have already occurred), more than 900 healthcare facilities in Ukraine were damaged and 127 hospitals were destroyed completely.

Methods: Mobile medical units (MMU) were deployed in the frontline-bordering areas.

Adaptive changes in bodybuilders in conditions of different energy supply modes and intensity of training load regimes using machine and free weight exercises.

Background: The research was aimed at comparing the effect of using two types of training load different in intensity and energy supply. We studied the influence of the proposed load variations (machine and free weight exercises) on long-term adaptation of the body at the stage of specialized basic training in bodybuilding.

Methods: A total of 64 athletes aged 18-20 years were examined.

Dietary Supplementation with Resveratrol Attenuates Serum Melatonin Level, Pro-Inflammatory Response and Metabolic Disorder in Rats Fed High-Fructose High-Lipid Diet under Round-the-Clock Lighting.

This study aims to investigate the effect of resveratrol on systemic inflammatory response and metabolic disorder in rats fed a high-fructose high-lipid diet (HFHLD) and exposed to round-the-clock lighting (RCL). 21 adult male Wistar rats were randomly divided into 3 groups: control (group 1, = 7); HFHLD for 8 weeks + round-the-clock lighting (RCL) (group 2, = 7); HFHLD + RCL + Resveratrol (in a daily dose of 5 mg/kg intragastrically (group 3, = 7). Results show that the combined effect of HFHLD and RCL reduces the serum melatonin ( < 0.

Computational method of the cardiovascular diseases classification based on a generalized nonlinear canonical decomposition of random sequences.

Decision support systems can seriously help medical doctors in the diagnosis of different diseases, especially in complicated cases. This article is devoted to recognizing and diagnosing heart disease based on automatic computer processing of the electrocardiograms (ECG) of patients. In the general case, the change of the ECG parameters can be presented as a random sequence of the signals under processing.

Criteria for assessing the adaptive changes in mixed martial arts (MMA) athletes of strike fighting style in different training load regimes.

Background: To study the peculiarities of changes in functional indicators and body composition parameters of mixed martial arts (MMA) athletes of strike fighting style and a number of biochemical blood indicators during two months of using different intensity training load regimes, and to determine the most informative criteria for assessing adaptive body changes in these training conditions.

Methods: We examined 40 MMA athletes (men) aged 20-22, who used mainly strike fighting style in their competitive activity, and divided them into 2 research groups (A and B), 20 athletes in each group. Group A athletes used medium intensity (  = 0.

BIOFLAVONOIDS AS AGENTS FOR CORRECTING NITRO-OXIDATIVE STRESS AND SALIVARY GLAND FUNCTIONS IN RATS EXPOSED TO ALCOHOL DURING MODELED LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE.

Objective: The aim: To investigate the effects of bioflavonoids (curcumin, epigallocatechin-3-gallate and quercetin) on nitro-oxidative stress and the functions of submandibular SGs in rats under alcohol exposure during SIR.

Patients And Methods: Materials and methods: The studies were conducted on 35 rats of the Wistar line weighing 205-220 g, divided into 5 groups of seven animals in each: the 1st group, control group I, included animals receiving isotonic sodium chloride solution intragastrically twice a day; the 2nd group, control group II, included rats exposed to alcohol (in a dose of 24 mg/kg intragastrically through gavage a twice a day) for last 2 weeks during lipopolysaccharide (LPS)-induced SIR; the rats of the 3rd, 4th and 5th groups exposed to alcohol during LPS-induced SIR, which also received bioflavonoids. The bioflavonoids ("Sigma-Aldrich, Inc.

MODERN DIAGNOSTIC CRITERION FOR ESTABLISHING THE REGIONAL ORIGIN OF BLOOD IN SEXUAL CRIMES.

Objective: The aim: Determination of regional blood origin in cases of sexual violence, establishing the possibility of using prostaglandin F2alpha as a marker of blood of menstrual origin.

Patients And Methods: Materials and methods: The material for the study were samples of vaginal fluid, menstrual blood and capillary blood from females, the age distribution of women was carried out according to the gynecological classification according to the age periods of women's lives depending on the functional state of their reproductive system: the first group - women at the age of 18-29, the second group - women at the age of 30-45.

Results: Results: Among objects of biological origin, fluids, especially blood, occupy an important place.

PRODUCTION OF INTERLEUKINS 1β, 2, 4, 10 AND C-REACTIVE PROTEIN IN ISCHEMIC STROKE.

Objective: The aim: The aim of this study was to determine the content of interleukins (IL) 1β, 2, 4, and 10, as well as the generally accepted marker of inflammation - C-reactive protein (CRP) - in the peripheral blood on the first and tenth days of ischemic stroke (IS).

Patients And Methods: Materials and methods: The study involved 25 patients with IS (including 8 people with mild case of neurological disorders, 9 - moderate case and 8 - severe case) and 14 people of the control group. The levels of IL-1β, IL-2, IL-4 and IL-10 in the blood were determined by the immunoenzyme method.

Machine Learning Techniques for Increasing Efficiency of the Robot's Sensor and Control Information Processing.

Real-time systems are widely used in industry, including technological process control systems, industrial automation systems, SCADA systems, testing, and measuring equipment, and robotics. The efficiency of executing an intelligent robot's mission in many cases depends on the properties of the robot's sensor and control systems in providing the trajectory planning, recognition of the manipulated objects, adaptation of the desired clamping force of the gripper, obstacle avoidance, and so on. This paper provides an analysis of the approaches and methods for real-time sensor and control information processing with the application of machine learning, as well as successful cases of machine learning application in the synthesis of a robot's sensor and control systems.

Application of closed kinematic chain exercises with eccentric and strength exercises for the shoulder injuries prevention in student rock climbers: a randomized controlled trial.

Purpose: The aim of this work to determine the influence of a program containing exercises in a closed kinematic chain, eccentric and strength exercises on injuries of students - rock climbers.

Methods: Participants in this study were 84 male amateur climbing students, aged 18-19, 40 athletes were in the intervention group and 44 in the control group. In the intervention group, the program for the injuries prevention has been stalled.

EATING BEHAVIOUR AND OBESITY: GENDER-AGE FEATURES.

Objective: The aim: Identify the types of eating behaviour in overweight and obesity depending on gender and age.

Patients And Methods: Materials and methods: A survey of 210 people (men -105, women -105) was conducted. The age of women ranged from 19 to 60 years, the average age was 41.

Frequency of implementation and impact of appendectomy at activation of the pathological process in patients with chronic non-atrophic gastritis.

Objective: The aim: Determine the frequency of surgery-appendectomy of patients with chronic non-atrophic gastritis and the impact of this transaction on the pathogenesis of chronic gastritis.

Patients And Methods: Materials and methods: Data of disease history and life were analyses, as well as the results of a comprehensive survey of 245 patients with chronic non-atrophic gastritis. Comprehensive examination included: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous.

Mathematical modeling of the stress-strain state of the "bone-implant" system during the osteosynthesis with a philos with polylactic acid implants.

Objective: The aim: To study was to use mathematical modeling in assessing the stress-strain state of the bone-implant system during plate osteosynthesis with a PHILOS plate of a proximal humerus fracture with polylactic acid implants.

Patients And Methods: Materials and methods: Two bone-implant systems with a three-fragment humerus fracture according to the Neer classification (type 11-C1 according to the AO / ASIF classification) were selected for the study, one of which was with additional reinforcement of the head fragment with two polylactic acid implants (PLA - polylactide Ingeo™ Biopolymer 4032D). Sawbones (Europe AB, Malmö, Sweden) built the humeral model on 3D scanning of the composite model № 3404 of the left humerus.

Pain as leading syndrome of the somatoform disorders at the pediatrics.

Objective: The aim: Study of somatoform vegetative dysfunction' clinical features at adolescent age with a chronic pain (HA syndrome and AP syndrome), and also socially-psychological factors of its formation too.

Patients And Methods: Materials and methods: There are 82 teenagers have been examined in this research: 48 girls (58,5 %) and 34 young men (41,5 %) at the age of 16 - 17 years. Research will be done according to diagnostic criteria of ICD-10.

Statistical analysis of the сhronic gastritis in students.

Objective: The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university.

Patients And Methods: Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4courses, aged 17 to 25 years, a total of 50 people.

The effect of intracellular “depot” helicobacter pylori infection on the quality of eradication with monotheraphy of patients with chronic non-atrophic gastritis by the bismuth colloidal subcitrate.

Introduction: Noted that monotherapy by the bismuth colloidal subcitrate in the treatment of chronic HP- infection is effective only in 14-40% of cases, but all the reasons that reduce its effectiveness, are not fully explored. The aim: To determine the effectiveness of monotherapy by the bismuth colloidal subcitrate among patients with chronic non-atrophic gastritis with or without intracellular “Depot” of HP- infection.

Material And Methoda: The 36 patients took comprehensive examination: step-by-step рН-metry, esophagogastroduodenoscopy, helicobacter infection test (НР) (helicobacter urease test and microscopic examination of stained smears), histological investigations of the gastric stump mucous, stool test, HELIC – test, the level of natural killers (CD-16).

Usage of histological methods in determining the prescription of spleen injuries in forensic medical practice.

Objective: Introduction: The article presents data from literary sources and a statistical analysis of one's own research on the nature, mechanism and prescription of spleen injury in the case of mechanical trauma and the absence of alcohol intoxication. The aim: To study the dynamics of changes in the histological parameters of the spleen injured tissues in case of mechanical trauma depending on the prescription of injury.

Patients And Methods: Materials and methods: The material of the study was the spleen tissue of 56 males and females aged from 20-60 who died at known and unknown time in the presence and absence of alcohol in the blood.

The case of formation of «kissing» ulcers of duodenal bulb of the patient with chronic nonatrophic gastritis on the background of the eating of a vegetable salad and physical exertion.

Objective: Introduction: In certain situations the constituents of food can serve as a catalysator for the formation of such a pathology as peptic ulcer. Not the last role in the formation of ulcerous defects under certain conditions play physical excertion, which is accompanied by sharp rhythmic contraction of the muscles of the anterior abdominal wall. The aim: To analyze the case of formation of "kissing" ulcers of the duodenal bulb of the 25-year-old patient.

Dynamics of biochemical markers of connective tissue metabolism in patients with knee osteoarthritis during conservative treatment with laser therapy.

Objective: Introduction: The biochemical markers of the connective tissue metabolism in blood serum may characterize the disturbances in inflammatory, destructive processes, and also serve the criteria for diagnostic evaluation of the state of cartilage and bone tissue of the joints in knee osteoarthritis to control the effectiveness of conservative treatment. The aim: determination of biochemical markers of connective tissue metabolism in the blood of patients with the 1st and 2nd stages of knee osteoarthritis in order to prove the effectiveness of the complex conservative treatment of patients with the use of low-intensity infrared laser radiation.

Patients And Methods: Materials and methods: During the study we examined 80 patients with the 1st and 2nd stages of knee osteoarthritis according to the Kellgren and Lawrence classification.