Normothermic Machine Perfusion vs. Static Cold Storage in Liver Transplantation: A Systematic Review and Meta-Analysis.

Background: Normothermic machine perfusion (NMP) represents an alternative to prolong liver preservation and reduce organ discard rates. We performed an updated systematic review and meta-analysis to compare NMP with static cold storage (SCS) in liver transplantation.

Methods: MEDLINE, Embase, and Cochrane were searched for randomized controlled trials (RCTs) or observational studies.

Women's mental health in the doctoral context: Protective function of the psychological capital and academic motivation.

Background: Science recognizes the anxieties, depression, stress, and "turbulences" that women face in doctoral studies, but women's mental health in this context is still little addressed, even though it is a critical aspect for the well-being, persistence, and success of women doctoral candidates, who continue to be underrepresented in many professional fields.

Objectives: The study aims to evaluate the relationship between academic motivation, psychological capital, and university academic performance (UAP) and to identify factors of female mental health success.

Design: A cross-sectional, mixed-methods study was conducted with a sample of 108 female doctoral students from a university in Lima, during the first quarter of 2024.

Antibacterial Activity of Peruvian Species: A Comparative Study of the Antimicrobial Effects of Extracts From Three Different Species, , and , Against Human Pathogens.

The growing problem of antibiotic resistance has driven the search for new sources of antimicrobial agents. Plants, particularly those from the Malvaceae family, have showed promising potential in this field. The present study is based on extracts, and the antimicrobial action was assessed using and as experimental bacterial strains.

Impact of the COVID-19 pandemic on small vulnerable newborns: an interrupted time series analysis in Peru and Brazil.

Background: We examined COVID-19's impact on the number of small vulnerable newborns (SVN) at national and regional levels in Peru and Brazil.

Methods: Using national birth registries, we examined monthly numbers of preterm (PT), low birthweight (LBW), and small for gestational age (SGA) newborns. We analysed COVID-19's impact on SVN using two interrupted time series models.

Perceptions of primary care services among Afro-Peruvians in Lima, Peru.

Introduction: The Peruvian public healthcare system is characterized by various shortcomings that adversely affect healthcare quality as perceived by the general and minority populations, including the Afro-Peruvian community. This population has demonstrated reduced healthcare access due to discrimination and differential treatment, reflecting broader societal inequities.

Objective: This study explores the experiences and perceptions of Afro-Peruvian individuals regarding the treatment they receive from public primary healthcare providers in metropolitan Lima.

Efficacy of Pressure Cooker Technique in Redo Embolization for High-Flow Torcular Dural Sinus Malformation.

Torcular dural sinus malformations (tDSMs) with high-flow fistulas pose complex management challenges due to their vascularity and the delicate neuroanatomy involved. This report presents the case of a child with tDSM and hydrocephalus, who underwent 3 staged embolization procedures but required a redo intervention due to residual malformation and venous hypertension. Utilizing the pressure cooker technique (PCT) in a redo setting allowed for high-pressure, targeted embolic delivery with minimized reflux, achieving near-complete occlusion and significant symptom relief.

Adjuvant Atezolizumab for Early Triple-Negative Breast Cancer: The ALEXANDRA/IMpassion030 Randomized Clinical Trial.

Importance: Triple-negative breast cancer is an aggressive subtype with a high incidence in young patients, a high incidence in non-Hispanic Black women, and a high risk of progression to metastatic cancer, a devastating sequela with a 12- to 18-month life expectancy. Until recently, one strategy for treating early-stage triple-negative breast cancer was chemotherapy after surgery. However, it was not known whether the addition of immune therapy to postsurgery chemotherapy would be beneficial.

Direct economic costs related to antimicrobial resistance in bloodstream infections isolated from newborns in a perinatal hospital in Peru.

Background: Antimicrobial resistance (AMR) has emerged as a priority for both public health and the global economy. Moreover, information on AMR is scarce, particularly in low/middle-income countries. We evaluated the direct economic cost of microorganisms and AMR.

Beyond the faucet: social-geographic disparities and trends in intermittent water supply in Peru.

This study aimed to estimate the percentage of households with intermittent water supply (IWS) in Peru and determine the association between socioeconomic characteristics and the presence of IWS. The National Household Surveys (ENAHO) of 2017, 2018, 2019, 2019, 2021, and 2022 were used. IWS was defined as a piped water supply for less than 24 hours per day, one or more days per week.

Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Trials.

Background: A minority of patients with stroke qualify for intravenous thrombolysis (IVT) within 4.5-hour window. The safety and efficacy of IVT beyond this period have not been well studied.

Inflammation severity, rather than respiratory failure, is strongly associated with mortality of ARDS patients in high-altitude ICUs.

Introduction: In high-altitude cities located above 2,500 m, hospitals face a concerning mortality rate of over 50% among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS). This elevated mortality rate is largely due to the absence of altitude-specific medical protocols that consider the unique physiological adaptations of high-altitude residents to hypoxic conditions. This study addresses this critical gap by analyzing demographic, clinical, sex-specific, and preclinical data from ICUs in Bogotá, Colombia (2,650 m) and El Alto, Bolivia (4,150 m).

Phylogeny of spp. (Decapoda, Pleocyemata) from Peru based on mitochondrial and nuclear data reveals a species complex comprising (Bouvier, 1895) and Holthuis, 1950.

Prawns of the genus represent a highly diverse group of high commercial value worldwide. Eight species have been reported from the Peruvian Pacific slope, but their phylogenetic relationships are still unknown. To investigate the systematics of species from Peru, morphological identification and molecular data from nucleotide sequences of three genes were used: cytochrome oxidase subunit I, 16S rRNA, and 28S rRNA.

Sodium fluorescein video Angiography-Assisted clipping of intracranial Aneurysms: A systematic review and Meta-Analysis.

Objectives: Ensuring aneurysm exclusion while maintaining vessel patency is crucial during intracranial aneurysm clipping. Although digital subtraction angiography (DSA) is the gold standard for intraoperative vascular imaging, some centers have reported using fluorescein sodium video angiography (FNa-VA). However, a synthesis of these findings is still lacking.

Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.

Background: For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now permit randomized, controlled trials of shortened-duration, all-oral treatments for rifampin-resistant tuberculosis.

Methods: We conducted a phase 3, multinational, open-label, randomized, controlled noninferiority trial to compare standard therapy for treatment of fluoroquinolone-susceptible, rifampin-resistant tuberculosis with five 9-month oral regimens that included various combinations of bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C), and pyrazinamide (Z).

"The state has a debt to us, it ended our dreams, our life projects": Reconstructing life projects after torture.

Introduction: The concept of 'life project' is at the core of several decisions in the inter-American human rights system. The concept has also become part of the legal consciousness of torture survivors in Peru and is often referred to when they describe the impact of torture and imprisonment on their lives and on the lives of their children.

Methods: The paper is based on qualitative interviews with seven Peruvian torture survivors.

Effect of Time-Lapse Incubation System on In Vitro Development of Alpaca Embryos.

Currently, incubators with a time-lapse system are widely used for in vitro embryo production in several species, however, their effect on alpaca embryo development compared to conventional incubators remains unknown. The aim of this study was to compare early in vitro embryo development in alpacas using a time-lapse incubator system versus a conventional incubator. Ovaries were obtained from a slaughterhouse and 1048 cumulus-oocyte complexes (COCs) were collected and in vitro matured for 26 h in either a time-lapse system (n = 542) or a conventional incubator (n = 542).

The Impact of Mercury from Dental Amalgams on Pregnancy and Childhood: A Health and Risk Assessment Evaluation.

Mercury is a pervasive global pollutant, with primary anthropogenic sources including mining, industrial processes, and mercury-containing products such as dental amalgams. These sources release mercury into the environment, where it accumulates in ecosystems and enters the food chain, notably through bioamplification in marine life, posing a risk to human health. Dental amalgams, widely used for over a century, serve as a significant endogenous source of inorganic mercury.

Transitions through the HIV continuum of care in people enrolling in care with advanced HIV disease in Latin America.

Objectives: Advanced HIV disease (AHD) at HIV care enrollment is common in Latin America and may bias cross-sectional care continuum estimates. We therefore explored the impact of AHD on HIV care continuum outcomes using a longitudinal approach.

Methods: We analyzed trajectories of 26,174 adult people with HIV enrolled at Caribbean, Central and South America network for HIV epidemiology (CCASAnet) sites (2003-2019) using multi-state Cox regression across five stages: (i) enrolled without antiretroviral therapy (no-ART); (ii) on ART without viral suppression (viral load ≥200 copies/m; ART + non-VS); (iii) on ART with viral suppression (viral load <200 copies/ml; ART + VS); (iv) lost to follow-up; (v) death.

Closed Preservation Rhinoplasty in the Mestizo Patient: Challenges and Techniques for Nasal Tip Support.

Background: Closed preservation rhinoplasty continues to grow in popularity. Nevertheless, many surgeons remain wary of doing closed preservation rhinoplasty in certain patient populations. Mestizo noses have a thick soft-tissue envelope and weak nasal tip support.

Diagnostic Capacity and Correlation of Optic Nerve Colorimetry with Structural Parameters in Primary Open-Angle Glaucoma.

Prcis: The discriminant function of glaucoma, obtained by the Laguna ONhE colorimetric program, significantly correlates with the BMO-MRW. Furthermore, the diagnostic capacity was inferior to other structural tests in POAG patients.

Purpose: To evaluate the diagnostic capability for glaucoma and the correlation between peripapillary and macular parameters using spectral domain optical coherence tomography (SD-OCT) and optic nerve head hemoglobin (OHN Hb) levels assessed by the Laguna ONhE® software using colorimetric analysis.

Voices and visions: Navigating the landscape of sexual, reproductive, and maternal health and rights in Latin America and the Caribbean: A stakeholder mapping and analysis.

This article presents the results of a mapping and analysis of key stakeholders operating in the field of Sexual, Reproductive, and Maternal Health and Rights (SRMHR) who are involved in the entitlement of health rights and access to health services for women, adolescents, LGBTQI+ individuals, migrants, indigenous people, Afro-descendants, and people with disabilities in Latin America and the Caribbean. Our study focuses on Argentina, Colombia, Guatemala, Guyana, Jamaica, Mexico, and Peru. The primary objective was to identify and comprehensively categorise the activities undertaken by them, since their actions shape, and promote or hinder the SRMHR political agenda in the region.