[Experience of using bacteriophages in the complex treatment of children with aphthous stomatitis].

Unlabelled: Aphthous stomatitis (AS) is one of the most common diseases of the oral mucosa in children. A significant role in the pathogenesis of AS is assigned to the infectious-allergic factor.

The Aim: Of the work was to evaluate the clinical effectiveness of topical application of bacteriophages in the complex treatment of children with aphthous stomatitis.

[Nutrition monitoring in secondary education institutions].

Nutrition provided to children at school is a factor that exerts most significant influence on their health. However, certain issues remain unresolved in the sphere and this initiated nutrition monitoring within the "Demography" Russian National Project. of this study was to analyze the results of nutrition monitoring in secondary education institutions located in Perm region in order to determine priority indicators for its further estimation.

[ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis].

Aim: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.

Materials And Methods: The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.

[Evaluation of the dynamics of prosthetic dental care provided to patients with the complete absence of teeth in the Perm district].

Background: Currently, one third of the world's population aged 65-74 years has partially or completely missing teeth. In our country, the data of epidemiological studies are scattered.

Objective: The aim of the study is assessment of the dynamics of the volume of orthopedic care provided to patients with complete absence of teeth in the Perm Region.

[Psychoneurological and degenerative-dystrophic disorders in patients with pathology of the temporomandibular joint].

Objective: The aim of the study is to detail neuropsychiatric and degenerative-dystrophic disorders in patients with dysfunctional TMJ syndrome and develop principles for their correction.

Material And Methods: 84 patients with complaints of impaired TMJ function were examined: 14 men (16.67%) and 70 women (83.

Effect of Glycodelin on the Cytokine Profile of Rats during Allogeneic Bone Marrow Cell Transplantation.

The protein glycodelin (PP14, PAEP) is associated with pregnancy and exhibits pronounced immunotropic properties. We studied the effect of glycodelin on the cytokine profile of blood serum during transplantation a suspension of allogeneic red bone marrow cells to Wistar rats. Recombinant glycodelin was administered to the animals 4 times (14 μg each time).

[A new one in the lung and pleura neoplasms classification (WHO, 2021, 5th edition)].

The article contains an overview of the new WHO classification of thoracic tumors (2021). As in the previous edition of 2015, considerable attention is paid to neoplasms of the lungs and pleura. The article presents current data on molecular genetic features and morphological manifestations of a number of new lung tumors, with a detailed histological and immunohistochemical data.

[Features of the formation of interzonal connections of the brain according to quantitative electroencephalography in full-term and premature infants].

Objective: To study the features of functional interzonal integration and its dynamics in infants from 0 to 9 months during prospective observation, taking into account the timing gestation, clinical picture and morphological changes on neurosonography (NSG).

Material And Methods: A comprehensive unified examination was carried out in dynamics in 89 infants three times at the age of 3, 6, 9 months and included, in addition to assessing the neurological status, the Denver Developmental Screening Test (DDST), transfontanellar ultrasonography with a vector sensor according to the generally accepted method. We also evaluated the parameters of electroencephalography (EEG) recorded in the waking state with an analysis of background parameters, zonal differences, and the identification of pathological types of activity and calculation of the average coherence power (ACP).

The effect of ŽP strain with a conjugation-based colicin E7 delivery on growth performance, hematological, biochemical, and histological parameters, gut microbiota, and nonspecific immunity of broilers.

The  ŽP strain (ŽP) was constructed based on the known probiotic  strain Nissle 1917. It was genetically modified to carry the colicin E7 synthesis gene encoding DNase on a conjugative plasmid and the colicin E7 immunity gene in the chromosome. The aim of this study was to evaluate the effects of the daily ŽP per oral administration (5 × 10 or 5 × 10 CFU per bird) on the growth performance, hematological, biochemical, histological parameters, gut microbiota, and nonspecific immunity of the 4-24 days old broilers.

Use of folic acid nanosensors with excellent photostability for hybrid imaging.

Sentinel lymph node (SLN) mapping and tumor-boundary delineation play a key role in cancer surgery, as they have great potential to reduce surgical intervention and increase relapse-free survival rates of patients. The autofluorescence imaging (AFI) method can improve the efficiency of tumor delineation and optimize the scope of surgical intervention, but there are still no fluorescent drugs that can be used with such a method to form a hybrid imaging technique. Another problem is bleaching when fluorescent dyes are conjugated with folic acid.

Rupture of a deep femoral artery aneurysm with pulsating hematoma: a case report.

True deep femoral artery aneurysms are a rare abnormality of the human vascular system and account for approximately 0.13% of all peripheral arterial aneurysms. We report a 66-year-old man with a ruptured deep femoral artery aneurysm and a pulsating hematoma.

[Liver echinococcosis in a non-endemic region].

Objective: To study clinical manifestations and difficulties in diagnosis of liver echinococcosis in a non-endemic region and to assess the long-term results of surgical treatment and quality of life.

Material And Methods: The study included 36 residents of a non-endemic region with liver echinococcosis operated on in the Perm Regional Clinical Hospital over the past 15 years. IgG antibodies to echinococcal antigens were determined using enzyme immunoassay.

Numerical Modeling of a New Type of Prosthetic Restoration for Non-Carious Cervical Lesions.

The paper considers a new technology for the treatment of non-carious cervical lesions (NCCLs). The three parameterized numerical models of teeth are constructed: without defect, with a V-shaped defect, and after treatment. A new treatment for NCCL has been proposed.

Comparative Content of Neuron-Specific Enolase in Human Blood Serum and Seminal Plasma.

We studied the content of neuron-specific enolase (NSE) in 69 paired samples of blood serum and seminal plasma from men with azoospermia (n=11) and oligoastenozoospermia (n=10) and from men with fertile ejaculate (n=48). NSE concentration was determined by ELISA (Vector-Best kit). The median concentration and the interquartile range of the NSE content in seminal plasma were 65.

Vaccination With Oral Polio Vaccine Reduces COVID-19 Incidence.

Background: Effective response to emerging pandemic threats is complicated by the need to develop specific vaccines and other medical products. The availability of broadly specific countermeasures that could be deployed early in the pandemic could significantly alter its course and save countless lives. Live attenuated vaccines (LAVs) were shown to induce non-specific protection against a broad spectrum of off-target pathogens by stimulating innate immune responses.

[Iron deficiency in Russia heart failure patients. Observational cross-sectional multicenter study].

Aim    To evaluate the prevalence of iron deficiency (ID) in Russian patients with heart failure (HF).Material and methods    Iron metabolism variables were studied in 498 (198 women, 300 men) patients with HF. Data were evaluated at admission for HF (97 %) or during an outpatient visit (3 %).

Elucidation of retention mechanism of dipeptides on a ristocetin A-based chiral stationary phase using a combination of chromatographic and molecular simulation techniques.

Two chiral stationary phases virtually reproducing the Nautilus-R column were modeled in silico to study the enantiorecognition mechanism of some selected dipeptides, taking into consideration the two different anchoring alternatives to the silica layer involving the two ristocetin A amino groups. A mobile phase composed of water-methanol (40:60, v/v) was included in the system. The analyses of the trajectories supported the experimental L(LL) View Article and Find Full Text PDF

Remote Analysis of Respiratory Sounds in Patients With COVID-19: Development of Fast Fourier Transform-Based Computer-Assisted Diagnostic Methods.

Background: Respiratory sounds have been recognized as a possible indicator of behavior and health. Computer analysis of these sounds can indicate characteristic sound changes caused by COVID-19 and can be used for diagnostics of this illness.

Objective: The aim of the study is to develop 2 fast, remote computer-assisted diagnostic methods for specific acoustic phenomena associated with COVID-19 based on analysis of respiratory sounds.

Lactoferrin of oral fluid is normal and in Alzheimer's disease: laboratory and diagnostic aspects (review of literature).

The article discusses the clinical value of determining the lactoferrin protein in oral fluid - one of the representatives of the saliva proteome. The review is based on the analysis of modern literature, including systematic reviews, the results of multicenter prospective studies, review and original articles by leading experts in this field, presented in the databases PubMed, Scopus, CyberLeninka. The problems of the preanalytical stage, methods for determining lactoferrin are highlighted and information about its content in mixed saliva according to various authors is provided.

[Modern algorithm of diagnosis and treatment of acute gestational pyelonephritis in a large industrial city].

The Purpose Of The Study: to develop a modern algorithm for the diagnosis and treatment of acute gestational pyelonephritis in a large industrial city and to study the possibilities of phytotherapy as an integral part of this algorithm.

Materials And Methods: The study consisted of two stages and included 629 patients treated over 12 years (2010-2021) in Perm city with a population of 1.1 million people.

[Molecular mechanisms of adaptive and therapeutic effects of physical activity in patients with cardiovascular diseases].

Physical activity is one of the main components of the rehabilitation of patients with cardiovascular disease (CVD). As shown by practice and the results of evidence-based studies, the beneficial effects of physical activity on disease outcomes in a number of cardiac nosologies are comparable to drug treatment. This gives the doctor another tool to influence the unfavorable epidemiological situation in developed countries with the spread of diseases of the cardiovascular system and CVD mortality.

An Effective and Lightweight Deep Electrocardiography Arrhythmia Recognition Model Using Novel Special and Native Structural Regularization Techniques on Cardiac Signal.

Recently, cardiac arrhythmia recognition from electrocardiography (ECG) with deep learning approaches is becoming popular in clinical diagnosis systems due to its good prognosis findings, where expert data preprocessing and feature engineering are not usually required. But a lightweight and effective deep model is highly demanded to face the challenges of deploying the model in real-life applications and diagnosis accurately. In this work, two effective and lightweight deep learning models named Deep-SR and Deep-NSR are proposed to recognize ECG beats, which are based on two-dimensional convolution neural networks (2D CNNs) while using different structural regularizations.

Express detection of Escherichia coli and bacteria of the Escherichia coli group at the oral cavity.

Currently, in the diagnosis of diseases, a decisive place is given to laboratory methods, which should be informative, relatively simple to perform and rapid. The article describes the approbation of a method for rapid detection of Escherichia coli and bacteria of Escherichia coli group in the oral cavity. Research involved 44 volunteers, who were sampled from the oral cavity, followed by incubation in Koda's medium.