1 results match your criteria: "Perinatal Research Center Tampa (R.R.M.). rmagness@health.usf.edu.[Affiliation]"
Domain-Specific Partitioning of Uterine Artery Endothelial Connexin43 and Caveolin-1.
Hypertension
October 2016
From the Department of Ob/Gyn, University of Wisconsin, Madison (B.C.A., T.J.M., R.R.M.); Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station (J.R.); and Department of Ob/Gyn, University South Florida, Perinatal Research Center Tampa (R.R.M.).
Article Synopsis
- Uterine vascular adaptations during pregnancy enhance blood flow through the interaction of gap junction connexin (Cx) proteins and endothelial nitric oxide synthase, with a specific role for Cx43.
- ATP activates endothelial nitric oxide synthase in pregnant uterine artery endothelial cells, leading to increased nitric oxide production and significant increases in various signaling molecules compared to nonpregnant cells.
- The study shows that ATP induces a rapid repartitioning of Cx43 to caveolar domains, where it interacts with endothelial nitric oxide synthase, facilitating the increase in uterine blood flow necessary for a healthy pregnancy.