109 results match your criteria: "Perforating Folliculitis"

Article Synopsis
  • A 39-year-old woman with Noonan Syndrome and a RAF1 mutation presented with itchy lesions on her limbs that developed two months prior, characterized by multiple dome-shaped papules.
  • Blood tests showed no abnormalities, but a skin biopsy revealed features consistent with Kyrle's disease, a type of perforating dermatosis.
  • The patient was treated with narrowband UVB phototherapy, resulting in complete resolution of symptoms despite leaving residual atrophic scars.
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Recalcitrant Reactive Perforating Collagenosis Successfully Treated with Dupilumab: A Case Report.

Clin Cosmet Investig Dermatol

June 2024

Department of Dermatology, Peking University People's Hospital, Beijing, People's Republic of China.

Reactive perforating collagenosis (RPC) is the most common form of the perforating dermatoses, which include RPC, elastosis perforans serpiginosa (EPS), perforating folliculitis (PF), and Kyrle disease (KD). In RPC, altered collagen of the dermis is extruded through the epidermis, which can be misdiagnosed as other skin diseases, such as vasculitis or prurigo nodularis. RPC is associated with a number of conditions, including diabetes mellitus, hepatitis, and renal failure, and thus the management of the coexisting diseases is important.

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Article Synopsis
  • * A dermatological examination showed erythematous and hyperpigmented papules around hair follicles, along with some erosions nearby.
  • * The condition is identified as perforating folliculitis, which is uncommon and typically occurs in people with chronic kidney issues or weakened immune systems.
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A Case of Noonan Syndrome and Kyrle Disease: Casualty or Causality?

Acta Dermatovenerol Croat

December 2023

Marco Brusasco, MD, Dermatology Section Department of Medicine and Surgery, University of Parma, Via Gramsci, 14, 43126 Parma, Italy;

Article Synopsis
  • A 39-year-old woman with Noonan Syndrome and RAF1 mutation presented with itchy skin lesions on her limbs, which were diagnosed as Kyrle disease (KD) after a detailed examination.
  • KD is characterized by dome-shaped papules with a central keratotic plug and is often linked to systemic conditions such as chronic renal failure and diabetes, although this patient did not have these issues.
  • Treatment involved narrowband UVB phototherapy, leading to complete resolution of symptoms, which highlights the importance of managing underlying health conditions in skin diseases like KD.
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Kyrle disease: a case report and literature review.

Eur Rev Med Pharmacol Sci

November 2023

Department of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy.

Article Synopsis
  • Perforating dermatoses are various skin disorders where skin tissue is eliminated through the epidermis, and they typically affect adults with other health issues like renal failure or diabetes.
  • Kyrle disease is one type of perforating dermatosis, and this case report discusses a patient with Kyrle disease who also has chronic kidney disease, highlighting the need for proper treatment.
  • The study emphasizes the importance of addressing itching and managing underlying health problems to improve the quality of life for patients suffering from Kyrle disease.
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Article Synopsis
  • - The report examines a peculiar type of hair loss (alopecia) in 8 juvenile American red squirrels, with most cases reported between September and November, indicating a possible seasonal pattern.
  • - The affected squirrels showed a symmetrical, noninflammatory loss of hair on their bodies, while hair on their faces and paws remained normal.
  • - Histopathological analysis revealed specific hair shaft distortions, suggesting a genetic cause and indicating similarities to a condition known as canine seasonal flank alopecia.
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Article Synopsis
  • - The case involves an 18-year-old patient with end-stage kidney failure who experienced a rare skin issue called perforating folliculitis after a kidney transplant, showing unusual symptoms initially mistaken for chicken pox during dialysis treatment.
  • - After receiving a deceased donor kidney transplant, the patient developed skin eruptions on the chest, face, and forearms, leading to a biopsy that confirmed the diagnosis of perforating folliculitis.
  • - Treatment with prednisone and tacrolimus was effective, resulting in the progressive resolution of the skin lesions, while the patient's kidney function indicators (urea, creatinine, and electrolytes) showed continual improvement over four months.
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Acquired perforating dermatoses show increased levels of cutaneous advanced glycation end-products.

Clin Exp Dermatol

January 2022

Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.

Article Synopsis
  • Acquired perforating dermatoses (APDs) are skin conditions characterized by the elimination of skin materials, possibly linked to changes in glycation of dermal components.
  • A study with 109 participants compared levels of advanced glycation end-products (AGEs) among patients with different skin conditions, including APDs, healthy controls, and those with atopic dermatitis.
  • Results indicated that patients with APDs had significantly higher levels of skin AGEs, suggesting a potential role for AGEs in the mechanisms of skin elimination seen in these disorders.
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Article Synopsis
  • Reactive perforating collagenosis (RPC) is a rare skin condition associated with other perforating dermatosis, like perforating folliculitis and Kyrle's disease.
  • * RPC can be hereditary or acquired; the acquired form is often seen in diabetics with chronic kidney issues.
  • * A new case involving a 72-year-old woman treated with phototherapy showed positive results.
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Article Synopsis
  • Acquired perforating dermatosis (APD) is a rare skin disorder where connective tissue is eliminated through the skin, with most patients diagnosed with reactive perforating collagenosis (RPC).
  • A study of 80 APD patients revealed a higher prevalence of diabetes and a troubling mortality rate, as 23.8% of patients died during the follow-up period.
  • The comorbidity rate was notably higher in the RPC subgroup compared to perforating folliculitis, indicating a need for thorough evaluations of underlying health issues in patients with RPC.
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Article Synopsis
  • Perforating dermatoses are a diverse group of skin diseases characterized by the skin's expulsion of various materials, including collagen, elastic fibers, and keratin.
  • Four main types are identified: acquired reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle's disease, and perforating folliculitis, each differing in the material eliminated through the skin.
  • An updated Japanese treatment guideline for these conditions was created based on a comprehensive review of literature from 1989 to 2019, emphasizing consensus among experts despite the limited scope of existing studies.
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[Effectiveness of internal mammary artery perforator propeller flap repair combined with radiotherapy for chest keloid in female patients].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

September 2018

Department of Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Article Synopsis
  • The study looked at how well a new surgery method (IMAP propeller flap repair) works for fixing chest keloids in women after they have been removed.
  • 15 women, aged 28 to 75, had their keloids removed and then this surgery done, followed by radiation treatment to help them heal better.
  • Most of the women were happy with their results, had less pain and itching, and only a few had their keloids come back, showing the method is a good option for fixing chest keloids.
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Cutaneous adverse effects of chemotherapy are widely known but underreported. A significant advancement is made in the field of oncology with the advent of new classes of drug being added to the existing classes at a fast pace. Most of these cutaneous adverse effects are self-limiting and subsides on suspending the drug either temporarily or permanently.

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Article Synopsis
  • * A study involved 122 CKD patients, examining the prevalence of skin and mucous membrane disorders, revealing conditions like xerosis, skin pallor, and pruritus as common symptoms regardless of the patients' dialysis status.
  • * Key findings included a high occurrence of dry skin, nail abnormalities, and oral issues, suggesting that environmental factors, such as climate, may worsen these symptoms; ongoing follow-up for CKD patients is recommended to manage these problems.
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