Drug-Induced Pulmonary Fibrosis: National Database Analysis.

Background/objectives: Pulmonary fibrosis (PF) results in a progressive decline of lung function due to scarring. Drugs are among the most common causes of PF. The objective of our study was to reveal the structure of drugs involved in PF development.

Is Transforaminal Endoscopic Discectomy the Best Option for Recurrent Lumbar Disc Herniation? A Systematic Review.

Introduction: Recurrent lumbar disc herniation (rLDH) remains a challenge in spinal surgery. This systematic review analyzes the use of transforaminal endoscopic discectomy (TFED) for the treatment of rLDH.

Methods: A comprehensive search of 4 electronic databases, including PubMed, Google Scholar, Science Direct, and Cochrane, was conducted.

A MODERN VIEW ON THE TREATMENT OF CLASS IV RECESSION ACCORDING TO MILLER.

Introduction: Interproximal attachment has received much attention in modern periodontology because it is a key diagnostic and prognostic factor. Currently, we can find many articles with results of bare root coverage, but few data and studies that describe root closure and obtaining interproximal attachment at the same time.

Objectives: The purpose of this study is to introduce a double-layer tunnel surgical technique for gingival papilla reconstruction and regeneration of the supraalveolar interproximal attachment.

PROSPECTS AND LONG-TERM RESULTS AFTER ENDODONTIC SURGERY.

Aim: to analyze the current literature data on the topic of prospects and distant results after endodontic surgery.

Material And Methods: A systematic review was conducted following the PRISMA 2020 guidelines. This review was written with the help of literature searches in the electronic databases Google Scholar and PubMed.

Comparative Analysis of 3D Cephalometry Provided with Artificial Intelligence and Manual Tracing.

Objectives: To compare 3D cephalometric analysis performed using AI with that conducted manually by a specialist orthodontist.

Methods: The CBCT scans (a field of view of 15 × 15 cm) used in the study were obtained from 30 consecutive patients, aged 18 to 50. The 3D cephalometric analysis was conducted using two methods.

One-Pot Time-Induced Proteome Integral Solubility Alteration Assay for Automated and Sensitive Drug-Target Identification.

The proteome integral solubility alteration (PISA) assay is widely used for identifying drug targets, but it is labor-intensive and time-consuming and requires a substantial amount of biological sample. Aiming at enabling automation and greatly reducing the sample amount, we developed one-pot time-induced (OPTI)-PISA. Here, we demonstrate OPTI-PISA performance on identifying targets of multiple drugs in cell lysate and scaling down the sample amount to sub-microgram levels, making the PISA method suitable for NanoProteomics.

Synthesis and Biological Activity of Chromeno[3,2-]Pyridines.

The review summarizes all synthetic methodologies for the preparation of chromeno[3,2-]pyridines and chromeno[3,2-]quinolines. The proposed approaches are systemized based on ways for the construction of the heterocyclic system. The presence of these compounds in nature and their bioactivity are also discussed.

Arrhythmogenic Potential of Myocardial Edema: The Interstitial Osmolality Induces Spiral Waves and Multiple Excitation Wavelets.

Myocardial edema is a common symptom of pathological processes in the heart, causing aggravation of cardiovascular diseases and leading to irreversible myocardial remodeling. Patient-based studies show that myocardial edema is associated with arrhythmias. Currently, there are no studies that have examined how edema may influence changes in calcium dynamics in the functional syncytium.

Inflammatory Response of Monocytes/Macrophages in Patients with Systemic Sclerosis.

Background: Investigation of the inflammatory response of immune cells is a current focus of research on autoimmune disorders. The aim of this study was to evaluate the inflammatory status of monocytes/macrophages in systemic sclerosis (SSc).

Methods: The study included 35 SSc and 25 healthy participants.

Influence of Mechanical Loading on the Process of Tribochemical Action on Physicochemical and Biopharmaceutical Properties of Substances, Using Lacosamide as an Example: From Micronisation to Mechanical Activation.

Many physical and chemical properties of solids, such as strength, plasticity, dispersibility, solubility and dissolution are determined by defects in the crystal structure. The aim of this work is to study in situ dynamic, dispersion, chemical, biological and surface properties of lacosamide powder after a complete cycle of mechanical loading by laser scattering, electron microscopy, FR-IR and biopharmaceutical approaches. The SLS method demonstrated the spontaneous tendency toward surface-energy reduction due to aggregation during micronisation.

Application of the Nadaraya-Watson estimator based attention mechanism to the field of predictive maintenance.

Attention mechanism has recently gained immense importance in the natural language processing (NLP) world. This technique highlights parts of the input text that the NLP task (such as translation) must pay "attention" to. Inspired by this, some researchers have recently applied the NLP domain, based, attention mechanism techniques to predictive maintenance.

Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients.

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA is subject to alternative splicing, resulting in the translation of multiple splice variants. We have shown that Tregs from patients with amyotrophic lateral sclerosis (ALS) have reduced expression of full-length (FL) FoxP3, while other truncated splice variants are expressed predominantly.

From the principle of sustainable non-equilibrium to sustainable development.

Ervin Bauer was Hungarian and Soviet scientist, who had a short, but bright and talented life. In 1935, working at the Institute of Experimental Medicine in the USSR, he published the book «Theoretical Biology», in which he proposed an idea of a special "non-equilibrium" state of living systems and the existence of internal machineries in the organism that work against thermodynamic equilibrium and increase the organism's capacity for work. Currently, this idea is called "the principle of sustainable non-equilibrium" or "Bauer's principle".

Mechanisms of Myocardial Edema Development in CVD Pathophysiology.

Myocardial edema is the excess accumulation of fluid in the myocardial interstitium or cardiac cells that develops due to changes in capillary permeability, loss of glycocalyx charge, imbalance in lymphatic drainage, or a combination of these factors. Today it is believed that this condition is not only a complication of cardiovascular diseases, but in itself causes aggravation of the disease and increases the risks of adverse outcomes. The study of molecular, genetic, and mechanical changes in the myocardium during edema may contribute to the development of new approaches to the diagnosis and treatment of this condition.

Effect of LDL Extracted from Human Plasma on Membrane Stiffness in Living Endothelial Cells and Macrophages via Scanning Ion Conductance Microscopy.

Mechanical properties of living cells play a crucial role in a wide range of biological functions and pathologies, including atherosclerosis. We used low-stress Scanning Ion-Conductance Microscopy (SICM) correlated with confocal imaging and demonstrated the topographical changes and mechanical properties alterations in EA.hy926 and THP-1 exposed to LDL extracted from CVD patients' blood samples.

СOMPARATIVE SPECTROPHOTOMETRY ANALYSIS OF ZIRCONIUM DIOXIDE WITH THE CUBIC AND TETRAGONAL PHASE AFTER ARTIFICIAL AGING.

Aim - to evaluate optical features of the 3, 4 and 5Y-TZP zirconium dioxide with the spectrophotometry analysis under artificial aging procedure. For all experiments, identical standardized specimens of different types of zirconia with a diameter of 10 mm and a height of 1 mm were used. These types included Katana (Kuraray Noritake Dental, Tokyo, Japan) HTML (control) UTML, STML and ZirCAD Prime (Ivoclar Vivadent).

EFFECT OF SURFACE TREATMENT PROTOCOLS OF ZIRCONIUM DIOXIDE MULTILAYER RESTORATIONS ON FUNCTIONAL PROPERTIES OF THE HUMAN ORAL MUCOSA STROMAL CELLS.

Aim - to study the effect of protocols of surface treatment of zirconium dioxide multilayer restorations on the functional properties of stromal cells of the human oral mucosa using molecular biological methods. For all experiments, identical standardized specimens of different types of zirconia with a diameter of 10 mm and a height of 1 mm were used. These types included Katana (Kuraray Noritake Dental, Tokyo, Japan) HTML (control) UTML, STML and ZirCAD Prime (Ivoclar Vivadent).

Drug-Induced Anaphylaxis: National Database Analysis.

(1) Background: National health system databases represent an important source of information about the epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. Analysis of such databases may enhance the knowledge of healthcare professionals regarding the problem of drug-induced anaphylaxis. (2) Methods: A retrospective descriptive analysis was carried out of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) extracted from the Russian National Pharmacovigilance database (analyzed period 2 April 2019-21 June 2023).

MEDICAL AND SOCIAL ASPECTS OF PREVENTING SPORTS INJURIES AMONG CHILDREN AND ADOLESCENTS.

Sports injuries among children and adolescents typically involve mild bruises and sprains. However, any sport can cause injuries to the musculoskeletal system. It is crucial to prevent such injuries through proper training and supervision to ensure the safety of young athletes.

Mitochondrial DNA copy number in patients with systemic sclerosis.

Systemic scleroderma (SSc) is a chronic autoimmune disease of inflammatory origin. Mitochondrial dysfunction is considered as an important mechanism in the pathogenesis of SSc. Currently mitochondrial DNA (mtDNA) copy number is used as a surrogate marker of mitochondrial dysfunction.

THE INCIDENCE OF SPORTS INJURIES AMONG SCHOOL-AGED CHILDREN AND ADOLESCENTS.

It is estimated that approximately one in ten school-aged children experience sports-related injuries annually. These injuries are most common at 12 years of age. Boys are more likely to get injured and more likely to get seriously injured than girls.