EFFECT OF SURFACE TREATMENT PROTOCOLS OF ZIRCONIUM DIOXIDE MULTILAYER RESTORATIONS ON FUNCTIONAL PROPERTIES OF THE HUMAN ORAL MUCOSA STROMAL CELLS.

Aim - to study the effect of protocols of surface treatment of zirconium dioxide multilayer restorations on the functional properties of stromal cells of the human oral mucosa using molecular biological methods. For all experiments, identical standardized specimens of different types of zirconia with a diameter of 10 mm and a height of 1 mm were used. These types included Katana (Kuraray Noritake Dental, Tokyo, Japan) HTML (control) UTML, STML and ZirCAD Prime (Ivoclar Vivadent).

[Histology of fetal lungs at different gestational age].

The lecture is devoted to the morphological characteristics of the maturation of lung tissue structures in the fetal period. Fetal histology of the lungs presents the intrauterine development of lung tissue in four successive stages: pseudoglandular, canalicular, saccular and alveolar, each has specific morphological criteria. The following morphological features are predetermined: the development of alveolar epithelium, the ratio of mesenchyme towards the area in alveolar spaces, the degree of proliferation and location of vessels of the microcirculatory bed towards prealveolar partitions.

[Overcoming therapy resistance in prolactinomas: from perspectives to real clinical practice].

The main treatment option of prolactin-secreting pituitary adenomas is dopamine agonist therapy, which demonstrates prolactin level normalizing and reducing the size of an adenoma in the majority of cases. However, significant amount of patients - about 20% - poorly responds even to high doses of dopamine agonists that is explained by the resistance to therapy. The occurrence of pharmacodynamic characteristics is one of the causes responsible for the development of resistance to typical therapy.

[Analysis of the effectiveness of various methods of rehabilitation of patients with subacromial impingement syndrome].

Introduction: Subacromial impingement syndrome is a common pathology that leads to a persistent decrease in the functioning of the affected limb and, as a consequence, a decrease in the quality of life and work ability of patients. According to various authors, the study of the effectiveness of treatment and rehabilitation of this pathology is quite widely presented in the literature: surgical, including arthroscopic operations, rehabilitation using various factors of physical therapy, manual and other practices. However, the issue of assessing the effectiveness of movement therapy, both alone and in combination with other therapeutic methods, remains relevant.

Drug-Induced Anaphylaxis: National Database Analysis.

(1) Background: National health system databases represent an important source of information about the epidemiology of adverse drug reactions including drug-induced allergy and anaphylaxis. Analysis of such databases may enhance the knowledge of healthcare professionals regarding the problem of drug-induced anaphylaxis. (2) Methods: A retrospective descriptive analysis was carried out of spontaneous reports (SRs) with data on drug-induced anaphylaxis (SRsAs) extracted from the Russian National Pharmacovigilance database (analyzed period 2 April 2019-21 June 2023).

MEDICAL AND SOCIAL ASPECTS OF PREVENTING SPORTS INJURIES AMONG CHILDREN AND ADOLESCENTS.

Sports injuries among children and adolescents typically involve mild bruises and sprains. However, any sport can cause injuries to the musculoskeletal system. It is crucial to prevent such injuries through proper training and supervision to ensure the safety of young athletes.

Structure-Functional Examination of Novel Ribonucleoside Hydrolase C (RihC) from LR1.

Ribonucleoside hydrolase C (RihC, EC 3.2.2.

[Effect of L-carnitine and resveratrol complex on the profile of cytokines and regulatory proteins in normal and obese rats].

Chronic inflammation in adipose tissue, peripheral organs and some compartments of the brain are among pathogenetic factors in obesity. The use of bioactive compounds with anti-inflammatory and hypolipidemic activity in the composition of specialized products and dietary supplements is considered as an approach in the diet therapy of obesity and related conditions. of the research was to study the effect of a complex supplement containing resveratrol and L-carnitine (RC supplement) on the immunological parameters of inflammation (the profile of cytokines and regulatory proteins) in rats fed a balanced or hypercaloric diet.

[Methods for the identification and quantification of microplastics in foods (a review)].

The adverse effects of microplastics (MP) found in food on the health have recently been recognized as a new source of human health risks. In order to evaluate and minimize them, it is necessary to evaluate the exposure using sensitive and specific methods. of the research was the substantiation of methodological approaches to the identification and quantification of microplastics in food based on the analysis of literature data.

Mitochondrial DNA copy number in patients with systemic sclerosis.

Systemic scleroderma (SSc) is a chronic autoimmune disease of inflammatory origin. Mitochondrial dysfunction is considered as an important mechanism in the pathogenesis of SSc. Currently mitochondrial DNA (mtDNA) copy number is used as a surrogate marker of mitochondrial dysfunction.

Dual-mode colorimetric and fluorescence biosensors for the detection of foodborne bacteria.

Due to the growing demand for detection technologies, there has been significant interest in the development of integrated dual-modal sensing technologies, which involve combining two signal transduction channels into a single technique, particularly in the context of food safety. The integration of two detection signals not only improves diagnostic performance by reducing assumptions, but also enhances diagnostic functions with increased application flexibility, improved accuracy, and a wider detection linear range. The top two output signals for emerging dual-modal probes are fluorescent and colorimetric, due to their exceptional advantages for real-time sensitive sensing and point-of-care applications.

[Epstein-Barr virus (Herpesviridae: ) types 1 and 2 and other viral markers in patients with nasopharyngeal carcinoma in two geographically and ethnically distinct regions of Russia].

Introduction: The discovery of two types of Epstein-Barr virus (EBV) (EBV-1 and EBV-2) that have different biological properties stimulated the search for neoplasms associated with each type of the virus. The aim of the work is to study the nature of the association of nasopharyngeal cancer (NPC) with EBV-1 and EBV-2, serological activity for each viral type and the concentration of EBV DNA in the blood plasma of two gender, age and ethnic groups of NPC patients that represent geographically and climatically different regions of Russia,.

Materials And Methods: In the blood plasma of patients with NPC and other non- EBV associated tumors of oral cavity (OTOC) from the North Caucasian (NCFD) and Central (CFD) Federal Districts of Russia, the types of EBV and the concentration of viral DNA were determined using respectively «nested» and real time PCR; titers of IgG and IgA antibodies to viral capsid antigen (VCA) were measured in indirect immunofluorescence assay.

Development of an approach to determining enzymatic activity of ribonucleoside hydrolase c using hydrophilic interaction liquid chromatography.

Ribonucleoside hydrolase C (RihC, EC 3.2.2.

THE INCIDENCE OF SPORTS INJURIES AMONG SCHOOL-AGED CHILDREN AND ADOLESCENTS.

It is estimated that approximately one in ten school-aged children experience sports-related injuries annually. These injuries are most common at 12 years of age. Boys are more likely to get injured and more likely to get seriously injured than girls.

THE OCCURRENCE OF SPORTS INJURIES AMONG PRE-ADOLESCENTS.

Preschool children's harmonious development, cognitive and communicative abilities are enhanced through physical activities in sports, yet sports training and competition pose a risk of injury to children aged three to seven years due to their physiological and psychological features. Although sports injuries in preschool children are not common, they can be undesirable and unavoidable, and fortunately, these injuries are usually reversible. This review article presents data on the physiological features of the developing musculoskeletal system and its relationship to sports injuries in children, which together determine the nature of children's sports injuries.

[THE STATUS OF THE SERVICE OF MEDICAL STATISTICS ACCORDING TO THE STAFF SURVEY RESULTS].

Inroduction: The Medical Statistics Service plays an important role in providing a medical organization with timely, high-quality statistical information. Therefore, it is important to study the opinions of specialists on the organization of this work.

Purpose: To analyze the opinions of the staff of departments (offices) of medical statistics on the current work organization.

[Developing intellectual potential of medical organizations: Russian realities].

Introduction: The Russian healthcare system is in the process of transformation and changes, trying, on the one hand, to solve the accumulated problems, and on the other hand, to meet the modern agenda in the form of new challenges in the field of healthcare and rapidly developing information technologies. Meanwhile, in the course of ongoing reforms, questions of the formation and development of the intellectual potential of employees of medical organizations remain outside the brackets.

Purpose: The purpose of the study is to rethink various approaches to intellectual potential, and to identify trends in this area.

[Scientometric analysis of the main thematic fields and keywords in the subject area «Public health, environmental and occupational health»].

Research in the field of public health at the global, national, regional and organizational levels continue to be relevant, attracting attention of the researchers who find new aspects of various problems and issues for consideration and analysis in this area. The paper presents results of a scientometric analytical study of the publication landscape for 2019-2021 in the field of public health, using the analytical platform SciVal, the data source for which is the international scientific database Scopus. The study shows positive dynamics and steady growth in most scientometric indicators in the subject area under consideration during the study period.

[Dialogues with neural networks about the present and future of medical professions: risks and prospects].

The article examines the risks to social perception of health professions in the context of the growing popularity of generative textual and visual neural networks. The article is consistent with the growing body of research that tends to see more risks of this technology, including for healthcare. The second focus of the article - the stereotypes about health professions - is critical, as they have been associated with negative outcomes for the healthcare system.

[Characteristics of the value-based attitude of medical workers to healthy lifestyle].

Reduction in the medical labor reserve leads to economic losses, therefore, the issue related to medical personnel health improvement is relevant at all management levels in healthcare. The article presents results of the survey of doctors in Moscow, reflecting their own attitude to a healthy lifestyle and related self-preserving behavior patterns. The searches focused on the analysis of activities of medical workers related to health improvement and promotion and analysis of psychosocial attitudes of medical workers.

[Urban stress of a megalopolis resident: stress factors and correctioN].

Residents of a megalopolis are constantly exposed to urban stress - the combined effects of a number of different extreme factors and living conditions of the urban environment. Urban stress of a megalopolis resident has an extreme complex multifactorial effect on his body and psyche. The features of the existing subspecies of urban stress (ecological, psychological, social, informational, professional, related to the pandemic), as well as the main stress factors causing them, are considered.

[Behavior patterns of the population in relation to health].

In order to identify the basic patterns of behavior that reflect the attitude of Russians to their health, a large corpus of relevant scientific literature was analyzed, as well as actual statistical data and the results of representative sociological studies concerning various aspects of both self-preserving and self-destructive behavior of Russians. As a result, four basic models of behavior were formed and described, which differ in a set of positive and negative attitudes and characteristic lines of behavior in relation to one's health («a convinced healthy lifestyle person», «a beginner healthy lifestyle person», «irresponsible» and «self-destructive»). Based on the analysis of statistics and sociological information, it was concluded that even the behavioral model of a «beginner healthy lifestyle person» is implemented by a very minority of Russians.

Advantages and disadvantages of treatment of experimental ARDS by M2-polarized RAW 264.7 macrophages.

Innate immunity reactions are core to any immunological process, including systemic inflammation and such extremes as acute respiratory distress syndrome (ARDS) and cytokine storm. Macrophages, the key cells of innate immunity, show high phenotypic plasticity: depending on microenvironmental cues, they can polarize into M1 (classically activated, pro-inflammatory) or M2 (alternatively activated, anti-inflammatory). The anti-inflammatory M2 macrophage polarization-based cell therapies constitute a novel prospective modality.

Statistical model and method for analyzing AI conference rankings: China vs USA.

Artificial Intelligence (AI) is a rapidly developing field of research that attracts significant funding from both the state and industry players. Such interest is driven by a wide range of AI technology applications in many fields. Since many AI research topics relate to computer science, where a significant share of research results are published in conference proceedings, the same applies to AI.