3 results match your criteria: "People's Republic of China. shengdewu@hospital.cqmu.edu.cn.[Affiliation]"
Associations between maternal periconceptional exposure to PM and the risk of cryptorchidism: a case-control study of 4274.
Sci Rep
November 2024
Department of Urology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Children's Hospital of Chongqing Medical University, Chongqing, 400014, People's Republic of China.
Article Synopsis
- * It involved a case-control design with 2,137 children diagnosed with cryptorchidism and 2,137 matched controls, focusing on exposure levels of PM during the first two months of pregnancy.
- * The results indicate a positive correlation, suggesting that maternal exposure to PM2.5 in early pregnancy may increase the risk of their child developing cryptorchidism.
Multiple transcriptomic profiling: potential novel metabolism-related genes predict prepubertal testis damage caused by DEHP exposure.
Environ Sci Pollut Res Int
February 2022
Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
The toxic effect of di(2-ethylhexyl) phthalate (DEHP) on prepubertal testes was examined in this study. We treated 3-week-old male mice with 4.8 mg/kg/day (milligram/kilogram/day) (no observed adverse effect level), 30 mg/kg/day (high exposure dose relative to humans), 100 mg/kg/day (level causing a reproductive system disorder), and 500 mg/kg/day (dose causing a multigenerational reproductive system disorder) of DEHP via gavage.
View Article and Find Full Text PDFThe gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate.
Environ Sci Pollut Res Int
October 2020
Department of Urology, Children's Hospital of Chongqing Medical University, Yuzhong District, Chongqing, 400014, People's Republic of China.
Di-(2-ethylhexyl) phthalate (DEHP) is a common plasticizer, which is known to be an environmental endocrine-disrupting chemical that can jeopardize the male reproductive system. Prepuberal exposure to DEHP leads to steroidogenesis disorders. However, the specific mechanism remains ambiguous.
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