1 results match your criteria: "People's Republic of China. huangxiaoying@wzhospital.cn.[Affiliation]"
Fibroblast Growth Factor 21 Relieves Lipopolysaccharide-Induced Acute Lung Injury by Suppressing JAK2/STAT3 Signaling Pathway.
Inflammation
February 2024
Division of Pulmonary Medicine, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou Key Laboratory Interdiscipline and Translational Medicine, Wenzhou Key Laboratory of Heart and Lung, Wenzhou Medical University, Xuefu North Street, Wenzhou, Zhejiang, 325000, People's Republic of China.
Article Synopsis
- FGF21 shows promise as a protective agent against acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), conditions currently lacking effective treatments.
- Research demonstrated that FGF21 levels increased in lung tissues under inflammation but decreased in lung cells, leading to further investigation of its role in LPS-induced ALI.
- Results indicate that FGF21 deficiency worsens ALI, while its administration improves lung function and inflammation, potentially through inhibition of the JAK2/STAT3 signaling pathway, suggesting FGF21 could be a new therapeutic option for ALI.